LOCUS       NM_001408319            7072 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho GTPase activating protein 21 (Arhgap21),
            transcript variant 3, mRNA.
ACCESSION   NM_001408319 XM_006497543
VERSION     NM_001408319.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7072)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7072)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7072)
  AUTHORS   Bernusso,V.A., Vieira,K.P., Duarte,A.S.S., Lescano,C.H.,
            Monica,F.Z., Vicente,C.P., De Paula,E.V., Saad,S.T.O. and
            Lazarini,M.
  TITLE     Deficiency of ARHGAP21 alters megakaryocytic cell lineage responses
            and enhances platelet hemostatic function
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (6), 119012 (2021)
   PUBMED   33727037
  REMARK    GeneRIF: Deficiency of ARHGAP21 alters megakaryocytic cell lineage
            responses and enhances platelet hemostatic function.
REFERENCE   4  (bases 1 to 7072)
  AUTHORS   Ferreira,S.M., Costa-Junior,J.M., Kurauti,M.A., Leite,N.C.,
            Ortis,F., Rezende,L.F., Barbosa,H.C., Boschero,A.C. and Santos,G.J.
  TITLE     ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin
            Secretion Process
  JOURNAL   Front Endocrinol (Lausanne) 11, 599165 (2020)
   PUBMED   33324349
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7072)
  AUTHORS   Zangerolamo,L., Soares,G.M., Vettorazzi,J.F., do Amaral,M.E.,
            Carneiro,E.M., Olalla-Saad,S.T., Boschero,A.C. and
            Barbosa-Sampaio,H.C.
  TITLE     ARHGAP21 deficiency impairs hepatic lipid metabolism and improves
            insulin signaling in lean and obese mice
  JOURNAL   Can J Physiol Pharmacol 97 (11), 1018-1027 (2019)
   PUBMED   31247150
  REMARK    GeneRIF: liver of ARHGAP21-haplodeficient mice are more insulin
            sensitive, associated with higher lipid synthesis and lower lipid
            export
REFERENCE   6  (bases 1 to 7072)
  AUTHORS   Menetrey,J., Perderiset,M., Cicolari,J., Dubois,T., Elkhatib,N., El
            Khadali,F., Franco,M., Chavrier,P. and Houdusse,A.
  TITLE     Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi
            membranes
  JOURNAL   EMBO J 26 (7), 1953-1962 (2007)
   PUBMED   17347647
REFERENCE   7  (bases 1 to 7072)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 7072)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 7072)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7072)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773540.18, BX649226.1 and AL929100.11.
            
            On Jun 15, 2022 this sequence version replaced XM_006497543.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.1488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AL773540.18        5910-6031           c
            123-513             AL773540.18        4760-5150           c
            514-693             BX649226.1         31333-31512         c
            694-718             BX649226.1         28978-29002         c
            719-811             BX649226.1         8786-8878           c
            812-890             BX649226.1         6576-6654           c
            891-945             BX649226.1         3807-3861           c
            946-975             AL929100.11        194273-194302       c
            976-2866            AL929100.11        191034-192924       c
            2867-3025           AL929100.11        182683-182841       c
            3026-3128           AL929100.11        182465-182567       c
            3129-3165           AL929100.11        178875-178911       c
            3166-3291           AL929100.11        176338-176463       c
            3292-3576           AL929100.11        174153-174437       c
            3577-3641           AL929100.11        172259-172323       c
            3642-3778           AL929100.11        172044-172180       c
            3779-3921           AL929100.11        171377-171519       c
