LOCUS       NM_001409500            1562 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus Rho, GDP dissociation inhibitor beta (Arhgdib),
            transcript variant 16, mRNA.
ACCESSION   NM_001409500
VERSION     NM_001409500.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1562)
  AUTHORS   Yavari,A., Stocker,C.J., Ghaffari,S., Wargent,E.T., Steeples,V.,
            Czibik,G., Pinter,K., Bellahcene,M., Woods,A., Martinez de
            Morentin,P.B., Cansell,C., Lam,B.Y., Chuster,A., Petkevicius,K.,
            Nguyen-Tu,M.S., Martinez-Sanchez,A., Pullen,T.J., Oliver,P.L.,
            Stockenhuber,A., Nguyen,C., Lazdam,M., O'Dowd,J.F., Harikumar,P.,
            Toth,M., Beall,C., Kyriakou,T., Parnis,J., Sarma,D., Katritsis,G.,
            Wortmann,D.D., Harper,A.R., Brown,L.A., Willows,R., Gandra,S.,
            Poncio,V., de Oliveira Figueiredo,M.J., Qi,N.R., Peirson,S.N.,
            McCrimmon,R.J., Gereben,B., Tretter,L., Fekete,C., Redwood,C.,
            Yeo,G.S., Heisler,L.K., Rutter,G.A., Smith,M.A., Withers,D.J.,
            Carling,D., Sternick,E.B., Arch,J.R., Cawthorne,M.A., Watkins,H.
            and Ashrafian,H.
  TITLE     Chronic Activation of gamma2 AMPK Induces Obesity and Reduces beta
            Cell Function
  JOURNAL   Cell Metab 23 (5), 821-836 (2016)
   PUBMED   27133129
REFERENCE   2  (bases 1 to 1562)
  AUTHORS   Yan,C., Wang,X., Liu,Y., Abdulnour,R.E., Wu,M. and Gao,H.
  TITLE     Protective Role of Rho Guanosine Diphosphate Dissociation
            Inhibitor, Ly-GDI, in Pulmonary Alveolitis
  JOURNAL   PLoS One 10 (10), e0140804 (2015)
   PUBMED   26469087
  REMARK    GeneRIF: Ly-GDI is a critical regulator of inflammatory injury
            after deposition of IgG immune complexes and that it negatively
            regulates the lung NF-kappaB activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1562)
  AUTHORS   Huang,H.Y., Zhang,W.T., Jiang,W.Y., Chen,S.Z., Liu,Y., Ge,X.,
            Li,X., Dang,Y.J., Wen,B., Liu,X.H., Lu,H.J. and Tang,Q.Q.
  TITLE     RhoGDIbeta Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced
            Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell
            Differentiation
  JOURNAL   J Biol Chem 290 (17), 11119-11129 (2015)
   PUBMED   25778399
  REMARK    GeneRIF: these results indicate that RhoGDIbeta functions as a
            novel BMP4 signaling target that regulates adipogenesis and
            myogensis.
REFERENCE   4  (bases 1 to 1562)
  AUTHORS   Agarwal,N.K., Chen,C.H., Cho,H., Boulbes,D.R., Spooner,E. and
            Sarbassov,D.D.
  TITLE     Rictor regulates cell migration by suppressing RhoGDI2
  JOURNAL   Oncogene 32 (20), 2521-2526 (2013)
   PUBMED   22777355
  REMARK    GeneRIF: Rictor regulates cell migration by suppressing RhoGDI2.
REFERENCE   5  (bases 1 to 1562)
  AUTHORS   Wang,P., Xu,S., Wang,Y., Wu,P., Zhang,J., Sato,T., Yamagata,S. and
            Yamagata,T.
  TITLE     GM3 suppresses anchorage-independent growth via Rho GDP
            dissociation inhibitor beta in melanoma B16 cells
  JOURNAL   Cancer Sci 102 (8), 1476-1485 (2011)
   PUBMED   21518140
  REMARK    GeneRIF: Raptor siRNA suppressed the effects of GM3 on Ly-GDI
            expression and Akt phosphorylation at Thr(308) , suggesting GM3
            signals to be transduced to mTOR-Raptor and Akt-Thr(308) , leading
            to Ly-GDI stimulation
REFERENCE   6  (bases 1 to 1562)
  AUTHORS   Ota,T., Maeda,M., Murakami,M., Takegami,T., Suto,S. and Tatsuka,M.
