LOCUS       NM_001408684            5474 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 28 (Arhgef28),
            transcript variant 2, mRNA.
ACCESSION   NM_001408684 XM_006517518
VERSION     NM_001408684.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5474)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5474)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5474)
  AUTHORS   Choi,S.Y., Lee,E.B., Kim,J.H. and Lee,J.R.
  TITLE     Over-Expression of p190RhoGEF Regulates the Formation of
            Atherosclerotic Plaques in the Aorta of ApoE-/- Mice via Macrophage
            Polarization
  JOURNAL   Int J Mol Sci 24 (16), 12785 (2023)
   PUBMED   37628966
  REMARK    GeneRIF: Over-Expression of p190RhoGEF Regulates the Formation of
            Atherosclerotic Plaques in the Aorta of ApoE[-/-] Mice via
            Macrophage Polarization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5474)
  AUTHORS   Kleinschmidt,E.G., Miller,N.L.G., Ozmadenci,D., Tancioni,I.,
            Osterman,C.D., Barrie,A.M., Taylor,K.N., Ye,A., Jiang,S.,
            Connolly,D.C., Stupack,D.G. and Schlaepfer,D.D.
  TITLE     Rgnef promotes ovarian tumor progression and confers protection
            from oxidative stress
  JOURNAL   Oncogene 38 (36), 6323-6337 (2019)
   PUBMED   31308489
  REMARK    GeneRIF: A new role for Rgnef in ovarian cancer to facilitate
            NF-kappaB-mediated gene expression protecting cells from oxidative
            stress.
REFERENCE   5  (bases 1 to 5474)
  AUTHORS   Cheung,K., Droppelmann,C.A., MacLellan,A., Cameron,I., Withers,B.,
            Campos-Melo,D., Volkening,K. and Strong,M.J.
  TITLE     Rho guanine nucleotide exchange factor (RGNEF) is a prosurvival
            factor under stress conditions
  JOURNAL   Mol Cell Neurosci 82, 88-95 (2017)
   PUBMED   28495450
  REMARK    GeneRIF: observed that the expression of RGNEF is upregulated in
            murine spinal motor neurons following distal sciatic nerve injury
REFERENCE   6  (bases 1 to 5474)
  AUTHORS   Zhai,J., Lin,H., Nie,Z., Wu,J., Canete-Soler,R., Schlaepfer,W.W.
            and Schlaepfer,D.D.
  TITLE     Direct interaction of focal adhesion kinase with p190RhoGEF
  JOURNAL   J Biol Chem 278 (27), 24865-24873 (2003)
   PUBMED   12702722
REFERENCE   7  (bases 1 to 5474)
  AUTHORS   Zhai,J., Lin,H., Shamim,M., Schlaepfer,W.W. and Canete-Soler,R.
  TITLE     Identification of a novel interaction of 14-3-3 with p190RhoGEF
  JOURNAL   J Biol Chem 276 (44), 41318-41324 (2001)
   PUBMED   11533041
REFERENCE   8  (bases 1 to 5474)
  AUTHORS   van Horck,F.P., Ahmadian,M.R., Haeusler,L.C., Moolenaar,W.H. and
            Kranenburg,O.
  TITLE     Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide
            exchange factor that interacts with microtubules
  JOURNAL   J Biol Chem 276 (7), 4948-4956 (2001)
   PUBMED   11058585
REFERENCE   9  (bases 1 to 5474)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 5474)
  AUTHORS   Gebbink,M.F., Kranenburg,O., Poland,M., van Horck,F.P., Houssa,B.
            and Moolenaar,W.H.
  TITLE     Identification of a novel, putative Rho-specific GDP/GTP exchange
            factor and a RhoA-binding protein: control of neuronal morphology
  JOURNAL   J Cell Biol 137 (7), 1603-1613 (1997)
   PUBMED   9199174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123056.4, AC133507.4 and AC124397.5.
