LOCUS       NM_001205236            4559 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Rho GTPase activating protein 27 (Arhgap27),
            transcript variant 1, mRNA.
ACCESSION   NM_001205236
VERSION     NM_001205236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4559)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   2  (bases 1 to 4559)
  AUTHORS   Tossidou,I., Niedenthal,R., Klaus,M., Teng,B., Worthmann,K.,
            King,B.L., Peterson,K.J., Haller,H. and Schiffer,M.
  TITLE     CD2AP regulates SUMOylation of CIN85 in podocytes
  JOURNAL   Mol Cell Biol 32 (6), 1068-1079 (2012)
   PUBMED   22203040
REFERENCE   3  (bases 1 to 4559)
  AUTHORS   Gaidos,G., Soni,S., Oswald,D.J., Toselli,P.A. and Kirsch,K.H.
  TITLE     Structure and function analysis of the CMS/CIN85 protein family
            identifies actin-bundling properties and heterotypic-complex
            formation
  JOURNAL   J Cell Sci 120 (Pt 14), 2366-2377 (2007)
   PUBMED   17606992
REFERENCE   4  (bases 1 to 4559)
  AUTHORS   Peck,J., Douglas,G. 4th, Wu,C.H. and Burbelo,P.D.
  TITLE     Human RhoGAP domain-containing proteins: structure, function and
            evolutionary relationships
  JOURNAL   FEBS Lett 528 (1-3), 27-34 (2002)
   PUBMED   12297274
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772325.4 and AL662804.18.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.685.1,
                                           SRR13422600.692996.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-424               AL772325.4         7347-7770           c
            425-552             AL772325.4         6285-6412           c
            553-1224            AL772325.4         4325-4996           c
            1225-1644           AL662804.18        205501-205920       c
            1645-1827           AL662804.18        204971-205153       c
            1828-1908           AL662804.18        204712-204792       c
            1909-1992           AL662804.18        204541-204624       c
            1993-2060           AL662804.18        204204-204271       c
            2061-2151           AL662804.18        203823-203913       c
            2152-2256           AL662804.18        203241-203345       c
            2257-2355           AL662804.18        200717-200815       c
            2356-2461           AL662804.18        199774-199879       c
            2462-2584           AL662804.18        199527-199649       c
            2585-2683           AL662804.18        199356-199454       c
            2684-2761           AL662804.18        199087-199164       c
            2762-2896           AL662804.18        198861-198995       c
            2897-3002           AL662804.18        198667-198772       c
            3003-4559           AL662804.18        197000-198556       c
FEATURES             Location/Qualifiers
     source          1..4559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11"
     gene            1..4559
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /note="Rho GTPase activating protein 27"
                     /db_xref="GeneID:544817"
                     /db_xref="MGI:MGI:1916903"
     exon            1..424
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            425..552
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1224
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..3180
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rho-type GTPase-activating protein 27; CIN85-associated
                     multi-domain-containing Rho GTPase-activating protein 1;
                     SH3 domain containing 20"
                     /codon_start=1
                     /product="rho GTPase-activating protein 27 isoform 1"
                     /protein_id="NP_001192165.1"
                     /db_xref="CCDS:CCDS56815.1"
                     /db_xref="GeneID:544817"
                     /db_xref="MGI:MGI:1916903"
                     /translation="MAADVEGDVYVLVEHPFEYTGKDGRRIAIQPNERYRLLRRSTEH
                     WWHVRREPGGRPFYLPAQYVRELPALGDPAPAPQPSVPQQRPAVPEPLAYDYRFVSTP
