LOCUS       NM_001085355           11325 bp    mRNA    linear   ROD 21-SEP-2024
DEFINITION  Mus musculus AT-rich interaction domain 1B (Arid1b), mRNA.
ACCESSION   NM_001085355 XM_001474848 XM_139711 XM_888675 XM_983766
VERSION     NM_001085355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11325)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11325)
  AUTHORS   Zhang,M., Guo,T., Pei,F., Feng,J., Jing,J., Xu,J., Yamada,T.,
            Ho,T.V., Du,J., Sehgal,P. and Chai,Y.
  TITLE     ARID1B maintains mesenchymal stem cell quiescence via inhibition of
            BCL11B-mediated non-canonical Activin signaling
  JOURNAL   Nat Commun 15 (1), 4614 (2024)
   PUBMED   38816354
  REMARK    GeneRIF: ARID1B maintains mesenchymal stem cell quiescence via
            inhibition of BCL11B-mediated non-canonical Activin signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11325)
  AUTHORS   D'Ambrosio,A., Bressan,D., Ferracci,E., Carbone,F., Mule,P.,
            Rossi,F., Barbieri,C., Sorrenti,E., Fiaccadori,G., Detone,T.,
            Vezzoli,E., Bianchi,S., Sartori,C., Corso,S., Fukuda,A.,
            Bertalot,G., Falqui,A., Barbareschi,M., Romanel,A., Pasini,D. and
            Chiacchiera,F.
  TITLE     Increased genomic instability and reshaping of tissue
            microenvironment underlie oncogenic properties of Arid1a mutations
  JOURNAL   Sci Adv 10 (11), eadh4435 (2024)
   PUBMED   38489371
REFERENCE   4  (bases 1 to 11325)
  AUTHORS   Kim,H. and Kim,E.
  TITLE     Genetic background determines synaptic phenotypes in Arid1b-mutant
            mice
  JOURNAL   Front Psychiatry 14, 1341348 (2024)
   PUBMED   38516548
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11325)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 11325)
  AUTHORS   de la Serna,I.L., Carlson,K.A. and Imbalzano,A.N.
  TITLE     Mammalian SWI/SNF complexes promote MyoD-mediated muscle
            differentiation
  JOURNAL   Nat Genet 27 (2), 187-190 (2001)
   PUBMED   11175787
REFERENCE   7  (bases 1 to 11325)
  AUTHORS   Klochendler-Yeivin,A., Fiette,L., Barra,J., Muchardt,C., Babinet,C.
            and Yaniv,M.
  TITLE     The murine SNF5/INI1 chromatin remodeling factor is essential for
            embryonic development and tumor suppression
  JOURNAL   EMBO Rep 1 (6), 500-506 (2000)
   PUBMED   11263494
REFERENCE   8  (bases 1 to 11325)
  AUTHORS   Zhang,H.S., Gavin,M., Dahiya,A., Postigo,A.A., Ma,D., Luo,R.X.,
            Harbour,J.W. and Dean,D.C.
  TITLE     Exit from G1 and S phase of the cell cycle is regulated by
            repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
  JOURNAL   Cell 101 (1), 79-89 (2000)
   PUBMED   10778858
REFERENCE   9  (bases 1 to 11325)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   10 (bases 1 to 11325)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126929.3, BF462904.1, AC166064.4 and CK389103.1.
