LOCUS       NM_001003912            6807 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 11 (Arhgef11),
            transcript variant 1, mRNA.
ACCESSION   NM_001003912 XM_159702
VERSION     NM_001003912.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6807)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6807)
  AUTHORS   Houssin,N.S., Martin,J.B., Coppola,V., Yoon,S.O. and Plageman,T.F.
            Jr.
  TITLE     Formation and contraction of multicellular actomyosin cables
            facilitate lens placode invagination
  JOURNAL   Dev Biol 462 (1), 36-49 (2020)
   PUBMED   32113830
REFERENCE   3  (bases 1 to 6807)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6807)
  AUTHORS   Qasim,H., Karim,Z.A., Hernandez,K.R., Lozano,D., Khasawneh,F.T. and
            Alshbool,F.Z.
  TITLE     Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis
  JOURNAL   J Am Heart Assoc 8 (9), e011712 (2019)
   PUBMED   30994039
REFERENCE   5  (bases 1 to 6807)
  AUTHORS   Lee,S., Cieply,B., Yang,Y., Peart,N., Glaser,C., Chan,P. and
            Carstens,R.P.
  TITLE     Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for
            Epithelial Tight Junction Integrity
  JOURNAL   Cell Rep 25 (9), 2417-2430 (2018)
   PUBMED   30485810
  REMARK    GeneRIF: the ablation of Esrp1 and Esrp2 impairs epithelial tight
            junction (TJ) integrity through loss of the epithelial isoform of
            Rho GTP exchange factor Arhgef11.
REFERENCE   6  (bases 1 to 6807)
  AUTHORS   Francis,S.A., Shen,X., Young,J.B., Kaul,P. and Lerner,D.J.
  TITLE     Rho GEF Lsc is required for normal polarization, migration, and
            adhesion of formyl-peptide-stimulated neutrophils
  JOURNAL   Blood 107 (4), 1627-1635 (2006)
   PUBMED   16263795
  REMARK    GeneRIF: Required for normal polarization, migration, and adhesion
            of formyl-peptide-stimulated neutrophils.
REFERENCE   7  (bases 1 to 6807)
  AUTHORS   Yamada,T., Ohoka,Y., Kogo,M. and Inagaki,S.
  TITLE     Physical and functional interactions of the lysophosphatidic acid
            receptors with PDZ domain-containing Rho guanine nucleotide
            exchange factors (RhoGEFs)
  JOURNAL   J Biol Chem 280 (19), 19358-19363 (2005)
   PUBMED   15755723
REFERENCE   8  (bases 1 to 6807)
  AUTHORS   Barac,A., Basile,J., Vazquez-Prado,J., Gao,Y., Zheng,Y. and
            Gutkind,J.S.
  TITLE     Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G
            protein-linked Rho guanine exchange factor
  JOURNAL   J Biol Chem 279 (7), 6182-6189 (2004)
   PUBMED   14625312
  REMARK    GeneRIF: PDZ-RhoGEF interacts directly with p21-activated kinase 4
            to negatively regulate the activation of Rho
REFERENCE   9  (bases 1 to 6807)
  AUTHORS   Yoshizawa,M., Sone,M., Matsuo,N., Nagase,T., Ohara,O., Nabeshima,Y.
            and Hoshino,M.
  TITLE     Dynamic and coordinated expression profile of dbl-family guanine
            nucleotide exchange factors in the developing mouse brain
  JOURNAL   Gene Expr Patterns 3 (3), 375-381 (2003)
   PUBMED   12799088
REFERENCE   10 (bases 1 to 6807)
  AUTHORS   Swiercz,J.M., Kuner,R., Behrens,J. and Offermanns,S.
  TITLE     Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA
            and growth cone morphology
  JOURNAL   Neuron 35 (1), 51-63 (2002)
   PUBMED   12123608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139241.4 and AC161454.3.