            3922-4077           AL929100.11        170954-171109       c
            4078-4156           AL929100.11        170791-170869       c
            4157-4230           AL929100.11        170140-170213       c
            4231-4320           AL929100.11        169974-170063       c
            4321-4446           AL929100.11        166654-166779       c
            4447-4488           AL929100.11        166427-166468       c
            4489-4594           AL929100.11        166008-166113       c
            4595-4626           AL929100.11        164111-164142       c
            4627-7072           AL929100.11        159013-161458       c
FEATURES             Location/Qualifiers
     source          1..7072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 14.6 cM"
     gene            1..7072
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /note="Rho GTPase activating protein 21"
                     /db_xref="GeneID:71435"
                     /db_xref="MGI:MGI:1918685"
     exon            1..122
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            123..513
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            514..693
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            694..718
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            719..811
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            812..890
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            891..945
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            946..975
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            976..2866
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3025
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3128
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3165
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3291
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3576
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3641
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3778
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3921
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4077
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4156
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4157..4230
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4320
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4446
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..4488
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4594
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4626
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4627..7072
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7053..7058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /note="hexamer: AATAAA"
     polyA_site      7072
                     /gene="Arhgap21"
                     /gene_synonym="5530401C11Rik; ARHGAP10"
                     /note="major polyA site"
ORIGIN      
        1 gcgccccgcc gcgggccgag ctgccgagcg gagcccttgc ttcccgcacg cgccccggcc
       61 gcgcttcccg ggagcccgcg ccggcgaccc gcctcaggaa ggggcggagg aaatagtggt
      121 aggaaggctc tccgaaagct gatttttctc tggcctccga gtaacaccgc ctggaagcgg
      181 acctcttctc tctgcacttg gcttccaccc tacctgccaa ggaaacctgt cgcccttgaa
      241 ctttaagact ggagaaatga agagggctaa gtctgttgaa gaaggtattt gaaggggctt
      301 cctgcaaatc gtttttttga ccagtccttc atcgcctcag aatctgctgt ggaattgctt
      361 cccgtttggt gtgtggtggc acttctccaa tgtggactcc aaaggatttg tccctttaca
      421 atttgaaatg aaatgatggc cacacattgg actggtctgc ctgaggaaga tggtgacaaa
      481 ctcaaggcct gtggggcggc ctctgcctgt gaggtgtcaa aaaacaaaga tggaaaagac
      541 caaggtgaac ctgtgtcacc gtctgaagat gagccattct cctggccagg tcccaaaaca
      601 gtcatgctga agagaacatc tcaagggttt ggtttcacat tacgacactt catcgtttat
      661 cccccagagt ctgcaatcca gttttcatat aaggatgaag agaatggaaa cagaggagga
      721 aagcaaagga accgattgga gccgatggat accatatttg ttaaacaagt gaaggaagga