            
            On or before Jul 25, 2007 this sequence version replaced
            XM_983766.2, XM_139711.8, XM_888675.2, XM_001474848.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1419              AC126929.3         27641-29059
            1420-1884           BF462904.1         73-537
            1885-2128           AC166064.4         26376-26619
            2129-2218           AC166064.4         47580-47669
            2219-2398           AC166064.4         62751-62930
            2399-2726           AC166064.4         74504-74831
            2727-3141           CK389103.1         82-496              c
            3142-3351           AC166064.4         102189-102398
            3352-3556           AC166064.4         104821-105025
            3557-3695           AC166064.4         110824-110962
            3696-3868           AC166064.4         111197-111369
            3869-4019           AC166064.4         116035-116185
            4020-4116           AC166064.4         118512-118608
            4117-4900           AC166064.4         120073-120856
            4901-5031           AC166064.4         122764-122894
            5032-11325          AC166064.4         124911-131204
FEATURES             Location/Qualifiers
     source          1..11325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 2.83 cM"
     gene            1..11325
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="AT-rich interaction domain 1B"
                     /db_xref="GeneID:239985"
                     /db_xref="MGI:MGI:1926129"
     exon            1..1419
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..6756
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="AT rich interactive domain 1B (Swi1 like);
                     BRG1-associated factor 250b; ARID domain-containing
                     protein 1B; AT rich interactive domain 1B (SWI-like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein
                     1B"
                     /protein_id="NP_001078824.1"
                     /db_xref="CCDS:CCDS49929.1"
                     /db_xref="GeneID:239985"
                     /db_xref="MGI:MGI:1926129"
                     /translation="METGLLPNHKLKAVGEAPAAPPHQQHHHHHAHHHHHHHAHHLHH
                     LHHHHALQQQLNQFQQPQPPQPQQQQPPPPPQQQHPTANNSLGGAGGGAPQPGPDMEQ
                     PQHGGAKDSVAGNQADPQGQPLLSKPGDEDDAPPKMGEPAGSRYEHPGLGAQQQPAPV
                     AVPGGGGGPAAVSEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAA
                     GAPSSMDPLQNSHEGYPNSQYNHYPGYSRPGAGGGGGGGGGGGGSGGGGGGGGAGGAG
                     GAAAAAAGAGAVAAAAAAAAAAAAAAGGGGGGGYGSSSSGYGVLSSPRQQGGGMMMGP
                     GGGGAASLSKAAAGAAAAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYP
                     DYSSSSAPPPPSQPQSQAAAGAAAGGQQAAAGMGLGKDLGAQYAAASPAWAAAQQRSH
                     PAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGTHPHSQPQQSSPYPGGSYGPPGAQ
                     RYPLGMQGRAPGALGGLQYPQQQMPPQYGQQAVSGYCQQGQQPYYNQQPQPSHLPPQA
                     QYLQPAAAQSQQRYQPQQDMSQEGYGTRSQPPLAPGKSNHEDLNLIQQERPSSLPDLS
                     GSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPV
