LOCUS       NM_001405901            5420 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus CDC42 guanine nucleotide exchange factor 9 (Arhgef9),
            transcript variant 4, mRNA.
ACCESSION   NM_001405901 XM_036161928
VERSION     NM_001405901.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5420)
  AUTHORS   Wagner,S., Lee,C., Rojas,L., Specht,C.G., Rhee,J., Brose,N. and
            Papadopoulos,T.
  TITLE     The alpha3 subunit of GABAA receptors promotes formation of
            inhibitory synapses in the absence of collybistin
  JOURNAL   J Biol Chem 296, 100709 (2021)
   PUBMED   33901490
REFERENCE   2  (bases 1 to 5420)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   3  (bases 1 to 5420)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   4  (bases 1 to 5420)
  AUTHORS   Hines,R.M., Maric,H.M., Hines,D.J., Modgil,A., Panzanelli,P.,
            Nakamura,Y., Nathanson,A.J., Cross,A., Deeb,T., Brandon,N.J.,
            Davies,P., Fritschy,J.M., Schindelin,H. and Moss,S.J.
  TITLE     Developmental seizures and mortality result from reducing GABAA
            receptor alpha2-subunit interaction with collybistin
  JOURNAL   Nat Commun 9 (1), 3130 (2018)
   PUBMED   30087324
  REMARK    GeneRIF: Collybistin binds the GABAAR-alpha2-subunit with high
            affinity
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5420)
  AUTHORS   Jung,E.M., Moffat,J.J., Liu,J., Dravid,S.M., Gurumurthy,C.B. and
            Kim,W.Y.
  TITLE     Arid1b haploinsufficiency disrupts cortical interneuron development
            and mouse behavior
  JOURNAL   Nat Neurosci 20 (12), 1694-1707 (2017)
   PUBMED   29184203
REFERENCE   6  (bases 1 to 5420)
  AUTHORS   Jedlicka,P., Papadopoulos,T., Deller,T., Betz,H. and
            Schwarzacher,S.W.
  TITLE     Increased network excitability and impaired induction of long-term
            potentiation in the dentate gyrus of collybistin-deficient mice in
            vivo
  JOURNAL   Mol Cell Neurosci 41 (1), 94-100 (2009)
   PUBMED   19236916
  REMARK    GeneRIF: Data provide the first evidence that collybistin
            deficiency leads to significant changes of GABAergic inhibition,
            network excitability and synaptic plasticity in vivo.
REFERENCE   7  (bases 1 to 5420)
  AUTHORS   Papadopoulos,T., Eulenburg,V., Reddy-Alla,S., Mansuy,I.M., Li,Y.
            and Betz,H.
  TITLE     Collybistin is required for both the formation and maintenance of
            GABAergic postsynapses in the hippocampus
  JOURNAL   Mol Cell Neurosci 39 (2), 161-169 (2008)
   PUBMED   18625319
REFERENCE   8  (bases 1 to 5420)
  AUTHORS   Papadopoulos,T., Korte,M., Eulenburg,V., Kubota,H.,
            Retiounskaia,M., Harvey,R.J., Harvey,K., O'Sullivan,G.A., Laube,B.,
            Hulsmann,S., Geiger,J.R. and Betz,H.
  TITLE     Impaired GABAergic transmission and altered hippocampal synaptic
            plasticity in collybistin-deficient mice
  JOURNAL   EMBO J 26 (17), 3888-3899 (2007)
   PUBMED   17690689
  REMARK    GeneRIF: Cb is essential for gephyrin-dependent clustering of a
            specific set of GABA(A) receptors, but not required for glycine
            receptor postsynaptic localization.
REFERENCE   9  (bases 1 to 5420)
  AUTHORS   Xiang,S., Kim,E.Y., Connelly,J.J., Nassar,N., Kirsch,J.,
            Winking,J., Schwarz,G. and Schindelin,H.
  TITLE     The crystal structure of Cdc42 in complex with collybistin II, a
            gephyrin-interacting guanine nucleotide exchange factor
  JOURNAL   J Mol Biol 359 (1), 35-46 (2006)
   PUBMED   16616186
  REMARK    GeneRIF: The resolution crystal structure of the Cdc42-collybistin
            II complex reveals a novel conformation of the switch I region of
            Cdc42, and biochemical data indicate that gephyrin negatively
            regulates collybistin activity.
