LOCUS       NM_029270               3353 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Rho GTPase activating protein 24 (Arhgap24),
            transcript variant 1, mRNA.
ACCESSION   NM_029270
VERSION     NM_029270.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Xie,C., Abrams,S.R., Herranz-Perez,V., Garcia-Verdugo,J.M. and
            Reiter,J.F.
  TITLE     Endoderm development requires centrioles to restrain p53-mediated
            apoptosis in the absence of ERK activity
  JOURNAL   Dev Cell 56 (24), 3334-3348 (2021)
   PUBMED   34932949
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   Akilesh,S., Suleiman,H., Yu,H., Stander,M.C., Lavin,P.,
            Gbadegesin,R., Antignac,C., Pollak,M., Kopp,J.B., Winn,M.P. and
            Shaw,A.S.
  TITLE     Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is
            associated with familial focal segmental glomerulosclerosis
  JOURNAL   J Clin Invest 121 (10), 4127-4137 (2011)
   PUBMED   21911940
  REMARK    GeneRIF: Increased levels of active Rac1 and Cdc42 were measured in
            Arhgap24 knockdown experiments, which influenced podocyte cell
            shape and membrane dynamics.
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Brunskill,E.W., Georgas,K., Rumballe,B., Little,M.H. and
            Potter,S.S.
  TITLE     Defining the molecular character of the developing and adult kidney
            podocyte
  JOURNAL   PLoS One 6 (9), e24640 (2011)
   PUBMED   21931791
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Sewell,W., Sparrow,D.B., Smith,A.J., Gonzalez,D.M., Rappaport,E.F.,
            Dunwoodie,S.L. and Kusumi,K.
  TITLE     Cyclical expression of the Notch/Wnt regulator Nrarp requires
            modulation by Dll3 in somitogenesis
  JOURNAL   Dev Biol 329 (2), 400-409 (2009)
   PUBMED   19268448
REFERENCE   6  (bases 1 to 3353)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of ARHGAP24 and ARHGAP25 genes
            in silico
  JOURNAL   Int J Mol Med 14 (2), 333-338 (2004)
   PUBMED   15254788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080986.1, AK031879.1, BC027070.1 and AA221552.1.
            
            On Mar 22, 2008 this sequence version replaced NM_029270.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080986.1, SRR7345562.3952655.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               AK080986.1         1-540
            541-754             AK031879.1         128-341
            755-1038            AK080986.1         755-1038
            1039-3242           BC027070.1         283-2486
            3243-3353           AA221552.1         59-169
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.53 cM"
     gene            1..3353
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /note="Rho GTPase activating protein 24"
                     /db_xref="GeneID:231532"
                     /db_xref="MGI:MGI:1922647"
     exon            1..472
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            473..666
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..2736
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rho-type GTPase-activating protein 24"
                     /codon_start=1
                     /product="rho GTPase-activating protein 24 isoform 1"
                     /protein_id="NP_083546.2"
                     /db_xref="CCDS:CCDS19474.1"
                     /db_xref="GeneID:231532"
                     /db_xref="MGI:MGI:1922647"
                     /translation="MEERCESTESPQGQGRQNTKCGWLRKQGGFVKTWHTRWFVLKGD
                     QLYYFKDEDETKPLGTIFLHGNKVIEHPCNEENPGKFLFEVVPGGERDRMTANHESYL
                     LMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDF
                     IRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPE
                     PVVPYAKYEDFLSCATLLSKEEEAGVKELMKQVKSLPVVNYNLLKYICRFLDEVQSYS
                     GVNKMSAQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDRLFPKDTEPQ
                     SKPQDGPNSNNNDGHKKATMGQLQNKENNNTKESPVRRCSWDKPESPQRSSVDNGSPT
                     ALSGSKTNSPRNSIHKLDISRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGVEKPQT
                     TPNGSLQARRTSSLKSSGTKMGTHSVQNGTVRMGILNTDTLGNSLNGRSMSWLPNGYV
                     TLRDNKQKEPAGESGQHNRLSTYDNVHQQFSSMSLDDKHSVDSATWSTSSCEISLPEN
                     SNSCRSSTTTCPEQDFYVGNFEDPVLDGPPQDDLSHPGDYENKSDRRSVGGRSSRATS
                     SSDNSETFVGNTSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMLSL
                     HDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGDLTVEPRRSER
                     GNTIWIQ"
     exon            667..754
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            755..877
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1085
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1218
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1292
