LOCUS       NM_001405176            3640 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rac/Cdc42 guanine nucleotide exchange factor 6
            (Arhgef6), transcript variant 11, mRNA.
ACCESSION   NM_001405176
VERSION     NM_001405176.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3640)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3640)
  AUTHORS   Klambt,V., Buerger,F., Wang,C., Naert,T., Richter,K., Nauth,T.,
            Weiss,A.C., Sieckmann,T., Lai,E., Connaughton,D.M., Seltzsam,S.,
            Mann,N., Majmundar,A.J., Wu,C.W., Onuchic-Whitford,A.C., Shril,S.,
            Schneider,S., Schierbaum,L., Dai,R., Bekheirnia,M.R., Joosten,M.,
            Shlomovitz,O., Vivante,A., Banne,E., Mane,S., Lifton,R.P.,
            Kirschner,K.M., Kispert,A., Rosenberger,G., Fischer,K.D.,
            Lienkamp,S.S., Zegers,M.M.P. and Hildebrandt,F.
  TITLE     Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the
            Kidneys and Urinary Tract in Humans, Mice, and Frogs
  JOURNAL   J Am Soc Nephrol 34 (2), 273-290 (2023)
   PUBMED   36414417
  REMARK    GeneRIF: Genetic Variants in ARHGEF6 Cause Congenital Anomalies of
            the Kidneys and Urinary Tract in Humans, Mice, and Frogs.
REFERENCE   3  (bases 1 to 3640)
  AUTHORS   Mamula,D., Korthals,M., Hradsky,J., Gottfried,A., Fischer,K.D. and
            Tedford,K.
  TITLE     Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and
            Cofilin to couple T cell migration speed and persistence
  JOURNAL   J Leukoc Biol 110 (5), 839-852 (2021)
   PUBMED   33527537
  REMARK    GeneRIF: Arhgef6 (alpha-PIX) cytoskeletal regulator signals to
            GTPases and Cofilin to couple T cell migration speed and
            persistence.
REFERENCE   4  (bases 1 to 3640)
  AUTHORS   Zhu,C., Cheng,C., Wang,Y., Muhammad,W., Liu,S., Zhu,W., Shao,B.,
            Zhang,Z., Yan,X., He,Q., Xu,Z., Yu,C., Qian,X., Lu,L., Zhang,S.,
            Zhang,Y., Xiong,W., Gao,X., Xu,Z. and Chai,R.
  TITLE     Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing
            Loss in Mice
  JOURNAL   Front Mol Neurosci 11, 362 (2018)
   PUBMED   30333726
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3640)
  AUTHORS   Tedford,K., Steiner,M., Koshutin,S., Richter,K., Tech,L.,
            Eggers,Y., Jansing,I., Schilling,K., Hauser,A.E., Korthals,M. and
            Fischer,K.D.
  TITLE     The opposing forces of shear flow and sphingosine-1-phosphate
            control marginal zone B cell shuttling
  JOURNAL   Nat Commun 8 (1), 2261 (2017)
   PUBMED   29273735
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3640)
  AUTHORS   Matsuda,C., Kameyama,K., Suzuki,A., Mishima,W., Yamaji,S.,
            Okamoto,H., Nishino,I. and Hayashi,Y.K.
  TITLE     Affixin activates Rac1 via betaPIX in C2C12 myoblast
  JOURNAL   FEBS Lett 582 (8), 1189-1196 (2008)
   PUBMED   18325335
REFERENCE   7  (bases 1 to 3640)
  AUTHORS   Node-Langlois,R., Muller,D. and Boda,B.
  TITLE     Sequential implication of the mental retardation proteins ARHGEF6
            and PAK3 in spine morphogenesis
  JOURNAL   J Cell Sci 119 (Pt 23), 4986-4993 (2006)
   PUBMED   17105769
  REMARK    GeneRIF: ARHGEF6 is localized in dendritic spines where it
            contributes to regulate dendritic spine morphogenesis.
REFERENCE   8  (bases 1 to 3640)
  AUTHORS   Feng,Q., Baird,D. and Cerione,R.A.
  TITLE     Novel regulatory mechanisms for the Dbl family guanine nucleotide
            exchange factor Cool-2/alpha-Pix
  JOURNAL   EMBO J 23 (17), 3492-3504 (2004)
   PUBMED   15306850
REFERENCE   9  (bases 1 to 3640)
  AUTHORS   Yoshizawa,M., Sone,M., Matsuo,N., Nagase,T., Ohara,O., Nabeshima,Y.
            and Hoshino,M.
  TITLE     Dynamic and coordinated expression profile of dbl-family guanine
            nucleotide exchange factors in the developing mouse brain
  JOURNAL   Gene Expr Patterns 3 (3), 375-381 (2003)
   PUBMED   12799088
REFERENCE   10 (bases 1 to 3640)
  AUTHORS   Kutsche,K. and Gal,A.