                     GSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMTGTQR
                     NPQMSQYGPQQTGPSMSPHPSPGGQMHPGISNFQQSNSSGTYGPQMSQYGPQGNYSRT
                     PTYSGVPSASYSGPGPGMGINANNQMHGQGPAQPCGAMPLGRMPSAGMQNRPFPGTMS
                     SVTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGL
                     VASSSPYSQSMNNNSSLMSTQAQPYSMTPTMVNSSTASMGLADMMSPSESKLSVPLKA
                     DGKEEGVSQPESKSKDSYGSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISS
                     PGWPKTPSSPKSSSSSTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAV
                     GKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFA
                     FECKTERGEEPPPEVFSTGDSKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGD
                     LKPPTPASTPHGQMTPMQSGRSSTVSVHDPFSDVSDSAYPKRNSMTPNAPYQQGMGMP
                     DMMGRMPYEPNKDPFSGMRKVPGSSEPFMTQGQVPNSGMQDMYNQSPSGAMSNLGMGQ
                     RQQFPYGTSYDRRHEAYGQQYPGQGPPTGQPPYGGHQPGLYPQQPNYKRHMDGMYGPP
                     AKRHEGDMYNMQYGSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYNRERMQGPGQMQPH
                     GIPPQMMGGPMQSSSSEGPQQNMWATRNDMPYPYQSRQGPGGPAQAPPYPGMNRTDDM
                     MVPEQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQSSYQTPPSLPNHISRAPSPA
                     SFQRSLESRMSPSKSPFLPTMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEA
                     SQPILKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNL
                     SQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHRSGKKDDSQSLEDDSGKE
                     DDDAECLVEEEEEEEEEEEDSEKIESEGKSSPALAAPDASVDPKETPKQASKFDKLPI
                     KIVKKNKLFVVDRSDKLGRVQEFSSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPP
                     PPLSSTGKKKELEGKGDSEEQPEKSIIATIDDVLSARPGALPEDTNPGPQTDSGKFPF
                     GIQQAKSHRNIRLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDA
                     EMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLR
                     DNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQ
                     RLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSN
                     LAQGDTLAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMM
                     CRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQL"
     exon            1420..1614
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1773
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1884
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2128
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2218
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2398
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2726
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2872
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2982
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3141
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3351
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3556
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3695
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3868
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..4019
