LOCUS       NM_020260               7722 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho GTPase activating protein 31 (Arhgap31), mRNA.
ACCESSION   NM_020260
VERSION     NM_020260.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7722)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7722)
  AUTHORS   Castillo-Azofeifa,D., Wald,T., Reyes,E.A., Gallagher,A.,
            Schanin,J., Vlachos,S., Lamarche-Vane,N., Bomidi,C., Blutt,S.,
            Estes,M.K., Nystul,T. and Klein,O.D.
  TITLE     A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem
            cell response to fluctuating niche Wnt signaling
  JOURNAL   Cell Stem Cell 30 (2), 188-206 (2023)
   PUBMED   36640764
REFERENCE   3  (bases 1 to 7722)
  AUTHORS   Matsuda,J., Greenberg,D., Ibrahim,S., Maier,M., Aoudjit,L.,
            Chapelle,J., Baldwin,C., He,Y., Lamarche-Vane,N. and Takano,T.
  TITLE     CdGAP maintains podocyte function and modulates focal adhesions in
            a Src kinase-dependent manner
  JOURNAL   Sci Rep 12 (1), 18657 (2022)
   PUBMED   36333327
  REMARK    GeneRIF: CdGAP maintains podocyte function and modulates focal
            adhesions in a Src kinase-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7722)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7722)
  AUTHORS   Caron,C., DeGeer,J., Fournier,P., Duquette,P.M., Luangrath,V.,
            Ishii,H., Karimzadeh,F., Lamarche-Vane,N. and Royal,I.
  TITLE     CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for
            vascular development and VEGF-mediated angiogenesis
  JOURNAL   Sci Rep 6, 27485 (2016)
   PUBMED   27270835
  REMARK    GeneRIF: findings are the first to demonstrate the importance of
            CdGAP in embryonic vascular development and VEGF-induced signaling,
            and highlight CdGAP as a potential therapeutic target to treat
            pathological angiogenesis and vascular dysfunction
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7722)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 7722)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 7722)
  AUTHORS   Jenna,S., Hussain,N.K., Danek,E.I., Triki,I., Wasiak,S.,
            McPherson,P.S. and Lamarche-Vane,N.
  TITLE     The activity of the GTPase-activating protein CdGAP is regulated by
            the endocytic protein intersectin
  JOURNAL   J Biol Chem 277 (8), 6366-6373 (2002)
   PUBMED   11744688
REFERENCE   9  (bases 1 to 7722)
  AUTHORS   Sagnier,T., Grienenberger,A., Mariol,M., Berenger,H., Pradel,J. and
            Graba,Y.
  TITLE     Dynamic expression of d-CdGAPr, a novel Drosophila melanogaster
            gene encoding a GTPase activating protein
  JOURNAL   Mech Dev 94 (1-2), 267-270 (2000)
   PUBMED   10842085
REFERENCE   10 (bases 1 to 7722)
  AUTHORS   Lamarche-Vane,N. and Hall,A.
  TITLE     CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and
            Rac
  JOURNAL   J Biol Chem 273 (44), 29172-29177 (1998)
   PUBMED   9786927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB865916.1, AF151363.1 and AK129309.1.
