LOCUS       NM_001142701            3928 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Rho GTPase activating protein 45 (Arhgap45),
            transcript variant 1, mRNA.
ACCESSION   NM_001142701
VERSION     NM_001142701.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3928)
  AUTHORS   He,L., Valignat,M.P., Zhang,L., Gelard,L., Zhang,F., Le Guen,V.,
            Audebert,S., Camoin,L., Fossum,E., Bogen,B., Wang,H., Henri,S.,
            Roncagalli,R., Theodoly,O., Liang,Y., Malissen,M. and Malissen,B.
  TITLE     ARHGAP45 controls naive T- and B-cell entry into lymph nodes and
            T-cell progenitor thymus seeding
  JOURNAL   EMBO Rep 22 (4), e52196 (2021)
   PUBMED   33719206
REFERENCE   2  (bases 1 to 3928)
  AUTHORS   Voisinne,G., Kersse,K., Chaoui,K., Lu,L., Chaix,J., Zhang,L.,
            Goncalves Menoita,M., Girard,L., Ounoughene,Y., Wang,H.,
            Burlet-Schiltz,O., Luche,H., Fiore,F., Malissen,M., Gonzalez de
            Peredo,A., Liang,Y., Roncagalli,R. and Malissen,B.
  TITLE     Quantitative interactomics in primary T cells unveils TCR signal
            diversification extent and dynamics
  JOURNAL   Nat Immunol 20 (11), 1530-1541 (2019)
   PUBMED   31591574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159194.1, AK159474.1 and BB733889.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159194.1, AK170262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2281              AK159194.1         2-2282
            2282-3926           AK159474.1         2327-3971
            3927-3928           BB733889.1         396-397
FEATURES             Location/Qualifiers
     source          1..3928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3928
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /note="Rho GTPase activating protein 45"
                     /db_xref="GeneID:70719"
                     /db_xref="MGI:MGI:1917969"
     exon            1..247
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..3505
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /note="isoform 1 is encoded by transcript variant 1; minor
                     histocompatibility protein HA-1; histocompatibility
                     (minor) HA-1"
                     /codon_start=1
                     /product="rho GTPase-activating protein 45 isoform 1"
                     /protein_id="NP_001136173.1"
                     /db_xref="CCDS:CCDS48624.1"
                     /db_xref="GeneID:70719"
                     /db_xref="MGI:MGI:1917969"
                     /translation="MFSRKKRELMKTPSISKKNRAGSPNPQSSSGELPRKDWTEAPGL
                     EPPATSLSTVAKGTGTLKRPTSLSRHASAAGFPLSGTATWTLGRGYRSPLSAASPAEL
                     PTEGAFPDGVEDISTLLADVARFAEGLEKLKECVLQDDLLEARRPLAHECLGEALRVM
                     RQVISRYPLLNTVETLTAAGTLIAKVKAFHYECNNESDKREFEKALETIAVSFSCTVS
                     EFLLGEVDSSTLLAVPPGDPSQSMENLYGAGTEGPPHNVEECEEGCLPPEEVDMLLQR
                     CEGGVDAALQYAKDMARYMKDLISYLEKRTTLEMEFAKGLQKVVHNCRQSVTHEPHMP
                     LLSIYSLALEQDLEFGHGMVQAAGTLQTQTFMQPLTLRRLEHERRRKEIKESWHRAQR
                     KLQEAEANLRKAKQGYKQRCEDHDKARLQVAKAEEEQQGTGPGAGTAASKALDKRRRL
                     EEEAKNKAEEAMATYRTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATISY
                     YQLMHMQTAPLPVNFQMLCESSKLYDPGQQYASHVRQLQRGEEPDVRYDFEPYVSNNS
                     WSPIMRTRKGSFNPGDASGPEAAGSPPEEGGTSEAAPNKDHRGGRGHQVHKSWPISIS
                     DTEVGLDTSSGDLKKFDRTSSSGTMSSSEELGDQEAGLVASAFDSADLNGMDPELPVA
                     MPSGPFRHVGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETL
                     AIQCGHKKLQGRLQLFGQDFSQAALSTPDGVPFIVKKCVCEIERRALHTKGIYRVNGV
                     KTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRFYHELVGLAKD
                     SLKAEAEAKAASRGRQGGSESEAATLAMVGRLRELMQDLPAENRATLLYLLKHLRRIV
                     EMEQDNKMTPGNLGIVFGPTLLRPRPTDATVSLSSLVDYPHQARVIETLIVHYGLVFE
                     EEPEEAPGSQEGASTQCGQLESAEGIVFPLQEEAEDGSRESHAASNDSDSELEDASDP
                     LSSSDASALHRLSFLEQTEAGLEEGPQSHSGSEEQLEGEDGAPGPWLCHFNTNQSNNT
                     SRAPLPTMRLRGGQITGGTSQERQPQFV"
     exon            248..572
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..716
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..801
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..874
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..941
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1079
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1144
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1255
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1336
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1525
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1663
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1854
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1979
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2057
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2162
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2335
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2524
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2662
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2889
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3100
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3188
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3928
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /note="hexamer: AATAAA"
     polyA_site      3927
                     /gene="Arhgap45"
                     /gene_synonym="6330406L22Rik; Ha-1; Hmha1"
                     /note="major polyA site"
ORIGIN      
        1 acgtgtggct ctgacagctg gggagggggt ggccctgagc aatgtggtcc agagacagcc
       61 tgcaccagga gttgcaggac tgagaccacc cccagactcc caccctgccg ttgcccgcct
      121 gtcctcacct agggccactg gggctgactc caccatgttc tctcggaaga agcgagaact
      181 tatgaaaact ccctctattt ccaaaaagaa ccgcgcgggg agccccaacc cgcagtcctc
      241 ctcaggggag ctgcccagga aggattggac agaagctccc ggcctggagc caccagccac
      301 atccctgtcc acggtagcca agggcacagg gacactcaaa agacccacca gcctgagccg
      361 ccatgccagt gcagcaggct tcccgctctc gggcactgcc acctggaccc tgggccgtgg
      421 gtaccgaagc cccctttctg cggccagtcc ggcagagtta cccactgagg gagctttccc
      481 tgatggcgta gaagacatct caaccctgct ggcggatgtg gcccgctttg ctgagggctt
      541 ggagaagctc aaggagtgtg tgctgcagga cgaccttctc gaggcccgcc ggccactggc
      601 ccatgagtgc ctgggtgaag ctctgcgagt catgcgccag gtcatctcca gatacccact
      661 cctcaacacc gtggagacac tcacagccgc tggtacactc attgccaagg tcaaagcctt
      721 tcattatgaa tgcaacaatg aatcagataa gagggaattt gagaaggctc tggaaaccat
      781 tgcggtgtcc ttcagctgca ctgtgtccga gttccttttg ggtgaagtgg acagcagtac
      841 tctcctggcg gtgcctccgg gggaccccag ccagtccatg gagaaccttt atggggctgg
      901 cacggagggg cccccacata acgtggagga atgtgaagaa ggttgcctgc cccccgaaga
      961 ggtggacatg cttctgcagc gatgcgaagg gggtgtggac gctgcactgc agtatgcaaa
     1021 agacatggcc aggtacatga aggacctcat cagctacctg gagaagagga ccaccctgga
     1081 gatggaattc gccaaaggtc tccagaaggt tgtccacaac tgcagacaga gcgtcacaca
