LOCUS       NM_009707               5515 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus Rho GTPase activating protein 6 (Arhgap6), transcript
            variant 1, mRNA.
ACCESSION   NM_009707
VERSION     NM_009707.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5515)
  AUTHORS   Yeung,C.Y., Taylor,S.H., Garva,R., Holmes,D.F., Zeef,L.A.,
            Soininen,R., Boot-Handford,R.P. and Kadler,K.E.
  TITLE     Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress
            fibers
  JOURNAL   PLoS One 9 (9), e107036 (2014)
   PUBMED   25211221
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5515)
  AUTHORS   Wood,A.J., Roberts,R.G., Monk,D., Moore,G.E., Schulz,R. and
            Oakey,R.J.
  TITLE     A screen for retrotransposed imprinted genes reveals an association
            between X chromosome homology and maternal germ-line methylation
  JOURNAL   PLoS Genet 3 (2), e20 (2007)
   PUBMED   17291163
REFERENCE   3  (bases 1 to 5515)
  AUTHORS   Prakash,S.K., Cormier,T.A., McCall,A.E., Garcia,J.J., Sierra,R.,
            Haupt,B., Zoghbi,H.Y. and Van Den Veyver,I.B.
  TITLE     Loss of holocytochrome c-type synthetase causes the male lethality
            of X-linked dominant microphthalmia with linear skin defects (MLS)
            syndrome
  JOURNAL   Hum Mol Genet 11 (25), 3237-3248 (2002)
   PUBMED   12444108
REFERENCE   4  (bases 1 to 5515)
  AUTHORS   Cormier,T.A., Prakash,S.K., Magner,D.B., Zoghbi,H.Y. and Van den
            Veyver,I.B.
  TITLE     Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly
            (Xpl) and Patchy-fur (Paf) mutant mice
  JOURNAL   Mamm Genome 12 (10), 796-798 (2001)
   PUBMED   11668396
  REMARK    GeneRIF: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked
            polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
REFERENCE   5  (bases 1 to 5515)
  AUTHORS   Prakash,S.K., Paylor,R., Jenna,S., Lamarche-Vane,N.,
            Armstrong,D.L., Xu,B., Mancini,M.A. and Zoghbi,H.Y.
  TITLE     Functional analysis of ARHGAP6, a novel GTPase-activating protein
            for RhoA
  JOURNAL   Hum Mol Genet 9 (4), 477-488 (2000)
   PUBMED   10699171
REFERENCE   6  (bases 1 to 5515)
  AUTHORS   Van den Veyver,I.B., Cormier,T.A., Jurecic,V., Baldini,A. and
            Zoghbi,H.Y.
  TITLE     Characterization and physical mapping in human and mouse of a novel
            RING finger gene in Xp22
  JOURNAL   Genomics 51 (2), 251-261 (1998)
   PUBMED   9722948
REFERENCE   7  (bases 1 to 5515)
  AUTHORS   Schaefer,L., Prakash,S. and Zoghbi,H.Y.
  TITLE     Cloning and characterization of a novel rho-type GTPase-activating
            protein gene (ARHGAP6) from the critical region for microphthalmia
            with linear skin defects
  JOURNAL   Genomics 46 (2), 268-277 (1997)
   PUBMED   9417914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663056.11, AL805974.8 and AL831750.8.
            
            On Dec 18, 2013 this sequence version replaced NM_009707.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.21704.1,
                                           SRR10223971.19052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1713              AL663056.11        64096-65808
            1714-1873           AL805974.8         57037-57196
            1874-1945           AL805974.8         74329-74400
            1946-2205           AL805974.8         83361-83620
            2206-2401           AL805974.8         85355-85550
            2402-2457           AL805974.8         90417-90472
            2458-2608           AL805974.8         93325-93475
            2609-2757           AL805974.8         94491-94639
            2758-2937           AL831750.8         8436-8615
            2938-3035           AL831750.8         24974-25071
            3036-3310           AL831750.8         43076-43350
            3311-3391           AL831750.8         44769-44849
            3392-5515           AL831750.8         45330-47453
FEATURES             Location/Qualifiers
     source          1..5515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.77 cM"
