LOCUS       NM_008487               5727 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho/Rac guanine nucleotide exchange factor 2
            (Arhgef2), transcript variant 1, mRNA.
ACCESSION   NM_008487
VERSION     NM_008487.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5727)
  AUTHORS   Olivier,J.F., Langlais,D., Jeyakumar,T., Polyak,M.J., Galarneau,L.,
            Cayrol,R., Jiang,H., Molloy,K.R., Xu,G., Suzuki,H., LaCava,J.,
            Gros,P. and Fodil,N.
  TITLE     CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic
            cell function in neuroinflammation and colitis
  JOURNAL   Commun Biol 7 (1), 77 (2024)
   PUBMED   38200184
  REMARK    GeneRIF: CCDC88B interacts with RASAL3 and ARHGEF2 and regulates
            dendritic cell function in neuroinflammation and colitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5727)
  AUTHORS   Hu,Q., Lai,J., Chen,H., Cai,Y., Yue,Z., Lin,H. and Sun,L.
  TITLE     Reducing GEF-H1 Expression Inhibits Renal Cyst Formation,
            Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis
  JOURNAL   Int J Mol Sci 24 (4), 3504 (2023)
   PUBMED   36834937
  REMARK    GeneRIF: Reducing GEF-H1 Expression Inhibits Renal Cyst Formation,
            Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5727)
  AUTHORS   Chan,D.C.H., Xu,J., Vujovic,A., Wong,N., Gordon,V., de
            Rooij,L.P.M.H., Moreira,S., Joyce,C.E., La Rose,J., Sandi,M.J.,
            Doble,B.W., Novina,C.D., Rottapel,R.K. and Hope,K.J.
  TITLE     Arhgef2 regulates mitotic spindle orientation in hematopoietic stem
            cells and is essential for productive hematopoiesis
  JOURNAL   Blood Adv 5 (16), 3120-3133 (2021)
   PUBMED   34406376
  REMARK    GeneRIF: Arhgef2 regulates mitotic spindle orientation in
            hematopoietic stem cells and is essential for productive
            hematopoiesis.
REFERENCE   5  (bases 1 to 5727)
  AUTHORS   Zhou,P., Qi,Y., Fang,X., Yang,M., Zheng,S., Liao,C., Qin,F.,
            Liu,L., Li,H., Li,Y., Ravindran,E., Sun,C., Wei,X., Wang,W.,
            Fang,L., Han,D., Peng,C., Chen,W., Li,N., Kaindl,A.M. and Hu,H.
  TITLE     Arhgef2 regulates neural differentiation in the cerebral cortex
            through mRNA m6A-methylation of Npdc1 and Cend1
  JOURNAL   iScience 24 (6), 102645 (2021)
   PUBMED   34142067
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5727)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   7  (bases 1 to 5727)
  AUTHORS   Snyder,J.T., Worthylake,D.K., Rossman,K.L., Betts,L., Pruitt,W.M.,
            Siderovski,D.P., Der,C.J. and Sondek,J.
  TITLE     Structural basis for the selective activation of Rho GTPases by Dbl
            exchange factors
  JOURNAL   Nat Struct Biol 9 (6), 468-475 (2002)
   PUBMED   12006984
REFERENCE   8  (bases 1 to 5727)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 5727)
  AUTHORS   Whitehead,I., Kirk,H., Tognon,C., Trigo-Gonzalez,G. and Kay,R.
  TITLE     Expression cloning of lfc, a novel oncogene with structural
            similarities to guanine nucleotide exchange factors and to the
            regulatory region of protein kinase C
  JOURNAL   J Biol Chem 270 (31), 18388-18395 (1995)
   PUBMED   7629163
REFERENCE   10 (bases 1 to 5727)
  AUTHORS   Danilenko,D.M., Ring,B.D., Yanagihara,D., Benson,W., Wiemann,B.,
            Starnes,C.O. and Pierce,G.F.
  TITLE     Keratinocyte growth factor is an important endogenous mediator of
            hair follicle growth, development, and differentiation.
            Normalization of the nu/nu follicular differentiation defect and
            amelioration of chemotherapy-induced alopecia
  JOURNAL   Am J Pathol 147 (1), 145-154 (1995)
   PUBMED   7604876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145168.5.
