LOCUS       NM_153800               2598 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Rho GTPase activating protein 22 (Arhgap22), mRNA.
ACCESSION   NM_153800
VERSION     NM_153800.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Longatti,A., Ponzoni,L., Moretto,E., Giansante,G., Lattuada,N.,
            Colombo,M.N., Francolini,M., Sala,M., Murru,L. and Passafaro,M.
  TITLE     Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice
  JOURNAL   Mol Neurobiol 58 (12), 6092-6110 (2021)
   PUBMED   34455539
  REMARK    GeneRIF: Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice.
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2598)
  AUTHORS   Hoch,R.V., Lindtner,S., Price,J.D. and Rubenstein,J.L.
  TITLE     OTX2 Transcription Factor Controls Regional Patterning within the
            Medial Ganglionic Eminence and Regional Identity of the Septum
  JOURNAL   Cell Rep 12 (3), 482-494 (2015)
   PUBMED   26166575
REFERENCE   5  (bases 1 to 2598)
  AUTHORS   Aitsebaomo,J., Wennerberg,K., Der,C.J., Zhang,C., Kedar,V.,
            Moser,M., Kingsley-Kallesen,M.L., Zeng,G.Q. and Patterson,C.
  TITLE     p68RacGAP is a novel GTPase-activating protein that interacts with
            vascular endothelial zinc finger-1 and modulates endothelial cell
            capillary formation
  JOURNAL   J Biol Chem 279 (17), 17963-17972 (2004)
   PUBMED   14966113
  REMARK    GeneRIF: a multifunctional regulatory protein with Rac1-specific
            GTPase-activating activity; regulates transcriptional activity of
            the endothelin-1 promoter; involved in the signal transduction
            pathway regulating endothelial cell capillary tube formation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046097.1, AK078218.1 and BB370610.1.
            
            [WARNING] On Mar 20, 2025 this sequence was replaced by
            NM_153800.5.
            
            On Mar 13, 2009 this sequence version replaced NM_153800.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AK046097.1         2-276
            276-1590            AK046097.1         278-1592
            1591-1938           AK078218.1         1480-1827
            1939-2595           AK046097.1         1941-2597
            2596-2598           BB370610.1         279-281
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.15 cM"
     gene            1..2598
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /note="Rho GTPase activating protein 22"
                     /db_xref="GeneID:239027"
                     /db_xref="MGI:MGI:2443418"
     exon            1..23
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            24..183
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2240
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /note="rho-type GTPase-activating protein 22"
                     /codon_start=1
                     /product="rho GTPase-activating protein 22"
                     /protein_id="NP_722495.3"
                     /db_xref="CCDS:CCDS26926.2"
                     /db_xref="GeneID:239027"
                     /db_xref="MGI:MGI:2443418"
                     /translation="MLPTASSKRRTFAARYFTRSKSLVMGEQSRSPGRPLVPHKLGPV
                     LKAGWLRKQRSIMKNWQQRWFVLRGDQLFYYKDKDESKPQGFISLQGTQVTELLPDPE
                     DPGKHLFEITPGGATEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGRGIFG
                     QRLEDTVHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDC
                     GEKPLFDSTTDVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELA
                     KQVSNLPQANYNLLRYICKFLDEVQAHSDVNKMSVQNLATVFGPNILRPQIEDPVTIM
                     EGTSLVQHLMTVLIRKHGQLFAATSLEEPASPHGTVEWGSEEVTRDHRGEPGSPGLPT
                     HRTSSLDGPAAAVLSRTSPPRLGSQTGPAATSPGKKMHTLPVWKSSFRQQGSRSESPK
                     GVNSSLEVPIISSGGNWLINGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPPSSQF
                     SSTASVASTSWSVASSSREASVSSCTACRASNSSACSSLHTEWALEPSPLPSSSEGHQ
                     SPDLGHSLDEPCVGSGSSEPNDPGSPTQAHVRRCRALQGQVAELRAELCQQRTEYKRS
                     LKSIEEGSADLRKQMSRLEEELDQERKKYAMLEIKLRNSERAREDAERRNQLLQREME
                     EFFSTLGSLTTGTKGSRAPE"
