LOCUS       NM_001374831            7726 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus Rho GTPase activating protein 26 (Arhgap26),
            transcript variant 3, mRNA.
ACCESSION   NM_001374831 XM_006526268
VERSION     NM_001374831.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7726)
  AUTHORS   Bai,X., Zhu,Q., Combs,M., Wabitsch,M., Mack,C.P. and Taylor,J.M.
  TITLE     GRAF1 deficiency leads to defective brown adipose tissue
            differentiation and thermogenic response
  JOURNAL   Sci Rep 14 (1), 28692 (2024)
   PUBMED   39562682
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7726)
  AUTHORS   Zhu,Q. and Taylor,J.M.
  TITLE     ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics
            to drive mitochondrial clearance and promote fuel flexibility
  JOURNAL   Autophagy 20 (8), 1906-1908 (2024)
   PUBMED   38855880
  REMARK    GeneRIF: ARHGAP26/GRAF1 orchestrates actin remodeling and membrane
            dynamics to drive mitochondrial clearance and promote fuel
            flexibility.
REFERENCE   3  (bases 1 to 7726)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 7726)
  AUTHORS   Zhu,Q., Combs,M.E., Liu,J., Bai,X., Wang,W.B., Herring,L.E.,
            Liu,J., Locasale,J.W., Bowles,D.E., Gross,R.T., Pla,M.M., Mack,C.P.
            and Taylor,J.M.
  TITLE     GRAF1 integrates PINK1-Parkin signaling and actin dynamics to
            mediate cardiac mitochondrial homeostasis
  JOURNAL   Nat Commun 14 (1), 8187 (2023)
   PUBMED   38081847
  REMARK    GeneRIF: GRAF1 integrates PINK1-Parkin signaling and actin dynamics
            to mediate cardiac mitochondrial homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7726)
  AUTHORS   Lee,S., Salazar,S.V., Cox,T.O. and Strittmatter,S.M.
  TITLE     Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for
            Amyloid-beta Oligomer-Triggered Synapse Loss
  JOURNAL   J Neurosci 39 (10), 1910-1929 (2019)
   PUBMED   30626696
  REMARK    GeneRIF: Study shows that brain Pyk2 interacts with the RhoGAP
            protein Graf1 to alter dendritic spine stability via RhoA GTPase.
            Amyloid-beta oligomer-induced dendritic spine loss requires the
            Pyk2/Graf1 pathway.
REFERENCE   6  (bases 1 to 7726)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   7  (bases 1 to 7726)
  AUTHORS   Yokoyama,K., Tezuka,T., Kotani,M., Nakazawa,T., Hoshina,N.,
            Shimoda,Y., Kakuta,S., Sudo,K., Watanabe,K., Iwakura,Y. and
            Yamamoto,T.
  TITLE     NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling
            in neurons
  JOURNAL   EMBO J 30 (23), 4739-4754 (2011)
   PUBMED   21946561
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7726)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7726)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7726)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110730.10, AC132450.3 and AC129603.3.
