LOCUS       NM_008113               1032 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus Rho GDP dissociation inhibitor gamma (Arhgdig), mRNA.
ACCESSION   NM_008113
VERSION     NM_008113.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Yi,M.H., Kwon,K., Zhang,E., Seo,J.H., Kang,S.S., Son,C.G.,
            Kang,J.W. and Kim,D.W.
  TITLE     RhoGDI2 expression in astrocytes after an excitotoxic lesion in the
            mouse hippocampus
  JOURNAL   Cell Mol Neurobiol 35 (2), 167-174 (2015)
   PUBMED   25274045
  REMARK    GeneRIF: RhoGDI2 is required for PKB and CREB activation and cdc42
            expression in astrocyte migration after kainic acid-mediated
            excitotoxic lesion in mouse brain.
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Wang,J., Li,X., Cheng,H., Wang,K., Lu,W. and Wen,T.
  TITLE     Overexpression of Rho-GDP-dissociation inhibitor-gamma inhibits
            migration of neural stem cells
  JOURNAL   J Neurosci Res 91 (11), 1394-1401 (2013)
   PUBMED   23996536
  REMARK    GeneRIF: Our results indicate that the overexpression of
            Rho-GDIgamma maintains Neural stem cells in the stem cell state
            preventing migration
REFERENCE   5  (bases 1 to 1032)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 1032)
  AUTHORS   Ferland,R.J., Li,X., Buhlmann,J.E., Bu,X., Walsh,C.A. and Lim,B.
  TITLE     Characterization of Rho-GDIgamma and Rho-GDIalpha mRNA in the
            developing and mature brain with an analysis of mice with targeted
            deletions of Rho-GDIgamma
  JOURNAL   Brain Res 1054 (1), 9-21 (2005)
   PUBMED   16054116
REFERENCE   7  (bases 1 to 1032)
  AUTHORS   Dransart,E., Morin,A., Cherfils,J. and Olofsson,B.
  TITLE     Uncoupling of inhibitory and shuttling functions of rho GDP
            dissociation inhibitors
  JOURNAL   J Biol Chem 280 (6), 4674-4683 (2005)
   PUBMED   15513926
REFERENCE   8  (bases 1 to 1032)
  AUTHORS   Gebbink,M.F., Kranenburg,O., Poland,M., van Horck,F.P., Houssa,B.
            and Moolenaar,W.H.
  TITLE     Identification of a novel, putative Rho-specific GDP/GTP exchange
            factor and a RhoA-binding protein: control of neuronal morphology
  JOURNAL   J Cell Biol 137 (7), 1603-1613 (1997)
   PUBMED   9199174
REFERENCE   9  (bases 1 to 1032)
  AUTHORS   Zalcman,G., Closson,V., Camonis,J., Honore,N., Rousseau-Merck,M.F.,
            Tavitian,A. and Olofsson,B.
  TITLE     RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification
            of a non-cytosolic GDI protein interacting with the small
            GTP-binding proteins RhoB and RhoG
  JOURNAL   J Biol Chem 271 (48), 30366-30374 (1996)
   PUBMED   8939998
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC126438.3.
            
            On Nov 17, 2006 this sequence version replaced NM_008113.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002032.1, U73198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AC126438.3         103902-104181
            281-460             AC126438.3         104882-105061
            461-544             AC126438.3         105154-105237
            545-621             AC126438.3         105424-105500
            622-685             AC126438.3         105576-105639
            686-1032            AC126438.3         105723-106069
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.07 cM"
     gene            1..1032
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /note="Rho GDP dissociation inhibitor gamma"
                     /db_xref="GeneID:14570"
                     /db_xref="MGI:MGI:108430"
     exon            1..280
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..885
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /note="rho GDI 3; rho-GDI gamma; guanosine diphosphate
                     (GDP) dissociation inhibitor 5, Rho associated; Rho GDP
                     dissociation inhibitor (GDI) gamma"
                     /codon_start=1
                     /product="rho GDP-dissociation inhibitor 3"
                     /protein_id="NP_032139.1"
                     /db_xref="CCDS:CCDS28548.1"
                     /db_xref="GeneID:14570"
                     /db_xref="MGI:MGI:108430"
                     /translation="MLGLDACELGEQLLELLRLALCARVLLADKDGESTPSDEVLDEI
                     VPEYQAPGKKSMLAIWQLDPGDVSLVKYKQALLGPLPPIMDPSLPNVQVTRLTLLTEQ
                     APGPIIMDLTGDLDALKNQVFVLKEGIEYKVKITFKVNKEIVSGLKCLHHTYRRGLRV
                     DKAIFMVGSYGPRAQEYEFVTSVEEAPRGALARGLYVVRSLFTDDDRLNHLSWEWHLH
                     VCQDWKD"
     exon            281..460
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..544
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..621
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..685
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1032
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1011..1016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /note="hexamer: ATTAAA"
     polyA_site      1032
                     /gene="Arhgdig"
                     /gene_synonym="Gdi5; Rho-GDI-3; Rho-GDI2; RIP2"
                     /note="major polyA site"
ORIGIN      
        1 cgggcgcggc agggacgacc gggttccggc gcggtgcgga cgaaacgcgc gtctctgcgg
       61 gctgcgcggg gtccgcggag cggctggggg cgcgcggcgc gggcgcggcg ctgggcgcgg
      121 ggggcgctcc cggccgggat gagctcaccg cagtcgcgcc ggggctgagc cgagcgggcg
      181 gcggctccgc ggcgggccgc ggctaccatg ctgggcctgg acgcgtgtga gctgggggag
      241 cagctgttgg agctgctccg gctggcgctg tgcgcccgag tcctcttggc tgacaaggat
      301 ggggagtcaa ctccatcaga tgaggtgctg gacgaaattg taccagagta ccaggcccct
      361 gggaagaaga gcatgctggc aatctggcaa ctggaccccg gggacgtgag cttggtcaag
      421 tacaagcagg cgctgctggg acccctgcca cccattatgg accccagcct gcccaacgtg
      481 caggtgacta ggctgacact gctgacggag caggctccag ggcctatcat catggacctt
      541 acaggagacc tagatgcact gaaaaaccag gtgtttgtcc tgaaggaggg cattgaatac
      601 aaggtgaaga tcaccttcaa ggtcaacaag gagattgtca gtggcctcaa atgtctgcat
      661 cacacctatc gtcggggact gcgtgtggac aaggccatct tcatggtggg aagctacggc
      721 cccagagccc aggagtatga atttgtgact tcagtggagg aagcaccaag aggagcattg
      781 gcacgtggcc tctacgtggt caggtccctc ttcactgatg acgacaggct gaaccacctg
      841 tcctgggagt ggcacctcca tgtctgccag gactggaagg actgaacccc acttggggtc
      901 tgtattccca atttcttgtc agttgcagag acctgcaagc attccctaga cctcccagtt
      961 ggtgaccaga tgtcccccac tctctgctgt gtcccccctg cctggtgcct attaaatgtt
     1021 accttgtctt gc
//
