LOCUS       NM_001039692            5034 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus Rho GTPase activating protein 12 (Arhgap12),
            transcript variant 1, mRNA.
ACCESSION   NM_001039692
VERSION     NM_001039692.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5034)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   2  (bases 1 to 5034)
  AUTHORS   Wang,X., Cheng,Z., Xu,J., Feng,M., Zhang,H., Zhang,L. and Qian,L.
  TITLE     Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity
            by sponging miR-135a-5p
  JOURNAL   Life Sci 265, 118788 (2021)
   PUBMED   33245966
  REMARK    GeneRIF: Circular RNA Arhgap12 modulates doxorubicin-induced
            cardiotoxicity by sponging miR-135a-5p.
REFERENCE   3  (bases 1 to 5034)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   4  (bases 1 to 5034)
  AUTHORS   Rudnicki,A., Isakov,O., Ushakov,K., Shivatzki,S., Weiss,I.,
            Friedman,L.M., Shomron,N. and Avraham,K.B.
  TITLE     Next-generation sequencing of small RNAs from inner ear sensory
            epithelium identifies microRNAs and defines regulatory pathways
  JOURNAL   BMC Genomics 15 (1), 484 (2014)
   PUBMED   24942165
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5034)
  AUTHORS   Gentile,A., D'Alessandro,L., Lazzari,L., Martinoglio,B.,
            Bertotti,A., Mira,A., Lanzetti,L., Comoglio,P.M. and Medico,E.
  TITLE     Met-driven invasive growth involves transcriptional regulation of
            Arhgap12
  JOURNAL   Oncogene 27 (42), 5590-5598 (2008)
   PUBMED   18504429
  REMARK    GeneRIF: ARHGAP12 inactivates RAC1, thereby impairing cell
            motility, invasion and adhesion to the extracellular matrix. The
            gene is transcriptionally suppressed by Hepatocyte Growth Factor in
            human and murine cell lines.
REFERENCE   6  (bases 1 to 5034)
  AUTHORS   Matsuda,M., Kobayashi,Y., Masuda,S., Adachi,M., Watanabe,T.,
            Yamashita,J.K., Nishi,E., Tsukita,S. and Furuse,M.
  TITLE     Identification of adherens junction-associated GTPase activating
            proteins by the fluorescence localization-based expression cloning
  JOURNAL   Exp Cell Res 314 (5), 939-949 (2008)
   PUBMED   18241859
  REMARK    GeneRIF: Immunofluorescence staining and confocal laser-scanning
            microscopy demonstrated that Arhgap12 localizes at epithelial
            cell-cell adherent junctions in various mouse tissues.
REFERENCE   7  (bases 1 to 5034)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (bases 1 to 5034)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 5034)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077063.1, AK031648.1, BC037608.2 and AC168050.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077063.1, AK031648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AK077063.1         2-160
            160-533             AK031648.1         4-377
            534-1087            BC037608.2         326-879
            1088-3718           AK031648.1         932-3562
            3719-5034           AC168050.2         156999-158314       c
FEATURES             Location/Qualifiers
     source          1..5034
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.46 cM"
     gene            1..5034
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /note="Rho GTPase activating protein 12"
                     /db_xref="GeneID:75415"
                     /db_xref="MGI:MGI:1922665"
     exon            1..295
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            296..332
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            333..1087
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2926
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 12; rho-type GTPase-activating
                     protein 12"
                     /codon_start=1
                     /product="rho GTPase-activating protein 12 isoform 1"
                     /protein_id="NP_001034781.1"
                     /db_xref="CCDS:CCDS37723.1"
                     /db_xref="GeneID:75415"
                     /db_xref="MGI:MGI:1922665"
                     /translation="MAERSGKITAGQAYIEVEYDYEYDAKDRKIVIRQGERYLLVKKT
                     NDDWWQVRPDENSKAFYVPAQYVKEVTRKALMPPVKQATGLPNNSMKTIQSMHLQRST
                     ENVNKMPELSSFGKPSSSVQGTGLIRDANQNFGSNYNSGQTLNLSLDLTHNNGKFNSD
