LOCUS       NM_009706               9636 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus Rho GTPase activating protein 5 (Arhgap5), transcript
            variant 1, mRNA.
ACCESSION   NM_009706 XM_011243989
VERSION     NM_009706.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9636)
  AUTHORS   Watanabe,K., Nakayama,K., Ohta,S., Matsumoto,A., Tsuda,H. and
            Iwamoto,S.
  TITLE     ILDR2 stabilization is regulated by its interaction with GRP78
  JOURNAL   Sci Rep 11 (1), 8414 (2021)
   PUBMED   33863978
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9636)
  AUTHORS   Hinge,A., Xu,J., Javier,J., Mose,E., Kumar,S., Kapur,R.,
            Srour,E.F., Malik,P., Aronow,B.J. and Filippi,M.D.
  TITLE     p190-B RhoGAP and intracellular cytokine signals balance
            hematopoietic stem and progenitor cell self-renewal and
            differentiation
  JOURNAL   Nat Commun 8, 14382 (2017)
   PUBMED   28176763
  REMARK    GeneRIF: Study suggests a link between p190-B-RhoGAP and
            non-canonical TGF-beta signaling in hematopoietic stem and
            progenitor cell differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9636)
  AUTHORS   Teo,Z.L., McQueen-Miscamble,L., Turner,K., Martinez,G.,
            Madakashira,B., Dedhar,S., Robinson,M.L. and de Iongh,R.U.
  TITLE     Integrin linked kinase (ILK) is required for lens epithelial cell
            survival, proliferation and differentiation
  JOURNAL   Exp Eye Res 121, 130-142 (2014)
   PUBMED   24472646
REFERENCE   4  (bases 1 to 9636)
  AUTHORS   Raman,R., Kumar,R.S., Hinge,A., Kumar,S., Nayak,R., Xu,J.,
            Szczur,K., Cancelas,J.A. and Filippi,M.D.
  TITLE     p190-B RhoGAP regulates the functional composition of the
            mesenchymal microenvironment
  JOURNAL   Leukemia 27 (11), 2209-2219 (2013)
   PUBMED   23563238
  REMARK    GeneRIF: Loss of p190-B expression is associated with defective
            hematopoiesis.
REFERENCE   5  (bases 1 to 9636)
  AUTHORS   Heckman-Stoddard,B.M., Vargo-Gogola,T., Herrick,M.P., Visbal,A.P.,
            Lewis,M.T., Settleman,J. and Rosen,J.M.
  TITLE     P190A RhoGAP is required for mammary gland development
  JOURNAL   Dev Biol 360 (1), 1-10 (2011)
   PUBMED   21945077
REFERENCE   6  (bases 1 to 9636)
  AUTHORS   Chakravarty,G., Hadsell,D., Buitrago,W., Settleman,J. and
            Rosen,J.M.
  TITLE     p190-B RhoGAP regulates mammary ductal morphogenesis
  JOURNAL   Mol Endocrinol 17 (6), 1054-1065 (2003)
   PUBMED   12637587
  REMARK    GeneRIF: Results suggest that p190-B regulates ductal
            morphogenesis, at least in part, by modulating the IGF signaling
            axis
REFERENCE   7  (bases 1 to 9636)
  AUTHORS   Sordella,R., Jiang,W., Chen,G.C., Curto,M. and Settleman,J.
  TITLE     Modulation of Rho GTPase signaling regulates a switch between
            adipogenesis and myogenesis
  JOURNAL   Cell 113 (2), 147-158 (2003)
   PUBMED   12705864
  REMARK    Erratum:[Cell. 2003 May 16;113(4):547]
REFERENCE   8  (bases 1 to 9636)
  AUTHORS   Sordella,R., Classon,M., Hu,K.Q., Matheson,S.F., Brouns,M.R.,
            Fine,B., Zhang,L., Takami,H., Yamada,Y. and Settleman,J.
  TITLE     Modulation of CREB activity by the Rho GTPase regulates cell and
            organism size during mouse embryonic development
  JOURNAL   Dev Cell 2 (5), 553-565 (2002)
   PUBMED   12015964
  REMARK    GeneRIF: Mice lacking the Rho-inhibitory protein, p190-B RhoGAP,
            are 30% reduced in size and exhibit developmental defects
            strikingly similar to those seen in mice lacking the CREB
            transcription factor.
