LOCUS       NM_177566               4165 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 15 (Arhgef15),
            transcript variant 1, mRNA.
ACCESSION   NM_177566 XM_908479
VERSION     NM_177566.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4165)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4165)
  AUTHORS   Ding,X., Chen,Y., Guo,C., Fu,Y., Qin,C., Zhu,Q., Wang,J., Zhang,R.,
            Tian,H., Feng,R., Liu,H., Liang,D., Wang,G., Teng,J., Li,J.,
            Tang,B. and Wang,X.
  TITLE     Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral
            small vessel disease and osteoporotic fracture
  JOURNAL   Acta Neuropathol 145 (5), 681-705 (2023)
   PUBMED   36929019
  REMARK    GeneRIF: Mutations in ARHGEF15 cause autosomal dominant hereditary
            cerebral small vessel disease and osteoporotic fracture.
REFERENCE   3  (bases 1 to 4165)
  AUTHORS   Wang,Y.J., Li,S., Tao,H.P., Zhang,X.N., Fang,Y.G. and Yang,Q.E.
  TITLE     ARHGEF15 is expressed in undifferentiated spermatogonia but is not
            required for spermatogenesis in mice
  JOURNAL   Reprod Biol 23 (1), 100727 (2023)
   PUBMED   36603298
  REMARK    GeneRIF: ARHGEF15 is expressed in undifferentiated spermatogonia
            but is not required for spermatogenesis in mice.
REFERENCE   4  (bases 1 to 4165)
  AUTHORS   Chen,F., Wu,Y., Ke,L., Lin,X., Wang,F. and Qin,Y.
  TITLE     ARHGEF15 in Sertoli cells contributes to germ cell development and
            testicular immune privilegedagger
  JOURNAL   Biol Reprod 107 (6), 1565-1579 (2022)
   PUBMED   36001358
REFERENCE   5  (bases 1 to 4165)
  AUTHORS   Schaffer,T.B., Smith,J.E., Cook,E.K., Phan,T. and Margolis,S.S.
  TITLE     PKCepsilon Inhibits Neuronal Dendritic Spine Development through
            Dual Phosphorylation of Ephexin5
  JOURNAL   Cell Rep 25 (9), 2470-2483 (2018)
   PUBMED   30485813
  REMARK    GeneRIF: a substrate of PKCepsilon, Ephexin5, whose early-elevated
            expression in developing neurons may in part explain the mechanism
            by which PKCepsilon plays seemingly opposing roles that depend on
            neuronal maturity.
REFERENCE   6  (bases 1 to 4165)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 4165)
  AUTHORS   Zhou,P., Zhang,Y., Ma,Q., Gu,F., Day,D.S., He,A., Zhou,B., Li,J.,
            Stevens,S.M., Romo,D. and Pu,W.T.
  TITLE     Interrogating translational efficiency and lineage-specific
            transcriptomes using ribosome affinity purification
  JOURNAL   Proc Natl Acad Sci U S A 110 (38), 15395-15400 (2013)
   PUBMED   24003143
REFERENCE   8  (bases 1 to 4165)
  AUTHORS   Takase,H., Matsumoto,K., Yamadera,R., Kubota,Y., Otsu,A.,
            Suzuki,R., Ishitobi,H., Mochizuki,H., Kojima,T., Takano,S.,
            Uchida,K., Takahashi,S. and Ema,M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   9  (bases 1 to 4165)
  AUTHORS   Kusuhara,S., Fukushima,Y., Fukuhara,S., Jakt,L.M., Okada,M.,
            Shimizu,Y., Hata,M., Nishida,K., Negi,A., Hirashima,M.,
            Mochizuki,N., Nishikawa,S. and Uemura,A.
  TITLE     Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced
            Cdc42 activation and potentiating RhoJ inactivation in endothelial
            cells
  JOURNAL   PLoS One 7 (9), e45858 (2012)
   PUBMED   23029280
REFERENCE   10 (bases 1 to 4165)
  AUTHORS   Margolis,S.S., Salogiannis,J., Lipton,D.M., Mandel-Brehm,C.,
            Wills,Z.P., Mardinly,A.R., Hu,L., Greer,P.L., Bikoff,J.B., Ho,H.Y.,
            Soskis,M.J., Sahin,M. and Greenberg,M.E.
  TITLE     EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a
            developmental brake on excitatory synapse formation
  JOURNAL   Cell 143 (3), 442-455 (2010)
   PUBMED   21029865
  REMARK    GeneRIF: Study identified a RhoA guanine nucleotide exchange
            factor, Ephexin5, which negatively regulates excitatory synapse
            development until EphrinB binding to the EphB receptor triggers
            Ephexin5 phosphorylation, ubiquitination, and
            degradation.[Ephexin5]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603662.11.