     exon            184..383
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..471
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..600
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..808
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..941
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1015
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1137
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..2011
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2598
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2577..2582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /note="hexamer: ATTAAA"
     polyA_site      2596
                     /gene="Arhgap22"
                     /gene_synonym="B230341L19Rik; p68RacGAP; RHOGAP2"
                     /note="major polyA site"
ORIGIN      
        1 aagtctgctc tcagatcccc aagatgctga tcgcctgcta ctgaaactgg gaattagctt
       61 gtctgcctga ggatgtggct gctgccttcc agagaagaca caggagaaat ctgcacactg
      121 ccagcctagc aatgctgccg acggcttcca gcaaaagaag aaccttcgct gccagatact
      181 tcactcgctc gaagagcctg gtgatgggag aacagagccg gagcccaggg aggcccctgg
      241 tcccccacaa gctgggccct gtactcaagg ccggctggct gaggaagcag aggagtatca
      301 tgaagaactg gcagcagcga tggtttgtgc tacgagggga tcagctcttc tactacaaag
      361 acaaagatga aagcaagccc cagggattta tttctctaca agggacacaa gtgaccgaac
      421 ttcttccaga ccctgaggac ccaggaaagc acctgtttga gattacgcca ggtggtgcca
      481 cagagcggga gaaggtgcca gccaacccgg aggcgctcct gctcatggcc agctcccagc
      541 gggatatgga ggactgggtg caggccatcc gccgtgtcat ctgggccccg ctgggcagag
      601 ggatctttgg ccagcggcta gaggacacag tgcaccatga gcggaagttt ggtccccggc
      661 tggcacctct gctggtggag cagtgtgtgg acttcatccg ggagcgagga ctcagtgaag
      721 agggcctctt ccggatgcct ggccaggcca acctggtgag ggacctgcag gattccttcg
      781 actgtgggga gaagccgctg tttgacagca ccacagacgt gcacacagtg gcctccctgc
      841 tgaagctcta ccttcgggag ctcccagagc ccgtcatccc tttcgccagg tatgaggact
      901 tcctcagctg cgcccagctg ctcaccaagg acgaggggga ggggactgta gagttggcta
      961 aacaagtgag caaccttcct caggccaact acaacctgct cagatacatc tgcaagtttc
     1021 tggatgaagt gcaggcccac tcagatgtca ataagatgag tgtccagaac ttggcaactg
     1081 tctttggtcc taacattctt cggccacaga tagaggatcc agtaaccatc atggaaggca
     1141 cgtctctggt tcagcatctg atgactgtcc tcatccgcaa acatggacag ctctttgctg
     1201 caacctccct tgaagaacct gcttcaccac atggcacagt agagtggggc tctgaagagg
     1261 tcaccaggga tcaccggggt gagcctggca gccctggctt gcccacacat aggacttcat
     1321 ctctggatgg gccagctgca gcagtgctat ctagaacttc gccgccgcgc cttggcagcc
     1381 aaactggccc cgcagccacc agccctggga agaagatgca cactttgcct gtctggaagt
     1441 cttcttttcg gcagcaggga tcccggtcag agagccccaa aggggtcaac tcatccttag
     1501 aggtacccat catctcctct ggtgggaact ggctcataaa cgggctatcg tctcttcgca
     1561 gccaccgtcg ggcctcatcg ggggaccgcc ttaaagatac aggctcggca cagagactct
     1621 ccacctatga caatgtgccg ccatctagcc aattttctag cactgccagc gtggccagca
     1681 cgtcatggtc tgtagcctcg tcctcccgag aggcctctgt cagcagctgc acagcctgcc
     1741 gggccagcaa ctcttctgcc tgcagctcct tacacaccga gtgggctctc gagccctctc
     1801 ctctccccag cagcagtgag ggccaccagt ccccggacct gggccacagc ctggatgagc
     1861 catgtgtggg cagtggcagc agtgagccca atgacccagg cagccccaca caggcccatg
     1921 ttcgccgctg ccgggctctc cagggccagg tggccgagct cagggcagag ttgtgtcagc
     1981 agaggactga gtacaagagg agcctgaaaa gcatcgagga gggcagtgct gacctgcgga
     2041 agcagatgtc tcggttggaa gaggagctgg accaggagag gaagaagtat gccatgctgg
     2101 agatcaagct ccggaactcg gagcgagccc gggaggatgc ggagcgcagg aaccagctgc
     2161 tgcagaggga gatggaggag ttcttctcca ccctggggag cttgactaca gggaccaagg
     2221 ggtccagagc cccggagtga aaggagcaga ggcacgcgtc tgtctatgtc tgctcacgtt
     2281 tcctgcaggg ctggccacag tgcagaggaa gccagaagct tcaagtttgg gccaggccac
     2341 cagcagggcc atctgcctcc aagtgccaga gagagggagc ctgacaccag gatggggact
     2401 gtcagtatcc ccaagagtcc aggcaggatc tggatacttt tccaaacata cgggtcccag
     2461 caggggtcag aggggatggt gccccaggat catgagcatc cgcctctcat ccaggaagag
     2521 tcctcagtgg ccacccaaaa ggatggcacc ttgagagcca ggccaccaag aactttatta
     2581 aagtgctctg aaagcatg
//