            
            On Jun 22, 2022 this sequence version replaced XM_006517518.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.13789.1,
                                           SRR10223969.13073.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC123056.4         98050-98210         c
            162-205             AC123056.4         37278-37321         c
            206-353             AC133507.4         155649-155796       c
            354-647             AC133507.4         153475-153768       c
            648-831             AC133507.4         132267-132450       c
            832-1012            AC133507.4         129422-129602       c
            1013-1079           AC133507.4         122276-122342       c
            1080-1135           AC133507.4         108352-108407       c
            1136-1196           AC133507.4         107853-107913       c
            1197-1318           AC133507.4         75288-75409         c
            1319-1599           AC133507.4         72378-72658         c
            1600-1804           AC133507.4         66617-66821         c
            1805-1916           AC133507.4         63787-63898         c
            1917-1959           AC133507.4         59848-59890         c
            1960-2083           AC133507.4         56906-57029         c
            2084-2216           AC133507.4         56507-56639         c
            2217-2272           AC133507.4         48791-48846         c
            2273-2321           AC133507.4         47757-47805         c
            2322-2466           AC133507.4         45764-45908         c
            2467-2588           AC133507.4         45563-45684         c
            2589-2729           AC133507.4         43884-44024         c
            2730-2977           AC133507.4         39776-40023         c
            2978-3100           AC133507.4         36183-36305         c
            3101-3218           AC133507.4         35002-35119         c
            3219-3473           AC133507.4         32185-32439         c
            3474-3550           AC133507.4         30045-30121         c
            3551-3729           AC124397.5         1480-1658
            3730-3821           AC124397.5         2721-2812
            3822-4004           AC124397.5         3763-3945
            4005-4136           AC124397.5         5877-6008
            4137-4237           AC124397.5         8901-9001
            4238-4276           AC124397.5         11600-11638
            4277-4324           AC124397.5         11739-11786
            4325-4810           AC124397.5         17198-17683
            4811-5105           AC124397.5         18756-19050
            5106-5474           AC124397.5         48645-49013
FEATURES             Location/Qualifiers
     source          1..5474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 51.6 cM"
     gene            1..5474
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /note="Rho guanine nucleotide exchange factor 28"
                     /db_xref="GeneID:110596"
                     /db_xref="MGI:MGI:1346016"
     exon            1..161
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..5275
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rho-interacting protein 2; p190-RhoGEF; 190 kDa guanine
                     nucleotide exchange factor; Rho specific exchange factor;
                     Rho interacting protein 2; Rho-guanine nucleotide exchange
                     factor; Rho guanine nucleotide exchange factor (GEF) 28"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 28
                     isoform 2"
                     /protein_id="NP_001395613.1"
                     /db_xref="GeneID:110596"
                     /db_xref="MGI:MGI:1346016"
                     /translation="MRRRRARLARDAGAMELSCSEVPLYGQKTVYAKFGKNVYLPEDA