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4116
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            4117..4900
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            4901..5031
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..11325
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6899..6904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="hexamer: ATTAAA"
     polyA_site      6932
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="major polyA site"
     regulatory      8164..8169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="hexamer: AATAAA"
     polyA_site      8188
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="major polyA site"
     polyA_site      8653
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
     regulatory      9512..9517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="hexamer: AATAAA"
     regulatory      9524..9529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="hexamer: AAGAAA"
     polyA_site      9534
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
     polyA_site      9558
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
     regulatory      11305..11310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
                     /note="hexamer: AATAAA"
     polyA_site      11325
                     /gene="Arid1b"
                     /gene_synonym="8030481M12; 9330189K18Rik; Ardi1b;
                     B230217J03Rik; BAF250B; mKIAA1235"
ORIGIN      
        1 tcggcgggcc ccggctcgac catggagacc gggctgctcc ccaaccacaa actgaaagcc
       61 gttggcgagg cccccgctgc accgccccat cagcagcacc accaccacca tgcccaccac
      121 caccaccacc accatgccca ccacctccac cacctccacc accaccacgc actacagcag
      181 cagctaaacc agttccagca gccgcagccg ccgcagccac agcagcagca gccgccgcca
      241 ccgccgcagc agcagcatcc cactgccaac aacagcctgg gcggtgcggg cggcggcgcg
      301 cctcagcccg gcccggacat ggagcagccg caacatggag gcgccaagga cagtgtcgcg
      361 ggcaatcagg ctgacccgca gggccagcct ctgctgagca aaccgggcga cgaggacgac
      421 gcgccgccca agatggggga gccggcgggc agccgctatg agcacccggg cctgggcgcg
      481 cagcagcagc ccgcgccggt cgccgtgccc gggggcggcg gcggcccagc ggccgtctcg
      541 gagtttaata attactatgg cagcgctgcc cctgctagcg gcggccccgg cggccgcgct
      601 gggccttgct ttgatcaaca tggcggacaa caaagccccg ggatggggat gatgcactcc
      661 gcctctgccg ccgccggggc ccccagcagc atggaccccc tgcagaactc ccacgaaggg
      721 taccccaaca gccagtacaa ccattatccg ggctacagcc ggcccggcgc gggcggcggc
      781 ggcggcggcg gcggaggagg aggaggcagc ggaggaggtg gaggaggagg aggagcagga
      841 ggagcaggag gagcagcggc agcggcagca ggagccggag ctgtggcggc ggcggccgcg
      901 gcggcggcgg cagcagcagc agcagcagga ggaggcggtg gcggcggcta tgggagctcg
      961 tcctcggggt acggggtgct gagctccccg cggcagcagg gcggcggcat gatgatgggc
     1021 cccgggggcg gcggggccgc gagcctcagc aaggcggccg ccggcgcggc ggcggcggcg
     1081 gggggcttcc agcgcttcgc cggccagaac cagcacccgt cgggggctac accgaccctc
     1141 aaccagctgc tcacctcacc cagccccatg atgaggagct acggcggtag ctaccccgac
     1201 tacagcagct ccagcgcgcc gccgccgccg tcgcagcccc agtcccaggc ggcggcgggg
     1261 gcggcggcgg gtggccagca ggcggccgcg ggcatgggct tgggcaagga cctaggcgcc