            
            On Oct 3, 2022 this sequence version replaced NM_001003912.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1243              AC139241.4         76850-78092         c
            1244-1335           AC139241.4         12065-12156         c
            1336-1434           AC139241.4         11076-11174         c
            1435-1484           AC139241.4         9594-9643           c
            1485-1542           AC139241.4         8670-8727           c
            1543-1721           AC139241.4         7650-7828           c
            1722-1793           AC139241.4         6792-6863           c
            1794-1913           AC139241.4         125-244             c
            1914-1959           AC161454.3         178397-178442       c
            1960-2036           AC161454.3         177723-177799       c
            2037-2174           AC161454.3         176885-177022       c
            2175-2249           AC161454.3         173555-173629       c
            2250-2351           AC161454.3         173231-173332       c
            2352-2450           AC161454.3         166125-166223       c
            2451-2493           AC161454.3         164245-164287       c
            2494-2590           AC161454.3         162680-162776       c
            2591-2713           AC161454.3         162444-162566       c
            2714-2737           AC161454.3         159779-159802       c
            2738-2882           AC161454.3         158613-158757       c
            2883-2979           AC161454.3         158267-158363       c
            2980-3106           AC161454.3         153304-153430       c
            3107-3286           AC161454.3         150129-150308       c
            3287-3334           AC161454.3         150003-150050       c
            3335-3522           AC161454.3         149636-149823       c
            3523-3669           AC161454.3         149269-149415       c
            3670-3749           AC161454.3         148573-148652       c
            3750-3875           AC161454.3         148292-148417       c
            3876-3993           AC161454.3         147707-147824       c
            3994-4172           AC161454.3         147093-147271       c
            4173-4248           AC161454.3         146507-146582       c
            4249-4416           AC161454.3         146135-146302       c
            4417-4507           AC161454.3         145288-145378       c
            4508-4633           AC161454.3         144486-144611       c
            4634-4695           AC161454.3         143944-144005       c
            4696-4908           AC161454.3         142915-143127       c
            4909-5265           AC161454.3         142283-142639       c
            5266-5394           AC161454.3         141235-141363       c
            5395-5621           AC161454.3         140216-140442       c
            5622-5811           AC161454.3         139792-139981       c
            5812-6807           AC161454.3         137748-138743       c
FEATURES             Location/Qualifiers
     source          1..6807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.22 cM"
     gene            1..6807
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /note="Rho guanine nucleotide exchange factor 11"
                     /db_xref="GeneID:213498"
                     /db_xref="MGI:MGI:2441869"
     exon            1..1243
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             1212..5870
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /note="isoform 1 is encoded by transcript variant 1; Rho