REFERENCE   9  (bases 1 to 9636)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 9636)
  AUTHORS   Burbelo,P.D., Finegold,A.A., Kozak,C.A., Yamada,Y. and Takami,H.
  TITLE     Cloning, genomic organization and chromosomal assignment of the
            mouse p190-B gene
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 203-210 (1998)
   PUBMED   9838117
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114002.4 and AC155819.2.
            
            On or before Jun 22, 2022 this sequence version replaced
            XM_011243989.3, NM_009706.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.12684.1,
                                           SRR10223970.15237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AC114002.4         160144-160458
            316-4204            AC114002.4         172150-176038
            4205-4352           AC114002.4         198560-198707
            4353-4430           AC155819.2         83144-83221         c
            4431-4562           AC155819.2         80611-80742         c
            4563-4668           AC155819.2         78283-78388         c
            4669-9636           AC155819.2         68732-73699         c
FEATURES             Location/Qualifiers
     source          1..9636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 22.16 cM"
     gene            1..9636
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /note="Rho GTPase activating protein 5"
                     /db_xref="GeneID:11855"
                     /db_xref="MGI:MGI:1332637"
     exon            1..315
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /inference="alignment:Splign:2.1.0"
     exon            316..4204
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..4996
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 5; rho-type GTPase-activating
                     protein 5"
                     /codon_start=1
                     /product="rho GTPase-activating protein 5 isoform 1"
                     /protein_id="NP_033836.2"
                     /db_xref="CCDS:CCDS36443.1"
                     /db_xref="GeneID:11855"
                     /db_xref="MGI:MGI:1332637"
                     /translation="MMAKNKEPRPPSYTVSVVGLSGTEKDKGNCGVGKSCLCNRFVRS
                     KADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDITQNGEDGVECKIHVIEQTEFIDDQ
                     TFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFL
                     LCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASN
                     KKNLLVVETSARFNVNIETCFTALVQMLDKTRGKPKIIPYLDAYKTQRQLVVTATDKF
                     EKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKR
                     REEYISTLPRAFNTLLPDLEEIEHLNWLEALKLMEKRADFQLCFVVLEKTPWDETDHI
                     DKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRIEMKEKFKKTLEKIQFISPGQPW
                     EEVMCFVMEDEAFKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNA
                     TPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQYCTDI
                     KVENLLATSLLEMDHNRVRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYA
                     LDGKIYELDLRPVDAKSPYILSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEA
                     SQIRKDKYMTNLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPTGTYPRK
                     FNESQIKQALRGVLESVKHNLDVVSPVPINKDVSEADLRIVMCAMCGDPFSVDLILSP
                     FLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYS
                     AKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAK
                     FTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDC
                     FPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPVHSTPNCHDH
                     ERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDSS
                     DNYVEPLDTIFKQKGYSDEIYVVPDDSQNRIIKIRNSFVNNTQGDEENGFSDRTSKGH
                     GERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFTTSKTKRKGRHRGSEEDPLLSP
                     VETWKGGIDNPAITSDQEVDDKKIKKKTHKVKEDKKQKKKTKTFNPPTRRNWESNYFG
                     MPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNIN
                     LASMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERFHALKEIVKKF
                     HPVNYDVFRYVITHLNRVSQQNKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQ
                     SVVETFIQQCQFFFYNGEIVETANTVAPPPTSNPGQLVESMVPLQLPPPLQPQLIQPQ
                     LQTDPLGII"
     exon            4205..4352
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..4430
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4562
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..4668
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /inference="alignment:Splign:2.1.0"
     exon            4669..9636
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6473..6478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /note="hexamer: AGTAAA"
     polyA_site      6493
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /note="major polyA site"
     regulatory      7290..7295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /note="hexamer: ATTAAA"
     polyA_site      7312
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /note="major polyA site"
     regulatory      9617..9622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
                     /note="hexamer: AATACA"
     polyA_site      9636
                     /gene="Arhgap5"
                     /gene_synonym="p190-B; p190B"
ORIGIN      
        1 agagatccgt cagcgcgagg agcccgagtg gccgccatta ctgagcccag cgcgacggcg
       61 ggcgcggggg aaggggggag ggtcggggct gccgctgccg gcgagcgggc gggtgaccgg
      121 gcagcgcgag ccgcggggct cgggctttcg gggcgtgtgt gtcggcgagg gcgcggggag
      181 cgcgccggcc gcgagaggcg agccgagagt ggaggaggcg gcggcggcgg gagcgctccc
      241 caggaatgtc gctgccgccg ccaccgccgc ggccgctgcc gttgaggagg cgacggagga
      301 gaccggcgtt gttaggaaga tgatccatat gatctcgaag aagacctttc tttggcaatg
      361 agggaactac aaagaaccaa atataattct gaaattcagg atctgtattt tgagatggtt
      421 ttattttcag aatgaaaagt atatatggtt atctttatga atgtaaagac atgagaaaag
      481 agttatgatg gcaaaaaaca aagagcctcg acccccatct tatactgtca gtgtagttgg
      541 actctctggg actgaaaaag acaaaggaaa ctgtggagtt ggaaaatctt gtttgtgcaa
      601 tagatttgta cgttcaaaag cagatgaata ttatccagag catacttctg tgcttagcac
      661 cattgacttt ggaggccgag tagtaaacaa tgatcacttt ttatactggg gtgacataac
      721 acaaaatggt gaagatggtg tagaatgcaa aattcatgtc attgaacaaa cagagttcat
      781 tgatgaccag actttcttgc ctcatcgaag tacaaatttg caaccatata taaaacgtgc
      841 agctgcctca aaattgcagt cagcagaaaa actaatgtac atttgtaccg atcagctagg
      901 cttggagcaa gactttgaac agaagcaaat gcctgaaggg aaactcaatg tagatggatt
      961 tttattgtgt attgatgtga gtcaaggatg taataggaag tttgatgatc aacttaaatt
     1021 tgtgaataac ctttttgtcc agctatcaaa atccaaaaag cctgtgataa tagcagcaac
     1081 taaatgtgat gaatgtgtgg atcattacct tagagaagtt caagcctttg cctcaaacaa
     1141 aaagaatctt ctagtagtgg aaacatcagc acgatttaat gtcaacattg agacatgttt
     1201 cactgctttg gtacaaatgt tggataaaac tcgtggcaaa cctaaaatta ttccctatct