     1321 cagtacgccg ctgccagccc ggcctgggcg gccgcgcaac aaaggagtca cccggcgatg
     1381 agccccggca cccccggacc gaccatgggc agatcccagg gcagcccgat ggacccaatg
     1441 gtgatgaaga gacctcagtt gtatgggatg ggtactcacc cccactccca gccacagcag
     1501 agcagcccat acccaggagg ctcctacggt cccccaggtg cacagcggta tccccttggc
     1561 atgcagggcc gggctccagg ggccctggga ggcttgcagt acccgcagca gcagatgcca
     1621 ccgcagtacg gacagcaagc tgtgagtggc tactgccagc aaggccagca gccatactac
     1681 aaccagcagc cgcagccctc gcacctcccg ccccaggcac agtacctgca gccggcggcg
     1741 gcgcagtccc agcagaggta ccagccacag caggacatgt ctcaagaagg ctatggaact
     1801 agatctcagc ctcctctggc ccctggaaaa tccaaccatg aagacttgaa tttaattcaa
     1861 caggaaagac catcgagtct accagacctg tctggctcca tcgatgacct ccccacggga
     1921 acagaagcaa ctctgagctc agcagtcagt gcatccgggt ctacaagcag ccagggagat
     1981 cagagcaacc cagcgcagtc tcctttctcc ccacatgcat cacctcacct ctccagcatc
     2041 cctggagggc cgtcaccttc tcctgttggc tctcctgtgg gaagcaacca atcgaggtct
     2101 ggtccgatct cccctgcgag tattccaggt agccagatgc ctccgcaacc acctggaagc
     2161 cagtcagaat ccagttccca tcctgccttg agccagtcac caatgccaca ggaaagaggt
     2221 tttatgacag gcactcagag aaaccctcag atgtctcagt acggacctca gcagacagga
     2281 ccatccatgt cgcctcaccc atctcctggg ggccagatgc atcctgggat cagtaacttt
     2341 cagcagagta actcaagtgg cacgtacggc ccacagatga gccagtatgg accccaaggc
     2401 aactactcca gaaccccaac atatagcggg gtacccagtg caagctacag cggcccaggg
     2461 cccggtatgg gcatcaatgc caacaaccag atgcatggac aagggccagc ccagccatgt
     2521 ggtgctatgc ccctgggacg aatgccttca gctgggatgc agaacagacc atttcctgga
     2581 accatgagca gcgtcacccc cagttctcct ggcatgtctc aacagggagg gccaggaatg
     2641 ggcccaccaa tgcccactgt gaaccggaag gcccaggaag ctgccgcagc tgtgatgcag
     2701 gctgctgcaa actcagcaca aagcaggcaa ggcagttttc ctggcatgaa ccagagtggc
     2761 ctggtggcct ccagctctcc ctacagccag tccatgaaca acaactccag cctgatgagc
     2821 acccaggccc agccctacag catgacgccc acaatggtga acagctccac agcatctatg
     2881 ggtcttgcag atatgatgtc tcccagtgag tccaaattgt ctgtgcctct taaagcagat
     2941 ggtaaagaag aaggcgtgtc ccagcctgag agcaagtcaa aggacagcta tggctctcag
     3001 ggcatttccc agcctccaac cccaggcaac ctgcctgtcc cttccccaat gtctcccagc
     3061 tctgccagca tctcctcctt tcatggagat gagagtgaca gcattagcag cccaggctgg
     3121 cccaagacac catcaagccc taagtccagc tcttcctcca ccactgggga gaagatcacg
     3181 aaggtctatg agctggggaa tgagccggag aggaagctgt gggtcgaccg ttacctaacg
     3241 ttcatggaag agaggggctc cccggtgtcc agtctgccag cagtgggcaa gaagcccctg
     3301 gacctgttcc gactgtatgt ctgcgtcaag gagattggag gtttggcgca ggttaataaa
     3361 aacaagaagt ggcgtgagct ggcaaccaac ctgaacgttg gcacttccag cagcgcagcc
     3421 agctctctga aaaagcagta tattcagtac ctgttcgcct ttgagtgcaa aactgagcgc
     3481 ggggaggagc ccccacctga agtcttcagc accggggatt cgaagaagca gccaaagctc
     3541 cagccgccat ctcctgctaa ctcaggatcc ttacaaggcc cacagactcc acagtcaact
     3601 gggagcaatt cgatggcaga ggttccaggt gacctgaagc caccaacccc agcctctacc
     3661 cctcatggac agatgactcc catgcaaagc ggaagaagca gtacagtcag tgtgcatgac
     3721 ccgttctcag acgtgagtga ctcagcgtac ccaaaacgga actccatgac tccaaacgcc
     3781 ccataccagc agggcatggg catgccagac atgatgggca ggatgcccta tgaacccaac