            
            On Nov 17, 2022 this sequence version replaced NM_177566.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089365.1, SRR7652917.603009.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL603662.11        173356-173397       c
            43-698              AL603662.11        170928-171583       c
            699-1049            AL603662.11        170322-170672       c
            1050-1104           AL603662.11        169997-170051       c
            1105-1163           AL603662.11        168421-168479       c
            1164-1375           AL603662.11        168129-168340       c
            1376-1536           AL603662.11        167842-168002       c
            1537-1689           AL603662.11        167510-167662       c
            1690-1819           AL603662.11        166481-166610       c
            1820-1894           AL603662.11        164276-164350       c
            1895-1987           AL603662.11        164086-164178       c
            1988-2148           AL603662.11        163746-163906       c
            2149-2301           AL603662.11        163494-163646       c
            2302-2384           AL603662.11        163071-163153       c
            2385-2489           AL603662.11        162876-162980       c
            2490-4165           AL603662.11        159664-161339       c
FEATURES             Location/Qualifiers
     source          1..4165
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.21 cM"
     gene            1..4165
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /note="Rho guanine nucleotide exchange factor 15"
                     /db_xref="GeneID:442801"
                     /db_xref="MGI:MGI:3045246"
     exon            1..42
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            43..698
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1049
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1104
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1163
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1375
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1536
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1689
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1819
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1894
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1987
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2148
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2301
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2384
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2489
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..4165
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4143..4148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /note="hexamer: AATAAA"
     polyA_site      4165
                     /gene="Arhgef15"
                     /gene_synonym="D130071N09; D530030K12Rik; E5"
                     /note="major polyA site"
ORIGIN      
        1 actcagctct cggaggtgac tgggagtgga gggaactgga gggggatgac ttccgcagaa
       61 caccccactc cttggaaaca ctcagaagac gatgtctgca cagtctcttc ctgcagcaac
      121 gccccctacc ttgaagcccc ctcggatcat ccgcccccga cccccatctc ggcatagggc
      181 tccacactcc ccggggcctc tccacaatgg ctcctctccg aaagcacttc ctcaaatatc
      241 caatgatgca tcggcctcag tgtgcacctc catcttctgg gagcccccca cggcttccct
      301 gaagccccct gctcttctgc ctccctcagt ttctagaacc agcctggact ctcagacttc
      361 ccctgactca ccttccagca caccgagtcc cagcccagtg tcccggcgct ccatctcccc
      421 agaaccagct ccctgctctc cggtgccccc acccaagccc tctgggtctt cccgaacacc
      481 tctgccctcg ggccctacgc ctctccagga tggctctgct tcggcccctg gcacggttcg
      541 tagactggcc ggcaagtttg aatggggagc tgaaggcaaa gcccagtcct cagactccct
      601 ggaacggtgt tcccaaggga gcacggaagt gaatggggag aaagagactc ccgaagccgc
      661 cctttctggg aatgggtccc aggagaacgg cactcccgat gctgccctgg cctgccctcc
      721 atgctgcccc tgtgtctgcc atgtagcaaa gcctggcctg gagctccggt gggtgcctgt
      781 ggggagttct gaggacatcc tcaggatccc ctgccgggca tccccactcc gagcctcccg
      841 ctcccgcatc aatcctccag tcatcagtca ccctccagtt gtgctcacgt cctatcgctc
