LOCUS       NM_001368752            6601 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 38 (Arhgef38),
            transcript variant 1, mRNA.
ACCESSION   NM_001368752
VERSION     NM_001368752.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6601)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6601)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124605.4, AEKQ02022826.1 and AC124593.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               AC124605.4         147718-148039       c
            323-510             AC124605.4         119983-120170       c
            511-634             AC124605.4         89461-89584         c
            635-782             AC124605.4         73809-73956         c
            783-800             AC124605.4         67230-67247         c
            801-1000            AC124605.4         62541-62740         c
            1001-1134           AC124605.4         59510-59643         c
            1135-1239           AC124605.4         55277-55381         c
            1240-1356           AC124605.4         53863-53979         c
            1357-1627           AC124605.4         50397-50667         c
            1628-1668           AEKQ02022826.1     17725-17765
            1669-1812           AC124605.4         46685-46828         c
            1813-2011           AC124605.4         45479-45677         c
            2012-2253           AC124605.4         45131-45372         c
            2254-6601           AC124593.4         176227-180574       c
FEATURES             Location/Qualifiers
     source          1..6601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 61.57 cM"
     gene            1..6601
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /note="Rho guanine nucleotide exchange factor 38"
                     /db_xref="GeneID:77669"
                     /db_xref="MGI:MGI:1924919"
     exon            1..322
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2439
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative Rho guanine nucleotide exchange factor FLJ20184
                     homolog; Rho guanine nucleotide exchange factor (GEF) 38"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 38
                     isoform 1"
                     /protein_id="NP_001355681.1"
                     /db_xref="CCDS:CCDS89690.1"
                     /db_xref="GeneID:77669"
                     /db_xref="MGI:MGI:1924919"
                     /translation="MEPREAAGKETMGSKKKNLTFLRSRLYMLERRKTDTVVDSSVSG
                     DHSGSLRRSQSDRTEYNQKLQEKMTPQAECSSAETPTPEDEQQVGRMMAKRAKIIREL
                     IQTERDYLTDLELCLREVVQPLRSKQIDRLDVEGLFSNIESVHQISAKLLSLLEEATT
                     DVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSVLESYEKEEELKQHLSHCLQSL
                     KNIYLQEGKPNLLDMGSLMIKPIQRVMKYPLLLCELRNSTPPSHPDYRALGEAFAAVK
                     DINVNINELKRRKDLVLKYKKNEEEESLKDKLSKLNIHSISKKSKRVTNHLKILTRGE
                     SQVKDNTFNREEKLFRSLEKTVRLCVKNISSCLQHIEEATPFTLQSGAELREISYQDG
                     EKNGTEPQDQASKPYQDFAARSQRLILNPLSALLSLFPGPQKLIQKRYDKLLDYNSSL
                     PRSATTESDLAKREYEALNAQLVEELQAFNQAAKTILLNCLCSFVTLLRDLMQVALQA
                     YSTVKTVPLPVLGISEIQSRVLEEVHSLTFVKENSATFIERKLSFEKKKPAQILPEVP
