LOCUS       NP_033837                987 aa            linear   ROD 27-APR-2025
DEFINITION  rho GTPase-activating protein 6 isoform a [Mus musculus].
ACCESSION   NP_033837
VERSION     NP_033837.2
DBSOURCE    REFSEQ: accession NM_009707.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 987)
  AUTHORS   Yeung,C.Y., Taylor,S.H., Garva,R., Holmes,D.F., Zeef,L.A.,
            Soininen,R., Boot-Handford,R.P. and Kadler,K.E.
  TITLE     Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress
            fibers
  JOURNAL   PLoS One 9 (9), e107036 (2014)
   PUBMED   25211221
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 987)
  AUTHORS   Wood,A.J., Roberts,R.G., Monk,D., Moore,G.E., Schulz,R. and
            Oakey,R.J.
  TITLE     A screen for retrotransposed imprinted genes reveals an association
            between X chromosome homology and maternal germ-line methylation
  JOURNAL   PLoS Genet 3 (2), e20 (2007)
   PUBMED   17291163
REFERENCE   3  (residues 1 to 987)
  AUTHORS   Prakash,S.K., Cormier,T.A., McCall,A.E., Garcia,J.J., Sierra,R.,
            Haupt,B., Zoghbi,H.Y. and Van Den Veyver,I.B.
  TITLE     Loss of holocytochrome c-type synthetase causes the male lethality
            of X-linked dominant microphthalmia with linear skin defects (MLS)
            syndrome
  JOURNAL   Hum Mol Genet 11 (25), 3237-3248 (2002)
   PUBMED   12444108
REFERENCE   4  (residues 1 to 987)
  AUTHORS   Cormier,T.A., Prakash,S.K., Magner,D.B., Zoghbi,H.Y. and Van den
            Veyver,I.B.
  TITLE     Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly
            (Xpl) and Patchy-fur (Paf) mutant mice
  JOURNAL   Mamm Genome 12 (10), 796-798 (2001)
   PUBMED   11668396
  REMARK    GeneRIF: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked
            polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
REFERENCE   5  (residues 1 to 987)
  AUTHORS   Prakash,S.K., Paylor,R., Jenna,S., Lamarche-Vane,N.,
            Armstrong,D.L., Xu,B., Mancini,M.A. and Zoghbi,H.Y.
  TITLE     Functional analysis of ARHGAP6, a novel GTPase-activating protein
            for RhoA
  JOURNAL   Hum Mol Genet 9 (4), 477-488 (2000)
   PUBMED   10699171
REFERENCE   6  (residues 1 to 987)
  AUTHORS   Van den Veyver,I.B., Cormier,T.A., Jurecic,V., Baldini,A. and
            Zoghbi,H.Y.
  TITLE     Characterization and physical mapping in human and mouse of a novel
            RING finger gene in Xp22
  JOURNAL   Genomics 51 (2), 251-261 (1998)
   PUBMED   9722948
REFERENCE   7  (residues 1 to 987)
  AUTHORS   Schaefer,L., Prakash,S. and Zoghbi,H.Y.
  TITLE     Cloning and characterization of a novel rho-type GTPase-activating
            protein gene (ARHGAP6) from the critical region for microphthalmia
            with linear skin defects
  JOURNAL   Genomics 46 (2), 268-277 (1997)
   PUBMED   9417914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663056.11, AL805974.8 and AL831750.8.
            
            On Feb 15, 2006 this sequence version replaced NP_033837.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.21704.1,
                                           SRR10223971.19052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.77 cM"
     Protein         1..987
                     /product="rho GTPase-activating protein 6 isoform a"
                     /note="rho GTPase-activating protein 6; rho-type
                     GTPase-activating protein 6; rho-type GTPase-activating
                     protein RhoGAPX-1"
                     /calculated_mol_wt=108713
     Region          1..60
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Site            37
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Region          76..117
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Region          144..170
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Site            265
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Region          324..363
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Region          344..354
                     /region_name="SH3-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Region          404..610
                     /region_name="RhoGAP_ARHGAP6"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of ArhGAP6-like proteins. ArhGAP6
                     shows GAP activity towards RhoA, but not towards Cdc42 and
                     Rac1. ArhGAP6 is often deleted in microphthalmia with
                     linear skin defects syndrome (MLS)...; cd04376"
                     /db_xref="CDD:239841"
     Site            order(435,472,476,555,558..559,590)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239841"
     Site            435
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239841"
     Region          641..676
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Site            669
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Site            675
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Site            682
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Region          709..731
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Site            713
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Site            758
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Site            776
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Site            781
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Site            790
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Site            824
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Region          825..847
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Region          863..953
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54834.3)"
     Site            941
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     Site            944
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43182; propagated from
                     UniProtKB/Swiss-Prot (O54834.3)"
     CDS             1..987
                     /gene="Arhgap6"
                     /gene_synonym="RhoGAPX-1"
                     /coded_by="NM_009707.4:1123..4086"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30534.1"
                     /db_xref="GeneID:11856"
                     /db_xref="MGI:MGI:1196332"
ORIGIN      
        1 msaqsllhsv fscsspasgg tasakgfskr klrqtrsldp aliggcgsem gaegglrgst
       61 vsrlhspqll aeglgsrlas sprsqhlrat rfqtprplcs sfstpstpqe kspsgsfhfd
      121 yevplsrsgl kksmawdlps vlagsgsass rspasilsss gggpngifss prrwlqqrkf
      181 qpppnsrshp yvvwrsegdf twnsmsgrsv rlrsvpiqsl selerarlqe vafyqlqqdc
      241 dlgcqitipk dgqkrkkslr kkldslgkek nkdkefipqa fgmplsqvia ndrayklkqd
      301 lqreeqkdas sdfvssllpf gnkkqnkels ssnsslssts etpnestspn tpepaprarr
      361 rgamsvdsit dlddnqsrll ealqlslpae aqskkekard kklslnpiyr qvprlvdscc
      421 qhlekhglqt vgifrvgssk krvrqlreef drgvdvclee ehsvhdvaal lkeflrdmpd
      481 plltrelyta fintlllepe eqlgtlqlli yllppcncdt lhrllqflsi varhaddnvs
      541 kdgqevtgnk mtslnlatif gpnllhkqks sdkeysvqss araeestaii avvqkmieny
      601 ealfmvppdl qnevlislle tdpdvvdyll rrkasqsssp dilqtevsfs mggrhsstds
      661 nkassgdisp ydnnspvlse rsllamqedr arggseklyk vpeqytlvgh lsspksksre
      721 sspgprlgke mseepfniwg twhstlksgs kdpgmtgsyg difessslrp rpcslsqgnl
      781 slnwprcqgs ptgldsgtqv irrtqtaatv eqcsvhlpvs rvcstphiqd gsrgtrrpaa
      841 ssdpflslns tedlaegked vawlqsqarp vyqrpqesgk ddrrppppyp gsgkpattsa
      901 qlplepplwr lqrheegset aveggqqasg ehqtrpkkls sayslsaseq dkqnlgeasw
      961 ldwqrerwqi wellstdnpd alpetlv
//
