LOCUS       NM_030113               3038 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Rho GTPase activating protein 10 (Arhgap10),
            transcript variant 1, mRNA.
ACCESSION   NM_030113 XM_983351
VERSION     NM_030113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3038)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3038)
  AUTHORS   Hada,K., Wulaer,B., Nagai,T., Itoh,N., Sawahata,M., Sobue,A.,
            Mizoguchi,H., Mori,D., Kushima,I., Nabeshima,T., Ozaki,N. and
            Yamada,K.
  TITLE     Mice carrying a schizophrenia-associated mutation of the Arhgap10
            gene are vulnerable to the effects of methamphetamine treatment on
            cognitive function: association with morphological abnormalities in
            striatal neurons
  JOURNAL   Mol Brain 14 (1), 21 (2021)
   PUBMED   33482876
  REMARK    GeneRIF: Mice carrying a schizophrenia-associated mutation of the
            Arhgap10 gene are vulnerable to the effects of methamphetamine
            treatment on cognitive function: association with morphological
            abnormalities in striatal neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3038)
  AUTHORS   Sekiguchi,M., Sobue,A., Kushima,I., Wang,C., Arioka,Y., Kato,H.,
            Kodama,A., Kubo,H., Ito,N., Sawahata,M., Hada,K., Ikeda,R.,
            Shinno,M., Mizukoshi,C., Tsujimura,K., Yoshimi,A., Ishizuka,K.,
            Takasaki,Y., Kimura,H., Xing,J., Yu,Y., Yamamoto,M., Okada,T.,
            Shishido,E., Inada,T., Nakatochi,M., Takano,T., Kuroda,K.,
            Amano,M., Aleksic,B., Yamomoto,T., Sakuma,T., Aida,T., Tanaka,K.,
            Hashimoto,R., Arai,M., Ikeda,M., Iwata,N., Shimamura,T., Nagai,T.,
            Nabeshima,T., Kaibuchi,K., Yamada,K., Mori,D. and Ozaki,N.
  TITLE     ARHGAP10, which encodes Rho GTPase-activating protein 10, is a
            novel gene for schizophrenia risk
  JOURNAL   Transl Psychiatry 10 (1), 247 (2020)
   PUBMED   32699248
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3038)
  AUTHORS   Luo,N., Guo,J., Chen,L., Yang,W., Qu,X. and Cheng,Z.
  TITLE     ARHGAP10, downregulated in ovarian cancer, suppresses
            tumorigenicity of ovarian cancer cells
  JOURNAL   Cell Death Dis 7 (3), e2157 (2016)
   PUBMED   27010858
  REMARK    GeneRIF: ARHGAP10 may serve as a tumor suppressor through
            inactivating Cdc42, as well as inhibiting cell cycle, replication
            and BER pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3038)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   6  (bases 1 to 3038)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 3038)
  AUTHORS   Koeppel,M.A., McCarthy,C.C., Moertl,E. and Jakobi,R.
  TITLE     Identification and characterization of PS-GAP as a novel regulator
            of caspase-activated PAK-2
  JOURNAL   J Biol Chem 279 (51), 53653-53664 (2004)
   PUBMED   15471851
REFERENCE   8  (bases 1 to 3038)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 3038)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3038)
  AUTHORS   Ren,X.R., Du,Q.S., Huang,Y.Z., Ao,S.Z., Mei,L. and Xiong,W.C.
  TITLE     Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2
            interacting with PSGAP, a novel pleckstrin homology and Src
            homology 3 domain containing rhoGAP protein
  JOURNAL   J Cell Biol 152 (5), 971-984 (2001)
   PUBMED   11238453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041867.1, AC109139.15, CV783737.1, CN703944.1, BU151977.1,
            CF106470.1, BI736055.1 and AC119248.8.