            
            On Nov 15, 2004 this sequence version replaced NM_020260.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138870.1, AK155729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               BB865916.1         3-361
            360-2824            AF151363.1         1-2465
            2825-7722           AK129309.1         1250-6147
FEATURES             Location/Qualifiers
     source          1..7722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.87 cM"
     gene            1..7722
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /note="Rho GTPase activating protein 31"
                     /db_xref="GeneID:12549"
                     /db_xref="MGI:MGI:1333857"
     exon            1..462
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..4640
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /note="CDC42 GTPase-activating protein"
                     /codon_start=1
                     /product="rho GTPase-activating protein 31"
                     /protein_id="NP_064656.2"
                     /db_xref="CCDS:CCDS28172.1"
                     /db_xref="GeneID:12549"
                     /db_xref="MGI:MGI:1333857"
                     /translation="MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEF
                     IETHGIVDGIYRLSGITSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFREL
                     PNPLLTYELYEKFTEAVSHRPEEGQLARIQNVILELPPPHYRTLEYLIRHLAHIASFS
                     SKTNMHARNLALVWAPNLLRSKKIEATICNGDAAFLAVRVQQVVIEFILNHADQIFNG
                     GAPGALQQDESRTITKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRENSLPEI
                     VPPPFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVE
                     KATIRPAKSMDSLCSVPVEGKENKGNFSRTVTTGGFFIPATKMHASSTGSSCDLSKEG
                     EWGQEGMPAGAEGGCEVGGQIRPLPEQLKVFRPIGDPESEQSAPKLLGMFYTSSDSPG
                     KSVFTSSLFQMEPSPRHQRKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLS
                     SLEEFSFQGSESGGWPEEEKPLGAESFPGSVTKKAATEDTKPEPEVPGRAECSQSPPL
                     DPGTQVEKKTLHVSLGSQVSKEAEKRPKAEKVMEESQGASQPKPSTPQESLGAGTEPL
                     ILHEMDEEDLAQALIWPEIQQELKIIESEEEFSSLPPAAQKTSPIPESSPAPFPFPEA
                     PGSLPSSSAPREVWTRDAANQSIQEAAILTDREKLEPVCSLLESESQQELSPDPASLA
                     PLEMLLFEKVSSPARIEIGGPRNLSPPLTPAPPPPTPLEEEPEVLLSKEGPDREDAAR
                     DSRTDVYTEQPTPKESPGIPTPCQREEAIASPNEKQNARHAVPENKGPGLPSPTKEVD
                     IIPQEEGGAPHSAQEPSDCDEDDTVTDPAQHGLEMVEPWEEPQWVTSPLHSPTLKEVQ
                     ESQTQGSQGHRLERRLCHRPSLRQSHSLDSKTTGNSHWTLEAPFSSSCANLETERNYE
                     PLQPPAARTKIAGLEEKALKAFREFSGLKGLEVLPSQKGPSGIQPKPVETNFMGLAEG
                     KEQEPQLELSNRQMKHSDVPGPDSSKESSPRAQDSTLPGEHPLQLQLKNTECGPSKGK
                     HRPSSLNLDSATPIADLFRLENGAPFSSPGIELSELGDTKVTWMSSSHCKAAPWNSQD
                     TQDLDIVAHTLTGRRNSAPVSVSAVRTSFMVKMCQAKAVPVIPPKIQYTQIPQPLPSQ
                     STGEGGAQPLERSQEEPGSTPEIPQKSTKDDSPSSLGSPEEEQPKQETGASASRRQAS
                     ITSCMYEGSSCSPEPSASTLASTQDAVVQCRKRTSETEPSGDNLLSSKLERASGGPKA
                     FHRSRPGRPQSLILFPIMDHLPSSPTVIDSKVLLSPIRSPTQTVSPGLLCGELAENTW
                     ITPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSGRQIE"
     exon            463..565
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            566..710
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            711..793
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            794..901