            
            On Oct 16, 2019 this sequence version replaced XM_006526268.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.122278.1,
                                           SRR7345562.4670341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               AC110730.10        98859-99335
            478-573             AC110730.10        203336-203431
            574-635             AC110730.10        205278-205339
            636-707             AC110730.10        207875-207946
            708-809             AC110730.10        216161-216262
            810-920             AC110730.10        217496-217606
            921-1025            AC132450.3         146336-146440       c
            1026-1155           AC132450.3         144656-144785       c
            1156-1256           AC132450.3         139626-139726       c
            1257-1351           AC132450.3         134409-134503       c
            1352-1430           AC132450.3         116441-116519       c
            1431-1467           AC132450.3         61239-61275         c
            1468-1533           AC132450.3         39126-39191         c
            1534-1608           AC132450.3         36594-36668         c
            1609-1696           AC132450.3         22866-22953         c
            1697-1755           AC132450.3         21218-21276         c
            1756-1861           AC132450.3         19635-19740         c
            1862-2021           AC129603.3         116229-116388       c
            2022-2160           AC129603.3         105992-106130       c
            2161-2311           AC129603.3         96063-96213         c
            2312-2422           AC129603.3         45252-45362         c
            2423-2514           AC129603.3         39707-39798         c
            2515-7726           AC129603.3         26630-31841         c
FEATURES             Location/Qualifiers
     source          1..7726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 20.51 cM"
     gene            1..7726
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /note="Rho GTPase activating protein 26"
                     /db_xref="GeneID:71302"
                     /db_xref="MGI:MGI:1918552"
     exon            1..477
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..2603
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /note="isoform 3 is encoded by transcript variant 3; rho
                     GTPase-activating protein 26; rho-type GTPase-activating
                     protein 26"
                     /codon_start=1
                     /product="rho GTPase-activating protein 26 isoform 3"
                     /protein_id="NP_001361760.1"
                     /db_xref="CCDS:CCDS89226.1"
                     /db_xref="GeneID:71302"
                     /db_xref="MGI:MGI:1918552"
                     /translation="MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGK
                     SLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFAAVLRNLEDERS
                     RMIENASEVLITPLEKFRKEQIGAAREAKKKYDKETEKYCGTLEKHLNLSSKKKESQL
                     QEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELA
                     KDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQE
                     KRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRF
                     CFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNRDSQSEGTAQLDSIGFSI
                     IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETETDICAEWEIKTVT
                     SALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLPEKNRQMLQLLM
                     NHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEK
                     IFNTVPDVPLTNAQLHLSRKKSSDSKPPSCSKRPLTLFHAVPSTEKQEQRNSIINSSL
                     ESVSSSANSILNSSSSLQPNLNSSDSNLDVVKPSRPSSLPPNPSPTSPLSPSWPMFSA