            
            On Oct 14, 2006 this sequence version replaced NM_030113.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY179965.1, SRR7345562.1419637.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               AK041867.1         48-586
            540-610             AC109139.15        124844-124914       c
            611-624             AC109139.15        119248-119261       c
            625-1034            CV783737.1         3-412
            1035-1452           CN703944.1         222-639
            1453-1936           BU151977.1         279-762
            1937-2277           CF106470.1         214-554
            2278-2779           BI736055.1         62-563
            2780-3038           AC119248.8         84187-84445         c
FEATURES             Location/Qualifiers
     source          1..3038
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 36.6 cM"
     gene            1..3038
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /note="Rho GTPase activating protein 10"
                     /db_xref="GeneID:78514"
                     /db_xref="MGI:MGI:1925764"
     exon            1..278
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2485
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 10; rho-type GTPase-activating
                     protein 10; PH and SH3 domain-containing rhoGAP protein"
                     /codon_start=1
                     /product="rho GTPase-activating protein 10 isoform 1"
                     /protein_id="NP_084389.2"
                     /db_xref="CCDS:CCDS22425.1"
                     /db_xref="GeneID:78514"
                     /db_xref="MGI:MGI:1925764"
                     /translation="MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGK
                     NLISATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQRE
                     IMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHL
                     QEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELS
                     KDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQE
                     KRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDR
                     RFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLD
                     KMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADW
                     EVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVNAIHFLVHKLPEKNKE
                     MLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEIL
                     IENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGD
                     SPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTPSQTRP
                     SMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECVINRKARAVYPCE
                     AEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL"
     exon            279..374
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            375..436
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            437..508
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            509..610
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            611..721
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            722..826
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            827..956
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1063
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1158
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1240
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1286
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1352
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1427
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1515
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1574
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1680
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1840
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1991
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2151
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2304
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2396
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..3038