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1044
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1234
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1359
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1422
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1971
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2249
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..7722
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7705..7710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
     polyA_site      7722
                     /gene="Arhgap31"
                     /gene_synonym="5830477L08Rik; Cdgap; D330026I07Rik"
ORIGIN      
        1 aagacaggaa aaaagggacg gcgcaagggc gggcaagggg acgtgatgct ggctgttcgc
       61 ggtcctccag cgctctgaag gcagagcgcg ggcctagggc ggagcacact cagccccggg
      121 gcggtcccct aaccgccgcg ccccggcccc ggctcctcgc aaggctcagc cgagaagcgc
      181 ggggagacgc cgccggagcc cgagtaggga ggtgacaccc gcccggggcg gtgcacggcc
      241 caatctgcgc gcccatgcgg acccgcggcg ccgctctgcc ctggtgaccc gaccccgaaa
      301 ccctcatcag cggtgcggag cagagagcgc agacggaggg gcagcctctg tggggctaac
      361 tcatgaagaa caagggtgcc aagcagaagc tgaaacgaaa gggagccgcc agtgcgtttg
      421 gatgtgacct gacggagtat ctggaaagtt cgggacagga tgttccatat gtgctgaaga
      481 gctgtgctga attcatagag actcacggca ttgtggatgg aatctatcgc ctctcgggca
      541 tcacctcaaa catccagcgg ctgaggcaag agtttggctc agatcaatgc ccagatctga
      601 caagggaagt gtaccttcaa gacatccact gtgtgggctc cttgtgcaag ctctacttcc
      661 gggagctgcc caaccccctc ctgacctacg agctctatga gaaattcacg gaagcagtgt
      721 ctcatcgccc agaagaaggc cagctggcca gaatccagaa tgttatcctg gagcttcccc
      781 caccccatta taggaccttg gaatacctga ttcgacacct ggcccacatc gcctcattca
      841 gcagcaagac caacatgcac gccaggaacc tggccctggt gtgggcccca aacctcctca
      901 ggagtaagaa aatcgaagcc actatttgca atggagatgc ggcgtttctg gcagtccggg
      961 tccagcaggt ggtgattgag ttcatattaa atcacgctga tcaaatcttc aatggcggtg
     1021 ctccaggggc tctgcagcag gatgaaagcc gtactatcac aaagagcctg accttgccag
     1081 ccttgtccct gcccatgaag ttggtaagcc tggaggaggc tcaggcccga agcttggcga
     1141 caaaccaccc tgctcggaag gaaagacgag agaacagcct gcccgagatc gtccctcctc
     1201 ccttccacac cgtccttgag ttaccagaca acaagagaaa gctttccagc aaatcaaaga
     1261 agtggaaatc gatatttaac ctgggacgtt ctggatcgga ctcgaagtcc aagctgagta
     1321 gaaacgggag tgtgttcgtg agaggccaga ggctgtcagt ggaaaaggct actatccggc
     1381 cagcaaaaag catggactca ctgtgttcgg tgcctgtgga agggaaagaa aacaaaggaa
     1441 atttcagtcg aacagtcacc actgggggat ttttcattcc agccacaaaa atgcacgcga
     1501 gcagcaccgg aagctcctgt gacctcagca aggagggtga atggggtcag gaggggatgc
     1561 ccgcaggggc tgaggggggc tgcgaggtgg gcggtcagat ccggccactg cctgagcagc
     1621 tgaaggtgtt ccgccccatc ggagaccctg agagcgagca gtccgcccca aagcttctcg
     1681 ggatgttcta cacctccagc gacagtcctg gcaaatctgt cttcacaagc agcctgttcc
     1741 agatggaacc ctcaccccgc caccagcgaa aggcgctcaa catctccgag cccttcgccg
     1801 tgtctgtgcc actccgcgtg tccgccgtca tcagtaccaa cagcaccccg tgcaggacac
     1861 cccccaaaga gctacagtct ctctccagcc tcgaagagtt ttctttccaa ggttcagaga
     1921 gtggaggatg gccagaagaa gagaagcccc tgggggctga gtcttttcca ggctctgtta
     1981 ctaagaaggc agctaccgag gacaccaagc cagaacctga agtcccgggg agagcagaat
     2041 gtagccaaag ccctcccctg gacccaggca cccaagtgga gaagaaaacc ttgcatgtat
     2101 ccctgggctc tcaagtatca aaggaagcag agaagcggcc aaaggctgag aaggtgatgg
     2161 aggagagcca gggtgctagc cagccgaagc ccagcactcc acaagagagc ctcggggctg
