LOCUS       NM_027667               5150 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Rho GTPase activating protein 19 (Arhgap19),
            transcript variant 1, mRNA.
ACCESSION   NM_027667 XM_129333
VERSION     NM_027667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5150)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5150)
  AUTHORS   Liang,J., Li,K., Chen,K., Liang,J., Qin,T., He,J., Shi,S., Tan,Q.
            and Wang,Z.
  TITLE     Regulation of ARHGAP19 in the endometrial epithelium: a possible
            role in the establishment of uterine receptivity
  JOURNAL   Reprod Biol Endocrinol 19 (1), 2 (2021)
   PUBMED   33407571
  REMARK    GeneRIF: Regulation of ARHGAP19 in the endometrial epithelium: a
            possible role in the establishment of uterine receptivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5150)
  AUTHORS   Leduc,R.Y., Rauw,G., Baker,G.B. and McDermid,H.E.
  TITLE     What Goes Around Can Come Around: An Unexpected Deleterious Effect
            of Using Mouse Running Wheels for Environmental Enrichment
  JOURNAL   J Am Assoc Lab Anim Sci 56 (2), 194-201 (2017)
   PUBMED   28315651
REFERENCE   4  (bases 1 to 5150)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 5150)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 5150)
  AUTHORS   Kooistra,M.K., Leduc,R.Y., Dawe,C.E., Fairbridge,N.A.,
            Rasmussen,J., Man,J.H., Bujold,M., Juriloff,D., King-Jones,K. and
            McDermid,H.E.
  TITLE     Strain-specific modifier genes of Cecr2-associated exencephaly in
            mice: genetic analysis and identification of differentially
            expressed candidate genes
  JOURNAL   Physiol Genomics 44 (1), 35-46 (2012)
   PUBMED   22045912
REFERENCE   7  (bases 1 to 5150)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   8  (bases 1 to 5150)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145557.3 and BC086680.1.
            
            On Jul 28, 2009 this sequence version replaced NM_027667.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086680.1, AK220317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC145557.3         103734-103785
            53-5150             BC086680.1         1-5098
FEATURES             Location/Qualifiers
     source          1..5150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.19 cM"
     gene            1..5150
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /note="Rho GTPase activating protein 19"
                     /db_xref="GeneID:71085"
                     /db_xref="MGI:MGI:1918335"
     exon            1..113
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1542
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 19; rho-type GTPase-activating
                     protein 19"
                     /codon_start=1
                     /product="rho GTPase-activating protein 19 isoform 1"
                     /protein_id="NP_081943.2"
                     /db_xref="CCDS:CCDS37989.1"
                     /db_xref="GeneID:71085"
                     /db_xref="MGI:MGI:1918335"
                     /translation="MAAEAPSGGEAPVCDSGRSDAICNFVICNDSPLRGQPIIFNPDF
                     FVEKLRHEKPEVFTELVVSNITRLIDLPGTELAQLMGEVDLKLPGGAGPAAGFFRSLM
                     SLKRKEKGVVFGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQLLRDALNN
                     GTDIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKIADLMQFDDKGNKTNI
                     PDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVL
                     WPKNVTANDLQENIIKLNTGMAFMIKHSQKLFKAPAYIRECARLYYLGSRTQMSKDDL
                     DLTTSCHNMSFQLARCQRQNRVDPSSQQEETQQHTEEALRELFQHVHNWPDSAKKKQL
                     LRQFHKQSLTQTPGREPSTPRVQKRARSRSFSGLIKRKVLGSQMTSEKKNSSPAPESV
                     AMGELKKASKENMNLFFSGSPAGTVTPTRLKWSEAKREGRKGFF"
