LOCUS       NM_001145452            3278 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 33 (Arhgef33),
            mRNA.
ACCESSION   NM_001145452
VERSION     NM_001145452.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3278)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3278)
  AUTHORS   Hall,E.A., Nahorski,M.S., Murray,L.M., Shaheen,R., Perkins,E.,
            Dissanayake,K.N., Kristaryanto,Y., Jones,R.A., Vogt,J.,
            Rivagorda,M., Handley,M.T., Mali,G.R., Quidwai,T., Soares,D.C.,
            Keighren,M.A., McKie,L., Mort,R.L., Gammoh,N., Garcia-Munoz,A.,
            Davey,T., Vermeren,M., Walsh,D., Budd,P., Aligianis,I.A.,
            Faqeih,E., Quigley,A.J., Jackson,I.J., Kulathu,Y., Jackson,M.,
            Ribchester,R.R., von Kriegsheim,A., Alkuraya,F.S., Woods,C.G.,
            Maher,E.R. and Mill,P.
  TITLE     PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by
            Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic
            Proteins
  JOURNAL   Am J Hum Genet 100 (5), 706-724 (2017)
   PUBMED   28413018
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BB628974.1,
            CK793330.1, AK053944.1, AC161447.6, BE654086.1, BE950677.1,
            AI848431.1, CK793318.1 and BE653884.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164136,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               BB628974.1         2-411
            411-576             CK793330.1         89-254
            577-687             AK053944.1         211-321
            688-688             CK793330.1         366-366
            689-1574            AK053944.1         323-1208
            1575-1589           AC161447.6         142297-142311       c
            1590-1633           AC161447.6         141402-141445       c
            1634-2039           BE654086.1         20-425
            2040-2420           BE950677.1         7-387               c
            2421-2933           AI848431.1         1-513
            2934-3202           CK793318.1         25-293              c
            3203-3278           BE653884.1         8-83                c
FEATURES             Location/Qualifiers
     source          1..3278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.63 cM"
     gene            1..3278
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /note="Rho guanine nucleotide exchange factor 33"
                     /db_xref="GeneID:381112"
                     /db_xref="MGI:MGI:2685787"
     exon            1..110
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            111..220
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2748
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /note="DH and coiled-coil domain-containing protein
                     ENSP00000381780 homolog; Rho guanine nucleotide exchange
                     factor (GEF) 33"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 33"
                     /protein_id="NP_001138924.1"
                     /db_xref="CCDS:CCDS50189.1"
                     /db_xref="GeneID:381112"
                     /db_xref="MGI:MGI:2685787"
                     /translation="MEKSKAKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQEL
                     TRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQ
                     KIEQLQQEKRRESRKVKAKKAQKEEHGAQAGPASAPAPGSAPTQGSPFRSINVPEAGL
                     PSDDFTNMLPSQNYEKAQESRSVHVGDSNVKGMMGPGVNPTTPESDENLKPSLSAEIQ
                     SKGHHTPGLWRQPKEGKEWGEEYVTKDHPDKLKDAGQGRHSSLENVLCETSLAAKRQT
                     VALELLESERKYVINISLILKIKATFQGSDGKRNPKERSLFPGSLRYLVQQHLDLLHA
                     LQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLKEGDEEI
                     KSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYTLLFQ
                     CNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASPNAGQEAVHDSGVHSEEMLQP
                     YPSSSSSAPAVSHLMAPAKKGQQQQSLMESMQPGKPGDWELEGRKHERPESLLAPAQF
                     CAAEQDVKALAGPLQAIPEMDFEPSSAEPLGNVERSLRGPPELLPDARGFVPAGYEEF
                     EYGGEIFALPAPYDEEPFQAPALFDNCSPASSESSLDICFLRPVSFAMEAERPEHALQ
                     PLPKSATSPASSSGAYKLEAAQAQAHGKAKPLSRSLKEFPRTPPAEGVAPRLYSTRSS
                     SGGRAPLKVERAPAPHGPAAAAAASRGAPRTFFPQQRSQSEKQTYLEEMHLEDATRFC
                     PKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNSTGEDFCGPWGWW"
     exon            221..270
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            271..435
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            436..557
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            558..724
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            725..784
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1009
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1139
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1272
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1356
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1440