     gene            1..5515
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /note="Rho GTPase activating protein 6"
                     /db_xref="GeneID:11856"
                     /db_xref="MGI:MGI:1196332"
     exon            1..1713
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1873
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1945
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2205
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2401
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2457
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2608
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2757
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2937
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3035
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3310
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3391
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..5515
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5496..5501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /note="hexamer: AATAAA"
     polyA_site      5513
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /note="major polyA site"
ORIGIN      
        1 acttccgtcc tcaagacttt ctccctagag gccgggtatc agagaccagc tgctggctct
       61 ctgagctact tcccaggttt ggcgcctgga aaagttcacg ttctgcattc tcctgcttct
      121 ggctccgccc cggctccaga ccctgcgttc ttctggcctt acccgggacg ggccacccct
      181 ttccccgctg cctctggcgc gagggtgctg ggacatctct gagccagctc tgggcccaac
      241 caaggttggc agcaaatatc aagtgtcgct cttctagagg aacacggata ctcgcttcag
      301 agactgtctt ctgagcgcag acctttctga gtagtgctga gcgcagcggg ggagttcttt
      361 gacaccgttg tcgctcagtg cttggaaggc ccgggacgca gcacatatgg tgtcccactg
      421 agtcaacagc gggactgcgc gggaacgtga acttggagac actttggagc ctcgtcaatc
      481 agaaaggggg acttagcaac ccagctgatc ccccaaagca cagccgcggt ccccaagtta
      541 ccaagaaggt gcactggggg cgcagccgga cagctgagct ggggtgctcc agaggacttt
      601 tcactgcgcc gggagcacca aggatccgct cagggcggac tctcaggcag cctcctccct
      661 agccctcggg attgtcctca ggccacgagg aggagcttgc tggtgatttc gaggctgtcc
      721 ggagccagag agccgaagcg cagtgtctcc cgccttcagc tgggaagggg gagtggcgct
      781 ggcgggttgg agctgagatc tcagctagtc actgacctcc ttcctcctct tccttagcct
      841 ctttgagact tggactcctg aggaagattc tagagacggt aaagggacct ggacctcttg
      901 tttcccaaaa ggctggggat ggagctcctg tttctgcctc cgcagggaca cttggagtgc
      961 gctggtggcg cgtgaacggg gcactgcttt ctaccttcct cggcgagccc cgcctggcag
     1021 ttttccccta ctctactttg gccacttgtt ttctcaggtc acagtctccc gctatctagg
     1081 agggaagaca agaaggtggc cttcagaccc agccctgccg agatgtccgc gcagagcctg
     1141 ctgcacagtg tcttctcctg ctcctcgccc gcgtcgggcg gcacggcctc ggccaaggga
     1201 ttctccaaaa ggaagctgcg ccagacgcgc agcctggacc cagctctgat cggtggctgc
     1261 gggagcgaga tgggcgccga gggcggcctg cggggctcca cagtaagccg cctccattct
     1321 ccacagctct tagcagaggg tctcggttcc cgcttagctt cttctccccg gagtcagcac
     1381 cttcgggcta cccggttcca gactccgaga cctctgtgct cgtctttttc cacaccaagt
     1441 accccgcaag aaaagtcgcc ttctggcagc ttccactttg actacgaggt cccactgagt
     1501 cgcagtggtc tcaagaagag catggcctgg gacttgcctt ctgtcctggc cgggtccggg
     1561 tccgctagta gccgcagtcc cgcaagcatc ctcagttcct ccgggggagg ccccaatggc
     1621 atcttctctt ctcctaggag atggctccag cagaggaagt tccagcctcc acctaacagt
     1681 cgcagtcacc cttacgtcgt gtggaggtcc gagggtgact tcacctggaa cagcatgtct
     1741 ggtcgtagcg tgcgcctgag gtcagtcccc atccagagcc tctcagagct ggagcgggca
     1801 cgactgcagg aagtggcttt ttatcagttg cagcaggact gtgacctggg ctgtcagatc
     1861 accatcccca aagatggaca aaagagaaag aaatctttga gaaagaaact ggattcacta
     1921 gggaaggaaa agaacaaaga caaagaattc atcccacagg catttggaat gcccttatcc
     1981 caagtcattg ctaatgaccg ggcatataaa ctgaagcaag acttgcagag ggaggagcag
     2041 aaggatgcat catcggattt tgtgtcttcc ctcctcccat ttgggaataa aaaacaaaac
     2101 aaagaactct caagcagtaa ctcatctctc agctcaacct cagaaacacc aaatgagtct
     2161 acatcaccga atactccaga accagctcct cgggccagga gaaggggcgc catgtccgtg
     2221 gattccatca ctgatctgga tgacaaccag tctcgactcc tagaagcttt acaactctcc
