LOCUS       NM_144529               3503 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Rho GTPase activating protein 17 (Arhgap17),
            transcript variant 1, mRNA.
ACCESSION   NM_144529
VERSION     NM_144529.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3503)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3503)
  AUTHORS   Wu,P.R., Chiang,S.Y., Midence,R., Kao,W.C., Lai,C.L., Cheng,I.C.,
            Chou,S.J., Chen,C.C., Huang,C.Y. and Chen,R.H.
  TITLE     Wdr4 promotes cerebellar development and locomotion through
            Arhgap17-mediated Rac1 activation
  JOURNAL   Cell Death Dis 14 (1), 52 (2023)
   PUBMED   36681682
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3503)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3503)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3503)
  AUTHORS   Rue,L., Banez-Coronel,M., Creus-Muncunill,J., Giralt,A.,
            Alcala-Vida,R., Mentxaka,G., Kagerbauer,B., Zomeno-Abellan,M.T.,
            Aranda,Z., Venturi,V., Perez-Navarro,E., Estivill,X. and Marti,E.
  TITLE     Targeting CAG repeat RNAs reduces Huntington's disease phenotype
            independently of huntingtin levels
  JOURNAL   J Clin Invest 126 (11), 4319-4330 (2016)
   PUBMED   27721240
REFERENCE   6  (bases 1 to 3503)
  AUTHORS   Galic,M., Jeong,S., Tsai,F.C., Joubert,L.M., Wu,Y.I., Hahn,K.M.,
            Cui,Y. and Meyer,T.
  TITLE     External push and internal pull forces recruit curvature-sensing
            N-BAR domain proteins to the plasma membrane
  JOURNAL   Nat Cell Biol 14 (8), 874-881 (2012)
   PUBMED   22750946
REFERENCE   7  (bases 1 to 3503)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 3503)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3503)
  AUTHORS   Harada,A., Furuta,B., Takeuchi,K., Itakura,M., Takahashi,M. and
            Umeda,M.
  TITLE     Nadrin, a novel neuron-specific GTPase-activating protein involved
            in regulated exocytosis
  JOURNAL   J Biol Chem 275 (47), 36885-36891 (2000)
   PUBMED   10967100
REFERENCE   10 (bases 1 to 3503)
  AUTHORS   Bedford,M.T., Sarbassova,D., Xu,J., Leder,P. and Yaffe,M.B.
  TITLE     A novel pro-Arg motif recognized by WW domains
  JOURNAL   J Biol Chem 275 (14), 10359-10369 (2000)
   PUBMED   10744724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161636.1, AK152266.1, AK147010.1, AI842721.1 and AV321044.1.
            
            On Mar 12, 2008 this sequence version replaced NM_144529.1.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147010.1, AB060553.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AK161636.1         2-65
            65-1599             AK152266.1         2-1536
            1600-1833           AK147010.1         1571-1804
            1834-2519           AK152266.1         1537-2222
            2520-2992           AK152266.1         2271-2743
            2993-3361           AK147010.1         2964-3332
            3362-3481           AI842721.1         23-142              c
            3482-3482           AV321044.1         240-240
            3483-3503           AI842721.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..3503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 67.42 cM"
     gene            1..3503
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /note="Rho GTPase activating protein 17"
                     /db_xref="GeneID:70497"
                     /db_xref="MGI:MGI:1917747"
     exon            1..162
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            163..202
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            203..307
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            308..381
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            382..493
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            494..570
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            571..682
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            683..751
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            752..833
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            834..961
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1073
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1155
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1236
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1350
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1442
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1599
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1833
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2003
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2519
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..3487
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /note="hexamer: AATAAA"
     polyA_site      3032