     3841 aaggaccctt tcagtggaat gagaaaagtg cctggaagta gtgagccctt tatgacacaa
     3901 ggacaggtgc ccaacagcgg catgcaggac atgtacaacc agagcccctc aggggccatg
     3961 tccaatctgg gcatgggaca gcggcagcag tttccctatg gaaccagtta tgaccgaagg
     4021 catgaggctt acggacagca gtacccaggc caaggccctc ccacaggaca gccaccgtat
     4081 ggaggacacc agcctggcct gtacccacag cagccgaatt acaaacgtca tatggatggc
     4141 atgtacgggc ctccagccaa gcggcacgag ggagacatgt acaacatgca gtatggcagc
     4201 cagcagcagg agatgtataa ccagtatgga ggctcctact ctggcccgga cagaaggccc
     4261 atccagggac aatatcccta cccctacaac agagaaagga tgcagggccc aggccagatg
     4321 cagccacacg gaatcccacc tcagatgatg gggggcccca tgcagtcatc ctccagcgag
     4381 gggcctcagc agaacatgtg ggctacacgc aacgatatgc cttatcccta ccagagcagg
     4441 caaggcccgg gcggccctgc acaggccccc ccttacccag gcatgaaccg cacagatgat
     4501 atgatggtac ctgagcagag gatcaatcac gagagccagt ggccttctca cgtcagccag
     4561 cgccagcctt acatgtcatc ttcggcctcc atgcagccca tcacgcgccc acctcagtca
     4621 tcctaccaga cgccgccgtc actgccaaac cacatctcca gggcacccag ccccgcctcc
     4681 ttccagcgct ccctggagag tcgcatgtct ccaagcaagt ctcccttcct gcccaccatg
     4741 aagatgcaga aggtcatgcc cacagtcccc acatcccagg tcaccgggcc ccccccacag
     4801 cctccaccaa tcagaaggga gattaccttt cctcctggct ccgtagaagc atcacagcca
     4861 atcctgaaac aaaggcgaaa gattacctca aaagatattg ttactcccga ggcgtggcgt
     4921 gtgatgatgt cccttaaatc gggtctgttg gctgagagca cgtgggctct ggacaccatc
     4981 aatattctcc tctatgatga cagcaccgtc gccaccttca atctttccca gctgtctgga
     5041 ttcctggaac tattagtaga gtactttcga aaatgcctaa ttgacatttt cggaattctt
     5101 atggaatatg aagtgggtga ccccagccaa aaggctcttg atcaccgttc agggaagaaa
     5161 gatgacagcc agtccctgga agatgattct gggaaggaag acgatgatgc tgagtgtctt
     5221 gtggaagagg aggaggagga agaggaggag gaggaagaca gtgaaaagat agagtcagag
     5281 gggaagagca gccctgccct agctgctcca gatgcctccg tggaccccaa ggagacgcca
     5341 aagcaggcca gtaagtttga caagctgccc ataaagattg tcaaaaagaa caagctgttt
     5401 gtggtggacc ggtccgacaa gctgggccga gtgcaggagt tcagcagcgg gctcctccac
     5461 tggcagctgg gtggtggcga cactaccgag cacatccaga ctcacttcga gagcaagatg
     5521 gagatccctc ctcgcaggcg tccacctccg cctctaagct ccacgggtaa gaagaaagag
     5581 ctggaaggca aaggtgattc tgaagagcag ccagagaaaa gtatcatagc caccatcgat
     5641 gacgtcttgt ctgcccggcc aggggctctg cctgaagaca ccaacccagg accccagacc
     5701 gacagcggca agtttccctt tggaatccag caggccaaaa gccaccggaa catcaggctc
     5761 ctggaagacg agcccaggag ccgagacgag acgccgctgt gcaccatcgc gcactggcag
     5821 gactcactgg ccaagcgctg catctgtgtg tcgaacatcg tgcggagctt gtctttcgtg
     5881 cctggcaacg acgcagagat gtccaaacac ccgggcttgg tgctgatcct gggaaagctg
     5941 attctgctgc atcacgagca tccggagaga aagcgggcgc cacagaccta tgagaaggag
     6001 gaggacgagg acaagggggt ggcctgcagc aaagatgagt ggtggtggga ctgcctcgag
     6061 gtcttgcggg ataacaccct ggtcacgttg gcgaacattt ccgggcagct agacttgtct
     6121 gcttacacag agagcatctg cttgccgatc ctggacggct tgctacactg gatggtgtgc
     6181 ccgtccgcag aggctcagga cccctttccc actgtggggc ccaactcagt cctgtcgccg
     6241 cagagacttg tgctggagac cctgtgtaaa ctcagtatcc aggacaacaa cgtggacctg