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1589
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1754
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2556
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2696
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2771
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..3261
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3183..3188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /note="hexamer: AATAAA"
     polyA_site      3206
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /note="major polyA site"
     regulatory      3242..3247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
                     /note="hexamer: AATAAT"
     polyA_site      3261
                     /gene="Arhgef33"
                     /gene_synonym="Gm941"
ORIGIN      
        1 atcaagggaa ggcaatcctc tccacagctt ctttctgtaa tctttaagtt acttcagaat
       61 ccagataagc cttggactgg ggatgcgcta accacagcag gcaccatggg gtgcagggaa
      121 ggggaggtgg cctgacccag ggcgaggatg acgaaatgct gaagcgtgag ctggaggaga
      181 gacgcaacgg gcaccatgga aaaatccaaa gccaagcaag gagagaatga acacatgccg
      241 gtgaataacc cttccacaca gatttaccag ctgcaggccc tggcctcgga actgaaaacg
      301 ggcttcacag aagcaatgca ggagctgaca cggatccaac atggagaata cgctttggaa
      361 gagaaggtca agagctgccg atgttcaatg gaagagaaag tcacggagat gaagaattca
      421 ttaaactact tcaaggaaga gctgagcaat gcaatgtcca tgattcaggc catcacttcc
      481 aagcaagaag aaatgcagca gaaaatcgaa cagctgcagc aggagaagag aagagaatct
      541 cgaaaggtca aagccaagaa agcccaaaag gaagaacatg gcgcgcaggc cgggccggca
      601 tctgcgcctg cgcctgggtc tgcgccgact caaggaagcc ccttccgctc catcaatgtc
      661 cctgaagccg gtctccccag tgacgacttc accaacatgt tgccttctca gaactatgaa
      721 aaagcccaag agtcaagatc tgttcatgta ggagatagca atgtcaaggg gatgatgggt
      781 cctggagtga acccaacaac tccagaatcc gatgaaaacc ttaagccttc tctctcagcc
      841 gagatccagt ccaagggcca tcacacacct ggcctgtgga gacagcctaa ggaaggcaaa
      901 gaatggggcg aggaatatgt cacaaaagac cacccagata agctgaagga cgctggccag
      961 ggcagacaca gctccctgga aaacgttctg tgtgaaacct ctttagctgc aaaaaggcaa
     1021 actgtggctc tggaactgct tgaatcagaa cggaagtacg tcatcaacat ctcgctgatc
     1081 ctgaagataa aggccacctt ccagggctcc gatggaaaga ggaaccccaa ggagagaagc
     1141 ctcttccctg gctccttgcg ctacctcgtc cagcagcact tggacttgct tcacgcgctg
     1201 caggagaggg tcctgaagtg gccacgccaa ggagtccttg gagacttatt cctgaagttg
     1261 acaaatgatg agaataattt cttggattat tatgtcgcct acctgaggga tttacccgaa
     1321 tgcatctcat tggttcatgt tgtggtactg aaggagggtg atgaagagat taagtcggat
     1381 atctacactc tgtttttcca catagtacag cgtatccccg aatatctgat acatctgcag
     1441 aatgttctga agttcacaga gcaggagcac ccagactatt acctcctact tgtgtgtgtt
     1501 cagcgcctcc gagtgtttat ctctcattat accctgctgt ttcaatgcaa tgaagatttg
     1561 cttattcaga aacggaaaaa actcaaaaag tcatctatgg caaagctgta caaagggctg
     1621 gcttcccagt gtgccaatgc tggccaagat gcttccccca atgcaggcca ggaggctgtc
     1681 cacgacagtg gggtccactc agaagaaatg ctccaaccct atccttcctc ttccagttcc
     1741 gcccctgctg tctcacatct gatggccccg gcaaagaaag gccagcagca gcagagcctc
     1801 atggagagca tgcagcccgg gaagcctgga gactgggagc tggagggcag gaagcacgag
     1861 cggcccgaga gcctgctggc gccggctcag ttctgcgcgg ccgagcagga cgtgaaggcg
     1921 ctcgccgggc ctctgcaggc catcccggag atggacttcg agccgtcttc cgccgagccg
     1981 ctaggcaacg tggagcgctc gctgcgcggt ccgcccgagc tcctgcccga cgcgcgcggc
     2041 ttcgtgcccg ccggctacga ggagttcgag tacggcggcg agatcttcgc gctgcccgcg
     2101 ccctacgacg aggagccctt ccaggcgccg gcgctcttcg acaactgctc gcctgcctcc
     2161 tccgagtcca gcctggacat ctgcttcctg cggcccgtca gcttcgccat ggaggccgag
     2221 aggccggagc acgcgctgca gccgctgccc aagagcgcca cgtcgccggc gagcagcagc
     2281 ggcgcctaca agctggaggc cgcgcaggcg caggcgcacg gcaaggccaa gcctctgagc
     2341 cgctcgctca aggagttccc gcgcacgccg cccgccgagg gcgtggcccc gcgcctctac
     2401 agcacgcgaa gcagcagcgg cggccgcgcg ccgctcaagg tcgagcgcgc tcccgccccg
     2461 cacggccccg ccgccgccgc tgccgcctcc cgcggggcgc cgcggacctt cttcccccaa
     2521 cagaggtccc aaagcgaaaa acagacctat ttggaagaga tgcacctaga ggatgccact
     2581 cgattctgtc caaaggaaga aagagagagt gaacagactt ctttcagcga tcaaaatccc
     2641 aggcaagacc agaaaggggg ctttcgcagc tcattccgca agctctttaa aaagaaaaat
     2701 gggaactcaa ctggtgaaga tttctgtggt ccttggggct ggtggtgaca tcaaagcttt
     2761 cccatttcca gattttaggt ccagtggatc agaatacagg gaaaaaacta atgagaaccc
     2821 ctcaatggat ccttcaccca ccaaacaaga tttcttcaga aaccgacttg ctcttgcaaa
     2881 tgaccttgac caaggaacag ctgtgtaaat acatttacag ttgtattgtc gagtggtaag
     2941 aggagggtaa aagcttgtat atatctctgc aggaatatat atatatatat atatcaatgt
     3001 ataaatccct aaggaaaact aatataaaca tttacatatg aaattaaatc aacatacaag
     3061 atactgaaga gatgaagatt agtctatggt taagacttgc ctttatgaac ctcaggattg
     3121 ggaaaaggga catgaagact ttccacatca ttacaggaaa aagcatacta aatttggagg
     3181 aaaataaatg tttgtaagac caaaaacttg caccttgaag tcattcccca agtataataa
     3241 taataatcgt gttcattttt aaaaaaaaaa aaaaaaaa
//