      781 gggccggcct tcgaggctgg cttatgcaca ggtgacagaa ttataaaagt caatggagaa
      841 agtgtcatag gaaagaccta ttcccaagta attgctctca ttcagaacag tgacaccacc
      901 ctggagctca gtgtaatgcc caaggatgaa gacattctcc aagtgctaca atttacaaag
      961 gatgttacag cactggcata ttctcaagat gcatacctga aaggcaatga agcttacagc
     1021 ggcaatgccc gtaatatacc tgaacctcca ccagtttgct atccctggtt gccatcgact
     1081 ccttcagcta ctgcacagcc ggtggaaaca tgccctcctg attcattacc gaacaaacag
     1141 caaaccagtg caccagtcct cacacaacct ggcagggcct atagaatgga aatacaagtg
     1201 cctccgtcac caacagatgt tgcaaagtca aacacagcag tgtgtgtttg caatgagagt
     1261 gtgaggaccg tcattgtgcc ttctgagaag gtggtagact tgctagccaa tagaaacaac
     1321 ccttcaggtc cttcacatag aactgaagag gtaaggtatg gtgtaaatga gcaggcctct
     1381 acaaaagcag catcgagaac aacgtcaccg gcatcagttc ccactgccca tctgattcat
     1441 cagaccacag gctccagatc cttagaacct tctggaattt tacttaaatc tggaaattac
     1501 agtggacatt cagaaggaat ctcaagcagt agatcacaag ccgtggattc ccctcctgtg
     1561 tctgtcaatc actactctgc aaactcccat cagcacatag actggaaaaa ttataagact
     1621 tacaaagaat acattgataa taggagattg cacataggtt gtcggacaat ccaggaaaga
     1681 ctggacagct tacgagctgc atctcagagc gcagcagact ataaccaggt ggtacccacc
     1741 cgcactactc tgcaggtacg acgtcgaagc acctctcatg accgagtgcc ccagtctgtt
     1801 cagatccggc agcgcagtgt atctcaggaa agactggaag attctgtgct gatgaagtat
     1861 tgcccaagga gcgcgtctca aggagcgctg acctcaccgc ctgttagctt caataatcat
     1921 agaactcgtt cgtgggatta catagaggga cagacggaag ccacagccac tgtcaattct
     1981 gaaagtcaga tacctgactc aaatggggaa cgaaaacaga cttacaagtg gagtggcttc
     2041 actgagcagg atgatagacg cggtattcac gaaagaccca ggcagcaaga aatgcacaag
     2101 cctttccgag gctcaaattt gactgtggct cccgttgtta attctgataa caggcgcctg
     2161 gttgggagag gggtaggacc tgtctcacag tttaaaaaaa tcccgccgga cctaagacca
     2221 ccacattcca acagaaattt tccaaccacg actggggtgt cacttcaacg gggtattgca
     2281 caagacaggt ccccactcgt gaaagtccga agtaattctc tgaaagtgcc acctccacct
     2341 gtgtcaaaac cgtccttcag ccagcactca ctggcttcca tgaaagacca aaggcctgtc
     2401 aatcatctgc atcaacacag tgtgctgagt cagcagacgc agttcagatc cgaaagcacc
     2461 ttcgagcacc agctggagac tgaggtatcc tcgtgtctac caggaacttc tgccaagacc
     2521 agtccacagc tcagtgagaa tttgggaaca tcagacttag aactacctgc catcccaagg
     2581 aatggagata taaacttaca ggaggctgaa attcagcagc cagatgtgct agataataaa
     2641 gaatctgtca ttctaagaga gaaacctcag tctggccgcc agacgccaca gcctttaaga
     2701 catcagtctt acatcctggc agtgaatgac caggagaccg ggtcagacac cacctgctgg
     2761 ctgccaaacg atgcacgcag agaggtccat ataaaaagaa tggaggagag gaaagcttca
     2821 agcaccagcc ctcctggtga ttccctggca tccatccctt ttatagatga gccaaccagt
     2881 cctagcatcg accacgagat tgcacatatt cctgcatctg ctgtcatctc cgcctctact
     2941 gcccacgtcc cctccattgc aactgttccc cccagcctca cgacctctgc tcctttgatt
     3001 cgacgtcagc tctcccacga ccaagaatct gttggacctc ccagcctgga tggccagcac
     3061 agctcaaaga cagaaagatc caaatcctac gatgaaggac tggatgatta tagagaagat
     3121 gcaaaactat cctttaagca cgtgtctagc ctgaagggaa tcaagattac agacagccag
     3181 aagtcatcag aagactctgg atcgagaaag ggttcttcct ccgaggtctt cagtgatgca
     3241 gcccgagaag gctggctcca gttccgacca ctggtcaccg ataagggcaa gagagttggt
     3301 ggcagtattc ggccatggaa acagatgtat gttgtccttc ggggccactc actttacttg
     3361 tacaaagaca gaagagagca gacaacgcca tcagaagaag agcagcccat cagtgtcaac
     3421 gcttgcctga tagacatctc gtacagtgag accaagaggc ggaatgtatt ccgacttacc
     3481 acgtctgact gtgaatgctt gttccaggct gaagacagag atgatatgtt atcatggatc
     3541 aagactattc aggaaagtag caacctaaat gaagaggaca ctggagttac caacagagat
     3601 ctaattagtc gaagaatcaa agagtataac agtctgctga gcaaaacaga acagttgcca
     3661 aaaacacctc gccagagtct tagcatcagg caaactttgc ttggtgctaa atcagagcca
     3721 aagactcaaa gcccacattc tccaaaggag gagtccgaga ggaagcttct cagtaaagat
     3781 gataccagtc cccctaaaga caaaggtact tggagaagag gcattccaag catcgtgagg
     3841 aagacgtttg agaaaaagcc ggccgccaca gggacctttg gagttaggct ggatgactgc
     3901 ccacccgccc acaccaacag gtacattcca ttaatcgttg acatatgttg caaattagtt
