LOCUS       NM_001168288            4583 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus Rho GTPase activating protein 39 (Arhgap39),
            transcript variant 1, mRNA.
ACCESSION   NM_001168288
VERSION     NM_001168288.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4583)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4583)
  AUTHORS   Huang,G.H., Guo,L., Zhu,L., Liu,X.D., Sun,Z.L., Li,H.J., Xu,N.J.
            and Feng,D.F.
  TITLE     Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth
  JOURNAL   Cell Mol Life Sci 75 (22), 4207-4222 (2018)
   PUBMED   29938386
  REMARK    GeneRIF: Porf-2 is capable of binding to the EphB1 receptor,
            causing the outgrowth of axons to stop and retract upon EphB
            forward signal transduction within the axon growth cone.
REFERENCE   3  (bases 1 to 4583)
  AUTHORS   Lee,J.Y., Lee,L.J., Fan,C.C., Chang,H.C., Shih,H.A., Min,M.Y. and
            Chang,M.S.
  TITLE     Important roles of Vilse in dendritic architecture and synaptic
            plasticity
  JOURNAL   Sci Rep 7, 45646 (2017)
   PUBMED   28368047
  REMARK    GeneRIF: Dendritic structures of CA1 pyramidal neurons were altered
            in Rho GTPase activating protein 39/Vilse homozygous knockout
            (Vilse(Delta/Delta) mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4583)
  AUTHORS   Ma,S. and Nowak,F.V.
  TITLE     The RhoGAP domain-containing protein, Porf-2, inhibits
            proliferation and enhances apoptosis in neural stem cells
  JOURNAL   Mol Cell Neurosci 46 (3), 573-582 (2011)
   PUBMED   21185940
  REMARK    GeneRIF: Data suggest that preoptic regulatory factor-2 (Porf-2)
            may inhibit neural stem cell proliferation by enhancing p21 protein
            levels followed by G1 phase arrest.
            Erratum:[Mol Cell Neurosci. 2011 Oct;48(2):183-4]
REFERENCE   5  (bases 1 to 4583)
  AUTHORS   Masuda,T., Kai,N., Sakuma,C., Kobayashi,K., Koga,H. and Yaginuma,H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   6  (bases 1 to 4583)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 4583)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 4583)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 4583)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4583)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156550.5.
            
            On Mar 21, 2019 this sequence version replaced NM_001168288.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1741564.1,
                                           SRR13422598.146283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC156550.5         195092-195266       c
            176-342             AC156550.5         142585-142751       c
            343-762             AC156550.5         128628-129047       c
            763-846             AC156550.5         118613-118696       c
            847-2200            AC156550.5         113556-114909       c
            2201-2762           AC156550.5         111977-112538       c
            2763-2855           AC156550.5         107464-107556       c
            2856-2929           AC156550.5         104503-104576       c
            2930-3129           AC156550.5         103729-103928       c
            3130-3221           AC156550.5         103023-103114       c
            3222-3391           AC156550.5         102423-102592       c
            3392-4583           AC156550.5         101085-102276       c
FEATURES             Location/Qualifiers
     source          1..4583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.28 cM"
     gene            1..4583
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /note="Rho GTPase activating protein 39"
                     /db_xref="GeneID:223666"
                     /db_xref="MGI:MGI:107858"
     exon            1..175
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            176..342
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..3586
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     preoptic regulatory factor-2; rho GTPase-activating
                     protein 39"
                     /codon_start=1
                     /product="rho GTPase-activating protein 39 isoform 1"
                     /protein_id="NP_001161760.2"
