LOCUS       NM_001372326            4680 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor (Arhgef7),
            transcript variant 9, mRNA.
ACCESSION   NM_001372326
VERSION     NM_001372326.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4680)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4680)
  AUTHORS   Cheng,K., Chahdi,A., Larabee,S.M., Tolaymat,M., Sundel,M.H.,
            Drachenberg,C.B., Zhan,M., Hu,S., Said,A.H., Shang,A.C., Xie,G.,
            Alizadeh,M., Moura,N.S., Bafford,A.C., Williams,R.T., Hanna,N.N.
            and Raufman,J.P.
  TITLE     Muscarinic receptor agonist-induced betaPix binding to beta-catenin
            promotes colon neoplasia
  JOURNAL   Sci Rep 13 (1), 16920 (2023)
   PUBMED   37805544
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4680)
  AUTHORS   Schlienger,S., Yam,P.T., Balekoglu,N., Ducuing,H., Michaud,J.F.,
            Makihara,S., Kramer,D.K., Chen,B., Fasano,A., Berardelli,A.,
            Hamdan,F.F., Rouleau,G.A., Srour,M. and Charron,F.
  TITLE     Genetics of mirror movements identifies a multifunctional complex
            required for Netrin-1 guidance and lateralization of motor control
  JOURNAL   Sci Adv 9 (19), eadd5501 (2023)
   PUBMED   37172092
REFERENCE   4  (bases 1 to 4680)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4680)
  AUTHORS   Cheng,K., Larabee,S.M., Tolaymat,M., Hanscom,M., Shang,A.C.,
            Schledwitz,A., Hu,S., Drachenberg,C.B., Zhan,M., Chahdi,A. and
            Raufman,J.P.
  TITLE     Targeted intestinal deletion of Rho guanine nucleotide exchange
            factor 7, betaPIX, impairs enterocyte proliferation, villus
            maturation, and mucosal defenses in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 320 (4), G627-G643 (2021)
   PUBMED   33566751
  REMARK    GeneRIF: Targeted intestinal deletion of Rho guanine nucleotide
            exchange factor 7, betaPIX, impairs enterocyte proliferation,
            villus maturation, and mucosal defenses in mice.
REFERENCE   6  (bases 1 to 4680)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4680)
  AUTHORS   Kim,T. and Park,D.
  TITLE     Molecular cloning and characterization of a novel mouse betaPix
            isoform
  JOURNAL   Mol Cells 11 (1), 89-94 (2001)
   PUBMED   11266127
REFERENCE   8  (bases 1 to 4680)
  AUTHORS   Kim,S., Kim,T., Lee,D., Park,S.H., Kim,H. and Park,D.
  TITLE     Molecular cloning of neuronally expressed mouse betaPix isoforms
  JOURNAL   Biochem Biophys Res Commun 272 (3), 721-725 (2000)
   PUBMED   10860822
REFERENCE   9  (bases 1 to 4680)
  AUTHORS   Bagrodia,S., Bailey,D., Lenard,Z., Hart,M., Guan,J.L.,
            Premont,R.T., Taylor,S.J. and Cerione,R.A.
  TITLE     A tyrosine-phosphorylated protein that binds to an important
            regulatory region on the cool family of p21-activated
            kinase-binding proteins
  JOURNAL   J Biol Chem 274 (32), 22393-22400 (1999)
   PUBMED   10428811
REFERENCE   10 (bases 1 to 4680)
  AUTHORS   Oh,W.K., Yoo,J.C., Jo,D., Song,Y.H., Kim,M.G. and Park,D.
  TITLE     Cloning of a SH3 domain-containing proline-rich protein, p85SPR,
            and its localization in focal adhesion
  JOURNAL   Biochem Biophys Res Commun 235 (3), 794-798 (1997)
   PUBMED   9207241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126800.3 and AC120785.13.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF343877.1, SRR9219379.15090.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC126800.3         41140-41292         c
            154-238             AC126800.3         18418-18502         c
            239-369             AC126800.3         17002-17132         c
            370-571             AC126800.3         13743-13944         c
            572-660             AC126800.3         8113-8201           c
            661-755             AC120785.13        180874-180968       c
            756-851             AC120785.13        180560-180655       c
            852-974             AC120785.13        176105-176227       c
            975-1113            AC120785.13        172574-172712       c
            1114-1173           AC120785.13        171852-171911       c
            1174-1320           AC120785.13        171031-171177       c
            1321-1407           AC120785.13        168745-168831       c
            1408-1486           AC120785.13        166407-166485       c
            1487-1626           AC120785.13        166128-166267       c
            1627-1851           AC120785.13        163544-163768       c
            1852-1945           AC120785.13        161697-161790       c
            1946-2035           AC120785.13        159379-159468       c