                     guanine nucleotide exchange factor (GEF) 11"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 11
                     isoform 1"
                     /protein_id="NP_001003912.1"
                     /db_xref="CCDS:CCDS38472.1"
                     /db_xref="GeneID:213498"
                     /db_xref="MGI:MGI:2441869"
                     /translation="MSIRLPHSIDRLSSLSSLGDSTPERTSPSHHRQPSDTSETTGLV
                     QRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMRAGVKEGDRIIKVNGTMVTNSSH
                     LEVVKLIKSGAYVALTLLGSSPSSIGVSGLQQNPSLSGGPRVNPMIPPPPPPPPLPPP
                     QHITGPKPLQDPEVQKHATQILRNMLRQEEKELQRICEVYSRNPASLLEEQIEGARRR
                     VTQLQLKIQQETGGLVDVLPLCGETSQRTCEGRLSVDSQEADSGLDSGTERFPSISES
                     LVNRNSVLSDPGLDSPQTSPVILARVGQHHRRQGSDAAVHPLNHQGIDQSPKPLIIGP
                     EEDYDPGYFNNESDIIFQDLEKLKSHPAYLVVFLRYIFSQADPGPLLFYLCSEVYQQT
                     NPKDSRNLGKDIWNIFLEKNAPLRVKIPEMLQAEIDLRLRNSEDPRSALYEAQEAVMP
                     EIQEQINDYRSKRTLGLGSLYGENDLLDLDGDPLRERQMAEKQLAALGDILSKYEEDR
                     SAPMDFAVNTYMSHTGIRLRESRPSSTAEKTQSAPDKDKWLPFFPKTKKSSNSKKEKD
                     ALEDKKRNPILRYIGKPKSSSQSIKPGNVRNIIQHFENSHQYDVPEPGTQRLSTGSFP
                     EDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSA
                     SSSASSLSTRSLENPTPPFTPKMGRRSIESPNLGFCTDVILPHLLEDDLGQLSDLEPE
                     PEVQNWQHTVGKDVVANLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKEN
                     LMPREELSRLFPNLPELIEIHNSWCEAMKKLREEGPIIRDISDLMLARFDGPAREELQ
                     QVAAQFCSYQSVALELIRTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTK
                     YPLLLENIIKHTAGGTSEYEKLCRARDQCREILKFVNEAVKQTENRHRLEGYQKRLDA
                     TALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLQVLLLEDLVVLLQRQE
                     EKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSELGPPQIYE
                     LVALTSSDKNIWMELLEEAVQNATKHPGDAPVLNHPSPPGSQEPAYQGSTSSRVEVND
                     SEVYPTEREPKKPSEGPGPEQRGQDKQLLAQEGPEQEEDAEELRALPCPPPSLDGENR
                     GIRTRDPVLLALTGPLLMEGLADAALEDVENLRHLILWSLLPGHTVKTQAAGEPEDDL
                     TPTPSVVSITSHPWDPGSPGQAPAISDNTQFPRPEGSQPEGEDVALCSLAHLPPRTRN
                     SGIWDSPELDRNPAEEASSSEPAGSYKVVRKVSLLPGGGVGAAKVAGSNVTPALPESG
                     QSESELSEVEGGAQATGNCFYVSMPAEPLDSSTEPPGTPPSLSQCHSLPAWPTEPPQH
                     RGVTGGQRSSLVLRDMGVIFHTIEQLTVKLHRLKDMELAHRELLNSLGGESSGGTTPV
                     GSFHTEAARWTDYSLSPPAKEALTSDPQNNQEQGSYPEEGSDTPLEDSATDTASSPGP
                     "
     exon            1244..1335
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1434
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1484
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1542
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1721
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1793
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1913
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..1959
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2036
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2174
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2249
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2351
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2450
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2493
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2590
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2713