                     VGADGSSAEPRGRASSLCGPARQRTGGQRNSLAPGGPACLYVRPAAPVRPAQSLDDLA
                     RGGTAPPAGLLGSAGHFKASSVAGSWVCPRPLAPSDSENVYEAIPDLRCPPRAESPKQ
                     VDDPPEPVYANVERQPRATSPRSAAAPPRLSPVWETHTDTGTGRPYYYNPDTGVTTWE
                     SPFETPEGTTSPATSRASVGSGESLETEWGQYWDEESRRVFFYNPLTGETAWEDETEE
                     LEEDHQEQLEMQPSLSPRSPGQQRPPTPETDYPELLASYPEEDYSPVGSFSDPGPASP
                     LVAPPGWSCQITPDKQMLYTNQFTQEQWVRLEDQHGKPYFYNPEDSSVQWELPQVPIP
                     APRSVRKSSQDSDTPAQASPPEEKIKTLDKAGVLHRTKTVDKGKRLRKKHWSTSWTVL
                     EGGVLTFFKDSKTSAAGGLRQPSKLSTPEYTVELKGASLSWAPKDKSSKKNVLELRSR
                     DGSEYLIQHDSEAIISTWHKAIAEGISELSADLLQGEEGEPSSADFGSSERLGSWREE
                     DVRQNAASPSLSPGGLESDLSRVRHKLRKFLQRRPTLQSLRDKGYIKDQVFGCALAQL
                     CERERSPVPRFVQQCIRTVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGR
                     WEDVHVITGALKLFFRELPEPLFPFSHFHQFIAAIKLQDPAQRSRCVRDLVRTLPAPN
                     QDTLRLLIQHLCRVIEHGEQNRMTVQNVAIVFGPTLLRPEMEEASMPMTMVFQNQVVE
                     LILHQCADIFPPH"
     exon            1225..1644
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1827
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1908
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1992
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2060
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2151
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2256
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2355
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2461
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2584
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2683
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2761
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2896
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3002
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..4559
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4526..4531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /note="hexamer: AATAAA"
     polyA_site      4546
                     /gene="Arhgap27"
                     /gene_synonym="2310069I04Rik; 5730442P18Rik; Gm21552;
                     Sh3d20"
                     /note="major polyA site"
ORIGIN      
        1 agagtggccg gtgacttcct ccgacaagga tgagggtcag tgggagtcta atctggtcag
       61 aagctgagag aaactgcctc ccccgcagat ctccatccag gccctgccac cgcctcctcc
      121 ccggagacag tcaggtgtgg cccaggatcc tggggaagag gggggagggt ggcgtctctg
      181 ctcctagagc gctggcccgg cccagagggg acaggaagcc aggacaccgg ggattgtctc
      241 ttgcaagcac agcccagtcc cggcttggga ggaagttctg ccgagcgctc tccgccggtt
      301 atattgttga acaggaaaca gggcatcgcc ggagcagggc tgtggagcag gcagctccgg
      361 acgcggaccc cacgcgcgtc tgccgggaca agtggaagct aggccagcgg gcgaaagttc
      421 taagtgtctc ctgtttcgcg ctgtttcttc agtctcggtc cttggaagtc cctcccacag
      481 atatggtaga ggcctagtct gcttccctcc gtcagccccg cccatgggca gcctgagatc
      541 ctcccagcta acaaaagcgc ggtggtcgcg atggcggcgg acgtcgaggg ggacgtgtac
      601 gtgctggtgg aacacccctt cgagtacacc ggcaaagacg ggcgccgcat cgccatccaa
      661 ccgaacgagc gttaccgact gctgcgccgc agcaccgagc actggtggca cgtgcggcgg
      721 gagcccgggg gtcgcccctt ctacctcccc gcgcagtacg tacgcgagct gcccgcgctc
      781 ggcgaccctg ccccggcccc gcagccttcc gtaccgcagc agcgccccgc agtcccggaa
      841 cctctggcct acgactaccg cttcgtgagc accccggtgg gcgccgatgg gtcctctgcc
      901 gagccccggg gccgcgccag ctccctgtgt ggccctgcac gacagcgcac cggtggccag
      961 cgcaacagcc tggctccggg agggcccgcc tgcctttacg tgcggcccgc ggcgcctgtg
     1021 cgaccggcgc agtccctgga tgacttggcg cgcggcggta ccgcgccccc tgccggcctc
     1081 ctcggcagcg cgggccactt caaggcctcc agcgtggcgg gctcctgggt ttgtccccgg
     1141 cccctggcgc ctagcgactc ggagaatgtc tacgaggcca ttccggactt gcgctgccct
     1201 ccgcgggcag agagcccaaa gcaggtggac gaccccccgg aaccagtgta tgccaatgta
     1261 gagaggcaac ctcgggccac gtcgcctcgc tcagctgcag ctcctcctcg gctcagccca
     1321 gtgtgggaga cacacacaga cacgggcact gggcgcccct actactacaa ccccgacacg
