LOCUS       NM_001037727            3695 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Rho GTPase activating protein 25 (Arhgap25),
            transcript variant 1, mRNA.
ACCESSION   NM_001037727
VERSION     NM_001037727.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3695)
  AUTHORS   Czaran,D., Sasvari,P., Horvath,A.I., Ella,K., Sudy,A.R.,
            Borbely,E., Rusznak,K., Czeh,B., Mocsai,A., Helyes,Z. and
            Csepanyi-Komi,R.
  TITLE     Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced
            arthritis in mice
  JOURNAL   Front Immunol 14, 1182278 (2023)
   PUBMED   37234175
  REMARK    GeneRIF: Lacking ARHGAP25 mitigates the symptoms of
            autoantibody-induced arthritis in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3695)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3695)
  AUTHORS   Lindner,S.E., Egelston,C.A., Huard,S.M., Lee,P.P. and Wang,L.D.
  TITLE     Arhgap25 Deficiency Leads to Decreased Numbers of Peripheral Blood
            B Cells and Defective Germinal Center Reactions
  JOURNAL   Immunohorizons 4 (5), 274-281 (2020)
   PUBMED   32434881
  REMARK    GeneRIF: Arhgap25 Deficiency Leads to Decreased Numbers of
            Peripheral Blood B Cells and Defective Germinal Center Reactions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3695)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3695)
  AUTHORS   Csepanyi-Komi,R., Wisniewski,E., Bartos,B., Levai,P., Nemeth,T.,
            Balazs,B., Kurz,A.R., Bierschenk,S., Sperandio,M. and Ligeti,E.
  TITLE     Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte
            Transendothelial Migration in Mice
  JOURNAL   J Immunol 197 (7), 2807-2815 (2016)
   PUBMED   27566826
  REMARK    GeneRIF: Using Arhgap25-deficient mice, it identified ARHGAP25 as a
            relevant negative regulator of leukocyte transendothelial
            migration.
REFERENCE   7  (bases 1 to 3695)
  AUTHORS   Wang,L.D., Ficarro,S.B., Hutchinson,J.N., Csepanyi-Komi,R.,
            Nguyen,P.T., Wisniewski,E., Sullivan,J., Hofmann,O., Ligeti,E.,
            Marto,J.A. and Wagers,A.J.
  TITLE     Phosphoproteomic profiling of mouse primary HSPCs reveals new
            regulators of HSPC mobilization
  JOURNAL   Blood 128 (11), 1465-1474 (2016)
   PUBMED   27365422
REFERENCE   8  (bases 1 to 3695)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   9  (bases 1 to 3695)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of ARHGAP24 and ARHGAP25 genes
            in silico
  JOURNAL   Int J Mol Med 14 (2), 333-338 (2004)
   PUBMED   15254788
REFERENCE   10 (bases 1 to 3695)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159941.1, AK037710.1 and AK137526.1.
            
            On Nov 8, 2013 this sequence version replaced NM_001037727.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037710.1, SRR13422591.113559.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AK159941.1         2-345
            345-2855            AK037710.1         78-2588
            2856-3695           AK137526.1         2927-3766
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 38.01 cM"
     gene            1..3695
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /note="Rho GTPase activating protein 25"
                     /db_xref="GeneID:232201"
                     /db_xref="MGI:MGI:2443687"
     exon            1..434
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..2320
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /note="isoform a is encoded by transcript variant 1; rho