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2737
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2882
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2979
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3106
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3286
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3334
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3522
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3669
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3749
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3875
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..3993
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4172
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4248
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4416
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4417..4507
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..4633
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4634..4695
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4696..4908
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            4909..5265
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5266..5394
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5395..5621
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5622..5811
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            5812..6807
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6685..6690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /note="hexamer: AATATA"
     regulatory      6703..6708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /note="hexamer: AATATA"
     polyA_site      6708
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
     polyA_site      6738
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
     regulatory      6785..6790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /note="hexamer: AAGAAA"
     polyA_site      6807
                     /gene="Arhgef11"
                     /gene_synonym="mKIAA0380; PDZ-RhoGEF; Prg; RhoGEF"
                     /note="major polyA site"
ORIGIN      
        1 gccggaagcg cagcggccgc gacgcggacg ccgggagcgg ccgagcgggg aggctgtggc
       61 tggcgggcgg gtgggcacgg aggccgaggc cgcggcccgg gctctccgcg ccgctgtgga
      121 gggcgccctg gccctaaccg agccgcaaca atactaggag cgggtcgccg gacacgatcg
      181 gcgggcgagg gggaagcggg actaccgctc cagagcgctg cggcgagaga gactttcgga
      241 gcctggacgt gctggagcac acagagctga ctgaggaaat tgtctgagaa aaaggccgat
      301 ctgaggctgg gttaggtgga ggaacctgca agtcgaaagg gaaaagaagg tttaagattt
      361 cctgggggtt tggccaatgc taccgttttg aaggtagaaa gcattgcgct tcaggtgttt
      421 tgtgattgtt gtgtgtgtgt ctgcacaatt ggttcatttc agaattcaaa aacctttact
      481 gtagaagaag atggttgttt tgttttgatt tttaaaagaa atccgcaaat tttgcttccc
      541 agggctgcac tggaccgtgt tgtgtacata ctgctgtgtg gttttattta ttttaactgt
      601 gcaaatcgtc tggaagattt ttctcccaag tgccatttcg gatttgttca gcctttttgt
      661 tttgttttgt tttgtttttg tttttccttc cctggaataa ttctgctgtt ggcattttaa
      721 gcatttggaa accagagatt ttttttttca acctttggag cttaaggctt ccctgtcaac
      781 agaaggacag ctggggaaac tggattgaaa ggatggcttt tatctgtctg caactaagac
      841 tgatattttg aagtcagatt ctttctgtgg ttcagttttt agcccgtagg gctaaccttg
      901 aagagatttg tggttaacag tttggtttct aagaaggtca tagtttttcc tctctttttt
      961 tcttttcatt ttctttttta agacgaggga ggggaaggtt aagggtgaag gaaggaggag
     1021 accatgttaa ccgatagaag cagaatagca ctgcagttac cagggtcctg acagctggaa
     1081 gaaacaagga ttcagtcttc aacttgggag gccttcctct caccttcctt caaaattgca
