LOCUS       NM_001358557            2480 bp    mRNA    linear   ROD 27-JUN-2023
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 25 (Arhgef25),
            transcript variant 3, mRNA.
ACCESSION   NM_001358557 XM_006513878
VERSION     NM_001358557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho
            A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH,
            Wieland T and Lutz S.
  TITLE     p63RhoGEF regulates auto- and paracrine signaling in cardiac
            fibroblasts
  JOURNAL   J Mol Cell Cardiol 88, 39-54 (2015)
   PUBMED   26392029
  REMARK    GeneRIF: In cultured neonatal cardiac fibroblasts, p63RhoGEF
            regulated the angiotensin II (Ang II)-dependent RhoA activation,
            the activation of the serum response factor, and the expression and
            secretion of CTGF.
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K and
            Orth JH.
  TITLE     Pasteurella multocida toxin prevents osteoblast differentiation by
            transactivation of the MAP-kinase cascade via the
            Galpha(q/11)--p63RhoGEF--RhoA axis
  JOURNAL   PLoS Pathog 9 (5), e1003385 (2013)
   PUBMED   23696743
  REMARK    GeneRIF: Pasteurella multocida toxin prevents osteoblast
            differentiation by transactivation of the MAP-kinase cascade via
            the Galpha(q/11)--p63RhoGEF--RhoA axis.
REFERENCE   5  (bases 1 to 2480)
  AUTHORS   Fan X, Hou N, Fan K, Yuan J, Mo X, Deng Y, Wan Y, Teng Y, Yang X
            and Wu X.
  TITLE     Geft is dispensable for the development of the second heart field
  JOURNAL   BMB Rep 45 (3), 153-158 (2012)
   PUBMED   22449701
  REMARK    GeneRIF: The Geft knockout mice develop normally and exhibit no
            discernable phenotype, suggesting Geft is dispensable for the
            development of the second heart field in mouse.
REFERENCE   6  (bases 1 to 2480)
  AUTHORS   Smith TK, Hager HA, Francis R, Kilkenny DM, Lo CW and Bader DM.
  TITLE     Bves directly interacts with GEFT, and controls cell shape and
            movement through regulation of Rac1/Cdc42 activity
  JOURNAL   Proc Natl Acad Sci U S A 105 (24), 8298-8303 (2008)
   PUBMED   18541910
  REMARK    GeneRIF: Bves directly interacts with GEFT and is a novel regulator
            of the Rac1 and Cdc42 signaling cascades.
REFERENCE   7  (bases 1 to 2480)
  AUTHORS   Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB and Liu
            M.
  TITLE     Modulation of muscle regeneration, myogenesis, and adipogenesis by
            the Rho family guanine nucleotide exchange factor GEFT
  JOURNAL   Mol Cell Biol 25 (24), 11089-11101 (2005)
   PUBMED   16314529
REFERENCE   8  (bases 1 to 2480)
  AUTHORS   Powles N, Babbs C, Ficker M, Schimmang T and Maconochie M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   9  (bases 1 to 2480)
  AUTHORS   Yoshizawa M, Sone M, Matsuo N, Nagase T, Ohara O, Nabeshima Y and
            Hoshino M.
  TITLE     Dynamic and coordinated expression profile of dbl-family guanine
            nucleotide exchange factors in the developing mouse brain
  JOURNAL   Gene Expr Patterns 3 (3), 375-381 (2003)
   PUBMED   12799088
REFERENCE   10 (bases 1 to 2480)
  AUTHORS   Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z
            and Liu M.
  TITLE     A Rac/Cdc42-specific exchange factor, GEFT, induces cell
            proliferation, transformation, and migration
  JOURNAL   J Biol Chem 278 (15), 13207-13215 (2003)
   PUBMED   12547822
  REMARK    GeneRIF: This protein induces cell proliferation, transformation,
            and migration.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA751787.1, AC144852.3, AF487515.1 and AK158684.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001358557.2.
            
            On Dec 1, 2017 this sequence version replaced XM_006513878.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363659.167629.1,
                                           SRR7974084.3556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CA751787.1         1-3
            4-13                AC144852.3         119267-119276
            14-585              CA751787.1         14-585
            586-750             AF487515.1         333-497
            751-2470            AK158684.1         470-2189
            2471-2480           AC144852.3         125506-125515
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..2480
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /note="Rho guanine nucleotide exchange factor 25"
                     /db_xref="GeneID:52666"
                     /db_xref="MGI:MGI:1277173"
     exon            1..522
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..2165
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /note="isoform 3 is encoded by transcript variant 3;
                     guanine nucleotide exchange factor GEFT; p63RhoGEF;
                     rac/Cdc42/Rho exchange factor GEFT; rhoA/Rac/Cdc42 guanine
                     nucleotide exchange factor GEFT; Rho guanine nucleotide
                     exchange factor (GEF) 25"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 25
                     isoform 3"
                     /protein_id="NP_001345486.1"
