LOCUS       NM_181416               5017 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus Rho GTPase activating protein 11A (Arhgap11a), mRNA.
ACCESSION   NM_181416
VERSION     NM_181416.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5017)
  AUTHORS   Xing,L., Gkini,V., Nieminen,A.I., Zhou,H.C., Aquilino,M.,
            Naumann,R., Reppe,K., Tanaka,K., Carmeliet,P., Heikinheimo,O.,
            Paabo,S., Huttner,W.B. and Namba,T.
  TITLE     Functional synergy of a human-specific and an ape-specific
            metabolic regulator in human neocortex development
  JOURNAL   Nat Commun 15 (1), 3468 (2024)
   PUBMED   38658571
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5017)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5017)
  AUTHORS   Huang,Y.R., Xie,X.X., Yang,J., Sun,X.Y., Niu,X.Y., Yang,C.G.,
            Li,L.J., Zhang,L., Wang,D., Liu,C.Y., Hou,S.J., Jiang,C.Y., Xu,Y.M.
            and Liu,R.T.
  TITLE     ArhGAP11A mediates amyloid-beta generation and neuropathology in an
            Alzheimer's disease-like mouse model
  JOURNAL   Cell Rep 42 (6), 112624 (2023)
   PUBMED   37302068
  REMARK    GeneRIF: ArhGAP11A mediates amyloid-beta generation and
            neuropathology in an Alzheimer's disease-like mouse model.
REFERENCE   4  (bases 1 to 5017)
  AUTHORS   Pilaz,L.J., Liu,J., Joshi,K., Tsunekawa,Y., Musso,C.M.,
            D'Arcy,B.R., Suzuki,I.K., Alsina,F.C., Kc,P., Sethi,S.,
            Vanderhaeghen,P., Polleux,F. and Silver,D.L.
  TITLE     Subcellular mRNA localization and local translation of Arhgap11a in
            radial glial progenitors regulates cortical development
  JOURNAL   Neuron 111 (6), 839-856 (2023)
   PUBMED   36924763
  REMARK    GeneRIF: Subcellular mRNA localization and local translation of
            Arhgap11a in radial glial progenitors regulates cortical
            development.
REFERENCE   5  (bases 1 to 5017)
  AUTHORS   Xing,L., Kubik-Zahorodna,A., Namba,T., Pinson,A., Florio,M.,
            Prochazka,J., Sarov,M., Sedlacek,R. and Huttner,W.B.
  TITLE     Expression of human-specific ARHGAP11B in mice leads to neocortex
            expansion and increased memory flexibility
  JOURNAL   EMBO J 40 (13), e107093 (2021)
   PUBMED   33938018
REFERENCE   6  (bases 1 to 5017)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   7  (bases 1 to 5017)
  AUTHORS   Pavel,E., Zhao,W., Powell,K.A., Weinstein,M. and Kirschner,L.S.
  TITLE     Analysis of a new allele of limb deformity (ld) reveals tissue- and
            age-specific transcriptional effects of the Ld Global Control
            Region
  JOURNAL   Int J Dev Biol 51 (4), 273-281 (2007)
   PUBMED   17554679
REFERENCE   8  (bases 1 to 5017)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 5017)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058105.1, BU052980.1 and AL772405.11.