     2281 ttgcctgctg aggctcagag taaaaaagaa aaggccagag ataagaagct gagtctgaat
     2341 cctatttaca ggcaggtccc caggctggtg gacagctgct gtcaacatct ggaaaaacat
     2401 ggcctccaga cagtggggat attccgagtt ggaagctcaa agaagagagt aagacaattg
     2461 cgtgaagaat ttgaccgtgg ggttgatgtc tgtctggaag aggagcatag tgttcacgat
     2521 gtggcagcct tgttaaagga gttccttaga gacatgcctg acccccttct cacaagggag
     2581 ctatacactg catttatcaa cactctcctg ttggagcctg aggaacaact gggcaccttg
     2641 caactcctca tttaccttct acctccctgc aactgcgaca ccctccaccg cctcctacag
     2701 ttcctctcca ttgtggccag gcatgctgat gataatgtca gcaaagatgg acaagaggtt
     2761 actgggaaca aaatgacatc tctgaactta gccactatat ttggacccaa cctgctccac
     2821 aagcagaagt catcagacaa agaatattct gttcagagct cagccagagc tgaggagagc
     2881 acagccatca tagctgtggt acagaagatg attgaaaatt atgaagcctt gttcatggtt
     2941 cccccagatc tccagaatga agtgctgatc agccttctag agacagatcc agatgttgtg
     3001 gactacttgc tcagaagaaa ggcttcccaa tcctcgagcc ctgacatact tcagacggaa
     3061 gtttcctttt ccatgggagg gaggcattca tctacagatt ccaacaaagc ctccagtgga
     3121 gacatctccc cttatgacaa caactcccca gtattgtctg agcgctccct gctggctatg
     3181 caagaggaca gggcccgggg gggctcggag aagctttata aagtgccaga gcagtataca
     3241 ctggtgggcc acttgtcatc gccaaagtca aagtcaagag aaagttctcc tggaccaagg
     3301 cttggaaaag aaatgtcaga ggagcctttc aatatctggg gaacttggca ttcaacatta
     3361 aaaagtggat ccaaagaccc aggaatgaca ggctcttatg gcgacatttt tgaaagcagc
     3421 tccctccgac cgaggccttg ttctctttct caagggaacc tttccctgaa ctggcctcgg
     3481 tgtcaaggga gcccgacagg gctggacagt ggcactcagg taattcggag gactcagacg
     3541 gcggccaccg tggagcagtg cagtgtccac cttccggtgt cacgtgtctg cagcactccc
     3601 cacatccagg acggcagcag ggggaccagg cggcctgcag ccagctctga tccatttttg
     3661 tccctaaaca gcacagaaga tctagctgag ggcaaggagg atgttgcctg gctgcaaagc
     3721 caggcccgac ctgtgtacca gagacctcag gagagtggaa aagatgacag gcgcccccct
     3781 cctccttacc cggggtcagg gaagcctgcc acaacctctg cccagctgcc actagagcct
     3841 cccctgtgga ggctccagag gcatgaagaa ggttcagaaa cagctgtgga aggaggccag
     3901 caggcctcag gggagcatca gaccaggcca aaaaaactga gcagcgccta ctccctctca
     3961 gccagcgagc aggacaaaca gaacttaggg gaagccagct ggctcgactg gcagcgagag
     4021 cggtggcaga tctgggagct tctatcaact gataaccccg acgccctccc ggaaacccta
     4081 gtataagccc gccagcagct ggagcccacc cttccaaaac acatcttccg gtccagaccc
     4141 ggaaaccttg cctatggaca attggacact tacttgtttt tcttttttgt ttttccacac
     4201 tttgaaaaag caacacaaaa gaaagtccac ttattgattc acttctaccc ctgccattta
     4261 tggtaagatt ctattgcata gccagcctta ggaaaaaaac aaataaacca acaaacatga
     4321 caattcccaa gctcaaaaca acccacattg gctctatgta agaaactctt gcttcgttat
     4381 agcttaattg tatttgtgtc ttcaattttg actattgtat attctgtaac aaattatgta
     4441 tatcaatatg atatattcac agagaagaca gaacaattaa aaatcactgc acttatatta
     4501 cacactgaga tatattaagc aaccagattc tatatgctct ggaatatgca caagcgggta
     4561 tctgtgcttt ttgccatcac cttttaactg ggggcagccc ctcccttcaa tgcctaagga
     4621 aatactaacc aaacaagaga gaaaatgaga agccatattt ttatatagta ttgagacaca
     4681 aaagttgtag tcactgaatg ctttttcata gcaagtatgt tttaaggaaa tattaaattt
     4741 gatacattgt gaaatatatt tttagaatct gtttagaaag gactcagaaa atcaaatcag
     4801 agacaggtgg gacccaagag tacttaagag agtttctatt ccactctagg tcaaatttaa
     4861 ttttatatag gccactaata atatatattt ataatggatt acttttatgt atttttcaaa
     4921 gctaccaact gaaatccaat tttaaaaagc tttaaaatcc aaatacacat tcaaattata
     4981 gatcatttcc cccatctgcc cagttatcaa tattagctca attacaagca attccttgta
     5041 aagtaaatcc tatggggggg gagcaaaaaa gctacatctt tgcgcttaca ttgtaccaaa
     5101 ggctgaggaa atgtgtcttg agtatcttca gtaatattgt gtgtattgta acgtatgtgt
     5161 tactacagta aacagtactt caacaatttc aagtgttaca actgcaaaac cacttttgac
     5221 cagcaggtgg cagtttgctt cagtattttc cattgttttg ttttgttttt caaatcagaa
     5281 gggtcagtgt attatatact aagtgggata tatatgacgt gttactctta atcttcatgt
     5341 tggcagtgaa atttttcagt ggtgtttatt aaaattctac cttgtgccat gatgagtaaa
     5401 atgttaagta aagatttgtt gtcagctctt agttttcatg ttggcaatga aatttttcag
     5461 tggtgtttct taaaattcta tcttgtgcca caatgaataa aatgttaagc aaaga
//