                     HQTDAHRSKLLSTYGAEELYRAKRKCNATQEHDINLLEGELVAVLEQKDPLGSTSRWF
                     VDTGCVKGYVYSSFLKPHNPGKGQKVDADNRFCDDDFENISLFVSCRPAGDRVSISDS
                     SSSLSGSCGKFETNGADADNFQEVDEQIFYAVHAFQARSDHELSLQEYQRVHILRFCD
                     LSGNKEWWLAEAQGQKGYVPANYLGKMTYA"
     exon            323..510
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            511..634
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            635..782
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            783..800
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1000
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1134
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1239
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1356
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1668
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1812
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2011
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2253
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..6601
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6249..6254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6276
                     /gene="Arhgef38"
                     /gene_synonym="9130221D24Rik; D630013G24Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcagtcaca gtcaggtaac cctgcagtga agctgtgtag ttagaagggg ggcagttaga
       61 tgctgaggtg cgccctgaga cacttaagcc acctgcaaac ctcagaactt tgtctctttg
      121 cctccgatgg agcccagaga agccgctggg aaggaaacca tgggaagcaa gaagaagaac
      181 ttgactttct tgagatccag gctgtatatg ctggagagga ggaagacgga tactgtggtg
      241 gacagcagtg tttctgggga ccactctggt tccttgagga gaagccagtc tgacaggacc
      301 gaatacaacc agaaactaca agaaaagatg actccacagg ctgagtgctc ctcagcagaa
      361 actcccaccc ctgaggatga gcaacaagtg ggacggatga tggcaaagcg ggccaagatc
      421 atcagggagc tgatacagac ggagagggat tacctcacag atctagagct gtgccttaga
      481 gaagtggtcc agccactgcg aagcaaacag attgacaggc tggacgtgga gggcttgttt
      541 agcaacattg aatctgtgca tcaaatatca gccaagctac tgtccttgct ggaagaggcc
      601 acaacagacg tggaaccggc catgcaagta atcggagagg tattcttgca gattaaagga
      661 ccgctggagg atatttataa aatctattgc tatcaccatg atgaagcaca cagcgtccta
      721 gagtcctatg aaaaggaaga ggagctgaag caacatctga gccactgcct ccagtcctta
      781 aagaatatat atttgcaaga aggcaagccg aacctgctgg acatgggctc tttgatgatc
      841 aaacccattc agcgagtgat gaaatatccc ctgctgctgt gcgaactccg gaactcgacc
      901 ccaccctccc acccagacta cagagccctg ggcgaagcct tcgctgctgt gaaggacatt
      961 aacgttaaca tcaatgagct gaaaaggagg aaagacctag ttctaaaata taagaagaac
     1021 gaggaggagg aatccctcaa agacaaacta tctaaactaa acattcattc aattagcaag
     1081 aagtcaaaaa gagtcacaaa tcatctgaag atcctaacca gaggagagtc acaggtgaaa
     1141 gacaatacct ttaacagaga agaaaagctt tttaggtcac tagaaaagac tgtgagactt
     1201 tgtgtgaaga acatctcctc ctgccttcag cacatagagg aagccacgcc cttcacgctg
     1261 cagagtgggg cggagctccg tgagatttca taccaggatg gagagaaaaa tggcacagaa
     1321 ccccaggatc aggcttcaaa gccctaccaa gactttgcag ctcgttctca gagacttatc
     1381 ctgaatcccc tgtcagcctt gctgtcctta ttccccggac ctcagaaact catccagaaa
     1441 cgctacgaca agctgctgga ctataatagc tccctgccgc ggtcagcaac cactgaatca