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1414
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..2492
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..3346
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3225..3230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3242
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /note="major polyA site"
     regulatory      3325..3330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /note="hexamer: AATATA"
     polyA_site      3342
                     /gene="Arhgap24"
                     /gene_synonym="0610025G21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaaacccgaa acccggctgc gtctgcgggc tggccccact cagttgttcc agcctcttgt
       61 actgtatatt tacacattca cacacaatca ctctttctaa cttcttgact ctttgcgcaa
      121 ctgctaggat ttctcaagtg catgtggcaa ttcagcccgg gtgagagaaa gccggtggga
      181 ctcggaaggg aatcacgggg ccgcggggcc gcccaggctg cagaggggac agaactagag
      241 cgagacagcg actgctgggg gagtcccccc caactttcca tgcagctgtg gctctggggc
      301 tgcccgggct tcctctgaga gcagcacgca ggcctggcga atggggttct gcgctcgccc
      361 tgggaagtaa agggcaccct gccgactgga actcatcttt aggccagtcc taggagcctg
      421 gacatcggag cagccgccag ccatcccttg taggtccggc atccctggca gggaaaatcc
      481 atcagcttga gaatggagga aaggtgtgaa tccacagaga gcccccaagg ccaagggcgg
      541 cagaacacca agtgtgggtg gctgaggaag caaggcggct ttgtcaagac ttggcacacc
      601 cggtggtttg tgcttaaggg ggatcagctt tattatttca aagatgaaga tgaaaccaag
      661 cccttgggga ctatttttct gcatggaaat aaagtcattg agcatccgtg caatgaagaa
      721 aacccaggaa agttcctttt cgaagtagtt ccaggaggtg aacgagatcg gatgacagcc
      781 aatcatgaga gctatctcct catggcgagc acccagaatg acatggaaga ctgggtgaag
      841 tccatccgcc gagtcatatg gggacctttt ggaggaggta tttttggaca gaaactggaa
      901 gacacagtcc gatatgaaaa gaggtacggg aaccggctgg cacccatgct ggtggagcag
      961 tgtgtggact tcatccgaca gcgggggctg aaggaagaag gcctcttccg gctgccgggc
     1021 caggcgaacc tggtcaagga gctccaggat gcgttcgact gtggagagaa gccctccttc
     1081 gacagcaaca ccgacgtcca cactgtggca tccctgctga aattgtatct ccgagaactt
     1141 ccagagcccg tcgttcctta tgcaaagtat gaagactttt tgtcctgcgc cacgctgctc
     1201 agtaaggagg aagaagcagg tgttaaggag ctaatgaaac aagtgaagag tttgcctgtg
     1261 gttaactaca accttctgaa gtacatttgc aggttcctgg atgaagtgca gtcctattca
     1321 ggagttaaca agatgagcgc acagaacttg gcaactgtct tcggtcctaa catcctgcgc
     1381 ccaaaggtgg aagatccctt gaccatcatg gagggcactg tggtggtcca gcagttaatg
     1441 tcagtgatga ttagtaagca tgatcgactc ttccccaaag acacagaacc acaaagcaag
     1501 ccccaagacg gcccgaacag caataataac gatggtcata agaaagccac catgggtcag
     1561 ttgcagaaca aagaaaacaa taataccaag gagagccccg tcagaaggtg ctcttgggac
     1621 aagcctgaat ccccccagag aagcagcgtg gacaatggat cccccacagc cctatcaggc
     1681 agcaaaacca acagcccaag gaacagtatc cacaagctgg atatttccag gagcccccct
     1741 ctcatggtca aaaagaaccc agccttcaac aagggcagtg ggattgtcac caacgggtca
     1801 ttcagcagca gcaatgcaga aggtgtcgag aagcctcaaa ctactcctaa tgggagttta
     1861 caagccagaa ggacctcttc actgaagagt tctggtacca aaatgggcac tcacagtgta
     1921 cagaatggca ctgtccgcat gggtattctg aacactgaca cactagggaa ttccttgaac
     1981 ggccggagca tgagttggct gcccaatggc tatgtgaccc tgagagataa caaacagaag
     2041 gagccagcag gagagtcagg ccagcacaac agactctcca cctacgacaa tgtccaccag
     2101 cagttctcct cgatgagcct cgacgacaag cacagcgtgg acagtgccac gtggtccacc
     2161 tcctcctgcg aaatctccct ccctgagaac tccaattcct gccgctcctc taccaccacg
     2221 tgcccagagc aagacttcta cgttgggaac tttgaggacc ctgttttaga cggcccacct
     2281 caggatgatc tttcccatcc cggggactat gagaacaaaa gtgaccgcag gagcgtaggg
     2341 ggccgaagca gccgcgccac gagcagcagc gataacagcg agacattcgt gggcaacacc
     2401 agcagcaacc acagtgcact tcacagttta gtttccagcc tgaagcagga gatgaccaaa
     2461 cagaagatcg agtatgagtc caggataaaa agcttagaac agcggaattt gactttggaa
     2521 acggaaatgc tgagcctcca tgacgaactg gatcaagaga ggaaaaagtt caccatgata
     2581 gaaatcaaga tgagaaacgc tgagcgcgca aaggaggatg cggagaaaag gaacgacatg
     2641 ctccagaagg agatggagca gttcttctcc acatttggag acctgacagt ggaacccagg
     2701 agaagcgaga gaggaaacac aatctggatc cagtgagcct ttctctgtcc tggaccgctc
     2761 gctccgcgga ggactctggg gactccgggg caaacagtgt tggggaacag gtgtgggatc
     2821 aggtggttgg tctgtgtaga gcttcatctg gtgcaggaat ctcatttcca gacatcacta
     2881 tccatatctg cagtgtgtac caaagttata tcatgctcca taatgctact gtcaagtgtt
     2941 acaactggat atgtgtatag agagtagttt ctaagatgtc aataagagta agaagcatat
     3001 atctcaatga ttattttatt gcaagtcctg tatttaaatg tcgaatcaat actttgttgc
     3061 aatttagctt gcattcaagc ttcaccccgt gcacttaaca taagctattt ttggcatcgt
     3121 gttatcatct gcttatttta tagatcaata tttttatttc cccttttgtc gaggaaatgg
     3181 agataagaag agatataaat atataaatat atataagatg agttattaaa gtcaaaagaa
     3241 tactttgtgg ctgtgctgtt tgtgccaata gaccttgcca tgaccaaaaa agagcaatgt
     3301 aaaacaaaaa aattcatttt ataaaatata gtagagtcac caggtaaaaa aaa
//
