LOCUS       NM_133674               5420 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 5 (Arhgef5),
            transcript variant 1, mRNA.
ACCESSION   NM_133674 XM_001481282 XM_915627
VERSION     NM_133674.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5420)
  AUTHORS   Bernadzki KM, Daszczuk P, Rojek KO, Pezinski M, Gawor M, Pradhan
            BS, de Cicco T, Bijata M, Bijata K, Wlodarczyk J, Proszynski TJ and
            Niewiadomski P.
  TITLE     Arhgef5 Binds alpha-Dystrobrevin 1 and Regulates Neuromuscular
            Junction Integrity
  JOURNAL   Front Mol Neurosci 13, 104 (2020)
   PUBMED   32587503
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5420)
  AUTHORS   Schaffer TB, Smith JE, Cook EK, Phan T and Margolis SS.
  TITLE     PKCepsilon Inhibits Neuronal Dendritic Spine Development through
            Dual Phosphorylation of Ephexin5
  JOURNAL   Cell Rep 25 (9), 2470-2483 (2018)
   PUBMED   30485813
REFERENCE   3  (bases 1 to 5420)
  AUTHORS   Sell,G.L., Schaffer,T.B. and Margolis,S.S.
  TITLE     Reducing expression of synapse-restricting protein Ephexin5
            ameliorates Alzheimer's-like impairment in mice
  JOURNAL   J Clin Invest 127 (5), 1646-1650 (2017)
   PUBMED   28346227
REFERENCE   4  (bases 1 to 5420)
  AUTHORS   Hamilton AM, Lambert JT, Parajuli LK, Vivas O, Park DK, Stein IS,
            Jahncke JN, Greenberg ME, Margolis SS and Zito K.
  TITLE     A dual role for the RhoGEF Ephexin5 in regulation of dendritic
            spine outgrowth
  JOURNAL   Mol Cell Neurosci 80, 66-74 (2017)
   PUBMED   28185854
REFERENCE   5  (bases 1 to 5420)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (bases 1 to 5420)
  AUTHORS   Kuroiwa M, Oneyama C, Nada S and Okada M.
  TITLE     The guanine nucleotide exchange factor Arhgef5 plays crucial roles
            in Src-induced podosome formation
  JOURNAL   J Cell Sci 124 (Pt 10), 1726-1738 (2011)
   PUBMED   21525037
REFERENCE   7  (bases 1 to 5420)
  AUTHORS   Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP,
            Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M
            and Greenberg ME.
  TITLE     EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a
            developmental brake on excitatory synapse formation
  JOURNAL   Cell 143 (3), 442-455 (2010)
   PUBMED   21029865
REFERENCE   8  (bases 1 to 5420)
  AUTHORS   Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L,
            Iwasaki A, Li L and Wu D.
  TITLE     Regulation of immature dendritic cell migration by RhoA guanine
            nucleotide exchange factor Arhgef5
  JOURNAL   J Biol Chem 284 (42), 28599-28606 (2009)
   PUBMED   19713215
  REMARK    GeneRIF: RhoA guanine nucleotide exchange factor Arhgef5 regulates
            immature dendritic cell migration
REFERENCE   9  (bases 1 to 5420)
  AUTHORS   Walentinsson A, Helou K and Levan G.
  TITLE     A dual-color FISH gene map of the proximal region of rat Chromosome
            4 and comparative analysis in human and mouse
  JOURNAL   Mamm Genome 12 (12), 900-908 (2001)
   PUBMED   11707776
REFERENCE   10 (bases 1 to 5420)
  AUTHORS   Thomas JW, Summers TJ, Lee-Lin SQ, Maduro VV, Idol JR, Mastrian SD,
            Ryan JF, Jamison DC and Green ED.
  TITLE     Comparative genome mapping in the sequence-based era: early
            experience with human chromosome 7
  JOURNAL   Genome Res 10 (5), 624-633 (2000)
   PUBMED   10810084
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC158671.3,
            AC153885.2, BY063820.1, AK037202.1, CB058042.1 and AA562620.1.
            
            [WARNING] On Jan 22, 2024 this sequence was replaced by
            NM_133674.2.
