LOCUS       NP_001359492             875 aa            linear   ROD 02-MAY-2024
DEFINITION  rho GTPase-activating protein 42 isoform 1 [Mus musculus].
ACCESSION   NP_001359492 XP_006509947
VERSION     NP_001359492.1
DBSOURCE    REFSEQ: accession NM_001372563.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 875)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 875)
  AUTHORS   Dee,R.A., Bai,X., Mack,C.P. and Taylor,J.M.
  TITLE     Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit
            Blood Pressure In Vivo
  JOURNAL   Cells 9 (4), 1042 (2020)
   PUBMED   32331391
  REMARK    GeneRIF: Molecular Regulation of the RhoGAP GRAF3 and Its Capacity
            to Limit Blood Pressure In Vivo.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 875)
  AUTHORS   Luo,W., Janostiak,R., Tolde,O., Ryzhova,L.M., Koudelkova,L.,
            Dibus,M., Brabek,J., Hanks,S.K. and Rosel,D.
  TITLE     ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to
            promote cell motility
  JOURNAL   J Cell Sci 130 (14), 2382-2393 (2017)
   PUBMED   28584191
  REMARK    GeneRIF: Phosphorylation of ARHGAP42 Tyr-376 is revealed as a novel
            regulatory event by which Src can affect actin dynamics through
            RhoA inhibition.
REFERENCE   4  (residues 1 to 875)
  AUTHORS   Bai,X., Mangum,K.D., Dee,R.A., Stouffer,G.A., Lee,C.R.,
            Oni-Orisan,A., Patterson,C., Schisler,J.C., Viera,A.J., Taylor,J.M.
            and Mack,C.P.
  TITLE     Blood pressure-associated polymorphism controls ARHGAP42 expression
            via serum response factor DNA binding
  JOURNAL   J Clin Invest 127 (2), 670-680 (2017)
   PUBMED   28112683
  REMARK    GeneRIF: Blood pressure-associated polymorphism controls ARHGAP42
            expression via serum response factor DNA binding
REFERENCE   5  (residues 1 to 875)
  AUTHORS   Bai,X., Lenhart,K.C., Bird,K.E., Suen,A.A., Rojas,M., Kakoki,M.,
            Li,F., Smithies,O., Mack,C.P. and Taylor,J.M.
  TITLE     The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of
            vascular tone and hypertension
  JOURNAL   Nat Commun 4, 2910 (2013)
   PUBMED   24335996
  REMARK    GeneRIF: GRAF3 is expressed in a smooth muscle-restricted fashion.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162803.2, AC113589.13 and AC160964.1.
            
            On Sep 4, 2019 this sequence version replaced XP_006509947.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927937.5279617.1,
                                           SRR11927932.3117020.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     Protein         1..875
                     /product="rho GTPase-activating protein 42 isoform 1"
                     /note="VRho GTPase activating protein 42"
                     /calculated_mol_wt=98553
     Region          19..225
                     /region_name="BAR_GAP10-like"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase
                     activating protein 10-like; cd07634"
                     /db_xref="CDD:153318"
     Site            order(28,31..32,36,38..39,42..43,45..46,49..50,52..53,
                     56..57,59..60,63,90,93..94,186,189..190,192,197,200..201,
                     203..204,208..209,212..213,215..216,218..219,221..222)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153318"
     Region          267..376
                     /region_name="BAR-PH_GRAF_family"
                     /note="GTPase Regulator Associated with Focal adhesion and
                     related proteins Pleckstrin homology (PH) domain; cd01249"
                     /db_xref="CDD:269953"
     Region          369..567
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(417,458,462,531,534..535,558)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:238090"
     Site            417
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     Region          821..875
                     /region_name="SH3_GRAF3"
                     /note="Src Homology 3 domain of GTPase Regulator
                     Associated with Focal adhesion kinase 3; cd12066"
                     /db_xref="CDD:212999"
     Site            order(826,828,831,835,854..855,868,870..871)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212999"
     CDS             1..875
                     /gene="Arhgap42"
                     /gene_synonym="9030420J04Rik"
                     /coded_by="NM_001372563.1:249..2876"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:71544"
                     /db_xref="MGI:MGI:1918794"
ORIGIN      
        1 mglptlefsd syldspdfre rlqcheiele rtnkfikell kdgslligal rnlsmavqkf
       61 sqslqdfqfe cigdaetdde isiaqslkef arlliaveee rrrliqnand vliaplekfr
      121 keqigaakdg kkkfdkesek yysildkhln lsakkkeshl qeadsqigre hqnfyeasle
      181 yvfkiqevqe kkkfefvepl lsflqglftf yhegyelaqe fapykqqlqf nlqntrnnfe
      241 strqeverlm qrmksanqdy rppsqwtmeg ylyvqekrpl gftwtkhyct ydkgskmftm
      301 svsdvkasgk mnglvtgspe mfklkscirr ktdsidkrfc fdievverhg iitlqafsea
      361 nrklwleamd gkepiytlpa iiskkeemyl neagfnfvrk ciqavemrgi tilglyrigg
      421 vnskvqklmn ttfspksppd mdidielwdn ktitsglkny lrclaeplmt yklhkdfiia
      481 vksddqnyrv eavhalvhkl peknremldi likhllkvsl hsqqnlmtis nlgvifgptl
      541 mraqeetvaa mmnikfqniv veiliehyek ifhtapdpni plpqpqsrsg srrtraicls
      601 tgsrkprgry tpclaepdsd syssspdstp mgsieslssh sseqnsttks tacqpreksg
      661 gipwittpss sngqksqglw ttspesssre datktdvesd cqsvasitip gnvsppidlv
      721 kkgpyglsgl krssassslr sisaaegnks ysgsiqslts igskespkai pnpelppkmc
      781 rrlrldtass ngyqrpgsvv aakaqlfena gspkpvssgr qaqamyscka ehshelsfpq
      841 gaifsnvhps vepgwlkaty egrtglvpen yvvfl
//