  TITLE     Activation of Rac1 by Rho-guanine nucleotide dissociation
            inhibitor-beta with defective isoprenyl-binding pocket
  JOURNAL   Cell Biol Int 31 (1), 92-96 (2007)
   PUBMED   17049467
  REMARK    GeneRIF: Impaired interaction of RhoGDIbeta with Rac1 isoprenyl
            groups possibly makes RhoGDIbeta function as a positive regulator
            for Rac1 during metastasis.
REFERENCE   7  (bases 1 to 1562)
  AUTHORS   Ishizaki,H., Togawa,A., Tanaka-Okamoto,M., Hori,K., Nishimura,M.,
            Hamaguchi,A., Imai,T., Takai,Y. and Miyoshi,J.
  TITLE     Defective chemokine-directed lymphocyte migration and development
            in the absence of Rho guanosine diphosphate-dissociation inhibitors
            alpha and beta
  JOURNAL   J Immunol 177 (12), 8512-8521 (2006)
   PUBMED   17142749
  REMARK    GeneRIF: Rho GDIalpha and Rho GDIbeta play synergistic roles in
            lymphocyte migration and development by modulating activation cycle
            of the Rho proteins in a lymphoid organ-specific manner.
REFERENCE   8  (bases 1 to 1562)
  AUTHORS   Olofsson,B.
  TITLE     Rho guanine dissociation inhibitors: pivotal molecules in cellular
            signalling
  JOURNAL   Cell Signal 11 (8), 545-554 (1999)
   PUBMED   10433515
  REMARK    Review article
REFERENCE   9  (bases 1 to 1562)
  AUTHORS   Yin,L., Schwartzberg,P., Scharton-Kersten,T.M., Staudt,L. and
            Lenardo,M.
  TITLE     Immune responses in mice deficient in Ly-GDI, a lymphoid-specific
            regulator of Rho GTPases
  JOURNAL   Mol Immunol 34 (6), 481-491 (1997)
   PUBMED   9307064
REFERENCE   10 (bases 1 to 1562)
  AUTHORS   Adra,C.N., Ko,J., Leonard,D., Wirth,L.J., Cerione,R.A. and Lim,B.
  TITLE     Identification of a novel protein with GDP dissociation inhibitor
            activity for the ras-like proteins CDC42Hs and rac I
  JOURNAL   Genes Chromosomes Cancer 8 (4), 253-261 (1993)
   PUBMED   7512369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125341.4.
            
            Summary: The protein encoded by this gene is a member of the Rho
            guanine nucleotide dissociation inhibitor (GDI) family. This gene
            is expressed at high levels in hematopoietic cells. This protein is
            cytosolic, and dissociation of Rho from this protein is required
            for membrane association and activation of Rho by Guanine
            Nucleotide Exchange Factors (GEFs). C-terminal truncations of this
            gene product have been reported to promote metastasis. Multiple
            transcript variants and protein isoforms exist. [provided by
            RefSeq, Aug 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.1047847.1,
                                           SRR17253011.2123618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC125341.4         101404-101598
            196-475             AC125341.4         105865-106144
            476-665             AC125341.4         107238-107427
            666-749             AC125341.4         108668-108751
            750-826             AC125341.4         111323-111399
            827-890             AC125341.4         114276-114339
            891-1562            AC125341.4         116685-117356
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.72 cM"
     gene            1..1562
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /note="Rho, GDP dissociation inhibitor beta"
                     /db_xref="GeneID:11857"
                     /db_xref="MGI:MGI:101940"
     exon            1..195
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /inference="alignment:Splign:2.1.0"
     exon            196..475