                     SHSPKVSSQNRTRLFGHFPGPEFLDIEKTSFSQEQSCDSAGEGSERIQQDSESGDELS
                     SSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQVNGEWETHKDSS
                     GRCYYYNRTTQERTWKPPRWARDVSTSRDFQSPGEQEPLSSEENYHSSCFSQSDSQCG
                     SPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASS
                     QQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTTTKLCLPENESPPTSSK
                     HQDPGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQS
                     KPEFTVDLKGAVIEMASKDKSSKKNVFELKTRQGTELLIQSDNDAVINDWFKVLSSTI
                     NNQVAEADEAAEEETPDSPGVEKHDKEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKK
                     FLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDVDGI
                     YRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFN
                     DFVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAI
                     VFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR"
     exon            1088..1348
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1489
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1570
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1696
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1771
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1833
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1915
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2017
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2116
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2219
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2336
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2435
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2513
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2648
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2751
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..5034
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4247..4252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4265
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /note="major polyA site"
     regulatory      5000..5005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5034
                     /gene="Arhgap12"
                     /gene_synonym="2810011M08Rik"
                     /note="major polyA site"
ORIGIN      
        1 atccccctct taagcgtctc gccacacctt ctcacgtccc tccgccccgc cctcccggga
       61 gaccaccagc ccctctcgtc acgtggccaa atgtcccgcc cctgcttgtg cctgccccac
      121 ccccgcgccg gcgcgcttcg acgtgccctg gaacttaccc tccctcagag accagcctgc
      181 ggggacgccc ggttgtagtt gcggccgagt gagcgctctt caggcggtct cttagtcgct
      241 cggccacagc attggatgag gagggagctg cccgtcgcga ggtctgcgac ccttggttta
      301 aatgaaacac cagatgttta cagccttcca agtgttatat taatgcatcg aggcacaagg
      361 cataatgtgg catgctatct gttttgagag tgagtattac tgagtagaaa tggccgagag
      421 aagtggaaag atcactgcag gacaagcgta tattgaggtg gagtatgatt atgagtatga
      481 cgcaaaggac agaaagattg tgatcagaca aggggagcgc tacctcctgg tgaagaagac
      541 caatgatgac tggtggcaag tcagacctga tgagaactca aaagcatttt atgtgccagc
      601 acagtatgtc aaggaggtca ctcgcaaagc tctgatgcca cctgtgaagc aggcaacagg
      661 actgccaaat aactctatga agacaataca gagtatgcat ctccagagat cgacagaaaa
      721 tgtgaacaaa atgcctgagc tttcaagttt tggaaagcca tcgtcatctg ttcaaggaac
      781 aggtcttatt cgtgatgcca atcagaattt cggatccaat tataattcag gccagactct
      841 caacctaagc ctggacctga cccataataa tggaaagttt aacagtgact cacattctcc
      901 taaagtttcc agccagaata ggacacgctt atttggtcat tttcccgggc cagagttctt
      961 ggacatagag aaaactagct tctctcagga acagtcatgt gactcagctg gagaaggctc
     1021 cgaaagaata cagcaggatt ccgagtctgg agatgaactt agcagcagct ccactgagca
     1081 gatgagggca accacacccc ctaatcaagg aaggccagat tctccagtct atgctaacct
     1141 acaggaactg aaaatatcac agtctgctct tcctcctctt cctgggagcc cagcaattca
     1201 agttaatggg gaatgggaga ctcacaaaga cagttcaggc cgttgttact actataaccg
     1261 cacaacccag gagcgaacct ggaaaccacc tcgatgggct cgagatgtga gcacaagccg
     1321 agattttcag agcccaggag agcaagagcc tctttcatca gaagaaaact accacagcag
     1381 ttgtttcagc cagtcagata gtcagtgtgg ctctcctccc aggggttggt cagaagagct
     1441 ggatgaacgt gggcatacct tgtataccag tgactatact aaggaaaagt ggctcaagca
     1501 tgttgatgat caaggtagac agtattacta cagcgcagat ggatctcggt cagagtggga
     1561 attgccaaag tataatgctt catctcagca gcaaagagaa ataattaaaa gtaggagctt