                     EFYFVYGGSHQRHVVIADRVQDNVLQSSIPGHWLQETVTVSVCLCSEGYSPVTMGSGS
                     VTYVDNMACRLARLLVTQADRLTACSHQTLLTPFALTVEALPALDEELVLALTQLELP
                     LGWTVLGNSSLEVSLHRESLLHLAVRWALPKLFHFLLCLPGGVKALKLPNEEATTPLD
                     LALQGGHSTLVEDITNFQGSHSPGFSRLRLNEEATLQFVHSSETLTLTVNHTAEHLLE
                     ADIKLFRKYFWDRAFLVKALEQEAKTEKATMPSGAAETEEEVRNLESGRSPSEEEEDA
                     KSIKSQVDGPSEHEDQDRLPLDRSFDGLKKSKHVPASLAAGQLSDVLNGGDEVYANCM
                     VIDQVGDLDINYINLEGLSTHTSPESGRSMLGPQACMHTLPPDTSPCGRPLIENSEGT
                     LDAAASQSFVTPSSSRTSNLNLSFGLHGFEKEQSHLKKRSSSLDALVADSEGEGGSEP
                     PICYAVGSQSSPRTGLPSGDELDSFETNTEPDCNISRTESLSLSSTLHSKESLLSGIR
                     SRSYSCSSPKISSGKSRLVRDFTVCSTSEEQRSYSFQEPPGEKRIQEEEWDEYVIPAK
                     SESEKYKVSRTFSFLMNRMTSPRNKSKMKNKDTKEKEKMNRHQFVPGTFSGVLQCSGC
                     DKTLLGKESLQCANCKANTHKGCKDAVPPCTKKFQEKYNKNKPQSILGSSSVRDVPAP
                     GLSLHPSSSMPIGLPAGRKEFAAQVHPLSRSVPGTTLESFRRAVTSLESEGDSWRSRS
                     HSDELFQSMGSSPSTESFMMEDVVDSSLWIDLSSDAQEFEAESWSLVVDPSFCSRQEK
                     DVIKRQDVIFELMQTEVHHIQTLLIMSEVFRKGMKEELQLDHSTVDKIFPCLDELLET
                     HRHFFFSMKERRQESCAGSDRNFVINQIGDILVQQFSEENASKMKRIYGEFCSHHKEA
                     MSLFKELQQNKKFQNFIKIRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKE
                     RTEEHRDLCKALGLIKDMIAAVDLKVSEYEKNQKWLEILNKIENKTYTKLKNGHVFRK
                     QALLSQERALLHDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSV
                     ISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEE
                     EGGRTSESDEERRKAEARVAKIQQCQEILSNQDQQICTYLEEKLHIYAELGELSGFED
                     VHLEPHLLIKPDPGEPPQAASLLAAALREAESLQVAVKASKMGDVSQSSEESPGGTVL
                     MDTPSTQDVPASPTASLVTEGTEGRGCWDVDPGLQGVVTDLAVSDAGEKVEYRSFSGS
                     SQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHKLVLQQRESLAPSHSFRGGPLQDQE
                     KSRYLEKQREELANIHKLQHQFQQEQRRWHRTCDQQQREQEAQESWLQARERECQSQE
                     ELLLRHRSELDHQLQEYQQSLERLREGQRMVERERQKMRVQQGLLGHCKHSRQRSLPA
                     VFSPGSKEVTELNRAESLCHENSFFINEAFGHMSLNTSNKPNPSGVPWDAHPLEGSHF
                     DLARTSESPTELKIDISQPPDVNSELWTTGPGHQRPALQENSKESYKNVADLDSFQSE
                     SSSPQDSNQRGPQPQTLTTEAKLSLPMAAGHGGDAGDGAEENILYL"
     exon            162..205
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            206..353
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..647
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..831
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1012
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1079
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1135
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1196
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1318
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1599
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1804
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1916
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1959
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2083
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2216
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2272
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2321
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2466
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2588
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2729
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2977
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3100
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3218
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3473
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3550
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3729
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3821