            
            On Dec 13, 2019 this sequence version replaced NM_008487.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156379.1, BC006589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AC145168.5         187246-187408
            164-308             AC145168.5         195874-196018
            309-376             AC145168.5         197998-198065
            377-440             AC145168.5         198363-198426
            441-570             AC145168.5         199000-199129
            571-680             AC145168.5         199345-199454
            681-827             AC145168.5         199587-199733
            828-1078            AC145168.5         200497-200747
            1079-1204           AC145168.5         201070-201195
            1205-1322           AC145168.5         201688-201805
            1323-1571           AC145168.5         201942-202190
            1572-1648           AC145168.5         204358-204434
            1649-1818           AC145168.5         205410-205579
            1819-1886           AC145168.5         206370-206437
            1887-2087           AC145168.5         208513-208713
            2088-2201           AC145168.5         209013-209126
            2202-2269           AC145168.5         209236-209303
            2270-2305           AC145168.5         209432-209467
            2306-2356           AC145168.5         209649-209699
            2357-2800           AC145168.5         209877-210320
            2801-2984           AC145168.5         212264-212447
            2985-5727           AC145168.5         212877-215619
FEATURES             Location/Qualifiers
     source          1..5727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.9 cM"
     gene            1..5727
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /note="Rho/Rac guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:16800"
                     /db_xref="MGI:MGI:103264"
     exon            1..163
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..3058
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     guanine nucleotide exchange factor 2; rhobin; oncogene
                     LFC; LBC'S first cousin; guanine nucleotide exchange
                     factor H1; lymphoid blast crisis-like 1; rho/rac guanine
                     nucleotide exchange factor (GEF) 2"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 2 isoform
                     1"
                     /protein_id="NP_032513.3"
                     /db_xref="CCDS:CCDS17481.1"
                     /db_xref="GeneID:16800"
                     /db_xref="MGI:MGI:103264"
                     /translation="MSRIESLTRARIDRSKEQATKTREKEKMKEAKDARYTNGHLFTT
                     ISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLRNN
                     TALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGHFN
                     DESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSW
                     SLAVDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEV
                     VQGLFPCVDELSDIHTRFLNQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQ
                     MRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRI
                     TKYPVLINRILQNSHGVEEEYQDLASALGLVKELLSNVDQDVHELEKEARLQEIYNRM
                     DPRAQTPVPGKGPFGRDELLRRKLIHEGCLLWKTATGRFKDVLLLLMTDVLVFLQEKD
                     QKYIFTSLDKPSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRV
                     IQQSVRLCPSREDFPLIETEDKAYLRRIKTKLQQKNQALVELLQKNVELFAEMVHFQA
                     LKAGFVGMPPPALPRGLFRLESFESLRGERLLKDALREVEGLKDLLLGPCVDLPMTSR
                     EPALPLDSDSGSCPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEEVLQP
                     LINLYGLLHGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRAAVASVTPEK
                     QATELALLQRQHTLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIR
                     RQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTV
                     RSLHRPFDDREAQELGSPEDRLQDSSDPDTGSEEEVSSRLSPPHSPRDFTRMQDIPEE
                     TESRDGEPTASES"
     exon            164..308
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            309..376
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            377..440
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            441..570
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            571..680