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /inference="alignment:Splign:2.1.0"
     exon            476..665
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..1090
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /note="isoform 1 is encoded by transcript variant 16; rho
                     GDP-dissociation inhibitor 2; rho GDI 2; rho-GDI beta;
                     Rho, GDP dissociation inhibitor (GDI) beta"
                     /codon_start=1
                     /product="rho GDP-dissociation inhibitor 2 isoform 1"
                     /protein_id="NP_001396429.1"
                     /db_xref="GeneID:11857"
                     /db_xref="MGI:MGI:101940"
                     /translation="MTEKDAQPQLEEADDDLDSKLNYKPPPQKSLKELQEMDKDDESL
                     TKYKKTLLGDVPVVADPTVPNVTVTRLSLVCDSAPGPITMDLTGDLEALKKDTFVLKE
                     GIEYRVKINFKVNKDIVSGLKYVQHTYRTGMRVDKATFMVGSYGPRPEEYEFLTPVEE
                     APKGMLARGTYHNKSFFTDDDKQDHLTWEWNLAIKKDWTE"
     exon            666..749
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /inference="alignment:Splign:2.1.0"
     exon            750..826
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /inference="alignment:Splign:2.1.0"
     exon            827..890
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1562
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1484..1489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /note="major polyA site"
     regulatory      1538..1543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /note="hexamer: AATAAA"
     polyA_site      1562
                     /gene="Arhgdib"
                     /gene_synonym="D4; Gdid4; Ly-GDI"
                     /note="major polyA site"
ORIGIN      
        1 gtactcttat ctctttctgc accgaaaaac agagctggaa gagcgcgctt ggaatgcata
       61 ggcaggaaag aagagtctgt ggtcctcagt gggagtggtg aggcccgact ttaattccag
      121 catttgaaag gcagggcatc tctgtgagtt ccaggtcagc caaggataca gagtgagacc
      181 ccgtctttta aaaagtaaca ttaagaccca gaactgcagt gacattggtc catgagtttc
      241 ctcatcccca gagaattccc agacgttccc agtgcctctg gatgagatga tgtgatgaag
      301 aatatcttag gtgtgtgact tataagaaat ggaggctttg gcattcttgc ctggatttca
      361 cctaggcagc atctcccgtg gcttgcagac acatgctatg acagtcgcag ctgtgtcatg
      421 aggaaccagt ctcttaattc tcgggactca attttcccag tgattcagtg agaagagagc
      481 aatcaagatg acggagaagg atgcacagcc acagctggaa gaggcggacg acgacctgga
      541 cagcaagctc aattataagc caccccctca gaagtccttg aaggagctgc aggagatgga
      601 caaggatgac gagagtctaa ccaagtacaa gaaaacactg ctgggagatg tccctgtggt
      661 agcagaccca acagttccca acgtgactgt tacccggctt agccttgtat gtgacagtgc
      721 accaggaccc atcaccatgg accttactgg cgatctcgag gccctcaaaa aggatacatt
      781 tgtgctaaag gaaggcattg aatacagggt gaaaattaac ttcaaagtga ataaggatat
      841 tgtgtctggc ctgaagtatg ttcaacacac ataccggact ggcatgagag tggataaagc
      901 cacattcatg gttggcagct atgggccccg accagaggag tacgaattcc tcactccagt
      961 agaggaagct cccaagggca tgctggcccg aggcacttac cacaacaagt ccttcttcac
     1021 ggatgacgac aaacaggacc acctcacctg ggaatggaac ctggccatta agaaggattg
     1081 gacagaatga gtgcgtctgt ccgtccctcc tgtcaccttc ctcacccacc agaagagttc
     1141 tcccgaccat gttgatcatc acaaactccc tcctccctcc ctgttcctag ctaggccctt
     1201 tctctgtcac acacacacac acacacattt catcaccaat atgttttatc ttaccccatc
     1261 tctcagagtg ttccctgcaa atgagactta aaaccctggc ttctcccacc ttgagtcctg
     1321 aaggtcaaga aatgggcaag ctccggctga cgcctccttg gccttctgtt cagaagttta
     1381 ttcttgccac tgggttcttc cggttcgatg aaccccgttg tcttctctgc caaggggagc
     1441 tctccttttg tgggagacac tgtaaacaac accaaaggaa aagaataaaa tcgttgtgtg
     1501 tgtgactgag aacctcattt gctttccttt gcccttaaat aaatatggta ccagaaagcc
     1561 ca
//