            
            On May 24, 2006 this sequence version replaced NM_181416.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.4076.1,
                                           SRR10223969.2775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1907              BC058105.1         1-1907
            1908-2597           BU052980.1         1-690
            2598-5017           AL772405.11        109209-111628       c
FEATURES             Location/Qualifiers
     source          1..5017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.47 cM"
     gene            1..5017
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /note="Rho GTPase activating protein 11A"
                     /db_xref="GeneID:228482"
                     /db_xref="MGI:MGI:2444300"
     exon            1..701
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     CDS             573..3536
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /note="GAP (1-12); rho-type GTPase-activating protein 11A"
                     /codon_start=1
                     /product="rho GTPase-activating protein 11A"
                     /protein_id="NP_852081.2"
                     /db_xref="CCDS:CCDS16562.1"
                     /db_xref="GeneID:228482"
                     /db_xref="MGI:MGI:2444300"
                     /translation="MWDQRLVRLALLQQLRAVYGIKVKGGRGQCDRRRHETAATEIKG
                     KVFGVPFNSLPHSVVPEFGHIPSFLVDACASLKEHIHTEGLFRKSGSVVRLKALKSKL
                     DQGEACLSSALPCDVAGLLKQFFRELPEPVLPADLHEALFKAQQLGAEERNKATLLLS
                     CLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANTE
                     KKLRLQAAVVQTFIDCASDIGRVPDFILEKIPAMLGIDGLCTTPSLEGFEGDFETPGE
                     CKRKRRQSVGDFVNGALNKLKSSRTPSITPQQDRTAQASASPLILTPSVKRKLPGESS
                     HAFSSKKRKSIKHNLNFELLPSHFFSSNSTPVSVHLDTSPDGSSQTSLSPIAMSGNHL
                     VSTELRRSKRIASKKVYRVESGKAGCFSPKVSRKEKTRRSLRLKFSLGKNRDSDGCSV
                     INRYENVGRRLANQQNLKSRIDSVKTGLLFSPDIDERLLKKGSEKISKSEEHLLTPDQ
                     LDGTGYRMSWTEPSNSSFQDMSANGTSPIMQNLEVKSFSLEPDITVEKSPVVSCELRP
                     STFHSQPDSSVLSLSGDEGNLASETLQKIQKAFSESGSDLHMVINHEQSSVTNTGEEV
                     EFRDVTVTESKGHDGSCAGEEENCPSERNFSPDQSPEFAREADEECYSTQMKVECEGL
                     HSETPKADPLILQAFPGEEPAEEPQSPRNQLSTPSRGNENGGESAGASGAPGEDESTC
                     SVAVLSKPRPQRLSRQQSLVEKCDSVAPGALQVTEHGKVSDHIQWFNKLSLNEPNRGK
                     VKSPLKFQRTPVRQSVRRINSLLEYGRQPVRQKLAIFGDAASPLVKSVSCDSALPSCV
                     QNTSKGPTAPLITSGLEAQKSTSCNKSSVELTSKSFTKMKRHPDPLSASLGTPRLCKQ
                     ENKSNGHIKFPLDDLTNHERLKFVVNNNVAFSPGMKNRVVRKPSEKERVWYKGSPKNP
                     IGKTQLLPTSKPVDL"
     exon            702..772
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            773..869
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1123
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1287
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1431
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1506
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1674
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1801
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1907
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2046
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..5017