     1261 ggatgcttat aaaacacaga gacaacttgt tgtcacagca acagacaagt ttgaaaaact
     1321 tgtacagact gtgagagatt atcatgcaac ttggaaaact gttagtaata aattaaaaaa
     1381 tcatcctgat tatgaagaat atatcaactt agagggaaca agaaaggcca gaaatacatt
     1441 ctcaaagcat atagagcaac tcaaacagga acatataaga aaaaggagag aagaatatat
     1501 aagtacctta ccaagggctt ttaatactct cttgccagat ctagaagaga ttgaacattt
     1561 gaattggttg gaagctttga agttaatgga aaagagagca gatttccagt tatgttttgt
     1621 ggtgctagaa aaaacacctt gggatgaaac tgaccatata gacaaaatta atgatagacg
     1681 gatcccattc gaccttctga gcactttaga agcagaaaaa gtctatcaaa accatgtaca
     1741 acatctgata tcagagaaaa gaagaataga aatgaaggag aaattcaaga agactttaga
     1801 aaaaattcag ttcatttcac ctgggcagcc atgggaggaa gttatgtgtt ttgtcatgga
     1861 ggatgaagca ttcaaataca tcactgaggc tgatagcaaa gaagtatatg gtaggcatca
     1921 gcgagagata gtagaaaaag ccaaagaaga gtttcaggaa atgctttttg agcattctga
     1981 acttttttat gatttagatc ttaatgcaac accaagttct gataaaatga gtgaaattca
     2041 taccgttcta agtgaagaac ctagatataa agctttacag aaacttgcac ctgatagaga
     2101 atctcttcta cttaagcata taggatttgt ttatcatccc actaaagaaa catgcctcag
     2161 tggccaatat tgtacagaca ttaaagtgga aaatttactt gccactagtc tattagagat
     2221 ggatcataac cgcgtacgct tgtatcatga tagtaccaat atagacaaag ttaatctttt
     2281 cattttaggg aaagatggcc ttgcccagga actagcaaat gagataagga ctcaatccac
     2341 tgatgatgag tatgccttag atggaaaaat ttatgaactt gatcttcggc ctgttgatgc
     2401 caaatcgcct tacattttga gtcagctatg gactgcagcc tttaaaccac atgggtgctt
     2461 ctgtgtattc aattccatcg agtcactgag ttttattgga gaatttattg gaaaaataag
     2521 aaccgaagca tctcagatca gaaaagataa atatatgact aatcttccat ttacattaat
     2581 tcttgctaat cagagggatt ccattagtaa aaatctacca attctcaggc accagggtca
     2641 gcagttggcc aacaaattgc agtgtccttt tgtagacgta cctactggta catatcctcg
     2701 taaatttaat gaatcacaaa taaagcaagc tctaagagga gtattggaat cagttaaaca
     2761 caatttagat gtggtgagcc cagttcctat caataaggat gtgtcagaag ctgacttgag
     2821 aattgtcatg tgtgccatgt gtggcgatcc atttagtgtg gatctcattc tttcaccttt
     2881 ccttgactct cattcttgca gtgctgctca agctggacag aataattctt taatgcttga
     2941 caaaattatt ggtgaaaaaa ggaggcgaat acagatcaca atattgtcat accactcctc
     3001 aattggagta agaaaagatg aactggttca tgggtatata ttagtttatt ctgcaaaaag
     3061 gaaagcatca atgggaatgc ttcgtgcatt tctatcagaa gttcaagata ctattcctgt
     3121 acaactggtg gcagttactg acagtcaagc tgatttcttt gaaaatgagg ctatcaagga
     3181 gttaatgact gaaggagaac acattgcaac tgagataacc gctaaattta cagcattata
     3241 ttctttatct cagtatcata ggcaaactga ggttttcact ttgtttttca gtgatgttct
     3301 agagaaaaaa aatatgatag aaaattccta tttgtctgat aatacaaggg aatccactca
     3361 tcagagtgaa gatgtttttc taccgtctcc aagagactgt tttccctata acaactaccc
     3421 tgattcagat gatgacacag aagcaccacc tccatatagt ccaattggag atgatgtaca
     3481 gttgcttcca acacctagtg accgttccag atacaggtta gatttggaag gaaatgagta
     3541 tcctgttcat agcactccaa attgtcacga tcatgaacgt aaccataaag tgcctccacc
     3601 tattaaacct aaaccagttg tacctaaaac aaatgtgaaa aaactggatc caaacctttt
     3661 aaaaacaatt gaagctggta ttggtaaaaa tccaagaaaa cagacttccc gggtgccttt
     3721 ggcacatcct gaagatatgg attcttcaga taactatgtg gaaccccttg acacaatttt
     3781 caagcagaag ggctattctg atgagattta tgttgtccca gatgatagtc agaatcgaat
     3841 tattaaaatt cgaaactcat ttgtaaataa cactcaagga gatgaagaaa atgggttttc
     3901 tgatagaacc tcaaaaggtc atggagagcg taggccttca aaatataaat ataaatctaa
     3961 aactttgttt agtaaagcca agtcatacta cagaagaaca cactcagatg caagcgatga
     4021 tgaggctttc actacttcca aaacaaaaag aaaaggaaga catcgtggaa gtgaagaaga