  TITLE     The mouse Arhgef6 gene: cDNA sequence, expression analysis, and
            chromosome assignment
  JOURNAL   Cytogenet Cell Genet 95 (3-4), 196-201 (2001)
   PUBMED   12063400
  REMARK    GeneRIF: The mouse Arhgef6 gene: cDNA sequence, expression
            analysis, and X chromosome assignment.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672128.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.215821.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AL672128.8         208216-208242       c
            28-122              AL672128.8         206859-206953       c
            123-218             AL672128.8         202525-202620       c
            219-341             AL672128.8         200542-200664       c
            342-480             AL672128.8         182768-182906       c
            481-540             AL672128.8         177937-177996       c
            541-687             AL672128.8         175610-175756       c
            688-774             AL672128.8         173034-173120       c
            775-853             AL672128.8         172199-172277       c
            854-999             AL672128.8         171252-171397       c
            1000-1125           AL672128.8         170037-170162       c
            1126-1146           AL672128.8         168453-168473       c
            1147-1240           AL672128.8         167241-167334       c
            1241-1318           AL672128.8         165813-165890       c
            1319-1418           AL672128.8         163633-163732       c
            1419-1473           AL672128.8         161504-161558       c
            1474-3640           AL672128.8         158132-160298       c
FEATURES             Location/Qualifiers
     source          1..3640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 31.26 cM"
     gene            1..3640
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /note="Rac/Cdc42 guanine nucleotide exchange factor 6"
                     /db_xref="GeneID:73341"
                     /db_xref="MGI:MGI:1920591"
     exon            1..27
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            28..122
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            123..218
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            219..341
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1614
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /note="isoform 8 is encoded by transcript variant 11;
                     Rac/Cdc42 guanine exchange factor (GEF) 6; rho guanine
                     nucleotide exchange factor 6; alpha PIX Rho GTPase guanine
                     nucleotide exchange factor; Rac/Cdc42 guanine nucleotide
                     exchange factor (GEF) 6"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 6 isoform
                     8"
                     /protein_id="NP_001392105.1"
                     /db_xref="GeneID:73341"
                     /db_xref="MGI:MGI:1920591"
                     /translation="MPHFKSMYLAYCANHPSAVNVLTQHSDDLERFMENQGASSPGIL
                     ILTTSLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIIAFKTLMGQCQDLRKRK
                     QLELQILSEPIQAWEGDDIKTLGNVIFMSQVVMQHGACEEKEERYFLLFSSVLIMLSA
                     SPRMSGFMYQGKIPIAGMVVNRLDEIEGSDCMFEITGSTVERIVVHCNNNQDFQEWME
                     QLNRLTKGPTSCGSLSKTSSSSCSTHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPP
                     LRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKASEEEYVIRKSTAALEEDA
                     QILKVIEAYCTSASFQQGTRKDSVPQVLLPEEEKLIIEETRSNGQTIIEEKSLVDTVY
                     ALKDEVKELKQENKKMKQCLEEELKSRKDLEKLVRKLLKQTDECIRSESSSKTSILQ"
     exon            342..480
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            481..540
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            541..687
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            688..774
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            775..853
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            854..999
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1125
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1146
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1240
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1318
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1418
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1473
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..3640
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3618..3623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /note="hexamer: AATAAA"
     polyA_site      3640
                     /gene="Arhgef6"
                     /gene_synonym="1600028C08Rik; 1700038J06Rik;
