LOCUS       NM_172751               5541 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus Rho guanine nucleotide exchange factor 10 (Arhgef10),
            transcript variant 1, mRNA.
ACCESSION   NM_172751
VERSION     NM_172751.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5541)
  AUTHORS   Lu,D.H., Liao,H.M., Chen,C.H., Tu,H.J., Liou,H.C., Gau,S.S. and
            Fu,W.M.
  TITLE     Impairment of social behaviors in Arhgef10 knockout mice
  JOURNAL   Mol Autism 9, 11 (2018)
   PUBMED   29456827
  REMARK    GeneRIF: Social behavior is impaired in Arhgef10 knockout mice.
            ARHGEF10 is a candidate risk gene for ASD.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5541)
  AUTHORS   Lu,D.H., Hsu,C.C., Huang,S.W., Tu,H.J., Huang,T.F., Liou,H.C.,
            Liao,H.M., Chen,C.H., Fu,W.M. and Gau,S.S.
  TITLE     ARHGEF10 knockout inhibits platelet aggregation and protects mice
            from thrombus formation
  JOURNAL   J Thromb Haemost 15 (10), 2053-2064 (2017)
   PUBMED   28799234
  REMARK    GeneRIF: ARHGEF10 serves as an important regulator of platelet
            shape change, spreading, and aggregation and plays important role
            in arterial thrombosis formation.
REFERENCE   4  (bases 1 to 5541)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5541)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 5541)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 5541)
  AUTHORS   Xue,W., Kitzing,T., Roessler,S., Zuber,J., Krasnitz,A., Schultz,N.,
            Revill,K., Weissmueller,S., Rappaport,A.R., Simon,J., Zhang,J.,
            Luo,W., Hicks,J., Zender,L., Wang,X.W., Powers,S., Wigler,M. and
            Lowe,S.W.
  TITLE     A cluster of cooperating tumor-suppressor gene candidates in
            chromosomal deletions
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8212-8217 (2012)
   PUBMED   22566646
REFERENCE   8  (bases 1 to 5541)
  AUTHORS   Verhoeven,K., De Jonghe,P., Van de Putte,T., Nelis,E., Zwijsen,A.,
            Verpoorten,N., De Vriendt,E., Jacobs,A., Van Gerwen,V., Francis,A.,
            Ceuterick,C., Huylebroeck,D. and Timmerman,V.
  TITLE     Slowed conduction and thin myelination of peripheral nerves
            associated with mutant rho Guanine-nucleotide exchange factor 10
  JOURNAL   Am J Hum Genet 73 (4), 926-932 (2003)
   PUBMED   14508709
REFERENCE   9  (bases 1 to 5541)
  AUTHORS   Yoshizawa,M., Sone,M., Matsuo,N., Nagase,T., Ohara,O., Nabeshima,Y.
            and Hoshino,M.
  TITLE     Dynamic and coordinated expression profile of dbl-family guanine
            nucleotide exchange factors in the developing mouse brain
  JOURNAL   Gene Expr Patterns 3 (3), 375-381 (2003)
   PUBMED   12799088
REFERENCE   10 (bases 1 to 5541)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147669.1, BC059212.1, BC066074.1 and CD774578.1.
            
            On Nov 6, 2013 this sequence version replaced NM_172751.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147669.1, SRR1660815.130998.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1648              AK147669.1         2-1649
            1649-4883           BC059212.1         814-4048
            4884-5521           BC066074.1         4687-5324
            5522-5541           CD774578.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..5541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 7.59 cM"
     gene            1..5541
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /note="Rho guanine nucleotide exchange factor 10"
                     /db_xref="GeneID:234094"
                     /db_xref="MGI:MGI:2444453"
     exon            1..101
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            102..272
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..4273