            2036-4680           AC120785.13        154279-156923       c
FEATURES             Location/Qualifiers
     source          1..4680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..4680
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /note="Rho guanine nucleotide exchange factor"
                     /db_xref="GeneID:54126"
                     /db_xref="MGI:MGI:1860493"
     exon            1..153
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            154..238
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            239..369
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            370..571
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..2250
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /note="isoform h is encoded by transcript variant 9; Pak3
                     binding protein; rho guanine nucleotide exchange factor 7;
                     PAK-interacting exchange factor beta; Rho guanine
                     nucleotide exchange factor (GEF7)"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     h"
                     /protein_id="NP_001359255.1"
                     /db_xref="GeneID:54126"
                     /db_xref="MGI:MGI:1860493"
                     /translation="MTDNTNSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWW
                     EGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNIL
                     ETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLVQSLEECTK
                     SPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGI
                     LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKR
                     KELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLS
                     ASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWV
                     EHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSH
                     HGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPK
                     RKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHV
                     LADDDQSSLDSLGRRSSLSRLEPSDLSEDSEYDSIWTAHSYRMGSASRKSCCSYISHQ
                     N"
     exon            572..660
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            661..755
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            756..851
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            852..974
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1113
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1173
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1320
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1407
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1486
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1626
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1851
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1945
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2035
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..4680
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4661..4666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /note="hexamer: AATAAA"
     polyA_site      4680
                     /gene="Arhgef7"
                     /gene_synonym="beta-Pix; betaPix; betaPix-b; betaPix-c;
                     Cool; cool-1; mKIAA0142; p85Cool1; p85SPR; Pak3bp; PIX"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcagccc ctaggaaggg gagcggatga agcgtccagc ccgctcagcg ccgctgtgtg
       61 ttgcaggtct acccggagcc gcggaacgag agcgagtgcc tgagcaacat ccgcgagttc
      121 ctgcgcgcct gcggggcgtc cctgcgccta gagacttttg atgcaaatga tttgtatcag
      181 gggcagaact ttaacaaggt cctcagctcc ttggtgacac taaataaagt gacagcagac
      241 attggactag gaagtgattc tgtgtgtgct cggccttcgt cccatcggat aaagtctttt
      301 gattccctgg gatcccagtc ttcacacagt aggacttcaa aattgcttca gagccagtac
      361 cgaagcttgg acatgactga taacaccaac agccaactgg tagtacgagc caagtttaac
      421 ttccagcaga ccaatgaaga tgaactctcc ttctcaaagg gtgatgtcat ccatgtcaca
      481 cgagtggagg aaggaggctg gtgggagggc acacacaatg gcaggaccgg ctggttcccc
      541 agcaactacg ttcgagagat caagccaagt gagaagcccg tgtcacccaa atcagggacc
      601 ttgaagagcc ctcccaaagg gttcgatacg actgccatca acaagagcta ttacaacgtg
      661 gtgctacaga acatcctgga aacagagcat gagtattcca aggagctgca gtctgtgctg
      721 tccacctacc tgcggccact gcagaccagt gacaagttga gttcagcaaa cacttcatat
      781 ttaatgggaa atctagagga aatatcttcc ttccagcaag tgcttgtaca gtccctagaa
      841 gaatgcacga agtctcctga agcccaacag agagttggtg gctgcttcct gagcctgatg
      901 ccgcagatga ggaccctgta cctcgcttac tgtgccaacc acccatctgc tgtgagcgtc
      961 ctcacagagc acagtgagga cctaggagag ttcatggaaa caaaaggtgc cagcagccct