     6301 atcttggcca cgcctccatt tagtcgtcag gagaaatttt atgctacatt agttaggtac
     6361 gttggggatc gcaaaaatcc agtctgtcga gaaatgtcca tggcgctttt atcgaacctt
     6421 gcccaggggg acacactggc ggcgagggca atagctgtgc agaaaggaag cattggtaac
     6481 ttgataagct tcctagagga cggggtgacg atggcgcagt accagcagag ccagcataac
     6541 cttatgcaca tgcagccccc acctctggaa ccccctagtg tagacatgat gtgccgggcg
     6601 gccaaagctc tgctggccat ggccagagtg gacgagaacc gctcggagtt ccttttgcac
     6661 gagggtcggt tgctggatat ctcaatatca gctgtcctga actctctggt tgcatctgtc
     6721 atctgtgatg tactgtttca gattgggcag ttatgacatc cgtgaaggca cacatgtgtg
     6781 agtgaacatt agagggtcac atataactgg ctgttttctg ttctcgttta tccagtgtaa
     6841 gaagaaggaa aagaaaaatc tttgctcctc tgccccgttt actatttacc aattgggaat
     6901 taaatcatta atttgaacag ttataaaatt aatatttgct gtctgtgtgt ataagtacat
     6961 cctctggcgg ttttctgttt cttttttttt taaccaaagt tgccgtctag tgcattcaaa
     7021 ggtcacaatt tttgtttgtt tgtttgtttg tttgtttttt cataattttt ttcatgttgt
     7081 attgcagtct ttgggaagtg aattgacttt ataaagaaaa acgttttggc aaaaagtgct
     7141 aagatagaaa aatgtcacca cactgggtca aaaacgtgaa aggaaaaatt gattcttaaa
     7201 ttgatttcct atgaatttta ttcttcacag aatgataaaa gctaaactgc accccgtcac
     7261 ccaaagctct gtgcaataga aacttctaga gatatagtgt aggggctgaa ggaggtatgg
     7321 cagcagtagt cagggtcaat gatactgctt tctccaccgg aaagtggtta cgttaggcct
     7381 cgagcaaaaa acagcgctct cagataggtg caaaaatcca ctcctagcag ccaacagcag
     7441 gatcgcttcc tcaccacgac cgccatgtct gctgtggctc agcctccacg ggacaaagct
     7501 tcaagatttc tttcatcatt tttttaaata ttttttttac tgcctatggg ctgtgatgta
     7561 tatagaagtt gtacattaaa cataccctca tttttttctt cttttctttt tttctttttt
     7621 tctttttctt tttttttttt tttagtacaa agtttttagt ttctttttca tgatgtggta
     7681 actacgaagt gatggtagat ttaaataatt ttttattttt attttatata ttttttcatt
     7741 aggaccatat ctccaaaaaa caagaaaaag aaacaaaaaa tacaaaaaat aaaaacaaac
     7801 aaaaaaagag ggtaatgtac aagtttctgt atgtataaag tcatgctctg ttgggagagc
     7861 ggctgatccc agtttgcttc atgaatcaaa gtgtggaaat ggttgcatac agattgattt
     7921 agaaaatgga caccagtaca tacaaaaaaa gaaaaaagaa agaaaaccaa ctaaatggaa
     7981 gaaacacaac ttcaaagatt tttctgtgac aagaatccac atttgtattt caagataatg
     8041 tagtttaaga aaagaaaaaa aagaaaaaaa aagaaaaaaa cttgatgtaa attcctcctt
     8101 ttcctctggc ttaatgaata tcatttattc agtataaaat ctttatatgt cccacatgtt
     8161 aagaataaat gtacattaaa tcttgttacg cactgtgatg ggtgttcttg aatgctgttc
     8221 tagtttgcct agcatggttg ccatagtaac caagttattt acaggaaata gggaagatgt
     8281 aacaactgct tcctggtaat gatgcccaaa ggccagaagg gactttcagg gtttcctact
     8341 tgagagtggg agcaacaatt tgattttctc agattgttta gctaattagg tcttctttga
     8401 agcaattaac tctggtgaca ttgagaagtg gtaattccct catggatggg tggtggctgc
     8461 caacccactg tgacatgggg ccctgcaagc taactggcct gaaaccacga ccttctgcct
     8521 ctcactactg atttaaccca agtctgcacc cgtcatgttt cttctgtgtg cctccaagtt
     8581 actctgcgtt agtttgctcc agcgtgtata atatttatat tgtgcaatgt taaagagaac
     8641 gtgtcatatt gtatgccgtg tgtatagtgc caagtgatga ttctgtttca gagcatacct
     8701 tccttcctgc ccagtccctg gctctctaat accccaccct gatggaaagt gcttcttcct
     8761 gggtaattga ctgttactgt gtaacgctca gtctcattga aacttacata accatgctgc