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /note="isoform a is encoded by transcript variant 1; Rho
                     guanine nucleotide exchange factor (GEF) 10"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 10
                     isoform a"
                     /protein_id="NP_766339.2"
                     /db_xref="CCDS:CCDS40240.1"
                     /db_xref="GeneID:234094"
                     /db_xref="MGI:MGI:2444453"
                     /translation="MEQGEASPPVPAEHEAKCDTSNNEEEGELFDFDSGDEVPEADRQ
                     VPSADDRTRGAEAGGADENTCPAGNGTGAEPAPEAEPAKLVVPTKVNPYSVIDITPLQ
                     EDQPSSPDANTEEEGVGLRVPSGYSVPVPCGYAVPSNLPLLLPAYSSPVIIRAESVEE
                     EEAAETVGDGQCNSLSSEDLPHSSEQGSQEGSALARWAADPANTAWMENPEEAIYDDV
                     PRENSDSEPDEMIYDDVENGEEGGNSSPEYGWSSSEFESYEEPSDSEGKNGIPRSFLR
                     SSHKKQLSHDLTRFKAHCEEKMRGLVASTVGAMEIQQAKQRQERKMQKLMKAAKEGTK
                     DGLEKTKAAVKRGGSFIRTRSLVSQDHRCYFEEEQNLFIDVDCKHPEAVLTPMPEGLS
                     QQQVVRRYILGSIVESEKNYVDALRRILEQYEKPLSEMEPRLLSDRKLRMVFYRVKEI
                     LQCHSMFQIALASRVSEWDVVETIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKT
                     CATKPAFLEFLKLSQDSSPDRVTLHSLMMRPIQRFPQFILLLQDMLKNTAKGHPDRLP
                     LQMALTELETLAEKLNERKRDADQRCEIKQIAKAINERYLNKLLSSGNRYLVRSDDVI
                     ETVYNDRGEIVKTKQRRIFMLNDVLMCATASSRNSHESHAVMSQRYLLKWSVPLGHVD
                     VIQYNGGSGAGEHCRHHAAHSPESLAVVANAKPHKVYMGPGQLYQDLQNLLHDLNVVG
                     QISQLIGNLRGSYQNLNQSVAHDWTSGLQRLILRKEDAIRAADRCRIQLQLPGKQDKS
                     GRPTFFTAVFNTLTPAIKESWVSSLQMAKLALEEENHMGWFCVDDDGNLAKKETHPLL
                     VGHMPVMVAKQPEFKIECAAYNPEPYLSNESQPASPSTARGFLWIGSCSNQMGQVAIV
                     SFQGSNPKVIECFNVESRILCMVYIPAEESKPQETTETKDPEATASRAPHVPTICLGT
                     EEGSISIYKSSQGCKKVRLQHFYAPDKSTVMSLACSPQGLYAGLVNGSVASYTKAPDG
                     SWNSEPQQVIKLGVLPVRSLLLVEGALWAASGGQVFMASVETHTIENQLEAHQDEGMV
                     ISHMAVAGVGIWIAFTSGSTLRLFHTETLKHLQDVNIDAPVHSMLPGHQRLSVTSLLV
                     CHGLLMVGTSLGVVVALPVPRLQGIPKVTGRGMVSYHAHNGPVKFIVSATAFQNKDRA
                     RDSPRSGSELQDEDPKDLLCSEEGPSCPGQPDTYTSVWLGDSLGLPTQKNDLSSSSGS
                     LNLSHGSSSLEHRSVDSSLCDLLRDPSASPRSRPQGSRRARASSALVVCGGQGHRRVH
                     RKARQPSQEDLVSSVMVWQIPLLGM"
     exon            273..437
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            438..719
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            720..783
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            784..860
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            861..917
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1081
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1198
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1313
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1420
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1498
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1678
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1795
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1888
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2059
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2205
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2381
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2497
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2625
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2726
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2848
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2935
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3162
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3320