                     GTPase-activating protein 25; rho-type GTPase-activating
                     protein 25"
                     /codon_start=1
                     /product="rho GTPase-activating protein 25 isoform a"
                     /protein_id="NP_001032816.1"
                     /db_xref="CCDS:CCDS20321.1"
                     /db_xref="GeneID:232201"
                     /db_xref="MGI:MGI:2443687"
                     /translation="MSLKLPRNWDFNLKAEASKIARSRSVMTGEQMAAFHPPTTPNPL
                     ERPIKVGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDSKPQGCMYLPGSTVKEIAT
                     NPEEAGKFVFEVIPASSDQNRIGQDSYVLMASSQVEMEEWVKFLRRVAGTPSGAVFGQ
                     RLDETVAYEQKFGPHLVPILVEKCAEFILEHGVSEEGIFRLPGQDNLVKQLRDAFDAG
                     ERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLMNADEAKAQQELVK
                     QLSTLPRDNYNLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMR
                     GTPQIQRVMTMMIRDHEVLFPKSKDAPISPPAQKNDAKKAPVPRSSVGWDATEDPPLS
                     RTDSFSNTASSPDATSPTGPLPSDQHQEDSGKAPRENPGDWKMQSRKRTQTLPNRKCF
                     LTSAFQGTTSSKLEIFKNEFWSPSSEAKAGEGHRRTMSQDLRHLSNDQRTSTYDNVPT
                     SPQSQGNPAGALSPPASDSKRDALVSTDSEMEAGSKNSGEDDLDSLQRTVQSLQKEIE
                     TQKQVYEEQIKNLEKENYDVWAKVVRLNEELERERKKFAALEISLRNVERSREDVEKR
                     NRVLEEEVKEFVKSMEKPKTKTDP"
     exon            435..634
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            635..722
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..839
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1047
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1180
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1254
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1376
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1573
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..2106
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..3695
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      2845
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /note="major polyA site"
     regulatory      3497..3502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /note="hexamer: ATTATA"
     regulatory      3499..3504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3514
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
     polyA_site      3517
                     /gene="Arhgap25"
                     /gene_synonym="A130039I20Rik"
ORIGIN      
        1 agttgtttat cacaacttca cttcagtaag gcctgagatt ctgcccagca gggctctgct
       61 tcccaagagg cagtgtcaac tgggacattt ctggtaaatc tgaacgcaaa gcagggtgcc
      121 agcccctggg ggactgtggg tgggacttgg ggagtttggg tgccatcccc gagtgacaga
      181 tggatggacg gttcatgaga gagaaaggag gagacacgtg ggcagatcgg tctggagcgt
      241 aagagtgcct gcaaagcaag caacaggcag agaaggcaga ggaaccgaag tgaagatcag
      301 agaaacaaga agggcacagc ctgtgacaca ctgtgagcca cttgaccagc tactcaccca
      361 cctcggaagc aaaatgtctc tcaagctgcc aaggaactgg gatttcaatt tgaaagcgga
      421 ggcttcaaaa atagctcggt cgaggagtgt gatgaccggg gagcagatgg cggcctttca
      481 cccacccacc actcccaacc ccctggaaag gccaattaag gtgggctggc tgaagaagca
      541 gaggtccatc gtgaaaaact ggcagcagcg gtactttgtg ttgagagctc agcaactcta
      601 ctactacaag gacgaagagg actcaaagcc acagggctgc atgtatctgc caggcagtac
      661 agtcaaagaa attgccacaa accccgaaga agctgggaaa tttgtctttg aagttattcc
      721 agcctcaagt gaccagaacc gcattggaca agactcctac gtcctcatgg ccagctccca
      781 ggtagagatg gaggagtggg ttaagttcct caggagagtt gctggcacgc cctctggagc
      841 ggtgtttggc cagcgtctgg atgagactgt ggcctatgag cagaagtttg gccctcacct