                     /db_xref="CCDS:CCDS49654.2"
                     /db_xref="GeneID:223666"
                     /db_xref="MGI:MGI:107858"
                     /translation="MSQAQDYECRSHHVDEQEPRIPGSSTRLEWVEIIEPRTRERMYA
                     NLVTGECVWDPPAGVRIKRTSEDQWWELFDPNTSRFYYYSAASQRTVWHRPQNCDIIP
                     LAKLQTLKQNTESPRASADNSPGRGSRDGSTGSSLEPELEERTQELPVRSGRATTLVT
                     SKEDTSSCSPPGVLLEKDYEVYRDYSADGQLLHYRTSSLRWNSGNKERMLIKVADREP
                     SFLTPQGNGYPADNQPGGHHRRPSGSQHSPNLQTFVPDTDGTVFFPERRPSPFLRRAE
                     LSGNCSPLLIQPRKPSSDSQPSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEANS
                     PYQTGSPQRSPGRKPHPFLQTTKQTPTSPCQQLMRTKQKCPERFLSLEYSPVGKEYVR
                     QLVYVEQAGSSPKLRAGPRHKYAPNPGGGTYSLQPSPCLLRDQRLGVRSGDYSTMEGP
                     ESRPSQPPTPLPQAQEDAMSWSSQQDTMSSTGYSPGTRKRKNRKPSLCQVPSTSSTDG
                     AGGLLGEQPLTEERSPCRASLTPVKAEADLVRGTPEPFLAQARLAWEAQQAHFHMKQR
                     GSWDSQQDGSGYESDGAVPLPMPGPVVRAFSEDEALAQQDSKHWKRSTFDKLGFPQIL
                     LEKSVSVQTNLASPEPHLHPSQSEDLGACAQFESSRQNRSAMPSSSCVFPTFTLRKPS
                     SETDIENWASKHFNKHTQGLFRRKVSIANMLAWSSESIKKPMIVTSDRHVKKEACEIF
                     KLIQMYMGDRRAKADPLHVALEIATKGWSAQGLRDELYIQLCRQTTENFRLESLARGW
                     ELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKVTQHIKELLERNSKKKSKLRKKP
                     KPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGS
                     ALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVD
                     QWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYESPEAAVAVVHALPRI
                     NRMVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEM
                     SFLRVLIQHLDTSFMEGVL"
     exon            343..762
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..846
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            847..2200
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2762
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2855
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2929
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3129
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3221
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3391
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..4583
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4562..4567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /note="hexamer: AATAAA"
     polyA_site      4583
                     /gene="Arhgap39"
                     /gene_synonym="9530053N22; D15Wsu169e; Kiaa1688; Porf-2"
                     /note="major polyA site"
ORIGIN      
        1 gttgcgcttg gtgacggggg acgcgcggcc gcagcgcact ggaccagcgg cggagaccca
       61 ggacgtgaag cgctggctgc ggcggcgacg gcggccggga gccgccggga gctggggcgc
      121 agcgtgcggt cggtgatgag gggcagtggc ggcgctccgg gcgcagggcc ggctgtgtgg
      181 cctcttcctg tgtgatgctg gaggaggcaa cctgatgatc ctctgacaac tgttcacgtc
      241 agcactaagg aagcagatgg caatgtcaca ggcacaggat tatgaatgca gaagccatca
      301 tgtcgatgag caggagccca ggattccggg gtcgagtacc aggttggagt gggtggagat
      361 tatcgaacca cgcacgcgcg aacgtatgta tgccaacctg gtcaccggag agtgcgtgtg
      421 ggatccacca gccggtgtgc gcatcaagcg caccagcgag gaccagtggt gggagctctt
      481 tgaccccaat acatcacgct tctactacta cagtgctgct tcccagcgca ccgtgtggca
      541 tcgcccacag aactgcgaca tcattcctct ggccaaactg cagacgctga aacagaacac
      601 tgagtctcct cgtgcctctg cggacaacag cccagggagg ggcagccgtg atggtagcac
      661 tggctcctcg ctggagccag agctggaaga aaggacacag gagctgccag ttcgcagtgg
      721 gcgggcaaca accttggtca cgtcaaagga ggatactagc agttgttcgc caccaggtgt
      781 gctcctggag aaggactatg aggtataccg ggattacagt gccgacggcc agctccttca
      841 ctacaggacc tcctcactgc gatggaactc tggtaacaag gaacgcatgc tcatcaaggt
      901 tgccgaccgt gaacccagct tcctcactcc ccagggcaat ggctatcccg cagacaacca
      961 accagggggc catcaccgca gaccatctgg cagccagcac tcacctaacc tgcagacctt
     1021 tgtccctgac actgatggca ctgtcttttt tccagagagg cggccctcac ccttcctaag
     1081 gagggctgag ctctctggga actgttctcc actgctgata cagccccgga aaccctccag
     1141 tgactcacag ccctcctccc ctcgctatgg ttatgaaccc ccactctatg aggagcctcc
     1201 agtggaatac caggccccta tttatgatga gccccccatg gacgtgcagt ttgaagccaa