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3020..3025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /note="hexamer: AATAAA"
     polyA_site      3038
                     /gene="Arhgap10"
                     /gene_synonym="A930033B01Rik; PS-GAP; PSGAP; PSGAP-m;
                     PSGAP-s"
                     /note="major polyA site"
ORIGIN      
        1 cagggtcgct gggctgggct ggacatgacc gtgctgcgct cgccgcgcgc tcagccctgc
       61 tagccgctcg ctgccgccgc ctgggagccc agctcggcct gcgcccgcgc gcaccgccgc
      121 agtcatgggg ctgcagcccc tggagtttag cgactgctac ctcgacagcc cgtggttccg
      181 ggagaggatc cgcgcgcacg aagcggagct cgagaggacc aacaagttca tcaaagagct
      241 catcaaagac ggcaagaacc tcatctctgc caccaaaagt ctgtcagctg cccagaggaa
      301 gttcgctcac tcgctcagag acttcaagtt cgagtttatc ggcgatgctg agactgacga
      361 tgaacggtgc atagatgcct ccttacggga attttctaac tttctgaaga atctggaaga
      421 acagagagaa atcatggcat taagtgtgac tgaaaccctg attaaaccct tggagaaatt
      481 cagaaaagag cagcttggag ctgtaaagga agaaaaaaag aagtttgaca aagagacgga
      541 aaagaattac agtctcatcg acaagcactt gacgctgtct gccaggaaga aggactcaca
      601 cttgcaggag gccgacctcc aagtggagca gaaccggcag catttctacg agctctcgct
      661 tgaatatgtg tgcaagctcc aggaaatcca agaaagaaag aagttcgagt ttgtggagcc
      721 tatgctgtcc ttctttcagg gaatgttcac tttctatcat caaggccacg agctttccaa
      781 agacttcaat cactacaaga tggaactaca aatcaacatt cagaatacac ggaatcgatt
      841 tgagggaacc agatcagaag tggaggaact tatgaataaa attagacaaa atcccaagga
      901 ccagaagcga gccagccagt tcacagcaga aggctacctg tacgtccagg agaaaaggcc
      961 tgctccattt gggtccagtt gggtcaaaca ctactgcatg taccggaaaa cagccaagaa
     1021 attcaacatg attccatttg agcacagatc tggggggaaa ctgggggatg gcgaggcttt
     1081 ctttttgaaa gaatgcacca aaaggcacat ggactccacg gacagaaggt tttgctttga
     1141 catcgaagct gctgacaggc ctggcgtccc cttgaccgtg caggcgtttt cagaagaaga
     1201 gaggaagcag tggttggaag ctctgggtgg aaaagaagct ctgttccaca cgtttaacag
     1261 agccattgtc ccgagaccgg aaggaggtgc acagctggat aagatgggat tcacaattct
     1321 cagaaaatgc atcagcgccg ttgaaacccg aggtataaat gaccaaggac tgtacagagt
     1381 tgtgggggtg agttcaaagg tccagagact tctgagtatg ttgatggatg taaaaatgtg
     1441 caatgagctg gacctggaga attctgcaga ttgggaagtg aagacagtaa caagtgcctt
     1501 gaagcagtat ctgaggagtc ttccagagcc tctcatgacc tatgagttac acagagactt
     1561 cattgttcca gccaagagcg gcagcccgga atcccgagtt aatgccatcc acttcttggt
     1621 acacaaactg ccagagaaga ataaggagat gttggatatc ttggtgaagc atctaaccaa
     1681 cgtgtcaagt cactcgaagc agaatctaat gacagtggcg aatttagggg tggtgtttgg
     1741 accaactctg atgagaccac aggaagagac tgttgccgcc atcatggatt tgaagtttca
     1801 gaatatcgtt gtagaaatct taattgaaaa ccatgaaaag atttttcgaa cctcgcctga
     1861 taccacattt gctgagccca catgcctgtc agcatcaccc ccaaacgctc caccacgaca
     1921 gtccaagaga caagggcaga ggacgaagag accagtggcc gtgtacaacc tttgtcttga
     1981 gctggaggag ggtgacagtc ccagccctct caaggaggac ccccccagca gcagtcagga
     2041 ctctctctcc accccatctc ccacaacgtc agctgcccat gggcctcctg gactagacgg
     2101 aaaccaccta gcagcagacg gagggagctg tggagatgcc accgccacca cgccaagcca
     2161 gacccggcca tccatggtgc agtggctaaa tatgcagtct ccaaccacac caagctccaa
     2221 cccagctgga acacctcctt cacccagaat gtcaccgttc cccctctctc ctgctgcctc
     2281 cattgtagac aagctgcctg agtgcgttat caatcgaaag gctcgggcag tgtacccgtg
     2341 tgaagcagaa cacagctcgg aattgtcatt tgaaatagga gccatttttg aggatgttca
     2401 gacctcaagg gaacccggat ggctggaagg gaccctgaac ggcaagcgag ggctgattcc
     2461 acagaattat gtcaagctcc tgtagctccc ggccgtgggg ggtcctactg atcgtggcac
     2521 cccaagcagc agcctggaaa tggcacccaa acaccacggt cacgcttagg atctgcggtt
     2581 caccatgggt actccagggt ggggagggga tggaacagcc acctaggact gtgcagatgt
     2641 gggcggaagc agagcgtgac tggcgttgct ggagtcagtt ctcatctagc aggactgggc
     2701 attgattgtg atgtttaatt ctcccacctg tggaacagag agagggcaga cctcactgtc
     2761 cacacacccg ctgtggggtt ttcaggggga ctgcgtgact ctcgaaagtc ccaacctgga
     2821 gggaagcaga gagaaacttc ttcaagcttg tgccttcctt cctacctgcc tctcctcccc
     2881 ctccccaccc cctccccggg cctgcccacc ggcagctgca ccaagctcac ctgtgtgctt
     2941 caacagcctt ttccaggtgc tcacctgagt gctgtttgtc ctttgtcacc ttgttgccac
     3001 aaggcccctc tgtaaatgaa ataaaatgta atttacta
//