REFERENCE   10 (bases 1 to 5420)
  AUTHORS   Kneussel,M., Engelkamp,D. and Betz,H.
  TITLE     Distribution of transcripts for the brain-specific GDP/GTP exchange
            factor collybistin in the developing mouse brain
  JOURNAL   Eur J Neurosci 13 (3), 487-492 (2001)
   PUBMED   11168555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807821.8 and BX470092.12.
            
            On May 6, 2022 this sequence version replaced XM_036161928.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.69626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-773               AL807821.8         104011-104783       c
            774-840             AL807821.8         103437-103503       c
            841-1020            AL807821.8         69254-69433         c
            1021-1212           AL807821.8         50773-50964         c
            1213-1392           AL807821.8         39375-39554         c
            1393-1625           AL807821.8         19896-20128         c
            1626-1755           AL807821.8         15857-15986         c
            1756-1887           AL807821.8         9591-9722           c
            1888-2131           BX470092.12        90828-91071         c
            2132-2200           BX470092.12        86954-87022         c
            2201-5420           BX470092.12        80946-84165         c
FEATURES             Location/Qualifiers
     source          1..5420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 41.85 cM"
     gene            1..5420
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /note="CDC42 guanine nucleotide exchange factor 9"
                     /db_xref="GeneID:236915"
                     /db_xref="MGI:MGI:2442233"
     exon            1..773
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             769..2382
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /note="isoform c is encoded by transcript variant 4; rho
                     guanine nucleotide exchange factor 9; collybistin;
                     rac/Cdc42 guanine nucleotide exchange factor 9; CDC42
                     guanine nucleotide exchange factor (GEF) 9"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 9 isoform
                     c"
                     /protein_id="NP_001392830.1"
                     /db_xref="GeneID:236915"
                     /db_xref="MGI:MGI:2442233"
                     /translation="MTFAIEGFQFLIWKAAIVKTFVKALITGDSIVSAEAVWDHVTMA
                     NRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQN
                     GHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDM
                     FSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEY
                     CNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAE
                     LLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDIL
                     DRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKY
                     EVIDIEDGRDDDFNVSMKNAFKLHNKETEEVHLFFAKKLEEKIRWLRAFREERKMVQE
                     DEKIGFEISENQKRQAAMTVRKASKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIA
                     QSQVFEFTEPKRSQSPFWQNFSRLTPFKK"
     exon            774..840
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1020
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1212
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1392
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1625
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1755
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1887
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2131
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2200