      901 cactgccgag cgcaaactcc tacctcccct caagcccccc aagccaacta aagtcagaca
      961 ggatatcagc acctctgagg agcttccaca gccagatctg aaactgcctt cagaagatgg
     1021 gatccaaact gctacaaagg cctgggaagg ggacagacct gaaggagctc ctctgaatgc
     1081 tccccctgta gccttggagg gaagggagga ggaaggattg gatgggctga aggggctgca
     1141 gtgggaactg cccctgcagg acgaaccttt ataccagact taccgagcag ctgtgctgtc
     1201 agaggagctg tggggtgtgg gtgaggatgg gggtccctct ccagctaatc ctggagaagc
     1261 tcccaccttc tccaggctcc ctggacctcg aaacactctg tggcaggagc tcccggctgt
     1321 gagaggcagt ggcctcttag agagtctaag cccccaggag cggcgcatgc aggagagcct
     1381 gtttgaggtg gtgacatcag aggcctccta cctgcgatcc ctgaggctgc tgaccgacac
     1441 cttcgtcctg agccaggctc tccgggacac actcacgcct cgggatcatc atacgctgtt
     1501 ctccaacgtg cagcgagtcc agagcgtcag tgagcggttt ctaggaacac tgctgtctcg
     1561 tgttcgttcc tccccacaca tcactgacct gtgtgatgtg gtgcatgccc atgcagttgg
     1621 tcctttcttc gtgtatgtgg attatgttcg gaaccagcag tatcaggagg agacctatag
     1681 ccgccttatg gatacaaacg tgcgcttctc cgcagagctg cgaaggctgc agagcctccc
     1741 caaatgtgag cggctcccgc tgccatcttt cctgctgctg cccttccagc gcatcacccg
     1801 gctgcggatg ctgttgcaga atatcctaag ccagacagaa gaggggtcca gtcgtcagga
     1861 gaacgcccag aaggctctgg gtgctgtgag caagatcatt gagcgctgca gcgctgaggt
     1921 ggggcgcatg aagcagacgg aagagctgat acggctcacc caaaggttgc gcttccacaa
     1981 agtcaaggct ctacccctgg tctcctggtc acggcgcctg gaattgcagg gggagctgac
     2041 cgagctgggg tgtcggaggg ggggtgtgct cttcacctcc cgtccacgct tcactcccct
     2101 ctgcctactg ctcttcagtg acctgctgct tatcactcag cccaagagtg ggcagcggct
     2161 gcaggttctg gactatgccc atcgctccct ggtgcaggcc cagcaggttc ctgacccatc
     2221 tggaccccct actttccgcc tctcgcttct cagcaaccac cagggccgcc ccacccacag
     2281 gctactccaa gcggcctcac tatcagacat gcagcgctgg ctgggagcct tccccacccc
     2341 aggtcccctt ccctgttccc cagacaccat ctatgaggac tgtgagtgtt cccaggagct
     2401 atgttcagag ccatccacac cttccaagac tgaggggcaa agtctggagt ccaaggcccc
     2461 ccgaaagcat ctgcacaaga atccagaagg ttggcttaag gggcttcctg gagccttccc
     2521 tgcccaactg gtgtgtgaag tcacaggaga acacgagagg aggaagcatc ttcgccagca
     2581 ccagaagctc cttgaggctg taggaccctc ttcaggcact cctgacaccc ctcaacctta
     2641 aggcaggcta gggaggagca cagattggga tactggcagc agcatgggga agaaaaagtc
     2701 tatccatcca tctgtccaac cgtccaaccg tccatccatc catccatcca tctacttgct
     2761 gtcagtggaa acactacctc tagaggcaac caatagggat agagcagcta atgaaacaag
     2821 accatctgag cccacgacaa ggaagaatgg ggatggctcg aatgtgttgc caatggagac
     2881 aggggatgag tacagagtgg ccaaggctga ggccacggcc agagggtatc aaagtatgtc
     2941 cacaaccaag gaagattaag caggggcatt gcattgagaa atgacgtcat tgaagtagtc
     3001 ctgtagacaa cagggatggg atgggaccta tccagccaga gaagacggtg atttgggctc
     3061 aagagagcag tagtcaccct tgttggtttt acagaagcca ctggtcctgc tttttgagta
     3121 taggaagtat taaattaatc taatacttct gtttgagggc tactttcttt gcccatttta
     3181 aaccacttcc tttcttctag aagaatccag agtgcatctc agagaatatg agtgcatgtg
     3241 tgttcatgta tatatgtatc taggaaggca actgtgctga atgtggtgtg tgtgtgtgtg
     3301 tgtgtgtgtg agagagagag agagagagag agagagagag agagaacgca cctctcccct
     3361 ctcctgttgg tgactgaata cttcctttcc tctatcatct cacatttatc ctcttatttt
     3421 ctccaaaaaa agccatatgc cctgagatct aaaaaaagag tactgagcat agcttgccca
     3481 aggactggga ccgtgaatgc aagccatgga ttcagggtct cccgggtgtc tctgggttct
     3541 atgacagttg aaagctggta ttatgaagca gctggtggcc cgcaaggaag gcactgagga
     3601 ctaagccact gggatttgag atcctcagca gtctgtggac ctcttcctgt cccaggcatt
     3661 gacctctgtg atccatgtct gctctgtgtc atctcccgac ttgaattgtc atcatgatgt
     3721 cagccagcct cgggctgcag aacaagttgg gtcctgggtc agctggcaac catcctgatc
     3781 ttcttctatc ctgatcctct cagaagcaga aggctgaacc caggagggag tagagagctg
     3841 atggtgttac tcagactcaa ccacggtttc tgctagagaa cctgccctgt gtgatgctgg
     3901 agcggtgaag gcaaaggcag tagaatagac aattgctggg cttggggccc agacctgggc
     3961 aaaggctttc taaatcttca ggactgtgca atactgttcc ttcatgtatg acaacctgcc
     4021 cagatggaga ctgcttaggt gactatggga ggggtaatga gtctggggac ttgaaggcaa
     4081 tagggcactt tgtgtgtcca cagctttcat ccagcaaagt gccagccaca tgggaaaccc
     4141 tcaataaatg ttgctggaaa gagca
//