                     PSSPMPTSSTSSDSSPISTPFRKAKALYACQAEHDSELSFTAGTVFDNVHPSQEPGWL
                     EGTLNGKTGLIPENYVEFL"
     exon            478..573
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            574..635
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            636..707
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            708..809
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            810..920
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1025
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1155
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1256
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1351
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1430
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1467
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1533
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1608
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1696
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1755
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1861
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2021
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2160
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2311
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2422
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2514
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..7726
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7705..7710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /note="hexamer: ATTAAA"
     polyA_site      7726
                     /gene="Arhgap26"
                     /gene_synonym="1810044B20Rik; 2610010G17Rik;
                     4933432P15Rik; mKIAA0621"
                     /note="major polyA site"
ORIGIN      
        1 gagagggcgc tcgaggctgc ttgaggctgc tgaggagcaa gcccgcagag gaggcgggga
       61 ggcggtggcc cggctggttc gcttccaggc tccgccaagg gtccgccgcc gcgctttctg
      121 ccggtgtgca gttcggtggc tctccgcagg agcagccgcc gtccgtccgg gtccccgctg
      181 cggtcctgag tctcctgctc ccgctgaccc cgcgcgcggg gtagccggcg ccacccacac
      241 ctgtggatcg gccgtcgtcg cgggtgtccg ccgaccagcg tgcgaggcgc gtcccctcag
      301 cccggctggc tccgcgggca gaaatggggc tcccggcgct cgagttcagc gactgctgcc
      361 tcgacagccc tcacttccga gagacgctca agtcacacga agcggagctg gacaagacca
      421 acaaattcat caaggagctc atcaaggacg ggaagtcgct catcagcgcg ctcaagaatt
      481 tgtcttcggc aaagcggaag tttgcagatt ccttaaatga atttaaattt cagtgtatag
      541 gagatgccga aacagatgat gagatgtgta tagcgagatc tttgcaagaa tttgctgctg
      601 ttctcaggaa tcttgaagac gagcggagtc gaatgatcga gaatgccagc gaggtgctca
      661 tcacaccctt ggagaagttt cgaaaggagc agattggggc cgccagggaa gccaaaaaga
      721 agtatgacaa agagaccgag aagtactgcg gcaccttaga aaaacatttg aatttgtctt
      781 ccaaaaagaa ggaatcccag ctacaggagg cagacagcca agtggacctg gttcggcaac
      841 atttctacga agtatccctg gagtatgtct ttaaggtgca ggaagtgcaa gagagaaaga
      901 tgtttgagtt tgtagagcct ctgctggcct tcctgcaagg actcttcact ttctatcacc
      961 atggttatga gctggccaag gattttggtg actttaagac acagttgacc atcagcatac
     1021 aaaatacaag aaaccgcttt gaaggaacca ggtctgaggt ggaatcgctg atgaagaaga
     1081 tgaaggaaaa ccccctggag cacaagacca tcagcccgta caccatggaa gggtacctgt
     1141 acgtgcagga gaagcgtcac tttggaactt cctgggtgaa gcactactgt acctaccaac
     1201 gggattccaa acaaatcacc atggttccat tcgaccaaaa gtcaggagga aaggggggag
     1261 aagacgagtc cgttaccctc aaatcctgca cacggcgaaa gacagactcc atcgagaagc
     1321 gattctgctt tgacgtggaa gcagtagaca ggccaggggt tatcaccatg caggcgttgt
     1381 cggaagagga ccgtaggctc tggatggaag ccatggatgg ccgggaacct gtgtacaact
     1441 ccaacagaga cagccagagc gaagggaccg cacaattgga cagtatcggc ttcagcataa
     1501 taaggaaatg catccatgcg gtggagacca gagggatcaa tgagcagggg ctctaccgaa
     1561 tcgtgggggt caactccagg gtgcagaagt tgctgagcgt cctgatggac cccaaagcag