     3961 gaagaaaggg gtcttgaata tacaggtatt taccgagttc ccggcaacaa cgcagccatt
     4021 tcaagcatgc aggaagaact caacaagggg atggcagaca ttgacataca agatgataaa
     4081 tggcgagatt tgaatgtgat aagcagttta ctaaaatcct tcttcagaaa gctccctgag
     4141 cctctcttta cgaatgacaa atatgctgac ttcattgagg ccaatcgcaa agaggaccca
     4201 ctggatcggc tacgaacatt aaagagacta attcatgacc tgcctgagca tcattttgag
     4261 acgctcaagt ttctctcggc tcatctgaag acagtggcag agaactcaga aaagaataag
     4321 atggaaccca gaaacctagc gatcgttttt ggtccaactc tagtgagaac atcagaagac
     4381 aacatgaccc acatggtcac gcacatgcct gaccagtata agatcgtaga gactctcatc
     4441 cagcatcatg actggttttt cacagaagaa ggtgccgaag agcctcttac agcagtgcag
     4501 gaggagaaca cagtagactc ccagccagta ccaaacatag atcatttgct caccaacatt
     4561 ggaaggacag gcgtgctccc tggagatgta tcagattcag ctactagtga ctccgcaaaa
     4621 tctaagggct cctggggatc cgggaaggat cagtatagca gggaactgct tgtatcctcc
     4681 atcttcgcag ctgccagtcg caagaggaaa aagccgaaag agaaagccca gcccagcagc
     4741 tctgaggatg agctggacag tgtgttcttt aagaaggaga atacggaaca gagtcacagt
     4801 gagattaaag aagagtccaa aagagaaagc gagacatcag gtagcaagca gagggtcgtc
     4861 gttgccaaag aaagtaacac taagaaagac tcgggtacaa cgaaggagga gaagaagata
     4921 ccgtgggaag aaccatcccc accacacagc tccaaacgca acaggtcacc aaccctcagc
     4981 tgtcgcctgg ccatgctgaa agagggcccc agatcacttc tgacacagaa gccccactgt
     5041 gaagagacag ggtctgactc aggcactctg cttagcacgt cttcccaggc ttcgctcttg
     5101 aggtcctcca ctaaaaaatc caccagtccg gaaaccaagc acagtgagtt tttgtccatt
     5161 gctggtacca ccacctcgga ttattctacc acatcatcca ctacctactt gaccagcctg
     5221 gactccagcc gcctgagccc tgaggtgcag tcagtggccg agagcaaggg ggatgaggct
     5281 gatgacgaga ggagcgagct ggtgagtgaa ggacggccag tggagaccga cagtgagagt
     5341 gagttccccg tgtttcccac caccctgact tcagaccggc tgttccgagg aaaattccag
     5401 gaggttgcca gggtgagccg caggaactcc gaaggcagtg aggccagctg caccgaggga
     5461 agcctcacac cgagtttaga cagccgcagg cagcagttca gctcccatag actgatcgaa
     5521 tgcgacacac tgtccaggaa gaagtctgct cgcttcaagt cagacagtgg gagccccgga
     5581 gacaccagga ctgagaaaga aactcctgcc ctggccaaga tgtttgacgt catgaagaaa
     5641 ggcaagtcga cagggagcct cctcacaccc agcagaagtg aatccgaaaa gcaggaggcc
     5701 acttggaaaa caaaaatagc agatcgttta aaactgagac ccagggcacc cgcagacgac
     5761 atgtttggag ttgggaatca aaaacctact gctgagacag cgaaaaggaa aaacatcaaa
     5821 cgcagacaca cgcttggagg ccacagagat gctactgaga tcagcgtcct gagtttctgg
     5881 aaagctcatg agcagagtgc ggacaaagag tctgaacttt cggctgtgaa tcggttaaaa
     5941 cccaaatgct cagcccagga cctttccatc tcagactggc tcgccaggga gcgcgtccgc
     6001 accagtgcct ccgaccttag cagaggcgaa ggcctcgagc cccaggctga gagccccagc
     6061 gtgctgggaa cacccatcag cacccactca ccaccgtctc agcagcccga agcaagggtt
     6121 gctgctacca gcaccttggc ttcaaccagc cagtcccctc ttttcacacc accacagtca
     6181 cctgaccaaa taaacagaga aagcttccag aacatgagcc aaaatgctag ttctacagct
     6241 aacatccacc cccacaaaca gtctgaaagt ccagacacta aagcagagac tcctccctga
     6301 ctttaagctg ggtctagcca ctctagcaag gaaaaactac tgttacacag tctagtaact
     6361 gtaaatattt ttcttgtacc agaattgtta ttatgcagcc ttgctttggg ctggattcac
     6421 cattttgcac tgtgaaatag ctttacagtg cattactaca gccagaagaa cacacgtata
     6481 tatttaagag tatattggat agttgtatac aaataagcaa ggtgtttgtt gcaactcact
     6541 acataatata ttccccaaat tactgaagaa agtcgctgcc tcctgcagcc aaattgttct
     6601 tttggttcct cactaacaaa agtgcctcat gataaaagta catttgattt ttagggtgcc
     6661 atattgttaa aattagaaaa ttgaataaat gaatgcattt tatcagtaac aagtttcctt
     6721 ccatttacca gttaacacag gtggatacag gacttcaagt ctttagtcat tccagacgga
     6781 tctgagtttt atattcaaac ttttaataca gtttttgagt tttgtgtgac ttgaattttt
     6841 aatctttctg taaaatacgt aataacttaa atgaacatat tctatgtgta tcttttcttc
     6901 agataccaga tttgatataa atgttgtaac ataggtatgt agatagtgta tcctggatgg
     6961 aactggcttc ttactgagaa aaatataatt ctgcatgagg actttatcca aacctgtgtc
     7021 atgcctgtgt gcatacccaa ctaaacactg gaaataaaat tgtcttggtg aa
//