     2221 ggactgaacc attgattctc cacgagatgg atgaagaaga cctggctcag gccttgatct
     2281 ggcctgagat tcaacaggaa ctgaaaatca ttgaatcaga ggaggagttc tcttccttgc
     2341 cacccgctgc tcagaagaca agcccgattc ctgagtcaag cccagcccca tttcccttcc
     2401 cagaagcccc tgggagcttg cctagtagct ctgctcctcg ggaggtgtgg actagggacg
     2461 cagccaatca gagcatacag gaagctgcta tcctcactga cagagagaag ctagagccag
     2521 tctgcagcct cctcgagtca gagtctcagc aggagctcag cccagaccca gccagtctag
     2581 cgcctctgga aatgcttctg tttgagaagg tatcttctcc ggctaggata gagataggag
     2641 gcccaaggaa tctctctccc cctcttactc ctgctcctcc tccccccaca cctctggagg
     2701 aggagcctga agtcctgctg tcaaaggaag gtcctgacag ggaagatgca gccagggatt
     2761 ccaggacaga tgtctacaca gagcagccaa cccccaaaga gagccctggc atccctaccc
     2821 cctgtcagag agaggaagct attgcaagcc caaatgagaa gcaaaacgca aggcatgctg
     2881 ttcctgagaa caaaggccct ggtcttccaa gcccaaccaa agaggttgac atcatcccac
     2941 aagaggaggg aggtgctccg cattcagcac aagagccttc agactgtgac gaagatgaca
     3001 ctgtgacgga ccctgcccag catggcctgg agatggtgga accctgggag gaaccccagt
     3061 gggtgaccag tccccttcat tctcccacct tgaaagaagt tcaggagtcc cagacgcaag
     3121 gctcccaggg ccaccgatta gagaggagac tttgccacag gcccagcctt cgccagagcc
     3181 attctctcga tagtaaaacc actggaaaca gccactggac tcttgaggcg cccttctcca
     3241 gcagttgtgc caatctggaa acagagagga actatgagcc tctgcagccc ccggcagcca
     3301 ggaccaagat tgccggattg gaagagaaag ccctaaaagc cttcagagag ttctctggcc
     3361 tgaaagggtt agaggttctt cccagtcaga agggaccatc tggtatacaa cccaaaccag
     3421 tagaaaccaa cttcatgggt ttagcagagg gaaaggagca ggaaccacaa ctggaactta
     3481 gcaaccgtca gatgaaacac agtgatgttc ccgggccaga tagcagcaag gagagttcac
     3541 cgagggctca agacagcacc ttacctgggg aacatccctt acagttacag cttaagaaca
     3601 ctgagtgtgg gccctcaaaa gggaaacaca ggccgtcttc cctcaacctg gactctgcca
     3661 ctcccatagc tgaccttttc cgacttgaga atggggctcc ctttagctca cctggaatag
     3721 agctctctga actaggagac accaaggtca cctggatgag ctcctctcac tgcaaagcag
     3781 ccccctggaa ttcccaggac acgcaggacc tggacattgt tgcccacacc ctgacaggcc
     3841 gcaggaattc ggctcctgta agtgtgtcag ctgtgagaac ctccttcatg gtcaaaatgt
     3901 gtcaggccaa ggcagtccct gtcatcccac ccaagatcca atacacacag atcccacagc
     3961 ccctgccctc tcagagcaca ggggagggag gggctcagcc tctggagaga agccaggaag
     4021 aacctggttc aacccctgag atccctcaga aatccaccaa agatgattct ccctcctccc
     4081 tgggaagccc agaggaagag caaccaaagc aagagacagg agcctccgca tcccggaggc
     4141 aggccagcat tacatcctgc atgtatgagg ggtcctcctg ctctccagaa ccaagtgcat
     4201 ccactctggc ctccacacag gatgcggtgg tgcaatgcag aaaacgcaca tcagagacag
     4261 agccatcagg agacaacctt ctttcttcca aactggagcg agcatctggg ggtcctaaag
     4321 ctttccacag gtcaaggcca ggaagacctc agagcctaat cttattccct atcatggacc
     4381 atctaccttc ctcacccaca gtgatagatt ccaaggtcct actgtcccct atcaggagcc
     4441 ctactcagac agtttcccct ggtcttctct gtggagagtt ggccgaaaac acatggatca
     4501 caccagaagg ggtcacgctt aggaataaaa tgaccatccc taagaatggc caaagactcg
     4561 agacttcgac aagctgtttt taccagcccc agcggagatc cgtgattctg gatggaagaa
     4621 gtgggagaca gatagaatga gaccatccga cctgctgttg tctgtaaatc tttcaggttc
     4681 atctggtcct tacgggcatc aactggccat tctccaggca cacgctatgg aaatttgtgc
     4741 ttttatttgc ctctggccac ctcctctctc tccctctctc cccacctctc ctttgtcttt
     4801 gaccgtgtat gagtccattt gcaagaagag tggtcaagac aaggaccgaa gagtgaggtt
     4861 taaggaagtc cacatgagca agtggggaag gttaggcaag gaagaggagg gaatgcttgc
     4921 ctccgatggc aatcggggct catctatgag acagattatg cctccattat cattctctta