                     4930592P22Rik; alpha-PIX"
                     /note="major polyA site"
ORIGIN      
        1 agcacagttg ggaccatcat cccccgggtg ttacagaaca tcttggacac tgaaaaagaa
       61 tatgccaaag aacttcagtc tcttcttgtt acttacctaa gacccttgca gtctaataac
      121 aacctgagta ctgtggagtt tacatgttta ttgggaaact ttgaagaagt atgcacattt
      181 caacagacac tctgccaagc cttggaagaa tgttcaaagt ttccagaaaa ccaacacaaa
      241 gtaggaggct gcctactgaa cctcatgcct catttcaaat cgatgtacct ggcttactgt
      301 gcaaatcatc catcagctgt caacgtgctc acccagcaca gtgatgatct agaacgattc
      361 atggaaaatc aaggtgcatc cagcccgggt atcctcattc taacaacaag tctcagcaaa
      421 ccattcatgc gactggaaaa gtatgttact ctcttgcaag aactggaacg acatatggag
      481 gacactcatc cagaccatca ggatattctg aaagcaatca tagcattcaa aacactcatg
      541 gggcagtgtc aagatctgag aaagagaaag cagctggaat tgcagatcct ttcagaacct
      601 attcaggcat gggaaggaga tgatattaag actttgggaa atgtgatctt tatgtctcaa
      661 gtagtgatgc agcatggggc ctgtgaggag aaagaggaac gatattttct gctgttttca
      721 agtgtcttga taatgttgtc tgcaagtcct cggatgagtg gctttatgta tcagggaaaa
      781 ataccaatag cagggatggt agtgaacaga ttggatgaaa ttgaaggcag tgactgtatg
      841 ttcgaaatca caggtagcac ggttgagaga attgtggtcc attgcaacaa taaccaggac
      901 ttccaggagt ggatggagca gctgaacaga ctgaccaaag gaccaacctc ttgcggttca
      961 ttgtctaaga cctcctcctc atcatgtagt actcattctt cttttagctc taccggacag
     1021 ccccgaggac ccttggagcc tcctcaaatt ataaaaccgt ggagtttaag ttgcctacga
     1081 cctgcacctc cacttagacc atcagcagca ctaggttata aagagaggat gtcttatatc
     1141 ttaaaggaat ctagtaagag ccccaaaaca atgaagaagt ttcttcacaa aagaaagacg
     1201 gagaggaaag catccgagga agaatacgtg attaggaaaa gtactgctgc cctggaagag
     1261 gatgctcaga ttcttaaggt gatcgaagct tattgcacca gcgccagttt tcaacaaggt
     1321 actcgtaaag attctgttcc acaagttcta ctccccgagg aagagaaact cattattgaa
     1381 gaaaccagaa gtaatgggca gaccatcatt gaagagaaga gccttgttga tactgtctat
     1441 gccttgaagg atgaggtcaa ggaactgaag caggagaata aaaaaatgaa gcaatgtctg
     1501 gaagaagaat tgaagtcgag gaaggaccta gagaagctgg tccggaagct gttgaaacaa
     1561 acagatgaat gcattcgatc tgaatccagc agcaagacct cgattctcca gtaaccatca
     1621 ctgtgcagct gagcacagtg ccttcagcac tccttaaagt ggccagctga atggtttcac
     1681 tgtgcatttg agctttgtgc tttgtggtgt tgggatgctc tctctttctt cctctctccc
     1741 ttcccctccc ccttccccct ccactgtttg attcagagtt tattgcttgg ttatcagttg
     1801 attgacactt gttttaacag ggggaaatag cctgacgtgg tggccaaaat ggccccaata
     1861 ctttgctatg cccaacagcc ctttactacc taattcgctg gaggctaagc ttctcaggct
     1921 atgtatagag taggtgaaaa tgaacacctt tgcccagtga cccagttgca cttcccttta
     1981 ctatcatatg gcccccttca gtactttaag aacttattgc ccatgttgtc tgttgagatc
     2041 aagaacagtg tagtgccctt atgccctctg ccctctgtgc tgttgtccat ttaaagtcag
     2101 tgtggtagga actccaacca tccacaccag caccaagtct ctcagcaaat tgcttcaggc
     2161 agtcctccgt cagcagcagg gcaaagcagc ttgatggagt acttatccct agtatagcgt
     2221 agctttacag cccagccctc tgcctctatg taagttttct acctcccctc aaccccatgc
     2281 ttttagccag ccatacaaag tggggtgtca atgatcatgg atttgctttg cttatcttgt
     2341 cagttactgt gagcaatgac tttactttga atattcccat gacaaccttt tcacctttct
     2401 aaacaacttg ggtgagaaaa tattgtgccc tcgtacacct tccatcccat ctcaccaagc
     2461 tctggtttct gcaatgagaa gttggactca tcagtggcct ctaggatgat gatccagatt
     2521 atagaccctg agttaaaggg cccctcctag ctggagcagg ctgtcagtga agctgactat
     2581 ttgaaactag tttgttcaag ttgtttataa tgtcaaacca ttgactttgt atgtggtcca
     2641 gaaaagtgac ccgtgagaaa gcagatttca cagagagccc cagaagaaca ctgtatacct
     2701 aaattcaaca caagtcaaaa tgggctgagg atggaggaac acagctctca cctacctcct
     2761 cagatgacag cacaacttgg ccagatggca aagtcactgg aaaaagatgc agaaagccaa
     2821 ccaaaggctt acgtgtatat tatttgattg ggccctgtaa gggttgtttc aaaaccaacc
     2881 ttgaggccta aaagcttgtt gaggagccct tttcctttgt gatatggagg ctctcacagt
     2941 ttccataact ttatggtaca gtgctattat ctcatgttac atggccaaca ttatagcacc
     3001 cacaggatgt ggagtattcc taaaggccaa cctcagacaa tcgcatagag ctatctttgt
     3061 cagcttagag agtaaaggtt gctaagaaca gctgtcctgt ttctaagccc agagatttct
     3121 atgagacatc tttcatgtaa aacattttta caaaaggaat aacagtagca acccacatgt
     3181 tcccatttgt cctgtctgtg cttggtcaat agttggcaat caatgtgcaa aatttgtcca
     3241 taggaaaaac cacttttgtg gtcgccaaat aatttagttc attgcttaag acattgaaag
     3301 gtctcataaa ggatgtgtac atatgcatgt ttggggactt tgcccttatg aggagaggcc
     3361 cttggtactc tggataagga aacttgtgca gtgggctgcc catgcttaca cactaaataa
     3421 tataaaggaa atgaagccat gttaactcca cagtcatgtc tccatagttg tgttgtttac
     3481 aatactctgg aagtaaactg ctgcccttag gggcctttca gtttcccctc tgttatgtcc
     3541 cttcttatag gagctcagat tttctaaact tgtttttatt ttaaagactt ttaaaatgga
     3601 cattttcaat aaacaagaat aaacagtgct ttataaataa
//