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3463
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3638
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3761
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..5528
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5498..5503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /note="hexamer: AATAAA"
     polyA_site      5521
                     /gene="Arhgef10"
                     /gene_synonym="6430549H08Rik; mKIAA0294"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggcggg gtgggagcgc atcgcgggcg gggcgcgcgg ggcgcgcggg gggcgcggga
       61 caactggcgg acgcagacgg cggatggcgc ccggtccctc ggtcgcctct ggaaagcccc
      121 gactggtgcc tcctgggaag gtttcgtatg ccaacctgac ggacagtgtt tctgcttgta
      181 ggggcccctg tcccctgatg ctgtccaagc gtggaggaag gaggcaaggc tgagcatgga
      241 gcagggagag gcctcacctc ctgttcctgc agaacatgaa gcgaaatgtg acaccagcaa
      301 caacgaagag gagggagaac tgtttgactt cgacagtgga gatgaagttc ccgaagcgga
      361 tcggcaagtc ccgtctgccg acgataggac gagaggtgct gaagcaggag gtgcagacga
      421 gaacacgtgc cctgcaggaa atggaactgg agctgaacct gcccccgagg cagagcctgc
      481 gaaacttgtg gtccccacaa aagtgaaccc gtattctgtc atcgacatca cgccgctgca
      541 ggaagaccag ccgtcatctc cagacgcgaa tacagaggag gaaggcgtgg ggctgcgtgt
      601 gcccagtggt tactctgtgc ctgtgccctg tggctatgct gtcccctcca acctgccatt
      661 gctgctgcct gcctactcca gtcctgtcat catccgagcc gagtctgtag aggaggaaga
      721 agcagcagaa actgtgggag atgggcagtg caattcccta agctccgagg accttccaca
      781 cagcagtgag caaggcagcc aagaaggcag tgccctggcc cgatgggcag ccgaccctgc
      841 caacacagca tggatggaaa atccagagga agcaatttac gacgacgttc cgagggaaaa
      901 ctcggactct gagccagatg aaatgattta tgatgatgtg gagaacggcg aagaaggtgg
      961 aaacagctcc ccagagtacg ggtggagttc cagcgaattc gaaagctatg aggagccaag
     1021 cgactcggag ggcaagaacg gaattcccag gtccttcctg cgcagcagtc ataaaaagca
     1081 actctctcat gacctaaccc gctttaaggc gcactgtgag gaaaagatga gaggcttggt
     1141 ggccagtacg gtgggagcca tggagattca gcaggcaaag cagaggcagg agcggaagat
     1201 gcagaagctt atgaaggcag ccaaggaggg caccaaagat gggctggaga aaaccaaagc
     1261 tgctgtgaag agaggcggct ccttcatcag gaccaggtcc ttggtctctc aagatcacag
     1321 gtgttatttt gaagaagagc agaatttgtt cattgacgtg gactgcaagc acccggaggc
     1381 tgtcctcacc ccaatgcccg agggcttgtc tcagcagcag gttgtgagaa gatacattct
     1441 gggctccatt gttgagagcg agaagaacta tgtagatgct ctccggagga ttttggagca
     1501 atatgagaag ccgctgtctg agatggagcc ccggctcctg agtgacagga agctcaggat
     1561 ggttttctac cgcgtcaagg agatcctgca gtgtcactcc atgttccaga ttgcgctggc
     1621 cagccgcgtg tccgagtggg atgtcgtgga aacaatcggc gacgtttttg tggcctcgtt
     1681 ctccaagtcc atggtgctgg atgcttacag cgagtacgtg aacaacttca gcacggccgt
     1741 ggctgtcctc aagaagacgt gtgccacaaa gcctgctttc cttgagttct taaagctgag
     1801 ccaggattcc agtccagacc gagtcacact ccacagcctt atgatgcggc ccatccagag
     1861 gttcccacag ttcatcctcc tactgcagga catgctgaag aacaccgcca aaggacatcc
     1921 tgacaggctg ccccttcaga tggcgctgac ggagctcgag accctggcag agaagctaaa
     1981 cgagagaaaa agagatgccg accagcgatg cgaaatcaaa caaatagcaa aagccataaa
     2041 cgagagatac ctgaacaagc tcctcagcag tggaaaccgg tacctcgtcc ggtccgatga
     2101 cgtcatcgag acggtttaca acgaccgggg agaaatcgtc aagaccaaac aacgccggat
     2161 cttcatgctg aatgacgtgc tcatgtgtgc caccgccagc tcacggaact cacatgaaag
     2221 ccatgccgtg atgagccaga ggtacctgct caagtggagt gtccctctag gtcacgtgga
     2281 tgtgattcag tacaatggag gctctggcgc cggggagcac tgtcggcacc acgctgcaca
     2341 ctcacctgag agcctggccg tggtggccaa cgcgaagcca cacaaagttt acatggggcc
     2401 agggcagctg taccaggatc tgcagaacct actgcacgac ctgaacgttg ttggccagat
     2461 ctcgcagctg ataggaaacc tccgagggag ctatcagaac ttaaaccagt ctgtagccca
     2521 tgattggacg tcgggcttac agcggctgat actgaggaaa gaagatgcga tcagagctgc