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            681..827
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1078
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1204
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1322
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1571
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1648
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1818
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1886
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2087
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2201
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2269
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2305
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2356
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2800
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2984
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..5727
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3105..3110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /note="hexamer: AGTAAA"
     polyA_site      3130
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
     regulatory      4226..4231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /note="hexamer: ATTAAA"
     polyA_site      4247
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /note="major polyA site"
     regulatory      5703..5708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
                     /note="hexamer: ATTAAA"
     polyA_site      5727
                     /gene="Arhgef2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40;
                     mKIAA0651; P40"
ORIGIN      
        1 agacttcctg tccccgaggc cgacgcgtgc ggccggaccc ctcccccgcc gttgctggac
       61 acccggggcc gccgcgtcct cccgcggctc acgctggatt atgtctcgga tcgaatccct
      121 cactcgcgcg cggatcgacc ggagcaagga gcaggcaacc aagacccggg aaaaggagaa
      181 gatgaaggaa gctaaagatg cccgctatac caacggccac ctcttcacca ccatctccgt
      241 ctccggcatg accatgtgct atgcctgtaa caagagcatc acagccaagg aagccctcat
      301 ttgtcctaca tgtaacgtga ccatccacaa ccgctgtaaa gacaccctgg ccaactgtac
      361 caaggtcaag cagaagcaac agaaagctgc actgctgagg aacaacactg ctttgcagtc
      421 tgtctccctt cgaagtaaga cgaccaccag agagcggcca acgtctgcca tttacccttc
      481 cgacagcttc cggcagtccc tcctgggttc tcggcggggc ctctcctcct tatctttggc
      541 caaaagtgtt tccactacca acattgctgg acatttcaat gatgagtctc ctctggggct
      601 gcgtcagatc ctctcccagt ccacagactc cctcaacatg cggaaccgaa ccctgtccgt
      661 ggaatccctt attgatgaag gtgtagaagt gttctacaat gagctgatga gcgactttga
      721 gatggatgag aaggactttg aggcggattc ttggagcctt gccgtggaca gcagcttcct
      781 gcagcagcac aaaaaggaag tgatgaagaa gcaagatgtc atctatgagc tgatccagac
      841 agagctgcac cacgtgagaa ccttgaagat tatgacccgc ctctttcgca ctgggatgct
      901 ggaagagttg cagatggagc cagaagtggt ccagggcctg ttcccctgcg tggatgaact
      961 cagtgacatt cacacacgtt tccttaatca gcttctggaa cggcggcgcc aggctctatg
     1021 tccaggcagc acccggaact ttgtcatcca tcgtttgggt gacttgctca tcagtcagtt
     1081 ctcaggttcc aatgctgagc agatgcgcaa gacctactca gagttctgca gccgccacac
     1141 caaggcctta aagctctata aggagctgta tgctcgagac aaacgcttcc aacagttcat
     1201 ccggaaaatg acccgctcag ctgtgttgaa gcggcatgga gttcaggaat gcattctcct
     1261 ggtgactcag cggatcacca aataccctgt gctcatcaac agaatcctgc agaattccca
     1321 cggggttgaa gaagagtacc aagacttggc gtcagcccta ggactagtga aggagttgtt
     1381 gtccaatgtg gaccaggatg tgcacgagct ggagaaagag gcccgcctgc aggagattta
     1441 caaccgaatg gatccccggg ctcagacccc cgtacctggc aagggcccct tcggccgaga
     1501 tgaactttta cggagaaaac ttatccatga aggctgcctg ctctggaaga cagccacagg
     1561 ccgcttcaaa gatgtcctgt tgctgctgat gacagatgtg ctcgtgtttc tccaggaaaa
     1621 ggaccagaaa tacattttca cgtctctgga caagccctca gtggtgtcct tgcagaacct
     1681 catcgtaaga gacatagcca accaggcgaa agggatgttt ctgattagtt ctggaccgcc
     1741 tgagatgtat gaggtgcatg cagcgtcccg agacgaccgg actacctgga tccgtgtcat
     1801 ccagcagagt gtgcgcctgt gcccgtccag ggaggacttt cctctgatcg agacagagga
     1861 taaggcgtat ctccggagga tcaagacgaa actgcagcag aaaaaccagg cgctagtgga
     1921 gctgctacag aagaatgttg agctgtttgc cgagatggtc cacttccagg ccttaaaggc
     1981 tggcttcgtt ggaatgcccc cacccgccct gcccaggggc cttttccgtc ttgagtcctt
     2041 tgagtccctc cgaggcgagc gcctgctaaa ggatgccctc cgtgaagtgg aaggcctgaa
     2101 agacctgctg ttgggcccat gtgtggacct gcctatgaca tcccgagaac cagccttacc
     2161 cttggactct gacagcggta gctgtcctgg ggtcactgcc aatggagagg ccagaacctt