     4081 tccactactg tctcctgttg aaacttggaa aggtggtatt gataatcctg caatcacatc
     4141 tgaccaggag gtagatgata agaagataaa gaagaaaacc cacaaagtaa aggaagataa
     4201 aaagcagaaa aagaaaacta agaccttcaa cccaccaaca cgtagaaatt gggaaagtaa
     4261 ttactttggg atgcccctcc aggatctggt tacagctgag aagcctatac cactatttgt
     4321 tgaaaaatgt gtggaattta ttgaagacac aggattatgt actgaaggac tataccgtgt
     4381 tagtggaaat aaaactgatc aagacaacat tcaaaagcag tttgatcaag atcataatat
     4441 caatctagca tcaatggaag tgacagtcaa tgctgtagct ggagctctca aagctttctt
     4501 tgctgacctg ccggatcctt tgattccata ttcactccac ccagagctat tggaagcagc
     4561 aaaaatccca gataaaacag agcgctttca tgccttgaaa gaaattgtta agaaatttca
     4621 tcctgtaaac tatgatgtat tcagatatgt gataacacat ctaaacaggg ttagtcagca
     4681 aaataaaatc aacctaatga cagcagacaa cttatccatc tgtttttggc caactttgat
     4741 gagacctgat tttgaaaatc gagagtttct gtctaccact aaaatccatc aatctgtcgt
     4801 tgaaacattt attcaacagt gccagttttt cttttacaat ggagaaattg tagaaactgc
     4861 gaacactgtg gctcctccac ctacttcaaa tccaggacaa ttggtagaat caatggtacc
     4921 acttcagttg ccaccaccat tgcaacctca gctaattcaa ccacaattgc agacagatcc
     4981 tcttggtatt atataaatag aatgtgattg cagatggcct gaaattggac aaaaacaaat
     5041 ctagacatgc atgtttcagg ggttagtagt atatttcatg tttcatacag ataatccaca
     5101 tcaaaataat gagacatttt ctctttgaac tatatggtat tccctattca gttacattat
     5161 gaatctaaaa acatgtggta agcatgactg gagaggttta atttttataa acaaaaaaaa
     5221 atagttataa aaatgcaaag ctgctgctgc atgcaacctt attgcaatca gtatatcatt
     5281 cccgtggcaa tttctgtcac agtatattgt gaatacagtt tttctataga aattaaatga
     5341 tttaaaaact catatatgaa atgtttaatg ctttcagcct gctttatggc tggttttgtt
     5401 atttgattgc taatttgggg acctaattcc agcagtctgt atagataact aaagcccagt
     5461 taagtatttt ttaatttcca gttactatgc catgcttggg atgtttgaaa gaaagaaagg
     5521 aaaatacatg taacatattt cacatttctg caccttcatc ttctaagtaa atttgtggat
     5581 gatttgatga ggagagagtg aacctgtttc ttttactcac gtaccaagga cacacttgtg
     5641 gttaaagtga gttgataatg tgatgtaaag aatagttgtc accaactcat ttctttatta
     5701 tctataatga aagatacatt ttgtatacac agttaattct gtaaacagat gcatgttcaa
     5761 aagatctatg atggtcttgt aatcttaatc taatatattt tagatatttt aatttttccc
     5821 tcttggggaa tacacttagt atagtgtaga aaaatacttc atgacatttt catataaggt
     5881 tatataactt ttcatacata aacatgaagt ttgttgtaga aagttcttta aaccaaacat
     5941 ttaatctagg atttcaattt aatctgttcc ttgaatctat ttttatgtgg cccttgagaa
     6001 tatatcccaa aaaattccat tgctaataca gcaataaaaa tactttgggt actgacagac
     6061 tccttggagt atgtatatat aaaataacaa acttgtattc atattctttc agtgatgtgt
     6121 tgttctacaa tccagaatgg cttttgcacc attttttaaa ccagttttcc cccctttgcc
     6181 gttggtacca gagttgctat aaatgactgc tgctttaagg gttaaatatt ttgttagtga
     6241 agatacaacc agaacactaa attatgataa aactttctga ctgagtgata ggtaaattta
     6301 gttgggctat attcaaaatt attttattat caaacccata ccatttgttt tactggaaaa
     6361 ggaaaagtgg tttgcttttt actgctggat catattttgt gtagtaaaga aattctttgg
     6421 tcaatgttgt aatctttata tttcaatttt aaggtttcct tatctgtatt atagtaaatt
     6481 catgattttg agattcaagg ctcctaagag tttgatttgc tccattttgt cttaaaatat
     6541 tctttctcaa ttgttatatc ttaggtattg tacttccaat ttcaacaaag atgtcaacat
     6601 gaaccaggct actgtttaag tacatgtata ttataaatta tcttgtgtta ttatcttttc
     6661 taagagaaca aagtccctat tattcctatt gcaaagcaca caggaattta agaaagtaca
     6721 gtaattttta aaaaaaaaaa tatccggtaa atgtagtatt cttacttgtt ctatattact
     6781 tatacctatt gtctatatag ctttaattta tagctgtcag tttaacattg gcatgtctgg