     2581 cgaccgctgc cggatccagt tacagctccc gggaaagcag gacaagtccg ggcggcccac
     2641 gttcttcact gctgtgttca atacgcttac accagccatc aaggagtcct gggtcagcag
     2701 cctgcagatg gccaagctgg cccttgagga ggagaaccat atgggatggt tctgtgtgga
     2761 tgacgatggc aacctagcca agaaggagac acaccctctc ctggtgggac acatgcctgt
     2821 gatggtggcc aagcagccag agttcaagat tgaatgtgca gcttataacc ctgaacctta
     2881 cctgagcaat gaaagtcaac cagcctcacc ctccacagcc cgtggctttc tgtggattgg
     2941 aagctgtagc aaccagatgg gtcaggtcgc cattgtctcc ttccaaggtt ccaaccccaa
     3001 agtcatcgag tgcttcaatg tggaatcacg catcctgtgt atggtataca ttcccgcaga
     3061 ggagtcaaag ccccaagaaa ccaccgaaac caaggatcca gaagccacag cctcgagagc
     3121 accccatgtg cccaccatct gcctgggcac agaagaggga agcatttcca tttacaaaag
     3181 cagtcagggc tgcaagaagg tgaggcttca gcacttctat gcaccggaca agtccacggt
     3241 catgagcttg gcctgctccc cacaaggcct gtatgcaggc ctggtcaatg ggtccgtagc
     3301 cagctacacc aaggctccag atggatcctg gaactcggaa ccccagcaag tgatcaagtt
     3361 gggtgtcctg ccagtcagaa gccttctcct ggtggagggt gcactgtggg cagcctcggg
     3421 agggcaggtg ttcatggcca gcgtggagac tcacactata gagaatcagc tggaggccca
     3481 ccaagatgaa gggatggtca tctcccacat ggctgtggct ggcgttggca tctggattgc
     3541 cttcacctcg gggtccaccc tccgcctctt ccacacagag accttgaagc acctgcagga
     3601 tgtcaacatt gatgcccctg tgcatagcat gctgccaggg caccagcgtc tatctgtgac
     3661 cagcctgctc gtctgccacg gcttgctcat ggtcggtacc agcctgggtg tcgtggtggc
     3721 cctgccagtc cctcggcttc agggtatccc caaagtgaca gggcgaggca tggtctccta
     3781 ccatgcgcat aacgggcccg ttaagttcat cgtctcagcc acggcgtttc aaaacaagga
     3841 cagagccagg gacagcccac gttccggttc tgagcttcag gatgaagacc ccaaggactt
     3901 gctctgcagc gaggaaggtc cttcctgccc gggccagcct gacacctaca catccgtttg
     3961 gttgggagac tccctaggat tgccaactca aaagaatgat ctgtcttcgt cctcggggtc
     4021 actgaacctg tcccatggct ccagttccct agagcacaga tctgtggaca gcagtctgtg
     4081 tgacctgctg agggacccca gtgcctcccc aaggagcaga ccacagggct ctaggcgagc
     4141 aagagccagt tcagcgctgg tggtatgtgg gggccagggc caccggcggg tgcacaggaa
     4201 ggccaggcag ccttctcagg aggacctggt ttcttcagtg atggtgtggc agatccccct
     4261 gctgggcatg taggtcagga ggctgctgcc tggcataagg tggcaatcaa ggacaactct
     4321 cagccggatg cagggccagc tgacagaggc tgcatccaca ccaccgggac caactggaag
     4381 cagagtttgg aaaagaaata ttctgtggtc actctgctct cctgccttcc tcccatcgca
     4441 caacggagcc cagctgtgcc agggaagcag gggagcgccc tggctgtggg gtcactggac
     4501 cacagtccag gataatgcta cagtctgccc catcattcac ctgatacata aagtgagctg
     4561 gctgtgtggg ctccagtccc atctcagaga gctgacaggg aaacaacata gcacctagta
     4621 gcataggagg tcattaacaa cccttaaaat cattctactt gactcagact cactactgtt
     4681 atttatattc tctatatttt tttaatccca gaatacagat tgtaacaatt tagaaagcca
     4741 ggtaacacac cccagtccag tcagcttgcc ctttttggaa ggagtgacca aggctttcca
     4801 aagtagactg ttgtgtgtac tgtgcccttt aacaaatagt gtttttatat tgcatttttt
     4861 ttctattaaa aatcaacagt taacatttta gtcaatgtac tctctgtagc atttcacaca
     4921 taatctttac ttgaagccaa aatgttcagt acctgtcaac attgaactcc agcttccacg
     4981 ccaaatcata cttgccttct catactaagt gacattaatg tctgcgtggg gcatgtgccg
     5041 gcccagtcat gcagggatgg tgctagatgt gtctctggtc ttctgtgcac ctgctgtcag
     5101 agagccatcc acacagttgg acactccttc tgagtggtcc atgatgctga tcagtcagcc
     5161 gctgcccgcc cctgcacctg cctgccatcc ctgtaccacc ctcccccccc ttcccaaaga
     5221 acacacaggg tcacgtggga cacttgaacg tcaaggggca tgagtaaccc atagactctg
     5281 tttgctccag ctgtattaca catcagtgtt tcacttactg gatggattaa aaaaaagttg
     5341 ttttttttaa atttaatgca gatattattc accaggaaca acttctcagc actttacaaa
     5401 ggactaaaat gctaactttt aacttagcca aatatttttc taaattgcac atatacccaa
     5461 gctttttcaa actgttagct gctatcttat ttgataaaat aaaagacttt ctattttaga
     5521 atacagtaaa aaaaaaaaaa a
//