            
            On or before Mar 2, 2008 this sequence version replaced
            XM_915627.3, XM_001481282.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC158671.3         372-471             c
            101-3221            AC153885.2         73300-76420         c
            3222-3363           BY063820.1         201-342
            3364-3584           AC153885.2         71679-71899         c
            3585-4595           AK037202.1         2-1012
            4596-5215           CB058042.1         74-693
            5216-5420           AA562620.1         1-205               c
FEATURES             Location/Qualifiers
     source          1..5420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 21.15 cM"
     gene            1..5420
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /note="Rho guanine nucleotide exchange factor 5"
                     /db_xref="GeneID:54324"
                     /db_xref="MGI:MGI:1858952"
     exon            1..100
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..3221
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..4858
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /note="Rho guanine nucleotide exchange factor (GEF) 5"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 5"
                     /protein_id="NP_598435.1"
                     /db_xref="CCDS:CCDS51759.1"
                     /db_xref="GeneID:54324"
                     /db_xref="MGI:MGI:1858952"
                     /translation="MEAEEPEYGVSTEVPDIEELKTIPEGIMRSSQIPALDPEAQEDR
                     DPSYKWTDGHRPVMNQSKVLRDMGDHTPNSMAIFFKKESSDMETSQEILLAEACNTPD
                     QQEAVIQSLKDRLSRTIAAPELLACAVQEEWLDIPSKLDNRVGAELQSELMSLTLAVS
                     KEKEEEETSPDTSIPRGSWPPCKTHPGETEQTQGSGSELLRQGKQLQLEATQENQGQE
                     GFLQSQEAQGLEEQEGQEVEIQEEGTLNEGICFGGLLGEQEEVEEGFNGNEEEQKQGQ
                     IQSYMLLGGQWENEGLSGELEGLNYSERGQENRERRVWVLRDSEEEGQDQESREVEER
                     RVATQYTENQRLVEKSEIVKRKQRDHDQTGKVMPVRDQKEVVDSGDRVQGNGDSGGQT
                     AVEGSRPGEDSKPSLPVASVDPEVLSPGTLFPGISSSVADIPQIQKEPVCEELSPQAP
                     ALEPTEWSHQPISPPASFAPEESLDNRTHNSQQEEFRLRKGIEVVSASTSVAPSGTRD
                     SPPFSPPNVFSSTATLSPVSSSVILPEETPTASASADTPHHCGPCETPPLPAKSSRYP
                     CATSDTANPHSPLSSYTGVTQHLRSNSFPGSHRTEQTPDSLGMSLSFSHLELPQRPPK
                     PAIYGSLTPRRNRRSRDGIVFSDSSTALFALKQDSEEFTSNPERPSSPHGSPTWGSPQ
                     NSAFAIGSPANVSSPPTVSMDMTIREALLPIPPEKRHSYSHIVERDGLLHEVASTLKR
                     HSHPPPLTLSSGLHRSSKGSFSLVPDSTVARQHRPLPSTPESPNHTQTSIPSRLRYNK
                     PLPPTPDMPEFYHPSISSSYISRMYRPLPPVPIIDPSSEPPPLPPKSRGRSKSIQGGV
                     IHSGGQAKPRPNNQDWTASTLSVGRTSWPPATGRSTESLPLTSRCNNEVSPGLAFSNM
                     TNLLSPSSPTTPWIPDLQRPTTKDESGLTEESEPPVRGSFRRSAPQEEFNNTRRSALG
                     SRKNSEKPLHHQLEKASSWPHRRDPARTSESSSEQVVLGQVPNKQKGWNRQGLRRPSI
                     LPESSSDLRNPAAGRLPGSSDSVVFREKKPKEGMGGFSRRCSKLISSQLLYQEYSDVV
                     LNKEIQSQQRLDSLAEPHGLSSPRHRRKALVSSDSYLQRLSMASSGSLWQEIPVVRNS
                     TVLLSMTHEDQKLQEAKFELIVSEASYLRSLNIAVDHFQHSAQLRGTLSNQDHQWLFS
                     RLQDVRDVSTTFLSDLEENFENNIFSFQVCDVVLNHAADFHRVYLPYVTNQTYQERTF
                     QSLMNSNSSFREVLEKLESDPICQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSS
                     EEAEATKAHHALEKLIRDCNSNVQRMRRTEELIYLSQKIEFECKIFPLISQSRWLVKS
                     GELTALEFSVSPGLRRKLTTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEK
                     CEMKLHGPHKNLFRLFLLHNAQGTQVEFLFRTETQSEKLRWISALAMPREELDLLECY
                     DSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGEQGWFPVQQVEF
                     ISNPEVRAQNLKEAHRVKTAKLQLVEQQV"
     exon            3222..3279
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3341
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3595
