LOCUS       NM_001112744            2717 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 16 (Arhgef16),
            mRNA.
ACCESSION   NM_001112744 XM_149562 XM_902459
VERSION     NM_001112744.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2717)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2717)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   3  (bases 1 to 2717)
  AUTHORS   Lee,J., Park,B., Kim,G., Kim,K., Pak,J., Kim,K., Ye,M.B., Park,S.G.
            and Park,D.
  TITLE     Arhgef16, a novel Elmo1 binding partner, promotes clearance of
            apoptotic cells via RhoG-dependent Rac1 activation
  JOURNAL   Biochim Biophys Acta 1843 (11), 2438-2447 (2014)
   PUBMED   25063526
REFERENCE   4  (bases 1 to 2717)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK153708.1 and
            AK042195.1.
            
            On or before Dec 22, 2007 this sequence version replaced
            XM_149562.8, XM_902459.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153708.1, AK042195.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1700              AK153708.1         162-1861
            1701-2577           AK042195.1         1697-2573
            2578-2717           AK153708.1         2739-2878
FEATURES             Location/Qualifiers
     source          1..2717
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.96 cM"
     gene            1..2717
                     /gene="Arhgef16"
                     /note="Rho guanine nucleotide exchange factor 16"
                     /db_xref="GeneID:230972"
                     /db_xref="MGI:MGI:2446219"
     exon            1..71
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            72..689
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2231
                     /gene="Arhgef16"
                     /note="ephexin-4; Neuroblastoma; Rho guanine nucleotide
                     exchange factor (GEF) 16"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 16"
                     /protein_id="NP_001106215.1"
                     /db_xref="CCDS:CCDS51399.1"
                     /db_xref="GeneID:230972"
                     /db_xref="MGI:MGI:2446219"
                     /translation="MSQRHSDSSLDEKLLEYRFHAELRLDANGNPIPGLPMVRSSLKA
                     RANAAFEPDASEPLPPPPSPEDEEPPRPIVLSTQSPAALKMGTQQLIPKSLAVASKAK
                     TKSPARHQSFGAAVLSKEAARRNPQLFSAPSFSLDDMDMDMVTTGNLRRNLRNQSYRA
                     AMKGPGPPSSKGDSVQLGPKLQALAEEAAQPPSRYPAKNKKTLGRKRAHKGSFKDDPQ
                     LYQEIRERGLNTSHESDDDILDEPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLES
                     GVLDTLSTEERKRQEAIFEILTSEFSYLHSLSILVTEFLQSRELRATMTQTEHHHLFS
                     NILDVMSASQKFFEALEQRHKAQVCVEDISDILEDHAQHHFHPYIAYCSNEVYQQRTL
                     QKLSNSNAAFRDVLKEIEKRPACGGLPMISFLILPMQRVTRLPLLTDTLCLKTQGHPE
                     RYKAASQALKAISKLVKQCNEGAHKMERTEQIYTLNMQLDFGKVKSLPLISASRWLLK
                     RGELFLLEESSIFRKIASRPTCYLFLFNDVLVVTKKKSEESYLVQDYAQLDHVQVRKL
                     EPSEPLLPGGSSRSSSVPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALTYKER
                     QWQGITNKGELPQVEVTKAYFAKQADEITLQQADIVLVLQEEDGWLHGERLRDGETGW
                     FPESFAHSITSRVAVEGNVRRMERLRVETDV"
     exon            690..735
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            736..905
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            906..962
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1123
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1276
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1406
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1481
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1574
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1726
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1915
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1989