     1501 gacttagcca aacgagagta tgaggccctc aatgcccaac ttgtggaaga gctgcaggct
     1561 ttcaaccagg ctgccaagac gatcctgctg aactgcctgt gcagttttgt caccctcctc
     1621 cgggacttga tgcaggtggc tctgcaggct tactccacag tcaagacggt gccactgcca
     1681 gtcttgggca tctcagagat tcagagtcga gtgctggaag aggttcacag cctgactttt
     1741 gtaaaggaga acagtgccac cttcattgag aggaaactta gctttgaaaa gaagaagcct
     1801 gcacagattc tgccagaagt gccacatcaa actgacgctc accgctccaa acttctgtcc
     1861 acatatggag cagaggaact ctaccgcgct aagcgcaagt gtaatgccac ccaagaacat
     1921 gacatcaatc ttctagaagg ggagttggta gctgtcctgg aacagaagga tcccctgggg
     1981 agtacaagca ggtggtttgt ggacaccgga tgtgtaaaag gctacgtgta ctcctccttc
     2041 ctaaagcccc acaacccagg aaaagggcag aaggtggatg cagacaacag attctgtgac
     2101 gacgatttcg agaacatcag tctctttgtg tcttgccggc cagctggtga cagagtcagc
     2161 ataagcgaca gcagctcatc tcttagtggc tcttgtggga agtttgaaac aaatggtgct
     2221 gatgctgata attttcaaga ggtagatgag cagattttct atgcagtcca tgctttccaa
     2281 gcacggagtg accacgaact cagccttcaa gagtaccagc gagtccatat acttagattc
     2341 tgtgatctaa gtggaaacaa agagtggtgg ttagctgaag ctcaaggtca gaaagggtat
     2401 gtgcctgcca actaccttgg gaagatgacg tatgcttaag aaaataagca acatttcttg
     2461 gcaagttgct tattgactac ctcataaaac cgacactgca gcttcaaacc agaaagcaag
     2521 aaacctccaa accatatgaa cagtgtatca cgttttgaag acaaatcttg cttcccaata
     2581 ggacaatttc attgatgtgt aaagaaaaat tgtagacata ctaccaacaa aaactgcaaa
     2641 gtaaaacagc ctcagctctg attatacact tagaggtaga gatcttttga aaagatatat
     2701 tttcatttca catcaccaag agagtggatc taacagtaag gtttttcact ttattgtaat
     2761 attttttctg tactctgcct taaacatatt tttcacattt tttaattttc acataaacat
     2821 gtttacatat acataatata tcctgcagtt tatacagtat gagtacaata cagattatac
     2881 atacatgtat aagtcaaaga ataaactaat tacacagaaa aataacaagc agttagaagt
     2941 ctttataggg atccatttta aatacctttt taattaaaag gaaaacacaa gatattaata
     3001 atatccaaaa cttactaagt gtgtatttca tgatgcacat gaccatttaa atgatttcta
     3061 tatcatgatt taatgcaaca caaagagtaa acactgctag caagtggtca agggggttca
     3121 aacagacaac gtggttccaa ggtctgttcc tactgattac actgtatgct ccttgagtac
     3181 aaaagaatga tgtaaacaag ggacctggag ggactcagac ttctctgact cacatttata
     3241 tatttaacag cttttcaaca tgaagagctt acatagacat gatcctggga gagaagaatg
     3301 aagagtcaaa attcattatt tgtacttttt tttgttttga ttaagcatta tgaaagtgta
     3361 atggttttaa agctgtcata aatgatgact gatgaggctt taatgaagaa acatttttgg
     3421 atcgctctga tttagaaggt acatgggcag tgttcattct acttcagagc caagatttaa
     3481 gtagttttag tggccagttt gtattcagac aaggtgcgga ggattgcatt agctataaca
     3541 tcatggtagg gcattatgct tcaaattcgg ctactcctct gagagctgtc ctccaaaact
     3601 ttaggcctat tcagtcaagg tattattgga ttaacataga gaaagtggga cagatgtgga
     3661 gatgaagtga acccaggcag gtgctcagaa ggaaggaagg aaaatgaaag tctttggagg
     3721 taacaactca atagagaata ttttatgaag accaaaacgt ctggcatgtt tacttggtca
     3781 gcattatcaa atagttgctg tttatcagga actctgataa ctttgagggc tttagcacag
     3841 tgcaaatcaa tgcagtgctc ggctatgcca agtttagttt aatgaggaca acagtgatat
     3901 cctagaagta aagccacgat gactatgact gataagcaga gtgtgtttaa gataatggga
     3961 cagtgagact tctaattttg tttgattttt agtggttact cttacaatta cagtagattt
     4021 tcatttccca taaaatccta atgacatttt aaaaaatgtg ttactttgaa agatttgata