     1141 agggactcag gcctgatcaa gacgcccaaa gaaactacag gattccagaa ctgtggagac
     1201 acggagaaac catgagcata cggttgcccc atagtataga caggttaagt agcctgtctt
     1261 ctctgggaga ttctacacct gaacgcacat ccccttctca ccaccgccag ccctctgaca
     1321 cctctgagac aacaggtctt gttcagcgct gtgtcatcat ccaaaaggac cagcatggct
     1381 ttggcttcac agttagtgga gatcgcattg tgctggtgca gtctgtgcgc cctggaggcg
     1441 cagccatgag agctggtgtg aaagagggtg accggatcat caaagtaaac ggcaccatgg
     1501 tgaccaatag ctcacacctg gaggtagtga agcttatcaa atctggcgcc tatgttgcgc
     1561 ttaccctcct gggctcttct ccttcctcca tcggtgtctc tgggctccag cagaaccctt
     1621 ctctgtcagg agggcccaga gttaacccca tgattcctcc accacctcct cctccaccct
     1681 tgccacctcc acaacacatt actggaccta aacctctaca ggatcctgaa gtccaaaagc
     1741 acgccactca aatcctcagg aatatgctaa ggcaggagga gaaggagtta cagcgtatct
     1801 gtgaggtgta tagtcggaac cccgccagcc tgctagaaga gcaaatcgaa ggtgcccggc
     1861 ggcgagtcac tcaattacag ctgaagatcc agcaggagac tggtggctta gtggatgtac
     1921 ttccactctg tggtgagacc agccagagaa catgtgaagg ccgcctctct gtggactccc
     1981 aggaggcaga cagtggcttg gactcaggga cagaacgctt tccctccatc agtgagtcat
     2041 tggtgaatcg gaactcagta ttgtcagatc ctggactaga cagcccacaa acctcccctg
     2101 taatcctggc cagggtgggc cagcaccaca ggcgacaggg ctcagatgca gcggtgcacc
     2161 ccctcaacca ccagggtata gatcaaagcc caaagcctct gattattggc ccagaggaag
     2221 attatgaccc aggctatttc aacaatgaga gtgacatcat ctttcaagat cttgaaaaac
     2281 tgaagtcaca tccagcttac ttggtagtat ttctacgtta catcttctct caggcagacc
     2341 ccggccccct gcttttttat ttgtgttcag aagtttatca gcagacaaat cccaaagatt
     2401 cccgaaatct ggggaaagac atctggaata ttttcctaga gaaaaatgcg cctctcagag
     2461 tgaagatccc tgagatgttg caggctgaga tcgacctacg cctgcgaaac agtgaggacc
     2521 ctcgcagcgc gctttatgaa gctcaggagg cagtcatgcc ggagatccag gagcagatca
     2581 atgactatag atcaaagcgc actctggggc tgggcagcct ctatggtgaa aatgacctac
     2641 tagacctgga tggggaccct cttcgagagc gccaaatggc tgagaagcaa ctggctgccc
     2701 ttggagatat cttgtccaaa tatgaggaag atcggagtgc tcccatggac ttcgctgtta
     2761 atacctacat gagccacact gggatccgtc ttcgggagtc tcgaccttcc agcacagcag
     2821 aaaagaccca gtctgccccc gacaaggaca agtggctgcc cttcttccct aagaccaaga
     2881 agagcagcaa ttccaagaaa gaaaaggacg ccttggagga caagaagcga aaccccatcc
     2941 tcagatacat tgggaagccc aagagctctt ctcagagcat taagccaggc aatgtgagga
     3001 acatcattca gcactttgag aacagccatc agtatgatgt cccagagccg gggacacagc
     3061 gactctcaac aggaagcttt cctgaggacc tgctggagag tgacagttca cgctcagaga
     3121 ttcgccttgg ccgctctgaa agcctcaagg gccgggagga gatgaagcga tcccggaagg
     3181 cagagaatgt gccccggtct cgaagtgatg ttgacatgga tgctgctgct gaggctactc
     3241 gccttcatca gtcagcctca tcctctgcct ccagcctctc caccaggtct cttgagaacc
     3301 caacccctcc cttcaccccc aaaatgggcc gcaggagcat tgagtccccc aatctggggt
     3361 tctgtacaga tgtcatcctt ccccacctcc ttgaggatga tctgggccaa ctgtctgacc
     3421 tggagccaga gccagaagtc caaaactggc agcatacagt gggcaaggat gtggtggcaa
     3481 acttgacaca gagggaaatt gaccggcaag aggtcatcaa tgagctcttt gtgacagaag
     3541 catcccacct gcgcacgcta cgagtcctgg acctcatctt ctaccagcgc atgaagaagg
     3601 agaacctaat gccacgggaa gagctgtcaa ggctcttccc taatctgcct gaactcatag
     3661 agatccacaa ttcctggtgt gaagccatga agaagctccg ggaggagggc cccattatca
     3721 gagacatcag tgacctcatg ctggctcggt ttgatggtcc tgcccgagaa gagctccagc
     3781 aagtagctgc acaattctgt tcctatcagt cagtagccct ggagctaatc aggactaaac
     3841 aacgcaagga gagtcgattc cagctcttca tgcaggaagc cgagagccac ccccagtgtc
     3901 ggcgtctgca gcttcgtgac ctgatcatct ctgagatgca gcggctcact aagtacccac
     3961 tgctgctaga gaacatcatc aagcacacag cgggtggcac atctgagtat gagaagctct