     1141 cgagccccac atgcctctct tgtccatcta ctcactggcc ctggaacaag atttggagtt
     1201 tggccacggc atggtgcagg cagcgggcac actgcagacc cagaccttca tgcagcccct
     1261 gacgctgcgg cggttggagc atgagaggcg caggaaggag atcaaagaat cttggcatcg
     1321 agcacagagg aagctgcaag aggcagaggc caacctgcgc aaggccaaac agggctacaa
     1381 acaacgctgt gaagaccacg acaaggcccg gctccaggtg gccaaggctg aggaggaaca
     1441 acagggcaca ggcccaggcg cagggactgc ggcctctaag gccctggaca agaggcgcag
     1501 actggaggaa gaggccaaaa acaaggccga ggaggccatg gccacttacc gcacatgcgt
     1561 ggcagacgca aagacacaga agcaggagct ggaggacaca aaggtgactg cgctgcggca
     1621 gattcaggag gtcatcaggc agagtgatca gaccattaag tcggccacca tctcctacta
     1681 ccagctgatg cacatgcaga cagcaccgct gcccgtgaac ttccagatgc tgtgcgagag
     1741 cagcaaacta tatgacccgg gccaacagta cgcatctcac gtgcgtcagc tgcagagagg
     1801 cgaggagccg gacgtgcgct acgactttga gccttatgtc tctaacaact cctggtcccc
     1861 aatcatgcgt acacggaagg gcagcttcaa ccctggtgat gcttcaggac ccgaagctgc
     1921 tggtagtccc cccgaggaag gtggcacctc tgaggcagca cccaacaagg accacagggg
     1981 gggacgaggt caccaggttc ataagtcctg gcccatctcc atctcagaca ccgaagttgg
     2041 tctggacacc agctcagggg acttgaagaa gttcgatcga acatcttcca gtgggacgat
     2101 gtcatccagt gaggagctgg gggatcagga agctggcttg gtagcttccg cctttgattc
     2161 agctgacctc aatggcatgg accccgagtt acctgtggcc atgcccagtg gacccttccg
     2221 ccatgtggga ttgtccaagg cagcccgcac acaccgactt cgcaaactgc gcacgccagc
     2281 caagtgcaga gagtgtaaca gctatgtgta cttccaagga gctgaatgtg aagagtgctg
     2341 tctggcttgt cacaaaaagt gtttggagac cctggccatc cagtgtggcc acaagaagct
     2401 tcagggccgc ctgcagctct ttggacaaga cttcagccag gcagccctca gcacccctga
     2461 tggggtgccc ttcattgtca aaaaatgtgt ctgtgagatt gagcggcggg cactgcacac
     2521 caaggggatc taccgggtca atggcgtgaa aacgcgtgtg gagaagctgt gccaggcttt
     2581 tgagaatggc aaagagttgg tggagttgtc acaggcctca ccccacgaca tcagcaacgt
     2641 cctaaagcta tacctgcggc agctaccgga gccccttatc tcttttcgct tctaccatga
     2701 gctggtggga ctagctaagg acagcctaaa ggccgaagcc gaagctaagg cagcgagccg
     2761 gggtcggcag ggtgggtccg agagtgaggc tgcaaccttg gctatggtgg gccgcctgcg
     2821 tgagctcatg caggatctgc cagccgaaaa ccgggccaca ctcttatacc tgctgaagca
     2881 cttgcgaagg atcgtggaaa tggagcagga taacaagatg acccctggga acctgggcat
     2941 cgttttcggg cccacactgt tgcggcctcg acccactgac gccaccgtgt ccctctcttc
     3001 tctggtggat tatccccacc aggcccgagt tattgagact ctgattgtcc actacggcct
     3061 ggtctttgag gaggagccag aggaggcgcc tggcagccag gagggggcat ccacccagtg
     3121 tggccagctg gagtctgctg agggcattgt cttccccctg caggaggagg cagaggacgg
     3181 aagccgagaa tctcacgcgg catctaatga ctcggactct gagctggaag acgcttctga
     3241 ccccctttca tcctcggacg ccagtgctct acaccgcctc agtttcctgg agcagaccga
     3301 ggcaggcctg gaggaaggtc cccagagcca tagtggcagt gaggaacagc tggagggtga
     3361 ggatggagcc ccgggtccgt ggctgtgtca cttcaacacc aaccagtcca acaacacatc
     3421 acgggcccct ctgcccacca tgcggctccg aggagggcag atcacaggtg gcaccagtca
     3481 ggagcggcag ccacagttcg tctgagctgg gtggtgatgg cagggaccat cagctcaatg
     3541 tcagcctttg actcgggggg aggggggtgt tcctcacaat gccgaggaac ttcagggaga
     3601 tcagggctcc ctggtaccat ggacacagat ggataacagt cccagatgga gttgcctggc
     3661 ctttgtgtgc ctgtggggat gcagctgcag attcccatga tggcctcatc tctcccatgg
     3721 tccccatcag tctggatgtg tctgagcggg tacagccctg acctctgtgt gtggagctgg
     3781 aggtggctct ggcttcagga atcttgcagg aggctggaca tggacagacg ggtgggggca
     3841 cacagtgggt ctctcccaag gagcagtaaa ggagctttcc acatgaactc acaattttct
     3901 tgaaataaac ttcttaacca actgccac
//
