LOCUS       NM_001081123            3049 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho GTPase activating protein 36 (Arhgap36),
            transcript variant 1, mRNA.
ACCESSION   NM_001081123 XM_135854
VERSION     NM_001081123.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3049)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3049)
  AUTHORS   Nam,H., Jeon,S., An,H., Yoo,J., Lee,H.J., Lee,S.K. and Lee,S.
  TITLE     Critical roles of ARHGAP36 as a signal transduction mediator of Shh
            pathway in lateral motor columnar specification
  JOURNAL   Elife 8, e46683 (2019)
   PUBMED   31305241
  REMARK    GeneRIF: AKT stimulates the Shh activity to induce lateral motor
            columnar motor neurons through the stabilization of ARHGAP36
            proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3049)
  AUTHORS   Hanley,O., Zewdu,R., Cohen,L.J., Jung,H., Lacombe,J.,
            Philippidou,P., Lee,D.H., Selleri,L. and Dasen,J.S.
  TITLE     Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of
            Motor Columns
  JOURNAL   Neuron 91 (5), 1005-1020 (2016)
   PUBMED   27568519
REFERENCE   4  (bases 1 to 3049)
  AUTHORS   Rack,P.G., Ni,J., Payumo,A.Y., Nguyen,V., Crapster,J.A.,
            Hovestadt,V., Kool,M., Jones,D.T., Mich,J.K., Firestone,A.J.,
            Pfister,S.M., Cho,Y.J. and Chen,J.K.
  TITLE     Arhgap36-dependent activation of Gli transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 111 (30), 11061-11066 (2014)
   PUBMED   25024229
  REMARK    GeneRIF: a new mechanism of Gli transcription factor activation and
            implicate ARHGAP36 dysregulation in the onset and/or progression of
            GLI-dependent cancers.
            GeneRIF: Arhgap36 acts in a Smoothened-independent manner to
            promote the activation of full-length Gli proteins and induces the
            accumulation of Gli proteins in the primary cilium. Its ability to
            induce Gli-dependent transcription requires kinesin family member
            3a and intraflagellar transport protein 88, proteins that are
            essential for ciliogenesis. Arhgap36 functionally and biochemically
            interacts with Suppressor of Fused.
REFERENCE   5  (bases 1 to 3049)
  AUTHORS   Davie,J.K., Cho,J.H., Meadows,E., Flynn,J.M., Knapp,J.R. and
            Klein,W.H.
  TITLE     Target gene selectivity of the myogenic basic helix-loop-helix
            transcription factor myogenin in embryonic muscle
  JOURNAL   Dev Biol 311 (2), 650-664 (2007)
   PUBMED   17904117
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670305.7, AK048167.1 and BC090672.1.
            
            On Oct 4, 2017 this sequence version replaced NM_001081123.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048167.1, BC145645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AL670305.7         22889-23001
            114-714             AK048167.1         2-602
            715-2394            AK048167.1         604-2283
            2395-2888           AL670305.7         52045-52538
            2889-3049           BC090672.1         2860-3020
FEATURES             Location/Qualifiers
     source          1..3049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 25.95 cM"
     gene            1..3049
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /note="Rho GTPase activating protein 36"
                     /db_xref="GeneID:75404"
                     /db_xref="MGI:MGI:1922654"
     exon            1..215
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1930
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 36; RhoGAP domain containing
                     protein"
                     /codon_start=1
                     /product="rho GTPase-activating protein 36 isoform 1"
                     /protein_id="NP_001074592.1"
                     /db_xref="CCDS:CCDS40963.1"
                     /db_xref="GeneID:75404"
                     /db_xref="MGI:MGI:1922654"
                     /translation="MAWMLDCLFASAFEPRPRRVSVLGGAPGQNSDRSMDMVSIHSLS
                     ELERLKLQETAYHELVARHFLSEFKPDRALPTDRPNTLEKWFLMLRGQDRAASLKTFG
                     IRLEEVLVNELTRRKQRELTPTMQVEDINGSTGRRRRGNVVQRMLGRMRRFFSRRRNE
                     PTLPREFTRRGRRGAVSADSADELENGALLLQILQLSQLSSPIGQRLLGSKRKMSLNP
                     IAQQIPQIVETCCKFIEKHGLSSVGIFTIEYSLRRVLELRELFDKGLDIVLDDSVNVH
                     DVAELLKEFFREMKDPLLPDDLYMSFLLTATLKPKDQVSALQLLVYLMPPCHSDTLER
                     LLKALHKITENCEDSIGVDGQLVPGNRMTSTNLALVFGTALLKKGKLANKESRKTKLG
                     IDHYVASVNVVRAMIDNWDILFQVPPHIQKEVAKRVWKSSPEALDFIRRRNLRKIQSA
                     RIKMEEDALLSDPVENSAEAQAAILAQSQPFDEDPEGAPDVHEVLNDNLNYDFEDESD
                     FEDQDHLDLAEVPYLDVIPNNEDTDSDADVIPGPSEEPAVPASTAGSPDKEEGAAGNP
                     PNADRPLPRVPQGKKGKFATRFFP"
     exon            216..374