     4021 gccgtgcccg ggaccagtgc cgagagattc tcaagtttgt gaatgaagca gtgaagcaga
     4081 cagagaaccg tcaccgctta gaagggtacc agaaacgcct ggatgccact gctctagagc
     4141 gggccagcaa ccccttggca gcagagttca agagcctgga tcttacgaca aggaagatga
     4201 tccacgaggg gcctctgacc tggaggatca gcaaagataa gaccctggac ctccaggtgc
     4261 tgttactcga ggacctggta gtgctgctgc agagacaaga ggagaagctg ctgctcaagt
     4321 gccacagcaa gacagctgtg ggctcctcag acagcaagca gaccttcagc cctgtgctga
     4381 agctcaatgc cgtgctcatc cgctctgtgg ccacagataa acgagccttc ttcatcatct
     4441 gcacctccga gctgggccct ccccagatct atgagctggt tgcattgaca tcatcagaca
     4501 agaatatatg gatggagctc ttagaagagg ctgtgcagaa tgccaccaag caccctggag
     4561 atgccccagt actcaaccat ccctcaccac caggatccca ggagccagcc taccagggct
     4621 ccacctccag cagggtagag gtgaatgact cggaagtgta tcccactgaa agagaaccca
     4681 agaagccatc tgaaggcccc gggcccgagc agagaggtca agacaagcag ctgctagcac
     4741 aagaggggcc tgagcaggag gaggatgcag aggagctgag ggccctgcct tgccctcctc
     4801 cctccctgga tggagaaaac agaggcatca ggacaaggga ccctgtcctt ctggccctca
     4861 caggccctct gctcatggag ggacttgctg atgctgccct ggaagatgtg gagaacttgc
     4921 ggcaccttat cctgtggagc ctgctgcctg gtcacactgt gaagactcag gctgctggcg
     4981 agcctgaaga tgaccttaca cccacccctt ctgtcgtcag cattacctct cacccctggg
     5041 acccaggatc cccagggcaa gctcctgcta taagtgacaa cacccaattt ccaaggccag
     5101 agggaagcca gccagagggc gaggatgttg ctctctgttc tctggcacac ttgccaccaa
     5161 ggaccagaaa ttctggcatc tgggactctc ctgagctgga taggaatcca gctgaagagg
     5221 cttcaagctc agaaccagca ggaagttaca aagttgtaag gaaagtctct ctactccctg
     5281 gtggtggtgt cggtgcagcc aaggtggcgg gcagcaatgt tacccctgca ctcccagaga
     5341 gtggccagtc agaatctgag ctatctgaag tggaaggcgg agcacaggct acggggaact
     5401 gtttctatgt cagcatgcca gcagaacctc tggactctag cactgagcct cctgggacac
     5461 ccccaagtct ctcgcagtgt cacagcctcc ctgcatggcc aacagagcct ccgcaacaca
     5521 ggggagtcac tgggggtcag cgttccagcc tggtcctcag ggatatgggt gtgatcttcc
     5581 acaccatcga gcaactgacc gtcaagcttc acagactcaa ggacatggag ctggcccaca
     5641 gagagctgct caactccctt ggaggagagt cgtctggtgg aaccactcct gtgggaagtt
     5701 ttcacacaga ggcagccaga tggacagact actccctctc tcctccagcc aaggaagccc
     5761 tgacctctga cccccaaaac aatcaggagc aggggtccta ccctgaagaa ggctccgaca
     5821 cccccctgga agacagtgcc acagacacag cttcgtcacc aggaccatag ccatccagac
     5881 aaccagagtc tggcctgagc cagagcgcca cattaggaga tccgagcctc cccgtgaaag
     5941 atactgtgag gcctgggaat ccctcatgtt gcctggtctg ttcccaccag acagtccagt
     6001 ttagtgtctc ttcctcctgt tagcccaagt ctccgtggct ttcgtctcct aagcatgctg
     6061 accacaatag aaaggcctcc accccacata gccagtgtgg ggtgtgctat gtgcacagtg
     6121 cccttgagga ggcttatgta taaatgcact ttcttcctcc tcttcttcct aggccccgag
     6181 acagctagat gcctggctct cctctttgcc ctttagtttc ctataaatat gtctattgta
     6241 tgtgtatctt tgccattgta aataacttag ccttttattc tgtccctggc atgttcaacc
     6301 agtcacagag agccaggcag cagccccgca cagggccatg attgtttatg tcccactggc
     6361 agggaggtct cccagattcc agtgctgtca agctccaggg cctgcccacc tctgaagcct
     6421 aggccttctc agtgtcagga aatgctcctg cagggagtgt cttacccagc ccttccccac
     6481 ttgccccata gaaacaatac accaggtacg gatctcaaca cagactctca agagagatgt
     6541 ggagtggatt gctggagtcc ctgagttaag tcagggccct tccttcccca ggggccacag
     6601 caccgttggc tcatcaccct gtcctcacgc cactccctac aatgaacata cacactgtgc
     6661 taggtgtata tatacatata tataaatata tataatatat aaaatataga tatggaaatg
     6721 actgttttac tgttaaaata atgtatactc ttattttctt cctttcatgg ttaagatttt
     6781 tttaaagaaa agttaaatat tcttcca
//