     1021 gggatcctgg tgctgaccac cggcctgagc aagcccttca tgcgcctgga caagtacccc
     1081 acactgctaa aggagctgga gagacacatg gaggattatc atcctgatag acaagatatt
     1141 cagaagtcta tgacggcctt caaaaacctt tcagctcagt gtcaagaagt tcgcaagagg
     1201 aaggagctgg agctgcagat cctgacggag cccatcagga gctgggaggg ggatgacata
     1261 aagaccctgg gcagtgtcac atacatgtcc caagtcacca ttcagtgtgc gggaagcgag
     1321 gagaagaatg agagatacct cctgctcttc ccaaaccttc tgctcatgtt gtctgcaagt
     1381 cccaggatga gtggtttcat ctatcagggg aagctgccaa caacaggaat gacaatcaca
     1441 aagcttgagg acagtgaaaa ccataggaat gcatttgaga tatcagggag catgatcgag
     1501 cggattctgg tgtcctgcac cagccagcag gacttacacg agtgggtgga acacctgcag
     1561 aagcagacga aggtcacatc tgtgagcaac cccaccatca aaccccactc ggtgccatca
     1621 cacacacttc cttcccatcc tctcactcca tccagcaaac acgcggacag caagcccgtg
     1681 gcactgacgc ctgcgtacca cacactcccc cacccctctc accatggcac cccacacacc
     1741 accatcagct ggggacccct ggagcctccg aagaccccca agccttggag cctgagttgc
     1801 ctgcggcctg cacctcccct ccggccctca gctgctctct gctacaagga ggatctcagt
     1861 aagagcccca agaccatgaa aaagctgctg ccgaagcgca agcccgagcg gaagccttcg
     1921 gacgaggagt tcgctgtgcg caagagcaca gcggcgctgg aagaagacgc tcagatcctg
     1981 aaggttatcg aagcttattg cacaagtgca aagacgcgcc agaccctgaa ctcaacatgg
     2041 caaggcactg acctgatgca taatcacgtc ttggctgatg acgaccaatc aagtctagac
     2101 tccttgggtc gtcgcagtag cctttctcgt ttggagccct cagacctctc ggaagactct
     2161 gagtatgaca gtatatggac agcccatagt tacagaatgg gttctgcatc ccgtaagagc
     2221 tgctgctcat atatctctca ccagaactaa ctaacgcact gagcctttct taacaatgct
     2281 tgtactgcag cctgcttttc ttagacgttt cttgctgttc cttgtctctc ttatgtgata
     2341 ttttaacaac tctggagagt gtcttggtat ttcccattgt acctagtgga ggcttaattg
     2401 ccaatctaag actgaattta aactgctgcc tgttggaggg aggtggcaag tccagtgagt
     2461 acctgatggg cttttcccaa cagggagctt tttcttacaa gctccatgta gcaactgttt
     2521 cccttccttt tggatacagc cgtatggaca cttttctatt ttatgcagcc acataggttt
     2581 gctccaagtg ccacaacgga gaagactagc cttacacaca gggatctaat tttttttttt
     2641 ttttaatata taatgcactt gaccaagttg ctgtggagag attgagagga ttgtctatga
     2701 ccgaagcact gaatcagttg acagctgctc tggtgacagt gcagaacacc gggctgatgc
     2761 acaccagggc tggtgccact gggtgttgag agcagagtct ggaatctgtg tccacccatt
     2821 gctctgtgcc ttttcctgtg tgtggcacgg ctgtgaggtg agaactctca ccgacacggc
     2881 ttagacattc accactgcac catacttccc tgaaccacag tgatgactag tgggaggtac
     2941 cattggtgtg tgactgtgct tggcttgcct gcagcctggc tgtcccacag ccacaggatg
     3001 ctgtgagagc catgagcacc ttgtggcagt gaagttattt cccgaagccc tgtactcagc
     3061 acagcacagt ctggaagtct gagcatgttc ccgcagggtg acctgggaga cgagccctcc
     3121 tggcgtttgt tgtaaggggt ttgcactggc cctgagaaga actgaatgcg aggctgcctc
     3181 agttagagca gacagccaca gctagctgct cgagaaacta cactgacctg ggtacggtgg
     3241 tgttacaatg tatcagagcg gacagccacc cgatagctcc tccaggggca gcacaggcct
     3301 gggtgttgtg gtgttacagt gtaaccttag ggttgttttt taagtgtttt tggacacctg
     3361 ctttagaaac ggtgccacag tgtccatagg gaataatgtt ctttccatcc ttcagggcat
     3421 ggagctctgg tggccatgac ctctgacccc tagtccttgt tgccaagcta gtggatacag
     3481 tattttgacc cctttgctcc ctctcctggg agctggtcct gctgctgcga gtagaggagc
     3541 acacacgctg tgcatgaagg gggttgacct ggagctgcag ggcagcacag ctgctcacac
     3601 tgagtctgtc tgtctgtccc cagtagctgt gcagcagctt tgcccctgaa gagtttgtat
     3661 ttttatatga aagtcaagga gcaagccttt caaacttgca cccagtatta atttccaata
     3721 ggaataaggt tgtatggatt cagccaaata gcaaatggga attttgaaaa acaaaacaaa
     3781 cacaaaccgt ctgtatttag tgatgaggcg gctctgttgt ccccccacat ggtggttgtc
     3841 gttgcctcag tatgggctgc ctgtcctcag ctgtgtgctg caacagtgag gcacagctgc
     3901 tgtactcggg ttttctcatc acaccgactg gagtggcact gctggctcaa ggagctgtcg
     3961 ctgtggtcgg cgctgctgag ctggttctga cagtttgccc ttgctcattt gtcccagtca
     4021 agagccattt gggtgacaat ttctgttgag gcccacactg tggaacaaca gctcaacctt
     4081 tttgcgtttg ttttgaatgt ctgacattag ttttgtgacc tggttagaaa tttgttagtg
     4141 ccacaggcac aggagatggt cctcatgtag cagaggggac acagcgttgg aggggccatc
     4201 gtttctacat ttgtggaact gtagtcatgc tgatagcacc taacatttct gcagctctgt
     4261 aaagccctgt atgcagtgag tgttaaacgg aagatgcaga ctgatggaga aggtaggtcc
     4321 aagccatctc gggccttctg taggtggccc aacagtgttc ctgtctaact gatactcgtc
     4381 agaagtcttt attaagctac actaactcgg tgtttggcgt aagattgcca aaacacaata
     4441 atatgtatat agtggtataa gatcttgggg aaattatata ttgtgctctt tatctgtgaa
     4501 tgggaaaagc cattttagta caagactccc atttgaaaac tcacttggat gtatatctga
     4561 atgttgcatt gtattgtaca gtatgcttat tgtctgtggt tgcatatggc aatgaagtgt
     4621 ctgttttata tttaaaaaga catctgttct gtacagttga aataaatttt gcatttgcta
//