     1261 cagcccttac cagacaggct caccacagag gtccccaggc cgaaagcccc atccattcct
     1321 gcaaactacc aaacagaccc caacatcacc ctgccagcag ctgatgcgca ccaagcaaaa
     1381 gtgccctgag cgttttctga gcctggaata tagtcctgtg ggcaaggagt acgtgcggca
     1441 gctggtgtat gtggagcaag caggctccag ccccaagctt agagctgggc ccaggcacaa
     1501 gtatgcaccc aacccaggcg ggggcaccta ctccctgcag cccagcccct gcctgctgag
     1561 agaccagcgc ctgggggtca ggtcaggaga ctacagcacc atggaagggc ccgagtcacg
     1621 cccaagccaa ccacccacac cactgcccca agcccaggag gatgccatgt cctggtccag
     1681 tcagcaggac accatgtctt ccacaggcta ctccccgggc actcgcaaga gaaagaacag
     1741 aaaaccctct ctgtgccaag tccctagcac ctcgtccact gatggtgctg ggggcctgct
     1801 aggagaacag cctctgactg aagagcgctc tccatgcagg gccagcctta ccccagtaaa
     1861 ggctgaggcc gacctagtcc gaggcacacc tgagcccttc ctggcacagg cccggttagc
     1921 ctgggaggca cagcaagccc acttccacat gaaacagagg ggcagctggg actcccagca
     1981 agatggctca gggtatgaga gtgatggcgc tgtcccactg cccatgcctg ggcctgtggt
     2041 gcgagcattc agtgaggatg aggcgctggc gcagcaggac agcaaacact ggaagcggag
     2101 cacctttgac aagcttggct tccctcagat cctgctggag aaaagcgtct ctgtgcagac
     2161 caacctggcc tcaccggagc cccacctcca cccctcacag tctgaggacc ttggtgcctg
     2221 cgcccagttt gagagcagcc gacagaaccg aagcgcaatg cccagctcca gctgtgtctt
     2281 ccccacattc acgctgcgga agccctcctc agagacggac atcgagaact gggcctccaa
     2341 gcacttcaac aagcacaccc aggggctctt ccggcgcaag gtgtccatag ctaacatgtt
     2401 ggcctggagc agtgagtcca tcaagaagcc catgattgtg actagtgacc ggcacgtgaa
     2461 gaaggaggcc tgcgagatct tcaagctaat ccaaatgtat atgggggaca ggcgcgccaa
     2521 ggcagaccca ctgcacgtag ccctagagat agccaccaaa ggctggagtg cacagggcct
     2581 gcgggatgag ctgtatatcc agctgtgccg gcaaaccaca gagaacttcc gcctagagag
     2641 cctggcccgt ggctgggagc tcatggccat ctgcctggct ttcttcccac caacccccaa
     2701 gttccactcc tacctagagg gctatatcta ccggcatatg gaccctgtta acgacaccaa
     2761 agtgacacag cacataaaag agcttctgga aagaaacagt aagaagaagt ccaaactgag
     2821 aaagaaaccc aagccttatg ttgaagagcc agatggggtg gcaataagca cctatgcgaa
     2881 gtactgttac cacaaactgc agaaggcagc tttgactggg gccaagaagg gcctgaagaa
     2941 gcctaatgtg gaggagatcc gacatgccaa gaacgcagtg ttcagcccat ccatgtttgg
     3001 cagtgcactg caggaggtga tgagcatgca gaaagagcgc tatcctgaca ggcagctgcc
     3061 ctgggtacag acacggctct ccgaggaggt cctggcactc aacggtgacc agacagaggg
     3121 tatcttcagg gtccctgggg acattgatga ggtgaatgcc ctcaagttgc aggtggatca
     3181 gtggaaggtg cctacaggcc tggaggatcc ccatgtccct gcatcgctgc tgaagctgtg
     3241 gtatcgggag ctggaagagc ccttgattcc tcatgaattc tacgaacaat gcattgcgca
     3301 ctacgagagc ccggaggctg ctgtggccgt ggtgcacgcg ctaccgcgca tcaaccgaat
     3361 ggtgctgtgc tacctcattc gcttcctcca ggtgttcgtg cagccagcca acgtagccat
     3421 caccaaaatg gacgtcagca acctggctat ggtgatggca cccaactgcc tgcgctgcca
     3481 gtcggatgat cctcgcgtca tcttcgagaa tacacgaaag gagatgtcct tccttcgagt
     3541 gctcattcag catttagata ccagcttcat ggagggcgtg ctatagcacg cgggctatgg
     3601 acgcctgcta gggtgacacc cgggaaggtg ggagggaagg ccccagcgcg aggcagcatg
     3661 ccaggccccg ccagacgccg gccccgccct aggccctccc ggggccaagc agccgcgcca
     3721 tatctcgcgg ccagttcctg caggtaccgg ctcgccctgc cagtcgcaag ccagccccga
     3781 gaagtgcctt ctgtttcccg gagccgagcg acactgccct cctggtcggc tgaagcacat
     3841 accgcgttgc tcagggcaac aggaccttgt cccctcttca gggcaatcct ccaccaaggc
     3901 actctcgccc tgatccctcc caccctagtc taggggcctc tggctggggc cagaaggaga
     3961 gttagaggcg ttctggagag ctgtgctggc cactactagg acttggctcc gtcggctcga
     4021 tgcctaatag gtctttgtgc aaggggaggc cccaaaccaa agccctctgg gttagggcca
     4081 gggctaggca ggctttcttg gggcgggtga gggagggcga gaggtttttt gttttttgac
     4141 tacagaatct atccgatacc cagcctactt gtgtataaag atataaatag aacgacagaa
     4201 ctaagtttgc taaggacata gttttaacca gatgctattt agctcttgaa ctgccattgc
     4261 ggtcctcgcg ctgagcaagt tagcaccacc ctcctttgac ctcgcggcct ctgaccaaac
     4321 tccacacacg ggcggcgcgt ggatgagacc tgcctggact cgtttgcgtt ttccattctg
     4381 gaatctgagt tccaacagtt gtcaaacttc atttctcctg tttatatata tatattttta
     4441 gagtttttat ttattaaaaa caaaagtccc gtcatgcgga ggtcctggcc tctctctcca
     4501 gggcctctcg gccgcaggcg ctccctcgta cgtgtggctc gaggggacag tgctccgtgt
     4561 gaataaagtt caagtgcaca ctc
//