     1621 cttctgagac agaaactgat atctgtgccg aatgggagat aaagaccgtc accagtgctc
     1681 tgaagaccta cctgagaatg ctcccaggac ccctcatgat gtaccagttt caaagaagtt
     1741 tcatcaaagc agcaaagctg gaaaaccaag agactcgagt gtctgagatc cacagtcttg
     1801 tccatcggct cccggagaag aatcggcaga tgttgcagct gctcatgaac cacctggcca
     1861 atgttgctaa caaccacaag cagaatctga tgactgtggc aaacctgggc gtggtgtttg
     1921 gacccacctt gcttcggcct caggaagaaa ctgtggcggc catcatggac atcaagtttc
     1981 agaacattgt catcgagatc ttaatcgaga accatgagaa gatattcaac acggtgcctg
     2041 atgtgcccct caccaacgcc cagctacacc tgtcccggaa gaaaagcagt gactccaagc
     2101 ccccatcctg cagcaagagg cccctgacgc tcttccatgc tgtgccatcc acagaaaaac
     2161 aggagcagag gaacagcatc atcaactcca gtttggaatc ggtctcctcg agtgcaaaca
     2221 gcatccttaa ctctagcagc agcctgcagc ccaatctgaa ttccagcgac tcaaacctgg
     2281 atgtggtcaa acctagtcgg cccagttcac tccccccgaa tccaagccca acttcacccc
     2341 tctcgccatc atggcccatg ttctcggcac catccagccc tatgcccacc tcatccacgt
     2401 ccagcgactc atcccccatc agcacaccat tccggaaggc aaaggctttg tacgcctgcc
     2461 aagctgagca cgactcggag ctctccttca cagcgggcac cgtcttcgat aatgttcatc
     2521 catctcagga gcctggctgg ttggagggga ctctgaatgg aaagactggc ctcatcccag
     2581 agaactacgt ggaattcctc taaccttgag ccccagtgga gctgctgagc ttcacgtggt
     2641 ctccatgaca actgctgctt ctggtgttgt gggccacttt tcattgccac tgagaaagca
     2701 gggagcccga ctgttgcttc ctgccaacac aaatgcatct gggaacgtgt gccaccattc
     2761 tccatgatca tctcagctta cagcacagta atgctgcaag aactgcacag caatcagcag
     2821 aggaggccat tggattttga taacccagag gaaggcttgc aaagctgtct tctcacgagt
     2881 gccctaaata gagagccctg atttcatttc agcagtcatc caaaccccca gccttctggg
     2941 aagaagaagc aggatgagaa tagtgctaaa gaaagtgcat cgctgctgag ttggaagagg
     3001 cagggcaaag aaactggcac aaggtgcagg ctgcctctac tgctgttgct tatagcaggc
     3061 gctctttctc tctccttcct tctcccagag acacagtgct acaggcagct gggtctgtct
     3121 gcaagcacac aggatgaagg ggttgccgca ctgtttatat atggtccaat ctctcaccat
     3181 ctcttgagca gctgttggcc tataatcagc agatttcagt ccagtcctct catgcaaaga
     3241 aacacacgcc cctcacgttc tctgccgctg aaggcttcca tcactgccat cacctagtaa
     3301 ccatagcaac ccaacctact ctaaaactaa gccaaaaata atacttctct ttgtataaca
     3361 acctcccccc cccccccagc tctggcgagt tttttttttt tttttttttt ttaatggtct
     3421 tccaacaatc tgaagcagag gattagacca ttagagtagt ctatttgggg cagatagccc
     3481 ttagaatttt ttgttactga ggtcctggga ttttagagat gattcttggg ccaaactttg
     3541 tagcctgatt tttaaaagga catctatatc actgccaccc agaacaaaaa gagggaatca
     3601 ttaaatagga taggccatta agaatctgta ggacgccaaa tgttgaggcc tggaggctag
     3661 gctgggtacc ttcaaagaga gggaattctc attacaagga caagcatcac atgacctcaa
     3721 aagaacacaa tcatggtatc ttcgcactcg aatgtccttg atagagggac tctggacaaa
     3781 ctgtcacact ttccaggagc ctctctgatg gcaacgttgc accagagagt gtctcaggct
     3841 cctggaattc ccttagggtt ctttaatgaa gagaagaaaa cttgaattgt gttgaattac
     3901 tgtatcttct gctttttttt tttaaagata aacttgtaaa tagaatgatt tgaaatatta
     3961 tatggtaaag ttttatattt gatattcttt aagctagttt gctccataca tttagtattt
     4021 tgattgctga acagatgtgt ttaaaaggtt gcaagagagg ccgggctaaa gagtcaaggt
     4081 catgtcccct ctctggccca gtgaaagaat gtgtcctcaa tggttcctgt tggtgagcct
     4141 ggaaagttgg ttgcattcag ttgtctttat ctacatgtga tttggggctt tggagttcaa
     4201 aagagcatct tcaagcagtg aattttcaaa gaactcccac ccaacagtaa agtgacactc
     4261 aggatctcag gatttaaata ggtggggtga gggcgacatg tttgtttttt gtttgtgtgt
     4321 ttgttcttct caggtgtatt tcttggtacc ccaggatgtc cagacaaaag gagatgagcc
     4381 aacactcctt tttcccccac atctccaagc tagtttataa atgtgtctat caactctaag
     4441 aactaaacaa gaaagccagc tgctgtggtt cttggtcatt ggtgaacttt actctcttcc
     4501 tatagacgtg ttcccgcact tccccttcac ctccaaagtc ccggcagccc caaagtaaaa
     4561 aagaatcccc aagatgacac tgttacagtt tttagaggtg ctgtaatgtt aatagttcat
     4621 tgtcgggatt cagtattgag tttaccagct caggattata ctgttgccaa ccaaggaccc