     exon            114..379
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            380..460
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            461..670
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            671..897
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            898..984
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1050
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1242
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1341
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1452
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1531
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..5140
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5119..5124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /note="hexamer: ATTAAA"
     polyA_site      5140
                     /gene="Arhgap19"
                     /gene_synonym="4933411B03Rik; mFLJ00368"
                     /note="major polyA site"
ORIGIN      
        1 tctaagggct aaggggcggt gcctgaggcg gggctgcaga ccaagctgcc gcggaagatg
       61 gcggctgagg cgccgagtgg aggggaggcg ccggtctgcg actctggccg gagtgatgcc
      121 atctgcaatt ttgtcatttg caatgactct ccccttcgag gtcagcctat tatcttcaat
      181 cctgactttt ttgtggagaa actccgacat gagaaaccag aggtgttcac cgaattggtg
      241 gtcagcaaca tcacaaggct tattgatttg ccgggaactg agttggctca gctgatgggt
      301 gaagtggacc ttaagctgcc tggaggggct ggcccagcag caggattctt caggtctcta
      361 atgtctctca agcggaaaga aaaaggagtg gtatttggat ctccgttgac ggaggaaggc
      421 attgcccaga tttatcagct gattgaatat ctgcacaaaa acttgcgagt ggagggcttg
      481 tttagagtac caggcaacag tgttcgacag cagcttttga gggatgctct caataacggg
      541 actgatattg acttggattc aggagagttt cactcaaatg atgtggccac gctgctgaag
      601 atgtttctag gagagttacc cgagcccctg ctgacccata aacattttca tgtacacctc
      661 aaaattgctg atctgatgca gtttgatgat aaaggaaata agaccaacat accagacaag
      721 gagcggcaga ttgaggccct gcagctgctc ttcctcatcc tccctccagc caatcgtaac
      781 ttgctaaagt tactgcttga tctcctgtat cagacagcga agaagcaaga caagaataag
      841 atgtctgccc ataaccttgc tcttatgttt gcaccccatg tcctgtggcc caaaaatgtc
      901 actgcaaatg atcttcagga gaatatcata aagttaaaca caggaatggc ttttatgatc
      961 aaacactctc agaaactttt taaggctcct gcttatattc gcgaatgtgc cagattatac
     1021 tatttgggct ccagaactca aatgtcaaag gatgaccttg atctgacaac ctcatgtcat
     1081 aacatgtcct tccagctggc aagatgtcag agacagaaca gggtagatcc ttcctctcag
     1141 caggaggaga cccagcagca cacagaagag gcgctgagag aactcttcca gcatgttcat
     1201 aactggccag actccgcgaa gaagaaacaa cttctcagac agttccataa gcagtctctg
     1261 actcaaacac cagggagaga accttctact cccagggtcc agaagagagc ccgctcacgc
     1321 tccttcagtg ggcttatcaa gcgcaaagtc ctgggcagtc agatgacttc agaaaagaaa
     1381 aacagttctc ctgctccaga gtctgtggcc atgggggaac tgaagaaagc cagcaaagaa
     1441 aatatgaacc tgttcttctc tggctctcca gctgggacag tgacaccaac aagattgaaa
     1501 tggtctgagg cgaagagaga ggggagaaaa ggattctttt gaaggctctc tttattactt
     1561 ctgtcctcta cagtgaagtt tctcttcagt gggacaagtg ttatttctct tctcagtgaa
     1621 gcttggacct gcagctgctt gctgcatttt gacttgtgaa agccaactca taccctgacc
     1681 cgactgatac ctctaacccc ctcactggat gtctctgaag ctgtgcgtct gtggaagtgc
     1741 tgtgctccgt gtttgttttt aatgtcagaa gccactagtg cctgccccag cttacacagt
     1801 gcagcaggta ggcagggcca gccacaccta ctcagtgtgc ttaggtcggt tggtttcttc
     1861 aaacaggata ttttgtgtta attgttagta atatttttaa aagtactgta ggtcttagtg
     1921 gagtattatt atttccaact ggtatttgag gctttcctct gtgtcagtaa ctgcttgttt
     1981 tagaagccat tattttgata attaagcgaa ttacaagtta aatgcttttg accccttttt
     2041 attttaagct tgagtaatct ctttatcttt gtgttcaaag aacttacagc tttcctagac
     2101 aatctattat ttcttgtgtc taatatagag gacttgacct ggcaatgaga aagaggtcag