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3756
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3909
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            3910..4039
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..4114
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            4115..4204
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            4205..4362
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            4363..4524
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4595
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..4700
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..5407
                     /gene="Arhgef5"
                     /gene_synonym="2210412D05Rik; Tim1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgccgg ggcggcctgg cctggctggg gaccgcggcg ggcgcccgga cctggagggg
       61 actctcgggc cagcccgggg cagcatgtga ctccgaccag gattcagccc tgatggaggc
      121 tgaggagcct gaatatggag tatctacaga agtccctgac atagaagaat tgaaaactat
      181 ccctgaaggt atcatgagga gcagtcagat ccctgccttg gatcctgaag ctcaagaaga
      241 ccgagaccca tcctataagt ggacagatgg acacagaccc gtgatgaacc agtcaaaagt
      301 gttaagggac atgggtgacc atacacctaa tagtatggca attttcttca agaaagaatc
      361 ttcggatatg gagacaagcc aggaaatcct tctggctgag gcctgtaaca ctccagacca
      421 gcaggaagct gtaatccaga gccttaaaga cagactgtca agaacaatag ctgcccctga
      481 gctcttggca tgtgctgtcc aggaagaatg gctagacata cccagcaaac tagacaacag
      541 agtgggggca gaattgcagt cagaacttat gtctttgact ttggcagtta gcaaagagaa
      601 agaagaggaa gaaacctccc cagacacctc aatccctaga ggatcttggc ctccctgcaa
      661 aactcaccct ggtgagactg agcagaccca gggcagtgga agtgaactgc ttaggcaggg
      721 gaaacagctg cagttggagg ccacacaaga aaatcaaggg caagaaggct tccttcaatc
      781 tcaggaagcc cagggactgg aggagcagga gggacaggaa gtagaaattc aggaggaagg
      841 aactctgaac gaaggcattt gttttggtgg gctcctggga gagcaggagg aggtggaaga
      901 ggggtttaac ggcaacgagg aagaacagaa gcagggacag atccaaagct atatgctact
      961 tggaggacaa tgggaaaatg aggggctcag tggggaatta gaaggtctga attacagtga
     1021 gagaggccaa gagaacaggg aaaggagggt ttgggttctg agagattcag aagaggaggg
     1081 acaggaccag gaatccaggg aggtggaaga gagaagggta gccactcagt atacagagaa
     1141 tcaaaggtta gtagagaaat cagagattgt aaagagaaag cagagagatc atgatcaaac
     1201 aggaaaagtg atgcccgtaa gggaccagaa ggaggttgta gactcaggtg acagggtcca
     1261 agggaatggg gatagtggtg ggcagacagc agtggaaggg agcagaccag gagaggacag
     1321 caagccttct cttccagtgg cttccgtaga tcctgaggtt ctctccccag gtacattgtt
     1381 cccaggtatt tcttcctctg tggctgatat tccacagatt cagaaggagc ctgtgtgtga
     1441 ggaactgagc cctcaagctc ctgcactgga gccaacagaa tggtctcacc aacccatttc
     1501 tccccctgcc tcttttgctc ctgaagaatc tcttgataat aggactcaca acagccagca
     1561 agaagaattc aggctaagga aggggattga ggttgtctct gctagtacat ctgtggctcc
     1621 ttcagggaca cgagattcac ctcctttcag tcctcctaat gttttctcca gcactgccac
     1681 cttgtcacct gttagctctt cagttatcct tcctgaggag accccaacag cctctgcctc
     1741 agctgacact ccacatcatt gtgggccatg tgagactcct ccactacccg caaaatcctc
     1801 caggtaccca tgtgccacct ctgacacagc caaccctcac agccctctta gcagctacac
     1861 tggagttacc caacatctaa gaagcaactc gttcccaggc tctcacagga cagagcagac
     1921 tccagactct ctgggaatgt cactctcttt ctctcatttg gaattacctc agaggcctcc
     1981 taaaccagcc atctatggct ctctgacccc aagaagaaac agaagaagta gggatggtat
     2041 cgtcttttca gactcctcta ctgctttgtt tgctttgaaa caggactctg aagaattcac
     2101 ttcaaatcca gagaggccca gcagtcctca tggtagtccg acatggggct ccccacagaa
     2161 ctcagccttt gccataggct ctcctgcaaa tgtttcttca ccacccactg tctccatgga
     2221 tatgacgata cgtgaagctt tactccctat tcccccagag aagagacata gctacagtca
     2281 catagtggag agggatggcc ttcttcatga agtagcctct acactgaagc ggcatagtca
     2341 tcctcctcca ctgaccctaa gttcagggct ccatagatct tctaaaggct cattttccct