     4081 tactcaatat atataatata taacatatat tatatacatc atttatatga tatgataatc
     4141 atatatatgg ttacatctat tactgagcaa tatctacaac aaaataaaga gttctacaac
     4201 aaaataatcc agctggctga atacgatacc tgctccccaa accagaaata gaattctatt
     4261 atgaaagaaa cagcttatac tactactaag tgcattaaag tagctttata aagttcttgt
     4321 gactttgatt tagtataaag ttttcttttt taagtagggc aacaaaatac tttctaaaag
     4381 atattagaga ctttaaaaaa gattagttgc tctttaaatt caattttaaa gcatgaattt
     4441 gtttgcctaa ggttaagcaa aaagaaatcc aaagttgcta cttaaggaca ctatgaaaat
     4501 gtcgaaagag gcatgattta ttcatggctg tgtgcacctg cacacctgta caccaaactt
     4561 caatgtttta cacaaaaatg aaggattata taaatagcac agttgtgctt tctggctgaa
     4621 atcagtgatt agatgcagga gaagttttgt gtactgatgt ggccctagga gtgatgcttc
     4681 ctgtctgacc tgtgaaaaat ccatgccagg aaaagcaacc cttgagttaa ctcctgagaa
     4741 agaactgtca tgaagccagt gactgcaact ttcctatcat gatgagcact ttactataca
     4801 tgagctctga aaaattatat acgaccttca ttttctactt cttttactta aaatcaagta
     4861 ccctgtaatt ctgaaattag acattatttt aatagacctc agaaaaatac atttccaaga
     4921 tagcttatag gttgtatata tatgtaagca attcaaaaga ttaagccatt agttgcattg
     4981 ttataattac aactaggcat gctaatgtat tttgttatat tcctttttaa attaatatta
     5041 tacagaatag gatcctctga agtgggcaat attttgttta ccaagatgaa gaggaagctt
     5101 ttgtagctag ttttttttaa ataaataaaa atatatgcat cttatttaca tttcattttg
     5161 agattctagt agttaaaaac tactagtata tataatatag agtgtaaaat atctgtctgg
     5221 taatataaaa ttatcattgg tgcagattca tgaaaaaaat cacaaagcca ctttcttaac
     5281 ctatcttata cttcagaaaa aatatcttga ctttgaagga caggaggagg taaggaagag
     5341 ataaatgcat gtttagtcac agcagtgaag caatgggtac cagatgttaa atgctggaac
     5401 attccaaatc gttccaaaat acaatccaga tttaaataca atccagattt tgagaaactg
     5461 cttttaaaat gcctgatgct atttgtaatg aacacagtct gggtggttta cacaaagggt
     5521 tgtttcagct actgagacat ggaattgtca cttcttggat ctttatttac cacattgact
     5581 tcaacagagc tgtatgaata aaaggaggaa attataagaa ataaagccct caccctttaa
     5641 gttgtttgta gtactacagc ttcctaatat atgcactgca ttgctaacta gtgaaaatat
     5701 tcagacctta caaaattcag accaaatgat cctatacgtt tatattatgg tcagtgaggt
     5761 ggttgcagtt cactgagtag acagacactg gacctggaat cctgtaggaa tagattctgt
     5821 gtaaagaata caaatcttca aagtctaatt ctgtagttgc ttccttctct atacacacat
     5881 agatgtaaaa tcaatccagt ccaaactata gtacttcagt tctactggct ctcaccctgg
     5941 ggtctttacg tagctacgat tttcacggtt gtacactctg gttagatgca ggtaaatttt
     6001 gcgtattttg aaaaacaggt caacacgttg gaaaagacta gacctaagat gttcttggtt
     6061 ggaaatcctg ggaatatatt tttactaaat taaatttgtt ttgttttgct taaaattcca
     6121 ctgaggcatc tgaatgtatc catcacattt ctaatttctt ctgacttttg tactactaaa
     6181 atttcatgtt gttaaaagtg atgtatttcc tgtgaaacct ggggtcgtga caatttataa
     6241 ttgtaactaa taaaactact atcatgccct cgtcaagatc tggaatcatc taacttttaa
     6301 atacagatgt gcttttatag tggacttata acctgatata ctcaccatgt gtttaaaaca
     6361 tcctgatcta ctgactatca cattgttcag aaagtcattg ctatatagag agtatcagtt
     6421 gcttggtggc atgatcacat gaatactggg agctgcaacc ttttgcccct gcctggaaat
     6481 gaaatagaat ttcagaatat gtgagcaaca caggaagatg acttgaagtg cagatgcaac
     6541 taaatgtatg tgactttcac actactgaaa aataagaaaa cagtaaagca ttataaacca
     6601 g
//