                     /db_xref="CCDS:CCDS88098.1"
                     /db_xref="GeneID:52666"
                     /db_xref="MGI:MGI:1277173"
                     /translation="MRGGHKGGRCACPRVIRKVLAKCGCCFSRGGRESYSIAVSEGSM
                     SASAVSGLAALSGPSSGLSSDPCSPIPPGPVTGLRRWLDHSKHCLSVETEAESGQTGQ
                     CENWTLEPTLTTGQELPELTLLTTLLEGPGDKAQPAEEETLSQAPKNEEEQKKMALER
                     SMFVLGELVETERTYVDDLGQIVEGYMATMATQGVPESLRGRDRIVFGNIQQIYEWHR
                     DYFLQELQQCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVLSEFGDSYFEELRQ
                     QLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYRRAGKDTEELEQAVEVMCFVPKRCN
                     DMMSLGRLRGFEGKLTAQGKLLGQDTFLVTEPEAGGLLSSRGRERRVFLFEQIIIFSE
                     ALGGGGRGGAQPGYVYKNSIKVSCLGLEGNLQGNPCRFALTSRGPEGGIQRYVLQASD
                     PAVSQAWIKQVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPGGPWVGSPGRMRPG
                     DLAQASMHTPINGSLPSLLLLPRGEVSRVLLPLDTQALSDTPQTPHDSPALPTVNTPP
                     CQARLAKLDEDEL"
     exon            523..737
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            738..833
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            834..910
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            911..977
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1081
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1151
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1241
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1334
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1385
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1463
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1664
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1845
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2057
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2480
                     /gene="Arhgef25"
                     /gene_synonym="2410008H17Rik; D10Ertd610e; GEFT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacccgcgc ggctccagtg gctctgggaa tcggcccccg cacctccctg cccgggccta
       61 gagccacccc taagccgagg ccggagacgg agctggagcg gctgtcgcat cccggccggg
      121 cctcccccat caccccttcc tctggctgga catctggacc ctgggccccg caccgccggg
      181 gttccggaaa ccctccccgc ccaactccgc ggcccagccc cgcacggccc tccctccaga
      241 ctcccctgcc tcgacttccg tctactcctg gacccccgcc tcccatcctt tttctccccc
      301 cctctccaag cctggacccc ggagggaggg aggggggtgt gcgccctgcg cccgccccgc
      361 cccgcccccc gtgattcccc ctgcatggcc ggcccgggtg gggggtgcgg ggggccccgg
      421 gcgccatgcg ggggggtcac aaagggggtc gctgtgcctg tccccgtgtg attcgaaaag
      481 tgctggcaaa atgcggctgc tgcttctccc gggggggacg tgaatcctat tctattgccg
      541 tcagtgaggg gagcatgtca gcgtctgctg tctcggggct ggctgccctg tctggcccca
      601 gctctggcct cagctctgat ccgtgttctc cgattccccc tggaccagta actggcctga
      661 ggagatggtt ggatcattcc aaacattgtc tcagtgtgga aactgaggca gagagtggtc
      721 agaccggaca atgtgagaac tggacgctgg agccaacttt aaccacagga caagagctgc
      781 ccgaactgac cttactgact acattgctgg agggtcctgg agacaaggca cagccagctg
      841 aagaggaaac tttgtcccaa gctcccaaga atgaggaaga gcagaagaag atggctctgg
      901 aaaggagtat gtttgtcctg ggtgagctgg tggaaacaga aagaacatat gtggacgact
      961 tgggacagat cgtagagggt tacatggcta ccatggctac tcagggggta cctgagagtc
     1021 tccgaggtcg tgacaggatt gtgtttggga acattcagca gatctatgag tggcaccgag
     1081 actacttcct gcaggagctg cagcagtgtt tgaaagatcc cgattggttg gctcagctgt
     1141 tcatcaaaca tgagcgccga ctgcatatgt atgtggtgta ctgccagaat aaacccaagt
     1201 cagagcatgt gctgtcagag tttggggaca gctactttga ggagctgagg cagcagctgg
     1261 gacaccgact gcagctcaat gacctcctca ttaaaccagt gcagcgaatc atgaaatacc
     1321 agttgctgct gaaggatttt ctaaagtatt acagaagagc tgggaaggat actgaagagc
     1381 tggagcaagc tgtggaggtc atgtgtttcg tacctaagcg atgcaatgat atgatgtccc
     1441 tggggagact tcggggattt gagggaaaac tgactgctca ggggaagctc ttgggccagg
     1501 acacattctt ggttacagag cctgaagctg ggggtctgct ttcttcccgg ggtcgggaga
     1561 ggcgtgtctt cctgttcgag caaatcatca tcttcagtga ggccctggga ggaggaggcc
     1621 gaggtggcgc gcagcctggc tacgtgtaca agaacagcat caaggtgagc tgcctagggc
     1681 tggaggggaa tctccaaggc aacccttgcc ggtttgcgct gacctctaga gggccagaag
     1741 gtgggatcca gcgctacgtt ctgcaggctt cagaccctgc tgtcagtcaa gcctggataa
     1801 agcaagtggc ccagatcctg gaaagccagc gtgactttct caacgcatta cagtcaccca
     1861 ttgaatacca gagacgtgag agccagacca atagcctggg gcgaccagga gggccttggg
     1921 tagggagccc tgggagaatg cggcctggag acctggccca ggccagcatg cacacaccca
     1981 tcaatggctc tctcccttcc ctgctacttc tgcccagagg ggaggtgtcc agagtgctgt
     2041 tgcccctgga tacacaggct ctcagtgata ccccccagac tcctcatgac tctccagccc
     2101 ttcccactgt gaacactcct ccctgtcagg ccaggctcgc caagctggat gaagatgagc
     2161 tgtaacccca aaagtgcagt gctattggcg caggcatgat tcctcaatga atttggaggg
     2221 ggaatcctgg aaatgtgcca gaatccatcc tccatgatgt atagaggatg ggagagactg
     2281 ggcctgaaag gactcttttc tgcccaaggg acacaggatc cgtcagttcc actccctgca
     2341 tgcaccacga cccactcaaa tggaggatat ggaggagctt ggagggagga tgagggcagg
     2401 gaccagatag aaattattgg cctgggttgt gattttgttt tcgagttttc ttgtgaataa
     2461 aagttttgct atatcactga
//