     2401 agttcctgac tccactgtgg caaggcagca ccgccctctg ccgtctaccc cagaaagccc
     2461 caaccataca cagacctcca tcccttccag actgagatac aacaaaccat tacccccaac
     2521 tcctgatatg cctgagttct accatccctc catctcttcc tcttatatct caaggatgta
     2581 taggcctcta cccccagtcc ctatcataga tccttcctct gaaccacctc cattgccccc
     2641 aaagtccagg gggagaagca agagtatcca gggaggagtt atacattcag gaggtcaagc
     2701 caagccaaga cctaataatc aagactggac agcttctact ctctctgttg gacgaacctc
     2761 ctggcctcca gccacaggca gatcaacaga atctttgcct ctcaccagta ggtgtaataa
     2821 tgaagtgtcc cctggcctgg ctttcagcaa catgacaaac cttcttagtc cctcttctcc
     2881 tactactcct tggatcccag accttcagag acctaccact aaggatgagt cagggctcac
     2941 tgaagagtct gagccaccag tgagaggatc atttagacga tctgcccctc aggaggaatt
     3001 taataataca aggaggtcag ctttaggatc aagaaagaac tcagaaaaac ccctccacca
     3061 ccaactggag aaggcatcca gctggcctca cagacgcgac ccagcaagga catcagaaag
     3121 tagcagtgaa caggttgttc tgggccaggt acccaacaag caaaagggct ggaaccggca
     3181 aggccttcgt agaccttcaa ttttgcctga aagctcttca gatttacgaa atccagctgc
     3241 gggaagactt cctggctctt cagattctgt tgttttccgg gagaagaaac caaaggaggg
     3301 gatgggaggc ttttcaagac gttgctccaa gctcatctcc tcccagctac tttatcagga
     3361 gtacagtgat gttgttctga acaaggagat tcagagccag cagcggctgg acagcctggc
     3421 cgagccacat gggctctctt ccccacggca tcgtcgaaag gcactggtct cttcagactc
     3481 ctacctacag cgcctctcta tggcctccag tggctccctc tggcaggaaa tccctgtggt
     3541 gcgcaatagc acagtgctgc tctccatgac ccatgaagat caaaaactgc aagaggccaa
     3601 gtttgagctg attgtgtcag aagcatctta cctgcgcagt ctaaacatag ctgtggatca
     3661 tttccaacat tcagcccagc tgcggggcac cctgtccaac caggatcatc agtggctctt
     3721 ctctcgtttg caggatgtac gagatgtcag caccacgttc ctttcagacc tagaagaaaa
     3781 ctttgagaac aacatcttct ccttccaagt gtgtgatgtt gtcttgaatc atgccgcaga
     3841 cttccaccgt gtctacctgc cttatgtcac caaccagacc tatcaggaac gcaccttcca
     3901 aagtctaatg aatagcaaca gcagtttccg ggaggtcttg gagaagctag agagcgaccc
     3961 catctgccaa cgcctgtctc tcaagtcctt tctgatactg cccttccaac gcatcacacg
     4021 tctcaagctg ctgctccaga acatactgaa gagaactcag cctggctcct cagaagaggc
     4081 agaggccacg aaggcacacc atgccctaga gaagctgatt cgagactgca acagcaatgt
     4141 gcagagaatg cggcggacag aggagctcat ctacctgagc cagaagattg agtttgagtg
     4201 caaaattttc ccacttattt cacaatctcg atggctggtg aagagtgggg agctgacggc
     4261 ccttgagttc agtgtctccc cagggctgag aaggaaactg accactcgtc cagtccacct
     4321 acatctcttc aatgactgtc tgttgctgtc tcggccccga gagggcagcc ggttcctggt
     4381 atttgaccat gctccgttct cctccatccg aggggagaag tgtgaaatga agcttcatgg
     4441 acctcacaaa aacctcttcc gtctctttct cctgcacaac gcacagggca cccaagtgga
     4501 attcctcttc cgcactgaga ctcaaagtga aaagcttcgc tggatctcag ccttggccat
     4561 gcccagagag gagttggacc tccttgagtg ttatgactcc ccacaagttc agtgcctccg
     4621 tgcctacaag cctcgagaga atgatgagtt ggcactagag aaggcggatg tggtgatggt
     4681 cactcagcaa agcagtgatg gctggctgga gggtgtaaga ctctcagatg gtgagcaagg
     4741 ctggtttcct gtccagcagg tagagttcat ttcaaaccca gaggtccgtg ctcagaacct
     4801 caaggaagcc catcgagtca agacggccaa actgcagctg gtagaacagc aagtctaact
     4861 gttcttgatg aggagtcttc tgagctcatg aacaagcatt cctggaaatg gctggtccta
     4921 gaaacctgct gcagaagctt tctagggatc aggaacctgg ccttctgaaa tcccaaggat
     4981 gagctcagtc ccttgttcca gtacttcttt gcgtttttgt gcttggtagg gaatattgag
     5041 tgactgcaca ctggattctg ggaacctttc ttcataggaa aagggactgt ggggcatgag
     5101 ccttggtgct gtacttccac taccagatgg tacttgtaca tcatctgcta ctacagtgca
     5161 gattcagagc tggccggatg taagttgtgg acagacctat gttaccagat agacctcagc
     5221 ccactcaatg gagggaggtg tttaatgggg attggcgcat cagttgggaa ggtgaacctg
     5281 ctgacctcta gaatagcttt caatcggaga ttgtcctcat tgcatgtgcc cctgcagtcc
     5341 ttgtttcttg gtggcaatgt gagggtggca ttctctcact ctaataaact tggcacttct
     5401 tcacgtgaaa aaaaaaaaaa
//