     1621 ggacaggcgg ctgcaagaac caatagtgtt aactaaatgg agacatagca ccattgtgtt
     1681 ggactccaac gacaaggatt ctccaactac cacaaaactc tgcttacctg aaaatgaatc
     1741 tcctcctact tcatcaaagc atcaagatcc aggtcaggag aaatatggac tgttaaatgt
     1801 aacaaaaatt actgaaaatg ggaaaaaagt tcgaaagaac tggttgtctt cttgggcagt
     1861 gctgcagggt tcgtctttac tttttacgaa aactcaagga agtagtacaa gctggtttgg
     1921 gagtaatcag tccaaaccag aattcacagt ggacctgaag ggggcagtga ttgaaatggc
     1981 atcaaaggac aaatcgagca agaagaatgt atttgagctg aaaactcgac aaggaacaga
     2041 actgctaatt cagtctgata atgatgctgt tattaatgat tggtttaaag ttcttagtag
     2101 tactatcaat aaccaggtag cagaggccga tgaagcagct gaagaggaaa caccagattc
     2161 accaggggta gaaaagcatg ataaagaaaa ggaccagaag gagcttaaaa aacttcgctc
     2221 aatgaaagga tccagcatgg attcttcaga gcagaagaaa actaagaaaa acttaaagaa
     2281 gtttcttacc cggcgcccca ctttgcaagc tgttcgtgag aaaggttata tcaaagatca
     2341 agtatttgga tctaatcttg ctaatctgtg tcagagggag aatgggacag tgccaaagtt
     2401 tgtgaagtta tgcattgagc atgtcgaaga gcatggttta gatgttgatg gtatttacag
     2461 agtgagtggc aaccttgccg tgatccagaa gctgaggttc gcagtcaatc atgatgagaa
     2521 gttggacttg aatgacagta aatgggaaga cattcatgtc atcacgggag cactcaaaat
     2581 gttttttcga gaactaccag aacctctttt tacgtttaat catttcaatg attttgttaa
     2641 tgcaattaaa caagaaccga gacagcgtgt cactgcagtt aaggacctaa tcagacagtt
     2701 gccaaagcca aatcaagata caatgcagat tctgtttaga catctcaaaa gggttataga
     2761 aaatggagaa aaaaaccgaa tgacctatca gagcatagcg attgtttttg gccccaccct
     2821 tctaaagcca gaaagagaga ctggtaatat agcagttcat actgtgtacc agaaccagat
     2881 tgtagagctg attctcctgg aattaagcac tgtctttgga cgttgactct cacaaaagac
     2941 agcctgtgga atagatgctg gattccaaga tttcaaatct tatacgtggt gtgtttcatt
     3001 ttggaccaag cagtgactct gattttgcac ttttttgaga gtgaaggcga cagctgggcc
     3061 ctcatttgct gcttgttgtg agcaaacagc aagttatgac tgtgtaaatt tggattcatt
     3121 ttatcctgga tgcttgcatt tcatcctctg actatcagta aacatcaaaa ctcagaattc
     3181 taaccagtca tatacactgg ataatttggt aaggacaact ctgtgagtcc cctgtggtat
     3241 tgtccttgct gactgcaaac tggataatgt agattccttc tcatggtccg taagctcttt
     3301 acttggtaca atgatactca ctgtcagtta tttttaaaat gctcttgggc atttaagaca
     3361 aatgaagttg atcatttgaa acctgtgtac tgcatatttc agggtgtttg catgagtggc
     3421 agtcttaagt gccgaagctc ataacccaga tagaatccct tgggtgaagg cttgctgtct
     3481 gattttactg tctcatggca ttcttgctag ataccttagt tgtctgttgg agcagcacac
     3541 tgacaggact taaaacactg tgatatactg gagttctggt tagtataagt caaatcaggg
     3601 tatttggtac ctgtcttgct gtactgaatt atagctaata atccttatta tatttagtgc
     3661 catattgagt ttttggtatg acactgtgga gacagacatt gtttgatgta agtatgggct
     3721 aaggacctaa tataatttac cttatgtata taaccgtgtt gtataggctc agagtacatc
     3781 taacccaatg tttctaatca tgacattggt aactgtttcc atgactatta ggcttcctgc
     3841 agatagaggc catgatttgg gaaagttaag ctgtgcactt ttaggtttca attacactta
     3901 gaagcagacc actgcaatga gaatggtact gggaaatact gagtagacct actaaatagt
     3961 gaacacacta caggagcagc tccttaggtt atttaatgtg tacagcagac attagaatca
     4021 tcattacaga atcctaaccc agctcaaata gtggaaacat gtaaattgga tgttggatag
     4081 aaaatgacac tgcgaaattt gagtatttcc tttttacatt actactgtag attgatttgt
     4141 acaataagac agggtttgga aggttttgtt acagggaggc atggtctgtt gaagattttt
     4201 aaatgtattt ttctagatta actgctgtat atgaaatgtc taatctaata aaggaaacta
     4261 caatatgctt agagtttttt tccattggaa atgtgcgttt tagttcttaa ttgtgttgtt
     4321 gttttgtttt tatttactgg catactttta tacctcattt tagaaaagtc aaccaaatcc
     4381 atatttcctg tggcagattg acttttctca cttcgtatgt tttctgttct tcctatacca
     4441 acatttccct agcaccacac acttccttat catcagtgtt tgaaaggaaa tgatttctga
     4501 ccatgattct ttttcctagg attgcattta tagtttccag attgccttcc tggggaacaa
     4561 tttgtgtgtg tgtgtgtatg atctgtccaa aacctttctc ctaagtcctg tggctaatat
     4621 cttgtgtgtg tcgttgtaat cttcttaaat aggtaacaaa ctaagctgtt tgacagctca
     4681 cgcagattgc tttgggtggg gaaaaattct aaaccagaat gtgtaacctg aagatgccat
     4741 taataacgca gtgtgcttta gggctcttgt gtcttgactg tgtaccagga aatcaattag
     4801 actcaaatct gtgatatgtg ctgttctttc tcttggtgat cataaacatg tcaaaggttt
     4861 aaaattgtcc tgtgtttctt gtttcaaagt acatgtgtgt atgcaaagtc tttaatgttg
     4921 tattggtcta ccactaataa ttgtattgta atagtgtatg tacaatgaga taagtgtctt
     4981 gtgttttcat cctttgtgaa ttaaaaatta ttgattgttt ttataataac aaaa
//