     8821 tggtgcccct tcctacccta cctctctcag cactcttcag ttgacacttc ccacacctgt
     8881 cactgtggcc caccttgctc acgctgacat ctggaagagt tagacaggag cacacactta
     8941 caacactagg agatgttatt ctggtgtcac gagaaagaaa ttggtttttc ctgcaaacag
     9001 tcccatcacc aagcagcccc cacatcaggt cagcaaaaag atctgtgttg aatcaaaact
     9061 ccatttataa ttctactaga tgggaataca tctgcttaca aaggacagat tttagtgttc
     9121 tgtgatgaaa atatggagag tgcaagagag agttcaatgg aatcctaatc ttgctcttgc
     9181 agacaatgaa tgaaaggtat agacaggctc agttccctgt cagaagagtg gtctcaaaga
     9241 caagtggctg tatagcagcc aggcccagaa cagcctcgca gcacacacta acaccaagcg
     9301 ggtgtctgag ctctcctagg aagccttgtg cctgccctcc ctccattcac ccagatccga
     9361 ctcctggaag cccacgaaag agtcaccctt tgcttcacat ttcctgacga taccgagttg
     9421 ctgctctgtc ctaaaaatat tagttctttt ccagggcttt cagaaatttg caggatgccc
     9481 atactctaaa tgtgtaccaa aaagagagag aaataaaggt gcgaagaaag tttagtattt
     9541 tggaatggtg cgataaaatg gaatctgttg gtttttaatg taacataaga tactattggc
     9601 tggcactggc taaaaaaaat atctaagtgt tggagttgga tgcacaatca acttttactt
     9661 agctattcaa agagtactta tgttttccaa gttaaaacag acttgttttt gacaggggcc
     9721 gtgggtggtc ttatacaatg ccagctccta actgcagctt ctgagaactg gatatcgttt
     9781 gccctgagag ctgcccgtct ccaactatgt gctgctgctg ccctgtgtgc tcagcccaca
     9841 aggatgtgga gactggatag acaacccctt gcttcttgct gggttgtgct gagttctttg
     9901 cagtccagtc aagtgcccag agctaccagc ctacgtccct catgcatcca agagaaatga
     9961 tcttgactat catgatcaaa acagctgtag taatatttct agtaaatatt tctgatgact
    10021 ctgtgtaatc tcctacaaca ggacactatt cattaacttg acagagacat gtgggcatgt
    10081 ggtcctgctt tagtttaaca gacaagtcaa ccagttctca ttacttagga agagtgaggc
    10141 tatgtctgtt acaatcccaa tgtggtgctt gcccttatcc aaagacagtc cgggggccct
    10201 gtctgcctga actatgtctc gctccctctt gggcttccca ctgggatgtg aaaagataac
    10261 caatggctcc caggttccca gtgcccccca aaccagtaat caggtctggg actacagaac
    10321 ccgcaaaatc atacacaggc tgtttcaaag ccagtactct ctttatactc ctgcttcctc
    10381 cagcccccat ttcacacccc acccaaatca caaggtcctc tgaagtctca gaactccaaa
    10441 ttaacgttgg gatttacgat gtgaatgctg aggagaaaat tgggagttgg tgggagatca
    10501 ccaaattgtc aaaactatga aactcatctg tcttcccaaa tctgacctca gggacttggg
    10561 gggttcactc tggcttctgc cacagtattt tctggggaac caaaggcctc gggaatagag
    10621 aaacaggttg ccggatatcc tggaagtcta agccatactg accagtttgt cttgagtgtt
    10681 ttctttgtga gcctggaact gtccccggac ccctttcttt taaacatggt tcaggacttt
    10741 aaaaaaaagc actgtatttt ttttatgtaa gccaagatgc cctccctagc agagatagcg
    10801 ttgaactgtc tctagttctg tagcctgaga gacttaaatc gtttaacttc agtgtctttg
    10861 tccactctgt tgaactgcta aggattctat tgaatgtgtt ctttgcggct ttggaggagt
    10921 tgctgggtgt gtaagtcctg catccctttg cctggtatgt gtatattatt cctttgcctg
    10981 gctgtgtatc gttcttcagt gtaagtacac ccacactctg tattcctttg cctgctcccc
    11041 gcccccccac acacacacat cctgcatagt tttaaaataa ggcctgagag actgtttcta
    11101 tttcctgtca tagctggtga cttttaacag ttgaggcgaa tggcctgtca cttgcctggg
    11161 ttcccgtcag gggtgatcca tggaactcct cagtggaaca gaatttagga cagaagatcc
    11221 caccttcctt ccaggcctgg ggagaatcag actgtgagat aaaccatgat gctgcccaat
    11281 cccactgccc caccttgctt ttaaaataaa gtgcctccta acgtc
//