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /note="major polyA site"
     regulatory      3340..3345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /note="hexamer: AATATA"
     polyA_site      3365
                     /gene="Arhgap17"
                     /gene_synonym="5730403H17Rik; Nadrin; Nadrin2; Rich1;
                     Wbp15"
                     /note="major polyA site"
ORIGIN      
        1 gtagcctccg tcaccgcctc cggggccggg aagcgatgta ggtaggaccc gccagacggt
       61 ccccagttct cctccgcccg cctgccgcgc cgccaccgcc gccgccgcca tgaagaagca
      121 attcaaccgc atgaagcagc tggccaatca gactgtcggc agagctgaga agaccgaagt
      181 cctcagtgaa gatctgctac agattgaacg tcgcctggac actgtgcgtt caatgtgcca
      241 ccattcacat aagcgtttga tagcctgctt ccaaggtcag catggcactg atgccgagag
      301 gagacataaa aagcttcctc tgacagctct tgcccagaac atgcaggagg cttcagccca
      361 gctggaagag tctctcttgg ggaagatgct ggagacctgt ggggacgctg agaaccagct
      421 ggctcttgaa ctctcacaac atgaagtctt tgtggagaag gagatcatgg accctctcta
      481 cggcatagca gaggtggaga ttcccaatat ccagaagcaa aggaagcagc ttgctagatt
      541 ggtgttggac tgggattcag tcagagcgag atggaaccaa gcacacaagt cttcaggaac
      601 caactttcag gggcttccat ccaaaataga taccctaaag gaagagatgg atgaagctgg
      661 gaataaagtt gaacagtgca aggatcaact tgcagcagac atgtacaact tcatggccaa
      721 agaaggggag tatggcaagt tcttcgtgac gttattagaa gcccaagcag attaccatag
      781 aaaagcatta gcagtcttag aaaaggccct tcccgaaatg cgcgcccatc aagataagtg
      841 ggcagagaag ccagccttcg gcacacctct ggaggaacac ctgaagagga gtgggcgtga
      901 gatcgccctg cctattgagg cctgtgtcat gttgttgctg gagactggca tgaaagagga
      961 gggccttttt cggattggag ctggagcctc caagttgaag aagctgaaag ctgctctcga
     1021 ctgctccaca tcgcatctgg atgaattcta ttctgatccc catgctgtcg caggtgcttt
     1081 aaagtcctat ctgcgggagt tgcctgagcc cttaatgact ttcagtctgt atgaagaatg
     1141 gacacaagtt gcaagtgtgc aggatcaaga caaaaaactt caatatttat ggacaacatg
     1201 tcagaagttg ccgccacaaa attttgttaa ctttaggtat ttaatcaagt tccttgcaaa
     1261 gcttgcccag accagtgacg ttaataaaat gactcctagc aacatagcca ttgtcctggg
     1321 ccctaacctc ctgtgggcca aacaagaagg aacgctggct gaaatagcgg ctgccacatc
     1381 ggtccacgtg gttgcagtga ttgagcccat catccagcat gcagattggt tcttccctgg
     1441 agaggtagaa ttcaatgtat cagaagcatt tgtgccactt gctaccccga attctaatca
     1501 ctcatcccat actggaaatg actctgactc ggggactctg gagaggaagc gacctgccag
     1561 catggcagtg atggaagggg acttggtgaa gaaggagagc tttggtgtga agctaatgga
     1621 cttccaggcc caccggcggg gtggcactct aaatagaaag cacatagccc ccgctttcca
     1681 gccgccactc ccgcccacgg atggcaacgc cttggctcca gcaggcccag agcccccttc
     1741 tcagagctct agggctgaca gcagctcagg gggtgggcct gtcttctctt ctacgggcat
     1801 attggagcag gggctgagcc caggtgacag cagtcctcca aaacccaaag actccgtgtc
     1861 tgcagctgtc cctgcagcag gaaggaacag caaccagatg accacggtcc caaaccaggc
     1921 tcagacaggt ggcaactccc atcagctctc agtaagcaca cctcacagtg cagccggtcc
     1981 cagcccgcac actctgcgtc gggctgtgaa gaaacctgcc cccgcacccc ccaaaccagg
     2041 aaacctacct cctggccacc ctggaggaca gagctctcct ggcacaggca catccccaaa
     2101 gccaagcgcc cgaagcccat caccgcctca gcagcagcag cagcagcaac aacagcagca
     2161 acaacagcag cagcagcaga ccccaggcat gcgccgctgc tccagcagcc tgcctcccat
     2221 ccaggcaccc agccacccac caccacagcc ccccacacag cctcggttgg gtgaacaggg
     2281 accagagcca ggccccacgc cacctcaaac ccccacacca cctagcaccc cacccctggc
     2341 caagcagaat ccatcgcaaa gtgagaccac acagctgcac ggaaccctcc caagaccacg
     2401 gccagtgccc aagccccgca accggcctag cgtgccacca cccccacatc cacctggcac
     2461 ccacacggtg gatggtggcc ttacatcctc agtgcccaca gcctccagaa tcgtcactga
     2521 caccaattct agggtttctg aatcacttcg cagcatcttt cctgaaatac attcagactt
     2581 ggcaagcaaa gaagtgcctg gccacatcct gctggacata gacaatgaca cagaaagtac
     2641 tgcattgtga agaaagccac ttgtcagcct ttggccctcc atcccagtga acggaactgg
     2701 gtcaggcaag cctctgtctc tgcagaccaa acagtgagaa gcttttagtg ggggaaggaa
     2761 ggtctgacta cgaaggacta gactcccacg gcccaaggag aaggtgaggg ccagtcctca
     2821 aagctgaatg acctgtgtcg taaagaagtt ggcttgcttt atctaggatg aaaatcatgc
     2881 caaaaatgat caggacaaag aaataccgac agcaggagta ttactgctga gaggtgtatg
     2941 ggaagctgtt gccagagctg tcagctcaga cagctctgat tgtgactaag aagagactta
     3001 cctatctatt taataaaaca ttaattatgc aagttgccta cttcctgcta cttggacttt
     3061 ggttctcaca taccagaagg agcttccatt ccttcagact tgctgcagaa tcattttgta
     3121 ttaaatagtc tgtctcctcc aacccccaga acctcgagca ttggcgactg ctggctctgt
     3181 cgcctcagca gaatggatgc aagtcgtgcc ttgtggattg ccagaatatg gagagaaata
     3241 taccgttctt tttaaaaaaa aaaacaaaac aaaacaaaac tataattgct acttgataaa
     3301 gagcgaatgt tattctagtt tcatgtttaa tttgaattaa atatattctg tggtttatat
     3361 gaaaacttgc taattcttag aggcaaattc tgggatatat acatttgtgt ttgtgcatat
     3421 atgtgcatgt gtgagcttgc ctgtgtgttt gtctatagga atttgaaaca ataaagagat
     3481 gctagcaaaa aaaaaaaaaa aaa
//