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..4004
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4136
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..4237
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4238..4276
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4324
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4810
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4811..5105
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5106..5474
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5451..5456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
                     /note="hexamer: ATTAAA"
     polyA_site      5474
                     /gene="Arhgef28"
                     /gene_synonym="9230110L08Rik; D13Bwg1089e; p190RhoGEF;
                     Rgnef; RhoGEF; Rhoip2; RIP2"
ORIGIN      
        1 aggtcccgct ccgtgcccgc cgccggagga aagccgaggc gaccggccgc cgccccgcga
       61 agggaggggg cggcggagcc gcagcagctt caggtttcct cctggagctg gtggcgggcg
      121 cggccatgtg atgaggcggc gacgagcccg gctggccaga gatgcaggag ccatggagtt
      181 gagctgcagt gaagtgcctc tttatggaca gaagacggtc tatgcaaagt ttggcaaaaa
      241 cgtgtatcta cccgaagatg cggagtttta ctttgtttat ggcgggtcgc atcagaggca
      301 cgtggtgatt gctgaccgtg tccaggacaa tgtcctccaa tctagcattc caggccactg
      361 gcttcaggag acggtgacgg tatctgtgtg cctctgctcg gaagggtact ccccagtgac
      421 catgggctct ggctcagtga cctacgtgga caacatggcc tgcaggctgg ctcgtctgct
      481 ggtcactcag gctgaccgac tcacggcctg cagtcaccag acgctgctga ccccgtttgc
      541 cctgacagtg gaagcgctgc ctgccttgga tgaggagctc gtgctggctc tgacccaact
      601 ggagctgcct ttgggttgga cagtcctggg aaattcctca cttgaagtat ctctacacag
      661 agagtctctc ctgcatctgg ctgtgagatg ggccctccct aagctattcc acttcctctt
      721 gtgtctccct ggaggagtca aggccttgaa gctacctaat gaagaggcca ccacaccatt
      781 agacttagct ttgcaaggtg gacactccac actggtagaa gacatcacaa attttcaggg
      841 tagccattcc ccaggcttct cccgactgcg tcttaacgaa gaggccactc tgcagtttgt
      901 tcattcatcg gaaacattga ccctgaccgt taaccacaca gctgagcatc tcttggaagc
      961 agacatcaaa ctcttccgga aatatttctg ggacagagcc tttcttgtca aggctcttga
     1021 gcaagaagcc aagactgaga aagcaaccat gccttctgga gctgcagaaa ctgaagaaga
     1081 ggttaggaat ttggagtctg gcagatcacc atcggaggag gaggaggatg caaagagcat
     1141 caaaagccag gtggatgggc cgagtgaaca cgaagaccag gaccgcctac ctctggatcg
     1201 ctcctttgat ggcctcaaaa aatccaagca tgtcccagcg tcccttgctg caggccagct
     1261 ctctgatgtt ctgaacgggg gtgatgaagt ctacgctaac tgtatggtga ttgaccaggt
     1321 tggcgatttg gatatcaact atataaacct agagggactc tccacccata cgagtcccga
     1381 gtctgggagg tccatgctgg ggcctcaggc ttgcatgcac acccttcctc ccgacaccag
     1441 tccctgcggg cgcccactca ttgagaacag tgaggggacc ctggatgctg cagcttcgca
     1501 gtctttcgtg acaccatcca gttctcgcac ttccaacttg aacctttctt ttggtctcca
     1561 tggatttgaa aaggagcaga gtcatctcaa gaaaaggagt tctagcctgg atgccctggt
     1621 tgccgacagt gagggggaag gaggttctga gccccccatc tgctatgctg tgggctctca
     1681 gagttcccca agaactggac tccccagcgg ggatgaactg gactcttttg agaccaacac
     1741 tgaaccagac tgtaatatct ccaggaccga atcactctct ctgtccagta ctctgcattc
     1801 aaaggagtcc ttgctttctg ggatccggtc tcgctcctac tcctgctcat cacccaaaat
     1861 ctcttcagga aaatcccggc tagtgcgcga cttcacagtg tgcagtacca gcgaagaaca
     1921 gagatcatat agtttccagg agccaccagg agaaaaaagg attcaggaag aagaatggga
     1981 tgaatacgtc attcctgcca aatccgagtc tgaaaagtac aaagtgagcc gaactttcag
     2041 cttcctcatg aacaggatga ccagcccacg gaacaaatct aagatgaaaa acaaggacac
     2101 taaagaaaaa gaaaaaatga atcgacatca gtttgtcccg ggaacgttct ccggggttct
     2161 gcagtgctcc ggttgtgata aaacactcct ggggaaagag tcactccagt gtgccaactg
     2221 taaggcaaac acacacaagg gctgcaaaga tgctgtgcct ccgtgtacca agaaattcca
     2281 agagaaatac aacaagaaca aaccacagag catccttgga agctcttcag tcagagacgt
     2341 cccagcacct gggctctcct tgcacccttc ttcctctatg cccatcggac tgccagctgg