     6841 caaagaaaat taaactttaa gagttttata aactgtttct aggttgctaa agaatttatt
     6901 tttctacgat aaatggtata gacaaagcat caactatgta caggataaaa gcctgactat
     6961 ttctattgaa agtaggctta caagagaatt ttcagaactg ttcatatctt tggttcattc
     7021 tgtcctaact ttacaattgt aatatgtgag tcccagttta tttaagctat tatcttttat
     7081 aatgtgttaa tttaacattc atttacattt aaaactattt ttgttattaa aattagcatt
     7141 tataagtttc cacattaacc accttacacc tcttccaaaa ctgatattac ttttctatgc
     7201 attctatcat tgatttgaca cactacatag tgaatcactt aaatattcta catctggttc
     7261 attttactac taggttacag atattgaaaa ttaaagtatg gtttaaagct cagtctgtta
     7321 cactgacttg tgtttgtttt tggccaaggg tataggtatg tttttaaaca ttagaacagt
     7381 aaatctaaga agtgaataac ataattaaat catttgttgc ttgtaagtta ttgcactgtt
     7441 tagggacaca cacgtacaca catgtgtata tagatttaat gggtttaaag aatagtagat
     7501 agtcttaaaa taatgggtca acatttgaca ttcacaatat ttaaaaagtc catctataca
     7561 cattgccgtt gtttcactta caattcagtg ctttttattc caaaatcagt ctcgacagtg
     7621 tttagataat ataaagaaga atagaggggt ctctgtttca ggcttttagt agatattttt
     7681 aggagtcaaa ttctatttgt tatgtacttg ccaaggaata catatatctt aacaaaattc
     7741 caggtgcaat ttatgtgttt aaagtgatat ttttagtagt acttccctcc cctccccggc
     7801 ccctgcccct taacacaggg taaatactgt aggtaacagc aatctaactt accccaaaaa
     7861 agcagacctt tttttttttc tatactgtat gtaaatatta aagacattat ggtcggctgg
     7921 ttggttggtt ggttggttgg ttgatttggt ttagttgggt attttttgtt ttcgtttgtt
     7981 ttttgttttt gtggtactga aatctacttt ctaatatctc ttagatataa acaaagggga
     8041 catttgaaat gaagtcttag gctttaactt ccgtgattat ttttagttta ttatagagta
     8101 ataattggga tgctatttgt cagtgacttt aaaatgtcaa aagtggtttg tttcttttta
     8161 tagttaatat aattttatgc tttatccaga cgctgctgcc attatcagta aagctgctga
     8221 atgctgaatg ctttgcataa cacattaaga agcagtgcga ttttaaatta aagttgccta
     8281 tatttaccat gttgttggta aaaattagct aatcttaggt aaagtaggaa catttaaatt
     8341 tttatattaa tataattaag attgtactgg atgactttgt tattgaactt tccttataca
     8401 atgaaaggaa atgaaaaact cattgtgaat ataagctttt aaaactaggg cctgagggtg
     8461 tgtagctcag ttggtagagt gtttgcgtag gttccacaaa gccttggagt cagccctcac
     8521 ccagcactac ataaaccaag cctgttggca cctatctata atcctagcat ataggagata
     8581 gaggcagaaa aatcaaaagt tcagaatcgt ccttgactac atagtttgag catagcctgc
     8641 aacacattag aacctacctt ttaaaaaggt ttaaaaatag gaaaacaaaa taaaatgtac
     8701 aaattaaaca attgtatgtg aatttggatt ttgagagaaa ttctttcaaa ccactagaaa
     8761 tgtttttaaa atattagagc agagctatca atgttggaaa ataatgtttc tgctttttct
     8821 tcatggcttg aaaataagat aagcccaact ttatgactat ctgctgtcat ctatggatct
     8881 ggtgagttct ctttgagtta aatacctatg catatcttgg atttgaattc ttaggctttt
     8941 ccagttacca aaaacccgta agtaatattt aattaaggag gataccattc ttcaaagtac
     9001 accaaaccat tttttattat aggatctgtt tggttttaac atatattctt aaattcagtg
     9061 atttgctgtg atacaggtac cctagttttt ataaaacagt taaaatataa ttttaatgaa
     9121 cttggagaaa tattagttga ctcatcatca tcctatatat gagaggatat catagacaca
     9181 attattcctt ttcctggagg atggagaaaa ggggaatcac aggatttcat attctcatct
     9241 tagttgaatg gtgagaaatt agtttttatg aaaattttag aagtagccaa attgattttg
     9301 gaaaaccagt gaatgacaga ggaagttaac attttttata tttagtatta cagtgttgac
     9361 atttcttgct taccagttgt tagaactgtt aaaatttgca aatatatatt tgtgtgttta
     9421 tatatacatg cctaatatac atctgtaagt agctgtcaaa gaatttgtgg ttgaaaaacc
     9481 aaacttgtta atcaccatag tgcagatttt atttttggtt tcttgaattg gtaaagtcac
     9541 catgagtaat ttagtaatgg actctcctaa cataacatgt tttcaaattt atattgtttt
     9601 tttcttcaac ataagcaata cagatttacc aactga
//