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2091
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2717
                     /gene="Arhgef16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef16"
                     /note="hexamer: CATAAA"
     polyA_site      2658
                     /gene="Arhgef16"
                     /note="major polyA site"
ORIGIN      
        1 gccccgggac gcggggaccc agcggcactg caggctacac cctcccggcc gaccctcggt
       61 tgcgcgcaca ggcctcctct gtcaccagca tgtcccagag acattctgac agctctctgg
      121 atgagaaact actggagtat cgcttccacg cagagctgcg cctcgatgcc aacgggaacc
      181 ctatccctgg actccccatg gtccggagct ccttgaaagc cagagccaat gctgcctttg
      241 agccagatgc ctcagaaccc ctgccgccac ctccgtcacc agaagacgaa gagcctcctc
      301 ggcccatcgt ccttagcacg caaagccccg cggccctcaa gatgggcacg cagcagctca
      361 tccccaaaag tctggctgtg gccagcaagg ccaagaccaa gtccccagcc cgccaccaga
      421 gctttggggc ggctgtgctc agcaaggagg ctgccaggcg gaatcctcag ctcttctcag
      481 cccccagctt ctcgttggat gacatggata tggacatggt tactaccggg aacctgaggc
      541 gcaacctgag gaaccagtcc tacagggcag ccatgaaggg gccggggcca cccagtagca
      601 agggggactc agtccagctt ggccccaagc tccaggctct cgctgaggag gctgctcagc
      661 ctccctcccg gtatccagcc aaaaataaga aaactctcgg tcggaaacgt gcgcacaagg
      721 gctctttcaa agatgacccc cagctgtatc aggagatccg agagcggggt ttgaacacca
      781 gtcacgagtc cgatgatgac attcttgatg agccctccgg cccagtggga actcagagag
      841 cggacaccac catcgtggtc aagagctatc ggcctgctca gctcacctgg agccagctcc
      901 cagaggtgct ggagtcaggt gtcctggaca cgctgtcaac ggaagaacgg aagaggcagg
      961 aggccatctt cgagatcctc acttctgagt tctcgtatct gcacagcctg agcatcctgg
     1021 tgactgagtt cctgcagtcc cgggagctga gggccactat gacccagacg gaacaccacc
     1081 acctcttctc caacatcttg gatgtgatgt ctgccagtca gaagttcttt gaagccctgg
     1141 agcagcggca caaagctcag gtgtgcgtgg aggacatcag cgacatcttg gaggaccatg
     1201 ctcagcatca tttccaccct tacatcgcct actgctccaa cgaggtctat caacagcgca
     1261 ccctgcagaa gctgtcgaac agcaacgcag ccttccggga cgttctgaag gagatcgaga
     1321 agcggcctgc gtgtgggggc ctgcccatga tctctttcct gattctcccc atgcagagag
     1381 tgacccggct gccgctgctg acagatacac tctgcctgaa gacgcaaggc catcccgaac
     1441 ggtataaagc tgccagccaa gccctgaagg ccatcagcaa gctggtgaag cagtgtaacg
     1501 agggagctca caagatggag cgcacagagc agatatacac actgaacatg cagctggact
     1561 tcggcaaggt caagtccctc ccgctcatct ccgcctctcg ctggctgctg aagcgtgggg
     1621 agctcttcct cttggaggaa tccagtatct ttaggaaaat cgccagccga cccacgtgtt
     1681 atctgttcct gttcaatgat gtcctggttg tcaccaagaa gaaaagtgag gaaagctacc
     1741 tggtccaaga ctacgcgcag ctagaccacg tacaggtcag gaaactggaa ccctcggagc
     1801 ccttgctgcc aggaggcagc agccgcagct cctccgtgcc ctacccattc caggtgaacc
     1861 tgctacataa cagcgagggc cgccaggagc agatactgct gtcgtccgac tctgcgagtg
     1921 accgggcccg gtggatcaca gcactcacct acaaggagag acagtggcag ggcatcacca
     1981 acaaaggaga actcccccag gtagaggtca ccaaggcgta ctttgccaag caggctgatg
     2041 agatcacact gcaacaggct gacatcgtcc tggtcctgca ggaagaggac ggttggctac
     2101 acggggagcg gcttcgggac ggagagaccg gctggtttcc cgagagcttt gctcactcca
     2161 tcaccagccg tgtggccgtg gaaggcaacg tgcgcaggat ggagcggctg cgggtggaga
     2221 cggatgtgta gctggaccga ctgctcaaag gccaagccat ggtggacaca gcttcagtcc
     2281 cccgaccagc aagtggtcct gcctgccccc aaggagtatg aggggtttgt catgggaagc
     2341 ccttcccctg ggctcacggt tgagtgcaga acactgaaca tctatagatc cggcttgctt
     2401 agacatcttt gaggcaagtc ccagaggctc acattctgga aggagcctag cctggcctct
     2461 tacaggacac ctgagctaca ccgggtaaca gtgtcattga agacaccata gggttacctc
     2521 ccagctgcac ccctccatcc caggtgggac aaaaagggct ggtgttctga gaggacggtg
     2581 ctggtggcag gtgacctgag gtgccagcag ggatattgtg attacagatc taaataacat
     2641 aaaagtattt ctttaaaatt ttgttttaca tgtgagccac ctgtttcagt gaaatataac
     2701 atataacagg taggtgg
//