     2161 tacagtgtat ttaacacatc tcagttatta agctgcaccc catacccctg tcttcccctt
     2221 atgatgtgag atggctgtgt ggttgttacc ttggtgatgt gagatggctg tgtggttgtt
     2281 accttggtga tgtgagatgg ctgtgtggtt gttaccttgg tgatgtgaga tggctgtgtg
     2341 tttgttacct tggtgatgtg agatggctgt gtggttgtta ccttggtgat gtgagatggc
     2401 tgtgtggttg ttacctttgt gatgtgagat ggctgtgtgg ttgttacctt gcttctttca
     2461 ttatcatcct ctcacctaga acatggctgg tgccactgat acactctgtg cctggttact
     2521 gtcactttgg aaatgtcatg atctgctact tagaggagct tgctgcagtg tgcatgtggt
     2581 gaaaacagaa gcaggccgag gggctggttg gcttgggtag gatgctgtca ctcattccta
     2641 gggatcaaat gtgctgctca cctgtctcct gagagcaggt tggcatcagg aaaggcacga
     2701 gtggcagtct ctgcagggtc cccagaggga gcagttgtta tgtgtccccg tagtctagaa
     2761 cagttgcttc ctgcccatct ccttgtctgg atgggtacag gaagtggtgg agcgtggaga
     2821 gccactgtct cctgagccgc aggtggcagt tgcggatgct gaggtatggg cctggctctg
     2881 tggaactaac tgtgaaacca tgctcaccct actgtgggga accagatacc cagcaaaata
     2941 cggttccaca ctgatgatag acagttgaac ttgtgttatt gttgagatga aggctgatgt
     3001 tgtctatctg tcggccctct cttccatcct acactgtttc attgctgtaa cagcagtgct
     3061 gaaggaaatg tgatgttttc ccttctagct ggatagtttg ggagcatgga ggtgtgtgat
     3121 ctatagtgga ttttaagttc cattctctaa agcagtttta ggtcatcctt aaggatcttt
     3181 attagcaaat tcatttgtct aggtttctga ctctttctgg tgatgttgtt actaagaaaa
     3241 aggttctttt ctttttgaaa tatatttctt atgccaggta tatagtgagg tcaaacagaa
     3301 acctcctttg tgttagcaaa tcagagatgt tctcctcagc atggagcctg ctttcagtgt
     3361 accccaccat gctggaatgt agcactatgc agggatgcaa gccaagcagt gccttgatgc
     3421 agccaggagt tacacactct gtgagcaaga aagagagagc gcgggactga ggagcctagt
     3481 gtgggtagag ggaagcgatg cccagggatg gtctgggtga gagagaggtg ccccatgcgc
     3541 ttgctctctg tggctggcct cttgggcagt gagttaccac gtgcatttgg gaatgtggat
     3601 ttcatttatt tattggatag tcattacttg ctgtaagggt attttaggtc attttttctt
     3661 gtagaagctg tgatccagtg cagaatagac ttgaggaaaa gcataacctt ttgagtcttg
     3721 taacatgtgg ctttgtaacc tgtggtatct tcttggaaac gcagacagaa gctccatcgt
     3781 cgtcacagaa ggttgctgcc gtccttctga caaggcgtac agttgctgtt ttgagccagt
     3841 atttaactaa tgtttttaac taatgtttgt ttgagacagg gtttctctgt ggtcctggct
     3901 gtcctggaac tcactctgta gaccaggctg gcctcgaact cagagttttc ctgcctctgc
     3961 ctccccaggg ctgggattaa aggcgtgagt gtagtcactg cctagctgac ctgtgtctta
     4021 agggttttta ttatatttat tttccatgtt ggcgtagtct ttgtgacaga acctttcttt
     4081 tctttctggg ttaatcgtca taggctttga tgttgtgtca aagtgtcatc tggtggttat
     4141 tgttgccaac tatgaagaga cagatcctat ctgatctgta tctgcactag gtaaatgaat
     4201 agaggctgtg ggccctttct ctgacgttcc acagaagtgg attttctcac tgagaccagt
     4261 gatcaggttt gaacccgccc ccgccctgtc cccccattcc ccatgtcaca tgcactgtgt
     4321 agggcacagg tgggagacag tattggttag aaccaagtgc tggaacattc tagaagcaca
     4381 gctgatgggg cctgagggaa cccacagtgg tccctccaca cagcatgtgc tatactctga
     4441 aggtcctccc agagtcagtc aggagtgatg aggaaacacc ctgggggatg aggcagcaca
     4501 ggatgctgac tggcaggttg tgtgctgagg tctcttttct gtgacatcct ttcctctgga
     4561 gacagcatca tccctgctct cctacactct aaagtcttca gactgaagtg agggtccaga
     4621 tctaaaccag caggactgtc ccagagtttg cagagaatct ggcttcctaa gatgaaggtt
     4681 ttgagtgacc ttagtcctgg tagcctgatg tcagactccc tgtcaaaaag ctggctttac
     4741 taggcagcca gtgctgaaag ctgtgtggag gtagggcagt gaggagatgg aggataaata
     4801 ataacctgag tgctttgtca ccatggaaac tggagttcct gaggccacag cccatgctga
     4861 agagcttttg agcatgcccc tgacatgctt ggtccagagg ctatagagaa ggagtgctct
     4921 cacccaaggc ctttcagcaa ggcgtgcctg tgcacgctct gtgtgctcgc tcgctcattt
     4981 gcttgctcac tcgaccccca aaaggtttct taggagaagg ttgtacctat ttgttatttt
     5041 ttattatttt gcatatatat atgtaattgt aaagaaacaa tcatatatat tgtcttttat
     5101 attcatgtaa tattctgaat taaatttttt ctgtttcata aaaaaaaaaa
//