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..5420
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2437
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
     regulatory      5400..5405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5420
                     /gene="Arhgef9"
                     /gene_synonym="9630036L12Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtagcctgg aatcccttga agagagctag cagacgagag agatcttagg aagctgatga
       61 actagaaaga gtaggggaga ctgagactga ccggtagcca gctaggcaga cagacgcatg
      121 cccggacaga ctctggagaa ccgataggtt cattttgcct ttctttttga aaagcaggat
      181 tttgattttt ctgtggcgcc caagagagaa tgctggactc tgctaccttc agcttaagct
      241 aagatttctc agttagggag gaaagatcag cccagtcccg agagggggag ggaagcaaaa
      301 gcccctgcct ccaaccccct tccctccccc ggaccaaact cggggaccaa acccagacct
      361 tccctaacca tctgacttcc tcctttcctt tttagcatgg tggctgtatg gacagtctga
      421 cagaacagag attgacatct cccaatctgc cggcccccca cctggaacac tacagtgttc
      481 tgcattgcac catgaccctg gatgtgcaaa ctgtagtcgt ttttgccgtg attgtagtcc
      541 tcctgcttgt caatgtcata ctcatgtttt tcttgggaac gcgctgaatg gagtccagcc
      601 acctgagctg ttgcgaactc tcactttgat ttcatcccaa gagcctctga gggggaaaaa
      661 atcaggagag acagtctgag acagggaaag agagggagaa aaagaacaag ctttcttact
      721 caggggggaa aacgttttga gcttcaacat ggcctcgctg tgatatgtat gacttttgct
      781 attgagggtt tccaatttct gatttggaaa gctgccatcg ttaaaacatt cgttaaagca
      841 ctgatcactg gagattccat cgttagtgct gaggcagtat gggatcacgt caccatggcc
      901 aaccgggagt tggcatttaa ggctggcgac gtcatcaaag tcttggatgc ttccaacaag
      961 gattggtggt ggggccagat cgacgatgag gagggatggt ttcctgccag ctttgtgagg
     1021 ctctgggtga accaggagga tggggtggag gaagggccca gtgatgtgca gaatgggcac
     1081 ctggacccca actcagactg cctttgtctg ggccggccac tacagaaccg ggaccagatg
     1141 cgggccaatg tcatcaatga gatcatgagc acggagcgcc attacatcaa gcacctcaag
     1201 gacatttgcg agggctacct gaagcagtgc cgaaagagaa gggacatgtt cagtgacgag
     1261 cagctgaagg tcatctttgg aaacattgaa gacatataca gatttcagat gggcttcgtg
     1321 agagacctgg agaagcagta caacaatgat gatccccacc tcagtgagat aggaccctgc
     1381 ttcttagagc atcaagatgg attctggata tactctgaat attgtaacaa ccacctggat
     1441 gcctgcatgg aactctccaa gctgatgaag gacagccgct atcaacactt ctttgaggcc
     1501 tgccgcctct tgcagcagat gatcgacatt gctattgatg gttttctttt gactccagta
     1561 cagaagatct gcaaatatcc cttacaattg gccgagctcc taaagtatac tgcccaagat
     1621 cacagtgatt acagatacgt tgcagctgct ttggctgtca tgagaaatgt gactcagcag
     1681 atcaatgaac gcaagcgacg tctggagaat attgacaaga ttgcgcaatg gcaggcctct
     1741 gtcctagact gggagggaga ggacatctta gacaggagct cggagctgat ctacactgga
     1801 gagatggcct ggatctacca gccctatggc cgcaaccagc agagagtctt cttcctgttt
     1861 gaccaccaga tggtcctctg caagaaggac ctaatccgga gagacatcct atactacaag
     1921 gggcgcattg acatggataa atatgaggta attgacatcg aagatggcag agatgatgac
     1981 tttaatgtca gcatgaaaaa tgctttcaag cttcataaca aggaaacgga agaagtgcat
     2041 ctgttctttg ccaagaaact ggaggagaaa atacgttggc ttagagcttt cagagaagag
     2101 agaaaaatgg tacaagaaga tgaaaaaatt ggctttgaga tttctgaaaa tcagaagaga
     2161 caggctgcaa tgactgtgag aaaagcttct aaacagaaag gtgtcaactc tgcccgctca
     2221 gttcctcctt cctacccacc accacaggac ccgttaaacc agggccagta cctggtcccc
     2281 gatggcatcg ctcagtctca agtgtttgag ttcactgaac cgaaacgcag ccagtcacca
     2341 ttctggcaaa acttcagtag gttaaccccc ttcaaaaaat aatacctata ggaaggcaga
     2401 taattttaaa ataaataaaa ttatatttat agatggacct ttttttcgga gaagcactgt
     2461 tgaaaattta tatatatata tatatataaa atgtgtgtgt gtgagagaga gtgagtgtgt
     2521 gtgtgtgcgt gtgtgtgcac acatacatgc acacacacac acgcacacat agacctttac