      901 ggtgcccatc ttggtggaga agtgcgctga gttcatcctg gaacatggtg tgagtgaaga
      961 gggcatcttc cgcctgcccg ggcaggacaa ccttgtgaag cagctgagag atgctttcga
     1021 tgcgggggag cggccctcct ttgacaggga cacagatgtg cacacggtgg catctctact
     1081 aaagctctac ctccgagacc tgccagagcc tgtggttcct tggagtcagt atgaagggtt
     1141 cctgctctgt gggcagctca tgaacgcaga tgaggcaaag gctcagcagg agttggtgaa
     1201 gcagctttct acccttcccc gagacaacta caacctcctg agctacatct gcagatttct
     1261 gcatgaaatc cagctgaact gtgccgtcaa caagatgagc gtggacaacc tggccactgt
     1321 gatcggggtg aacctcatca ggtcgaaggt tgaagaccca gctgtgatta tgagagggac
     1381 tcctcagatc caaagagtga tgaccatgat gatcagagac cacgaagtcc tcttccccaa
     1441 gtctaaggat gcaccgatct caccccctgc ccagaaaaac gatgccaaga aggctccagt
     1501 gccgcgaagc tctgtggggt gggatgccac ggaagaccca cccctttcta ggacagacag
     1561 cttcagtaac acagcaagta gtcctgatgc caccagtccc actggaccac tgcccagtga
     1621 ccagcatcag gaagacagcg gaaaagcccc cagggaaaac ccaggagact ggaagatgca
     1681 atcccgtaaa aggactcaaa cgcttcccaa ccggaagtgt ttcctgacgt ccgcattcca
     1741 aggcaccacc agcagtaaac tggaaatctt taaaaatgag ttctggtctc catcttcaga
     1801 ggctaaggca ggagaagggc acaggcgaac tatgtcccaa gacttgcgcc acctttccaa
     1861 tgaccagcgg acttctacct acgataatgt ccccacctca ccacagtccc aagggaaccc
     1921 agcaggtgca ctctctcccc ctgccagtga ctccaagaga gatgctcttg ttagcacaga
     1981 ctctgaaatg gaggctggaa gcaagaactc tggcgaggat gaccttgatt ctctgcagag
     2041 gacagtccag agcctacaga aggaaataga aacccagaag caggtctatg aggaacagat
     2101 taaaaacctg gagaaggaaa attacgatgt ctgggctaag gtggtgaggc tcaatgaaga
     2161 actcgagagg gagaggaaga aattcgcggc cctggaaatc agccttcgaa atgtggagcg
     2221 ctcccgggag gacgttgaga agaggaacag agtcttggaa gaagaagtca aggagtttgt
     2281 gaagtcgatg gagaagccca agacaaagac ggatccttga gggtctgagt ggtgtggcag
     2341 ggacagtcaa ctccactcca tttcttcatg ctcctagtga gctggaagca gggttacctc
     2401 ctaggatgga cagggtatct gagggatgtg ccacaatcct cagcaaatac acagaagttg
     2461 agagtgtaca ggagcacacc aggacacttg ccaccctgtg ctgtgctcca aggattgcgt
     2521 tattccactg tgggaagagt gaactggaat cttccagtgt atgaccaggt ccaaaggaga
     2581 catttaaggt gtgtgacatc tcaggacccc aggccagagc tgggccaagg cctcagttct
     2641 ttgttgtctc tgtggctgtc ttgcctagtc agatggttct ggtcgctcta aaacatggcc
     2701 agaaaatatt tcttcactct ccagtgctgg ccaactgagg gctgcttgga gaggctgaac
     2761 tgttggaatc caggatcaaa caatatttat gaaagcaaaa tgagtgagaa aattatattc
     2821 aaataaagaa aacagaaaac aaaaattgag caaggatatt ggcaatctaa tgaaacactt
     2881 ttattagaat tagtaaaagg gggtttggta aaattagtaa aagctggctc tgtggctgag
     2941 agcactggct gctctttcag aggactcagc atccacacga tgatggctaa caaacctctg
     3001 tagctccagt tccaggagat ctgacaccct ctgaggacac catatataca tatgctgccc
     3061 atacatatat gcaaacaaac aaacacccgt acacatcaaa tacacacaca cacacacaca
     3121 tacatacata catacataca ttccaacaac aaagaaaaaa ataattagta aaaggcacct
     3181 cttgcctgaa gcaggtgaat ctttcttgtg gtacatggct gtgtgaccag ggctttgggt
     3241 tccatcctga gtcaccctcc agtggacaaa acttgtctgc aaagtctcag agcaaaggtt
     3301 tccaactatg aaatgacttt aggggtgtgg atttgtatag tgaatagtca agattattaa
     3361 ttattattgt cattgttgtt attgctattc tacttcaaca aaatgaaaat gggtttattt
     3421 gctctttaga gggggatcag gcacaatcat ctgttttctc aactatagct aatgccacct
     3481 gccttttgct gagttaatta taaaaacaac caaccaacaa tatcgctgat tactctctgg
     3541 ccacaatggt ctccctgctc ccgtggcttg ccccaggtgg cagtaccgcc ccaattgctg
     3601 ctgttggctt gccactgaac ctctgtattc tcagtcatct attccttgcg gctagctgtc
     3661 acaaatcctc tgtaacccag taaaatcaaa actct
//