     2401 aaggaaggaa tttgcggctc aggtgcatcc actgtccaga agtgtccccg gcaccacttt
     2461 ggaaagcttc aggagggcag tgacatcgtt agagtctgag ggtgacagct ggagaagcag
     2521 gtctcattcc gatgagctgt tccagtctat gggctcttct ccttccacgg agtcattcat
     2581 gatggaagat gttgtggatt cttctctgtg gatcgacctc agtagtgatg ctcaggagtt
     2641 tgaagcagag tcttggagtc tcgtggtgga cccttccttt tgcagtaggc aggagaagga
     2701 tgtcatcaaa agacaagatg tcatttttga gctgatgcag acagaggtcc accacatcca
     2761 gactctgctc atcatgtccg aggtcttcag gaaaggcatg aaggaggaac tgcagctgga
     2821 ccacagcacg gtggacaaga tcttcccctg cttagatgag ctgctggaga ctcaccggca
     2881 cttcttcttc agcatgaagg agcgcaggca ggagtcctgc gctggcagtg acaggaactt
     2941 tgtgatcaac caaattggag acattctggt acaacagttt tcagaggaaa atgcaagcaa
     3001 aatgaagagg atctatggag aattctgcag ccatcacaaa gaagccatga gtctctttaa
     3061 agagctgcag cagaacaaga agtttcagaa ttttattaag atccgaaata gcaacctgtt
     3121 ggctcgtcgc cgcggaatcc cggagtgcat cctgctagtt acccagcgca tcacaaagta
     3181 cccagtcttg gtggaaagga tcctgcagta caccaaggaa aggactgaag agcaccggga
     3241 cctgtgcaaa gctctcggct taattaaaga catgatcgca gccgtggacc tgaaagtcag
     3301 cgaatacgag aagaaccaaa aatggctcga gatcctaaat aaaatcgaga acaaaacata
     3361 cacaaagctc aaaaatggcc acgtgtttag aaagcaggcg ctgctgagcc aggaacgggc
     3421 tctcctgcat gatgggcttg tctactggaa aaccgctacg ggtcgcttca aagacatcct
     3481 ggctctgcta ctaactgacg tgctgctctt cttacaagaa aaagaccaga aatacatctt
     3541 tgcagctgtt gaccagaagc catcagtgat ttccctccag aagctgattg ctagagaagt
     3601 tgccaacgag gagagaggca tgtttctgat cagtgcttcg tcagccggcc ccgagatgta
     3661 cgaaatccac accaattcca aggaggagcg gaataactgg atgaggcgga tccagcaggc
     3721 agtagaaagt tgtccagagg aagaaggagg aaggacgagc gagtcggatg aagagaggcg
     3781 gaaagctgaa gctagagtgg ccaagattca gcaatgtcaa gaaatactca gtaaccaaga
     3841 ccaacagatt tgcacgtact tggaagaaaa gctgcatatc tacgctgaac ttggggaact
     3901 gagtggcttt gaggatgtcc acctagaacc ccatctgctc atcaaacctg accctggaga
     3961 gcctccccag gcagcgtccc tgcttgcagc agccctgaga gaagccgaga gtctgcaagt
     4021 ggctgtgaag gcttcaaaga tgggcgatgt aagccagtca tccgaagaaa gccctggagg
     4081 gactgtcctg atggacacac ccagtacaca ggatgtacca gcgtcaccaa ctgcttcatt
     4141 agtcacagaa gggacagaag gaagaggctg ttgggatgtg gatcccgggc tccagggtgt
     4201 ggtaaccgac ttggcagtct ctgatgcagg ggagaaggtg gaatatagaa gtttctccgg
     4261 ttcttcacag tcagagatta tacaagcaat acagaattta acgcgtctcc tctacagcct
     4321 tcaggctgcc ttgaccatcc aggacagtca cattgagatc cacaaactgg ttctacagca
     4381 gcgggagagc ttggccccta gccactcctt ccgaggtggc cccttgcaag accaggagaa
     4441 atcccgctac ctggaaaagc agcgtgaaga gctggccaac atccacaagc ttcaacacca
     4501 gttccagcag gagcagcggc gctggcaccg cacgtgcgac cagcaacagc gcgagcagga
     4561 agcccaagag agctggctgc aggcgcggga acgtgagtgc cagtcccagg aggaattgtt
     4621 gctgcgccac cgtagcgagc tggaccacca actccaggag taccagcaga gccttgagcg
     4681 gctacgggag ggccagcgga tggtggagag ggagagacag aagatgcgtg tccagcaggg
     4741 tctgctgggc cactgcaagc atagtcgcca gcggagcctc ccagccgtct tctctccagg
     4801 gagcaaggag gtaacagaac ttaaccgagc tgagagtttg tgtcatgaaa attcattttt
     4861 catcaatgaa gcttttggac acatgtcact taacacgtcc aataaaccaa acccatcagg
     4921 ggtcccctgg gatgctcacc ccctggaggg gtctcatttt gatttggcaa ggactagtga
     4981 gagtccaaca gaactgaaga tagacatttc tcagcctcct gatgtcaact ctgaactctg
     5041 gacaacgggg ccgggccatc agagacctgc tctccaagaa aacagcaagg agtcttataa
     5101 aaatgttgca gatttggact ccttccagag tgaatcgtca tctccccagg actccaatca
     5161 gcgtggcccc cagccacaga cactcacaac agaagcaaaa ctaagtcttc cgatggcggc
     5221 tggacacggt ggcgatgctg gagacggggc tgaagaaaac attctttacc tctgattgtg
     5281 tggccatttg ttttcccaag caaacaaaca taaaccactg gcactttggg gagagtttct
     5341 ccttggcccc agcccttgag tgtgtgattc tctgtgccca acttgcttta agaagaatat
     5401 ttaatatccc atgcacgttc aatttttggc atgagtctaa taattaaatt attaaaaaaa
     5461 agaaaaaaga aaaa
//