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4996..5001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /note="hexamer: ATTAAA"
     polyA_site      5017
                     /gene="Arhgap11a"
                     /gene_synonym="6530401L14Rik; mKIAA0013"
                     /note="major polyA site"
ORIGIN      
        1 agaaggtggg gcgctggcgg agccgagtca ctaagcttta gcgggccggg gccacaggca
       61 aggctgatgg gctaggggaa aggctgcgtg tgagacgggg tgacggcggg gaccagcccg
      121 ggcagggacc gggactgggg atccctgagc agccggctgg cccggctgga gggagtagct
      181 taaggttgca tttccatctc aagaaatcag agcggggaag gccaccctgc ggggaagagg
      241 ataagtggaa gtgtccggaa gcgagaaact agctgcaggc gttagtctgg ggaaacggaa
      301 gagtcagaaa aaagggaagt ttgtggaagt aactgacagg gctgagcgac ccggaaagaa
      361 ggctggtgga agtgaaacaa gagtgaagag aggcgcgaga gaagaaggtc tgtgtaagtg
      421 gatcgaggga aagtggagga agagtgccag aggtggctgg aaggcagcgg agcagagcga
      481 gcctgagggc gtttggcaag tggaagagtt ggttggtggc aaagaaagtc aggacccgga
      541 gtcggcctcg gagagtaggc gacgtgttcg ggatgtggga tcagagactg gtcagattgg
      601 ccctgctgca gcagcttcga gctgtctatg gcattaaggt caagggtggc cgcggtcagt
      661 gcgatcgcag gagacatgaa actgcagcta cggaaataaa gggtaaggta tttggagtac
      721 cctttaattc cttgcctcat tcagtcgttc cagaatttgg acacattcca agctttcttg
      781 ttgatgcgtg cgcatcttta aaagagcata ttcatacaga agggcttttt aggaagtcgg
      841 ggtctgttgt tcgtctaaag gcactaaaga gtaaactgga tcaaggtgaa gcctgcctgt
      901 cttctgcact tccgtgtgat gttgcaggcc tgcttaagca gttcttccgg gaattgccag
      961 agcctgtcct cccagctgat ctgcatgaag cacttttcaa agctcagcag ttaggagcag
     1021 aggagaggaa taaagctaca ttgttgctgt cgtgtcttat ggcaaaccct acagttgata
     1081 tattaagata cttctttaac tttcttaaga gtgtttctct tagggcaagt gagaataaaa
     1141 tggacagcag caatcttgca gtaatatttg caccaaatct tcttcagaca agtgaaggcc
     1201 atgagaagat gtctgccaac acagagaaga agctacgtct gcaggcagca gtagtgcaga
     1261 cttttattga ctgtgcatca gacattggac gagtgccaga ttttatcctg gaaaagatac
     1321 cagccatgtt aggtattgat ggactctgta ctactccatc cctggaaggc tttgaaggag
     1381 actttgaaac tcctggtgaa tgtaagagaa aaagaagaca aagtgttgga gattttgtga
     1441 atggagccct aaataaactt aaatctagca gaacaccctc tattacacct caacaagata
     1501 ggacagctca ggcctctgca tcaccattga ttctcacccc gagtgttaag cgtaaactgc
     1561 caggagagtc ttctcatgct ttctcgagta agaaaaggaa atccatcaag cacaacttga
     1621 actttgagct gttgccaagt catttcttca gcagcaattc tacaccagta tcagttcact
     1681 tagatacaag tcctgacgga tcatctcaga cttctctctc accaatcgcc atgagtggaa
     1741 accacttggt cagtacagaa ttaaggcgaa gtaaaaggat tgccagcaaa aaagtttaca
     1801 gggtagagtc aggaaaagcg ggctgcttct ctcccaaagt cagtcgtaaa gaaaagaccc
     1861 gaagatctct ccgtctgaaa tttagtctgg ggaagaacag agattcagat ggatgttctg
     1921 tcatcaatag atatgaaaat gttggtcgac gactagcgaa tcagcaaaat ctaaaaagta
     1981 ggattgattc tgtaaagaca ggcctgcttt ttagcccaga tattgatgaa agattgctaa
     2041 agaaaggctc agaaaagatc agcaaatctg aggaacactt gttaactcca gatcaactag
     2101 atggaacagg ttaccggatg tcttggacag aacccagtaa ttcaagtttt caagacatga
     2161 gtgcaaatgg aacttctcca ataatgcaaa atcttgaggt gaagagcttt tctttggagc
     2221 ccgacattac tgttgaaaaa tcaccagttg tgtcctgtga gctcaggcct tccaccttcc
     2281 atagccagcc tgacagcagt gtgctgtctc ttagtgggga tgaagggaac ctggcctccg
     2341 agaccttgca gaagattcag aaagcatttt ccgaatctgg gagtgatctt catatggtga