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            375..440
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            441..676
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            677..869
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            870..925
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1076
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1225
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1402
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1500
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1607
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1778
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..3031
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3004..3009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /note="hexamer: AATAAA"
     polyA_site      3031
                     /gene="Arhgap36"
                     /gene_synonym="1100001E04Rik; rho-gap"
                     /note="major polyA site"
ORIGIN      
        1 tttctgacaa gcttgaggtg tccggtgacc aagattctca gagctgggtg cagggtgcgg
       61 cccagggcgt ggtcaccggg ggctacttag agcagtcctt gcggggagac tgcacggagg
      121 aggttagctg cgaggctgcc ggcactcagc acgggttatg gcgtggatgc tggactgcct
      181 attcgcatcg gcctttgagc cccgcccccg ccgtgtgagc gtcctgggag gagccccagg
      241 acagaactca gaccgcagca tggacatggt atccattcac agcctctctg agctggagcg
      301 cctgaagctg caagagactg cttaccacga actcgtggcc agacatttcc tctctgaatt
      361 caagccggac agagctctac ccactgaccg tccaaacacc ctggagaagt ggtttttgat
      421 gctgagagga caagacaggg ctgcatcact caagaccttt ggcatccgcc tggaagaggt
      481 actggtgaac gagcttaccc gtcgcaagca gcgtgaactg acacccacga tgcaggttga
      541 agatatcaac ggttctactg gtcgtcgtcg tcggggaaac gtggtgcaaa gaatgcttgg
      601 acgcatgagg cgctttttca gtcgcaggag gaatgagccc accctgccta gagagttcac
      661 tcgccgtgga cgtcgaggtg cagtttctgc agatagcgca gatgaactgg agaacggagc
      721 cctgctgctg cagatcctgc agctctccca gctttcatcg cctattggac agcggcttct
      781 gggatccaag aggaagatga gcctcaaccc aattgctcaa caaatccctc agattgttga
      841 gacttgttgc aaattcattg agaaacatgg cttaagctca gtggggattt tcaccattga
      901 atactctctg cggagggtgc ttgagctccg tgagttattt gacaaaggcc tggatattgt
      961 actggatgac agtgtgaatg tccatgatgt ggctgagctc ctcaaggagt tttttcgtga
     1021 gatgaaggac cctctgctgc ctgatgatct gtacatgtcc ttcctcctga ctgcaactct
     1081 gaagcccaag gatcaggttt ctgccctgca gcttctggtt tatctgatgc caccttgcca
     1141 cagtgatact ctcgaacgtc tgctgaaggc tctgcataaa atcactgaga actgtgaaga
     1201 ctccattggc gttgatggac agctggttcc aggtaaccga atgacttcca ccaacttggc
     1261 tttggtgttt ggaactgctc tcctgaagaa ggggaagttg gccaacaagg aatccaggaa
     1321 gactaaactg gggattgatc actatgttgc atctgtcaat gttgtccgtg ccatgattga
     1381 taactgggac atcctcttcc aggtgccccc ccatattcag aaggaggttg ctaagcgtgt
     1441 gtggaagtcc agccctgaag ccctggattt tatcagacgc cggaatctga ggaagatcca
     1501 gagtgctcgc ataaagatgg aagaggatgc tttactttct gatccagtgg aaaactctgc
     1561 tgaagcccag gctgctatcc ttgctcagag ccagcccttt gatgaagacc ccgaaggagc
     1621 cccagatgtg cacgaggtct tgaatgataa cctgaactat gactttgaag acgaatcgga
     1681 ttttgaagac caggaccatc tggatcttgc agaggttccc tatcttgatg taattccaaa
     1741 caacgaagat accgactcag acgctgatgt aatcccaggt ccctctgagg agcctgctgt
     1801 gcctgccagc actgctggtt cccctgacaa agaggaagga gcagccggta acccccccaa
     1861 cgcagaccgc ccactgcccc gtgtgcccca ggggaagaag ggcaaatttg ccacccgctt
     1921 ctttccttag atgttttccc ttctctaagt tgccagacag gggaaaaggg tgggggtaga
     1981 cctggaatgt cacaggaaac agtaaagagt cttgaagata aagaactaag gataagaagg
     2041 agttccacct gatgctcggg tcaggatggg aattccaaat acactgccag ccccactact
     2101 ggggatgctt ggtattttca ggtggtaaaa gcagagctat ttctgtgtca tgcccaggcg
     2161 ccttggtgct accttgcctt ctcttttacc cctgatctag gctttcctct cactacagca
     2221 gccccttcct ttaattgatg ttacatttgt gataaacatc tgtcccagag aagctcacaa
     2281 atctcgaggt gctttccctc cccccaaggg gattgcatgc ttttcctcac tttcctaccc
     2341 tcctcccaag agctcaactg gaaaggccct caagaggtat gttagaatgt taggtcagcc
     2401 tactgacaga tgacaacaat taatgctaaa ttgtgtcaca tcaactcata gccctgtccc
     2461 cgcagcaaat ccaccgcctc agaattttcc ccttcaaatt atttagacca gtggctcgtc
     2521 aaacagccgc tccaaaaaat tctgtgcagt tttgctcagg acatgccaac ggggaaacct
     2581 caagtgtaag cctaactagc ttttctggga tcaaaagtta gagggaaaac aattagattt
     2641 tagtcctaaa cgtgttttaa agacagctgg tgttcacacc cctgatgtct gcaaaacaac
     2701 tagttaggca cagacacata gtttcaagta gttaaactca cctgattaca aacactctta
     2761 tttatcgtct ctgtagatcc tctatgcagg acggtacaaa tttgcgggac ttgctctggt
     2821 aaaacactga tatgggttaa gtatgacatc caaactacaa ctgatattta tgggtaacaa
     2881 cagctaaggt ccttagagtg aagaatgtat tctattgagg gatagaaact gttcatacaa
     2941 tgggtaacaa ccacagagct cgaagatttg tgattgttca aacttctctg gcatttcatc
     3001 attaataaac atctgtgttg tgacagcagc aaaaaaaaaa aaaaaaaaa
//