     2581 gtatacacgt gtgtgtgtgg gcatgtgtgc acatatgcat gcacatgcat gcacacatac
     2641 atacatatac acacacagag aaggaccaaa accattttct gttgttttgg ggagttgaaa
     2701 tctgtagttg gtaagaagta ccactgattt ccaaacatgt aatcacttct tcaaattttt
     2761 agttcttaac cttgtttcct cccccttact ctctgttatt tttcctgtta agataactta
     2821 ttcgctcctc tagttcactg acctgtcatt attaccatag agtatttgca ttgttttatt
     2881 tccctttcct tatgatactg acgctgataa cttttgaatt gaatttatgt agtgggtttg
     2941 ggatttcatt tctctccctg tcactttcca ctgagaaggg gaggattccc gtctcctgtt
     3001 cctcatgcac ccatctgcaa atgttcctgt agccctgcag ttataccaac agcctcttcc
     3061 cagcatcctg tgtccacaat tgtgccagtc tatacatgct ctgttgtgcc ctgtgactta
     3121 tctgcttggt atttctattg ctttcactgt tttaggtatt gtggaaggat ataaaaccaa
     3181 acagaaacaa aggagtgaac gaatgtaatg agagtcgaga agatttctgt tagggggata
     3241 gtttttattt aggtgatttc ttcccatata acagcaatgc taagccattg aaagtttcca
     3301 cctaagaatt agtttgggtc cattagtctc ttttccaagc ctcttttgtt atggatctcc
     3361 ttttcagtct atctcttccc taggcaaaag gtttaactaa actagtagca aagaaattga
     3421 gactttgcat cctggggaag agatttatct ccaccccata actcatagat ggtaggtagg
     3481 tgtcaggcag ggctctcttt atagtgttct ggtaacccct gcttctgttt tcagattcat
     3541 aaggcatcat tgttagtagt ttatggaggc gttcaagaga aaaacctgct tggccaagag
     3601 cattagccac cttcagatta acctgaaaag agttcaaggt tgacaacagc atcttataga
     3661 gaccatcagg aaaagagaga ggcttgatct aagataatat accagtaatt tgcatcactg
     3721 aaattataag aaacatcccc aattgttagc agattgcatg gataatctct gtctcctttt
     3781 tttgccctta ctgtctttca ggtagaggat tgcgagtatg ggatagttag agccattatg
     3841 gcactcaaag caggctttgt tccagacaga ctcccatccc aggacaactg aggcaagtgg
     3901 tagagaagcc tagggctact tttacatctg ggggaaaaga aaagatctga ggtagaacac
     3961 tgaagttatt tcttggcagg gtttccattt gaccagaatg tttcccacaa aaatcagaat
     4021 cctcatgagt acaagagtgc ttattctttg tcatttagcc ctttctatgg ctagagattg
     4081 gagcaagaac aatagaatat aaagaagtgt gaaaacccac cctatccagg aatctggaga
     4141 ttgtgtctgt cctggacctc acaagaaaat acttcattat aaaaaaaaaa gatctaagct
     4201 taccaagtag caaccatagc tgtatgaggt cttcaaaaaa gctgaatttg tacttcttga
     4261 cctagattaa gccctacccc tgagaatctt tcccctctga aaaacaaatt acacattgtt
     4321 gtcagacttt gtagttatca aggctaacta gcagaatacc agggctcggg actggctatc
     4381 actgctcagc atatgataga gctacataag cccttatggc aagaaatctg gcatcgagca
     4441 catagactac aatgctctcc cttggcaaac tgaaatgtgt ttcacttcct atgcaggcct
     4501 cccttattgc accttcattt cctactttct acccattctc actaggcttg gccttggcaa
     4561 ctttctccca gggttaggag cacaccagga gggcttgttt tgaaaggttt ctagatctat
     4621 agtatctttt ggccagacct tctcattctt ttcccctttc tgagtccaac attcaaggct
     4681 cccagatcag gggtattacc tctcatcatc ctgtttctcc atccagtcca ctaaccttac
     4741 aagatgtagt aatttgtgaa ggcactacca actccgctct ccttggattg gaatgcctgg
     4801 ctccaccctc acacctacag ctccaaatag atcagtggcc agtagcccaa agggaaactc
     4861 atcaattccc tggactcagt agctgaacct gctgcagccc cacggccata taatcccccc
     4921 caaaaataac tctatacttc tcctgtttct gcatggcccc agactcccct ttcctcaact
     4981 caatgaggcc cgaactttct ttctccagtt ttgtgagttt gttctatgag ttctattata
     5041 gggaggtcct aaatacagaa atacaatttt tctctccttc tctcatccac tttctatgtg
     5101 tatatcttta attgatctat taaggacagc agcaagagag ttctaacaat tctagtatga
     5161 agccaaatag tgctatttta gtgctttggg ggtggggcgg gctgggtgac tagatgggca
     5221 acagtgattt tgacccctgc tgctctgcat ttgccggctt attcttttgt ttctattatc
     5281 cgactgtttg accctgtcaa acaagtgtca aaattgtgta tttggaaatg tttaacaaca
     5341 acaacaacaa aaaagatgtt gtaatgacat aaagccttat gaaaatattt atggagttca
     5401 ataaaagaag taaaaaagaa
//