     4981 tgctctcaag agctgcctgt gatagtaacc cttgaaagaa agaaattatt ttttgactgg
     5041 gtcagaaaaa tcttcctgtt ttgattggag gcttctttgt gctttttaat gctctttaaa
     5101 gcacttgttc ttttagagca gtttttaata agcttataaa ggtgtattta ctcccccctc
     5161 cccaaataga agcagatctg gaaatgcaaa ctaacatgca cgtaagatct ctaggtcggg
     5221 gaacctcctt gtgcgctttc cctgggatgg ctgcagacct gtccgaggcg acccacaaat
     5281 cagcacagaa agtcagagtc tgtactcaag agcaaagccc cgactggtcc cacctacaaa
     5341 tgcttcttgg tactggcttt attgtgactc cacctgccac cgtgctgatt aacaaatcca
     5401 gtagctaggc agactgagtc ctgagcggag gaccacaaga cgtctaggta ggcaggggtg
     5461 atgtgtctgc tctcttaata gtaccagagt ccgggtgcca catgtcatag aggaaggcac
     5521 aacttcagac ctgatgtgtc tgagctggtg aggcattaaa aggaaagctc tagctcacct
     5581 ttactctcca gccccagcct gggcccagcc ggatgtgtaa agaggccagg aggagcccca
     5641 tctgtcactg tcctcagaaa tgccttgcct ttagccagcg gctctcttcc tttctcctcc
     5701 tctcactgtt gctcaagggc agatttgaga cagcactgtc tgcatttccc atatccacca
     5761 tccactcggg tgctctgact tgctctgact cttgtctgga cacaagcaga tgcagtatac
     5821 ctgtctgatg tcccttacac ctgctggagg aaggtttctg gctcttcccc cacaaaggca
     5881 taacggggcg cttctcagat tccagcctgg ctaaactgtc cagaagcttg gtcactgcac
     5941 aagtttctct aaagactggc agtatctctg ggctgagccc acaaagccag tactggagtg
     6001 ggtaaggggc taagctgaag tcatctccag tgggagtgta gaagctgatg gcccattgca
     6061 gatctcatgc tctcctttcc ttccctgata caccttaagg atttgaaatc ttgcccttgg
     6121 tttgttttgt ttttgttttt tggttttttt ttgttgttgt tgttaagcca gcgcctgatg
     6181 caaggatacc tagagtgacc taaagagagt gaccctccat gaggagcaag gggaacagtt
     6241 aataggcctt cagtctttgc tttctcatta ggtgaggaaa gcactggacc aacaaaaact
     6301 gagatgttga ccaaacaaga agtcttagga catagcattt ctccctagtc atgaaaggtg
     6361 aagaaatatg gtgtggagag gcgaaaagtg gctatgttct ggagacctga aaagtgcatt
     6421 cctgcctcaa tcaggaaata cggtggacaa gcttggtgcc aggctcaatg tcggtgtatg
     6481 ctttgataaa gacgtgctcc agttagaatg tgacaggaaa agagccaagt accaaacgaa
     6541 acactgagac aacttaatgg ctgttctctt tcctaatatt tctgggtgta tttttattgg
     6601 cagcaagaca aaaaagcaat catttccaca ctggcaggtg acttaaattc tgaggactga
     6661 tttcaaaatg actaccacgt tcccttacac accattcact tatgacatca ccttcaggag
     6721 agcagacatg tgggcgtgtc catgccccac tgtcatctgt ttggaaatag tccttacttc
     6781 ggttttcctc agccagccaa ttccagaagg gcttggaatc ttcaccgtct cagtgccctc
     6841 cctgcctctc cagtgtggtc ctctaacaac tgtcacacac atggtggtaa atttagtgcg
     6901 ctgggtgagc ctggtgctcg taaaatccca tttcatgaca aaggcactgt tcctcaaaat
     6961 gctggggtcg ccatttggcc accacttgga gctctcatat tggacccctg agaatagcca
     7021 agtgagaatc actctacttg cttccatcca gggtctggga gaagcaccac tgttatcagg
     7081 acctgctgat gtgccagaaa gggcaggaga gcaggtcttc agggcaactg ccagtccaca
     7141 aaaaggggta gctcaaagac tgaagttcaa atgaaatatg tacacataca ctttttttgg
     7201 catattatct ttgcttaaga taattcatat ttatttacaa aatagtcctc ccagactact
     7261 ttttctccct tttgccaaaa cggactggag aaagagcatt tggtttttat tctctgctct
     7321 tggaatatga aaagacctaa ccaagaccaa gacctcgcta tgaaatacta gcttaatcca
     7381 agccttaaaa ttcaaaatat tacccaagtt caatttctgg tttctggagg cactaaacat
     7441 gtacgtgtca ccatccttac caagtactta cccaaaattt ggtaagaggg cactgggtac
     7501 cttagcagca ctccaacaca gttgagcgtg gtctaacaga gaaaagggat aaatggagca
     7561 gcctgaaaca actggagcag ggtgagaccc accattagac accaagccat ggcagaaagc
     7621 agcagctagc accttcacta ggactgttga cagtattcaa atgacctact aataaatatt
     7681 ctaattaagc agaattgcaa agccaataaa atatatcagt gg
//