     2221 caatggctcc attgaactct gtagagcaga ctcggattcc agccagaagg atcggaatgg
     2281 aaatcagttg agatcaccac aggaggaggt gttacagcca ttgatcaatc tttatggact
     2341 tctacatggc ctgcaggctg ttgtggtcca gcaggaaaga ctgatggaag ccctgttccc
     2401 tgagggccct gaacggtggg aaaagctatc ccgagccaac tctcgggatg gtgaagctgg
     2461 ccgggctgcg gttgcttctg taactcctga gaagcaggcc acggagctgg cactactgca
     2521 gaggcaacac accctgttgc aggaagagct gcggcgctgc cagcggctcg gggaagagcg
     2581 ggcaactgaa gctggcagcc tggaggccag gctccgagag agcgagcaag cccgggccct
     2641 gctggagcgg gaggctgaag agatccgccg gcagcttgca gccttgggcc aaaacgagcc
     2701 actcccggca gaagcgccct gggctcgcag gcctctggac ccacggcgcc gcagccttcc
     2761 agcgggcgac gctttatact tgagcttcaa tcccccccag cccagtcgag gccatgaccg
     2821 cctggatttg cctgtgactg ttcgttccct ccaccgaccc tttgatgacc gagaggcgca
     2881 agaacttggt agccccgagg atcgactaca ggacagcagt gaccctgata ctggtagtga
     2941 ggaggaagtc agtagccgcc tgtctccacc tcacagtcct cgagacttca cccgaatgca
     3001 ggacattcct gaagagacag aaagccgaga tggggagccc acagcttcag agagctaagg
     3061 ggacacttcc cccacccccg cctggtgccc cactgaagaa cattagtaaa gggggcaaac
     3121 cttgaaagaa ctgctgattg tccttaccag ttcctgagac ccctggatac ctaggggcca
     3181 tggggacttg gggacataga ggccactgca ctcctggtgt cctccaacag ccacaccgca
     3241 gatgccaact tttcatgcct tctcccccta cttaggaaaa attatttatt tattgtttaa
     3301 tggttacagg gggcgggcag ggagtaattt aaagggccag ggacatggga accaagccat
     3361 aagtattgga gagcctctcc tctaatacca ctgggatatg tttggcctta gccacacagc
     3421 ctaacaccca ccccagtgac acccatctgt ggccacagcc tactgcccct ttaaggaggg
     3481 ctgtgggtag gaccatgtcc cttcccccac tccccctagc ctctttctgc tcttcgttct
     3541 catcatcctc catggaaatc tggctccttg gagttgatgg agcagaggct agggcggcca
     3601 taatgtatgg gggaggggaa ggaagaacct acagggacca gaatgtttgg tttttagttt
     3661 ttgttttttt gtttttgtac caaagccaac cacacctgtt ttatattttt aaaagaagat
     3721 tgtaggcact tctagctcca tatctttgaa cttgaggaat tagggagaca gtgacttatt
     3781 tcattgaccg tcagggggct cctattcaga actcttcctc agccatttgg aagaagctct
     3841 aaggtgggtt gggaaacctc tacgaaccct cacctcatct cccacagcgg caacgtttga
     3901 aacgtaagca agaattgagg gagggggatt tttttttcaa tgcaacccta atgtccacca
     3961 gcgatagcca tttgtctgca aatttaattg ttaaaaaaca aaacaaagca aacagtaaca
     4021 acaaagaaaa gagaaagaga gagagagaga gagagagaga gagagagctc aagcagggaa
     4081 aagacctaaa gcgcatgagg tgctgactca gtgcccgatc caaggactgc ggtgcatgca
     4141 gccaggcagt gaccacggtt tctgaaaagg ggctgtcact acctcactga agagggcatg
     4201 aatggatgca gctgctcaaa ctcttattaa aaatcttaaa attgcaaggc tggaaatgaa
     4261 gcgccgttca gcctccagcg gctgttaatg atgcacacat tagaaaactc gtttgcatct
     4321 tattcatctg ccatgcttgg atagcacatc tggttcttgc cacccctctg ttcccctccc
     4381 tgcccctccc attttcatgc ccaccctggc ttaggtctct gagcagcagc ctgtaccgct
     4441 ctgtctcttg gagaggccgt aagtggtttc agttcttggt tttggcttat tccacttcct
     4501 gtttctaggc cctacgctta ggccacgggg cagggacagg gaatgcccat ccccacaacc
     4561 tgagaagcgg ggtgtgaaga agggtctcag gaccccaccg aaaaggggaa ttgaagttgc
     4621 gtgggctgca gcaggccttg tgggaagcat ccttgccctc cagcagcttc tggccctcag
     4681 gaggcacttt ctctctaaat catgggattc ttcggctata ggaattgttt tataaattta
     4741 tttactttag tatttattat ctttgagaca aggtcttgca gtgaagccca ggctggcctt
     4801 ggattcaagg caatcctctt gcttcggcct cccaaatgct gcaattacag gcgcaagcca
     4861 gtatgcccag cccactgtgt ttttctttta cataatgggt gcaaaaaagt tgccaggcca
     4921 aaaaaccagc ccccacttcc tctgcctgac aaatgcctca gattcaagcc ccccgatgct
     4981 cagcagctgt gctggaggca gcgctaagca ccggggccca agcatgcgaa ggtcaggtgg
     5041 acgagactat tacagagtct ggagaagagc aggacagttt cccagccttc cccagagggg
     5101 ccgggaggaa aacctagaac ctgagatgga tcttcagagt aggagttggg agagcctggg
     5161 ctccttccat tgccttatta ccatagccgc agtccagcat cagccagagc ctttcccttc
     5221 ctcctgtcat catctgtccc ttccttgtcc ccctccctga tcccactttc tgaacctaaa
     5281 gtcttcattt ttgcccccac cgtcctccct cccacccccg ctgccatttc aaagccctgt
     5341 gactgctctg agaaccaggg tcctgctagc tttttgctta aaccacatag ctcccttaga
     5401 ggaggctcta gacctgggca tgccgcgctc cactttccac ccccttttct ccatgctgcc
     5461 ccctccaagt cagggctaca caccgttcct tgagttggtt ttgtcaatat ttaccccctg
     5521 ggcactgtaa agcagatgcc cccagaaaag gcaatatccg gacccagcgg gacctgaggg
     5581 ggcaggagga aggatgctca ggcgcgggag gattacccac cttcctggat ggctgggagt
     5641 agaactggca ttttggagcc agtttaaaca tcataaagag gaaatgaaac atcgagaggc
     5701 taattaaatc ttgttcccgt cctttaa
//