     1381 ggcgtgacca cctgggagtc accctttgaa acacctgaag gcaccaccag cccggccacc
     1441 tcccgggcct ctgtgggtag cggggagagc ctggagacag agtggggcca gtactgggat
     1501 gaggagagcc gcagggtctt cttctacaac cccttgaccg gtgagacggc ctgggaggac
     1561 gagaccgagg agctggagga agatcaccag gaacaactgg aaatgcaacc cagcctgagc
     1621 ccgcgaagcc ccgggcagca gaggccccca actcctgaaa cagactaccc cgaattactg
     1681 gccagttacc ctgaagagga ctactctcct gtgggctcct tcagtgatcc gggccccgct
     1741 tctcctttgg ttgcaccccc tggctggtcc tgtcaaatta ccccagacaa acagatgctc
     1801 tacaccaacc agttcactca agagcagtgg gtaaggttgg aggaccagca cgggaagcca
     1861 tatttctaca acccagagga ctcctctgtt cagtgggagc taccccaggt cccgatccct
     1921 gccccccgaa gtgtccgcaa atccagccag gatagcgaca ctccagccca ggctagccct
     1981 ccagaggaga agatcaagac tctggacaag gcaggagtcc tccatcgtac caagacggta
     2041 gacaagggga agagacttcg gaagaaacac tggagcacct cctggacagt gttggagggc
     2101 ggggtcctga ccttcttcaa ggactcaaag acctcagctg caggcggcct gaggcagcct
     2161 tccaagctct ccacccctga atacacagtc gaactgaagg gggcctctct ctcttgggcc
     2221 cccaaagaca aatccagcaa gaagaatgtg ttagagcttc gaagccgaga tggctcggag
     2281 tacctgatcc agcacgactc cgaagccatc atcagcacct ggcacaaagc cattgccgaa
     2341 ggcatctcag agctgtctgc agacctgctc caaggggagg aaggtgagcc cagcagtgct
     2401 gatttcgggt ccagtgagcg cctcggaagc tggcgggagg aggatgtacg gcagaacgca
     2461 gcctcaccct cgctcagccc cggaggcctg gaaagcgact tgagcagagt ccggcacaag
     2521 ctccgtaaat tcctacagag acgacccact ctgcagtctt tgcgggacaa gggctacatc
     2581 aaagaccagg tgtttggatg cgcgctggct caactgtgtg agcgcgagag gagccctgtg
     2641 ccacgcttcg tgcagcaatg catccgcacc gtcgaggccc gggggctgga tattgatggg
     2701 ctgtaccgca tcagtgggaa cctggctacc atccagaagc tgcgctataa ggtggatcac
     2761 gatgaacgct tggacttgga cgacgggcgc tgggaagacg tccacgtgat cacgggtgcc
     2821 ctgaagctct tcttccgaga gctgccggaa cctctcttcc ccttctcgca cttccaccag
     2881 ttcatagcag ccattaagct gcaggaccca gcccagcgca gccgctgcgt gcgtgacctg
     2941 gtgcgcacgc tgccagctcc caaccaggac acgctccgac tgctcatcca gcatctctgc
     3001 cgggtcatcg agcatggcga gcagaaccgt atgactgtgc agaatgtggc catagtgttc
     3061 ggacccacgc tgctgcggcc agagatggag gaggccagca tgcccatgac catggtgttc
     3121 cagaaccagg tggtggagct catcctacat cagtgcgcgg acatcttccc accgcactga
     3181 ctgtggaccg tgggttagct ggaggccgtg aggctggacc tcctctgagg ctctccgctt
     3241 cccacccccg ctgcactgtg acttcaacgc ccttccattc agagggtaca gtgacccctg
     3301 gtgggcagtt catgaaatgt gatttctccc tctcgcgtcc ccattagggc catttcccta
     3361 attacagcgc cgcctattgt gtggatgtga gaacgtgcct ggtggaggga aatgaatgtc
     3421 tttctagttc caccaccacc acccacccac agctgggaga ggggattttg gtgagggcgt
     3481 tctggtttcc ttaagcctgt acctgtccag gccttggtgg agaccctgta ggccccatgc
     3541 tacgcaagag gtcatgaagc agctactgac attgtctctg ctgccagggg aggactgacc
     3601 ctggctgcca gcccaggcca ctgactgcct ccctcagcct tctgctccag tgccaccctg
     3661 atgcaggcct cctgagaact tttccgatgc ttccctctct ccttgggcca cacccgctct
     3721 ctacagacgt tcttcatact aaccacatac caaacctggc aatctggggc ttgcagaagt
     3781 cacagtactt caggggtcca taggtgatct gattccctgc aaaggctatc cccacagcaa
     3841 gcccagcttc tagaagaggg agtcacgccc ctgccccact gcagcacagc ctgtaggtag
     3901 accagagtaa atgctggagc acttcgtgta ggttagaggt tgggggcccc ccgaaggcag
     3961 cagggaacct accacagctg tttggggggg cagcatgaat agaagcctcc agctgctgtc
     4021 tacaccctgg ctgggtgcct acctaaagcc cccaaccact gtctacatcc tggctggctg
     4081 gatgcctacc tggtacccac ttgccatgca gaggcctgtc cgggaggtca cagccttagg
     4141 caaacagttg aacctgtgtc aactgcccgc ttcctccctc gtgcacctca atctatggat
     4201 ctgagccccc agctccaccc acccccactg actcaacaaa caataatagc taatatttat
     4261 tgagcattca gactatgcca gcctttccca caggcttctc ccttggtttc atgcagtcca
     4321 tatttattgt gggtcctcat gtgcctggca ctgtgccctg gggcaggggt tctacgcatg
     4381 cgttctggag cttggggctc ccagtgagta cggctgatgc aagcccagcc ctgatggtag
     4441 cagggcgcag aagagaacaa atagaggcct cttgctgtac acctatatat ttaaagtcct
     4501 aaggcaagct aatgactaac tgttaaataa aatgtttatt ctcctacttt ggcgaatgt
//