     4681 agccaggagc aagggagact tgaactttca gtcaggcaaa cacaggattc caaactgaca
     4741 atgctgggtg tgatggctca tgtgtggtct tagcacttgg aagacagaga caagaggatt
     4801 gctgaagact tacgccagcc agatgtgagg ctggaggagg gttgcaaacg gaaggaagaa
     4861 aggcagtaca ctcaggttcc agacctattc cctgtgagct tgagaaaagg ttgggcaatg
     4921 gggcccgaag ggcatgcaca ctcaagtagc attgctcctt ccaaattaaa agagcccagc
     4981 atgatacttt taatatatct gatggtttaa attgtcgcct gccccataat aaatgaacta
     5041 tgcttgtagt cagggcccag cacgactgct tggatacata ttctttctct cctgagctgg
     5101 ccctggtttg aaactgctct cttaggctga cctccttcca gtttccctga ggccatgtgt
     5161 ggcctatgac agatggtcgc tctgtttccc tttgtccagc taggcctccc tcctattcct
     5221 cctcctcgtc ctcctcagga aaaagaactg gagagattaa tatgagccaa gtaggaagga
     5281 acttgaagat taaaagtgtt atgtgccctt tctgctctct gaacacccct gagctcccca
     5341 caaataagga aaactggggt agatcatgag gaatgagttg atatcagaat ggaagttcat
     5401 tgaccagagt cccaaagatt tcccaggagc tttgagtttc tcttgtaaga ccctgggatg
     5461 ggttggttat ggtttgaatt ttggagcatc aagatggttg gtcttactct ctgagataga
     5521 gagttccata attgaacagt gccattctgt gctatgaaat gagaagatag ctgctttcac
     5581 atctctgccc ccaagcaagg aaaatgagct tgttcaacac tgatgaaatt ctctattttt
     5641 tcttttttta aaataaatgt gtgtgactga cctccattca gtggatgcct cagtctttag
     5701 tattagagcc agtttgtagt atttttaaag ccattatgtg aagtcttgtg gatgcttttt
     5761 ttaatttttt ttttaaatca gagaagaaat gagaagagag tacttccaac tgggcactgg
     5821 tgagccagag ccatgctggc tggttgggag ttacaggcgc tctagacctg agtgtgccac
     5881 atctggatct taagggaaat ccttcttaac tgcattcccc cccaaccccc ccaggacagt
     5941 agcaatcaca ccaaaagctg cttcagtcat agaacttcca gaagcatcca ttattgaggc
     6001 agggggaagt agactaaaga gggtgagatc atctgttctt ggccggctat atctgcttcc
     6061 tgtgacaagg ctgtttacct agcttcatag ccagcgagct tgggggtgca ccagtgacca
     6121 cacatttgcc ctggcaccca ctgttcttag tagacaaggg aaccaagcgt ctgcttagct
     6181 acctgtcttt caaaggaatg ttctggctgt ctaggaaggg agttgtctgc caattctgtc
     6241 aaacttgaca gtgatcactt acgttgatag ccctgtccca acagcccttt aatcagtcag
     6301 gtgcccctca ctccccatag tagtgcatga aaaaatatct tttgcattca aatatttctg
     6361 cacccatgca gatctagtgt ttgtctgtga atgtagtatc aaaatgacaa cagcagagag
     6421 ctgggactga accttggaca tgcctccaac atgctgagac aagactccac caggcgatga
     6481 cgggccttct tccctttgcc gcccacagca cgtgtctaac ttaaagagcc accctaagta
     6541 gacagagatt ccagacgtca ctcggaggca gccctgtact catggaagga aagcatagat
     6601 ataaaaacac ccggatcagg aaggaaaggt gagccaccct gagagcaaga actaagcata
     6661 gtcctaaccc acagagggag ggccaagaac tatcctgtca aaattcacat tagtgcagtc
     6721 agtggggagc aaggttgtgg taactcagtg tctgagtgac ctggagtagc ttcaggcagg
     6781 ctggcatact ctctgccatc atgcactcac acatgcatac ctaccattct tgcggcttct
     6841 gagtaaacac caacaaacag catccccggg gttcaagatg cccgagtcag cttggtgtct
     6901 gtgaaagcat acatgtgggg attctaaaat ttgtgtgtgc gtgtgttggt gtgtatgtgt
     6961 tcgtacatag cacatacaag cataaaggtg ccgcctcggg tgtagacaca cacacacaag
     7021 ctggcatttg taaagctctt acagccttga agatttggag ggaagagttt tcagaggaac
     7081 tagagtctgt cagtttccta gcaaaagatc aaagctacaa acgagctgtc atctgaagcc
     7141 tctgttcgtg tttatcacat agttatccac agctgcgttc cttggtgact tattaaaagt
     7201 caggttaaaa actcaaaccc ataaatttcc agtagctaat gctaggctag tgttcaaaag
     7261 cactctaaaa gacatttagt ccatattttg ggaaagaaac tatttgcatg tttaattcat
     7321 cttttaggct gctgttgagt atactgtaaa gtgctgtgtg atatcaagcc agtaaagtac
     7381 ttataaatgg cactttaata ttttcttttg agaaatcata aaacactgtt gtaaatttca
     7441 ctattgaata ttgactggta catagaatca aactctgtaa ttaaaaagta gcctgcagct
     7501 aggatagaac atttttcttg ttattagaga aaaaaaaaaa gtttgccatg ttcaggcttt
     7561 ttaaaaaaaa agtgtttctg tgccattgtt cgtatctata aagaaaatac aatttctgtc
     7621 aggcatctct gaaacctggc tttttttatg tttggttcgt gtctgtggca atccctataa
     7681 agtgagtgga agtatgattt ttgaattaaa tgactttccc atttga
//