     2401 taaatcatga gcagtcatca gtaacaaata cgggggaaga agtggaattc agagatgtga
     2461 ctgtgactga gtcaaaggga catgatggga gctgtgctgg ggaggaggag aactgtcctt
     2521 cagaacggaa tttctcaccg gatcaaagcc cagagtttgc cagagaagct gatgaggaat
     2581 gttactcaac tcagatgaag gtggaatgtg aaggcctgca ctcagaaaca cccaaagctg
     2641 accccctcat cctgcaagca ttccccggtg aggagccagc tgaggaacca cagtccccaa
     2701 ggaaccagct aagcactcca tcacggggga atgagaatgg gggggagagc gctggggcaa
     2761 gtggagctcc cggagaagat gagagcacgt gcagtgtggc ggtcctttcg aaacctcggc
     2821 cccagagact ttcgaggcaa cagtcactgg tggaaaaatg tgatagtgta gctcctgggg
     2881 ctctacaagt gacagagcac gggaaggttt ctgatcacat acagtggttt aataaacttt
     2941 ctctaaatga accgaacaga ggaaaagtga agtcacctct taaatttcag cgtactcctg
     3001 tccgtcagtc cgtcagaaga attaattctt tgttggagta tggcaggcag cctgtgaggc
     3061 agaagttggc aatctttggt gacgcagctt ctcctctcgt taaatcagtg agctgtgaca
     3121 gtgcccttcc ctcttgtgta caaaacacat caaaaggtcc cactgctcca cttatcacgt
     3181 caggcctcga agcacagaag tctacgtctt gtaataaatc aagtgttgag ttaacttcta
     3241 aatctttcac aaaaatgaag agacatccgg atcctttgag tgcttctctt gggactccca
     3301 gactttgtaa gcaggagaac aaatctaatg gccacattaa gtttcctttg gatgatctca
     3361 cgaatcatga gagattaaaa tttgttgtaa ataacaatgt ggccttttct ccagggatga
     3421 aaaacagagt tgttaggaaa ccatcagaaa aagaaagggt ctggtacaaa gggtctccta
     3481 aaaatcctat tgggaagact caactgctac caacgagtaa gcctgtcgac ttgtaaccgt
     3541 caaatgtggc gtgctcgtca tcagtgtaaa taaaattgct gggtcaggtt gcagaatgct
     3601 caagtgctgg tgtgtagata tgtcgggcgg gcagttgcag gatgcttgtg tgctggtgtg
     3661 tagatacagc gggcgggcag ttgcaggatg cttgtgtgct ggtgtgtaga tatgtcgggc
     3721 gggcagttgc aggatgcttg tgtgctggtg tgtagatatg gcgggcgggc agttgcagga
     3781 tgcttgtgtg ctggtgtgta gatatggcgg gcgggcagtt gcaggatgct tgtgtgctgg
     3841 tgtgtagata cagcgggcgg gcagttgcag gatgcttgtg tgctggtgtg tagatatggc
     3901 gggcgggcag ttgcaggatg cttgtgtgct ggtgtgtaga tatgtcgggc gggcagttgc
     3961 aggatgcttg tgtgctggtg tgtagatatg gcgggcgggc agttgcagga tgcttgtgtg
     4021 ctggtgtgta gatacagcgg gcgggcagtt gcaggatgct tgtgtgctgg tgtgtagata
     4081 tggcgggcgg gcagttgcag gatgcttgtg tgctggtgtg tagatatgtc gggcgggcag
     4141 ttgcaggatg cttgtgtgct ggtgtgtaga tacagcgggc gggcgggcag ttgcaggatg
     4201 cttgtgtgct ggtgtgtaga tcggggtgct tgttaagtag ggtctgtctg aagtggtccc
     4261 actgtagagc agtttggact ttcatacttg cacatggggc tactttgttt ttctttatta
     4321 ctgaagcatt tacacataac tttattgtga tttcctgaag caggggttat aataacttta
     4381 gaagatactg ttggctaggt ttatttatat aaaagggaca tgagttttat tctgcatgct
     4441 tgatcagaag aatacaggaa gttgtgcttg tgcctcttgt tattccttca catcaggaac
     4501 attgttcaca gaaacttcta gtacataaag ggaatgatga agccctgcaa accttatgtc
     4561 ttgaattatt catgtttgtt gccttgaccc aaaaccaaga agttaattgg cctcagtggt
     4621 atgtgaacac ttttgttgga gacagaggga tttatttggt cagcatcgcc tgtggtttca
     4681 cttgaatttt gaattaaaga cagtgaataa agcataatga caacaaaggt actgcatact
     4741 ttataatgtt gaggtaaatg attaatcgta agccatactt catttttaaa ggtgatttgg
     4801 atcatatttt gtccagtatg acaatgaaat ttttaggcag gtatagttaa actggaaaat
     4861 tttaatcaag ttgttttttt cctatgaaga tggttgattt tagaattgaa ttgttaatgt
     4921 acctctgtac attttactta gataaatatc agatagtgtt atcatgtgtt taaatgttat
     4981 ttatttagca tagacattaa aaatagctcc tgggaaa
//
