LOCUS       NM_001359970            2969 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus Rho GTPase activating protein 1 (Arhgap1), transcript
            variant 6, mRNA.
ACCESSION   NM_001359970 XM_006499246
VERSION     NM_001359970.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2969)
  AUTHORS   Zhu,M., Xiao,B., Xue,T., Qin,S., Ding,J., Wu,Y., Tang,Q., Huang,M.,
            Zhao,N., Ye,Y., Zhang,Y., Zhang,B., Li,J., Guo,F., Jiang,Y.,
            Zhang,L. and Zhang,L.
  TITLE     Cdc42GAP deficiency contributes to the Alzheimer's disease
            phenotype
  JOURNAL   Brain 146 (10), 4350-4365 (2023)
   PUBMED   37254741
  REMARK    GeneRIF: Cdc42GAP deficiency contributes to the Alzheimer's disease
            phenotype.
REFERENCE   2  (bases 1 to 2969)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2969)
  AUTHORS   Chichili,V.P.R., Chew,T.W., Shankar,S., Er,S.Y., Chin,C.F.,
            Jobichen,C., Qiurong Pan,C., Zhou,Y., Yeong,F.M., Low,B.C. and
            Sivaraman,J.
  TITLE     Structural basis for p50RhoGAP BCH domain-mediated regulation of
            Rho inactivation
  JOURNAL   Proc Natl Acad Sci U S A 118 (21) (2021)
   PUBMED   34006635
  REMARK    GeneRIF: Structural basis for p50RhoGAP BCH domain-mediated
            regulation of Rho inactivation.
REFERENCE   4  (bases 1 to 2969)
  AUTHORS   Lay,A.J., Coleman,P.R., Formaz-Preston,A., Ting,K.K., Roediger,B.,
            Weninger,W., Schwartz,M.A., Vadas,M.A. and Gamble,J.R.
  TITLE     ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell
            Alignment and Protects Against Atherosclerosis
  JOURNAL   J Am Heart Assoc 8 (2), e010057 (2019)
   PUBMED   30630384
  REMARK    GeneRIF: ARHGAP 18 is a protective gene that maintains EC
            alignments in the direction of flow. Deletion of ARHGAP 18 led to
            loss of EC ability to align and promoted
REFERENCE   5  (bases 1 to 2969)
  AUTHORS   Rossi,L., Lin,K.K., Boles,N.C., Yang,L., King,K.Y., Jeong,M.,
            Mayle,A. and Goodell,M.A.
  TITLE     Less is more: unveiling the functional core of hematopoietic stem
            cells through knockout mice
  JOURNAL   Cell Stem Cell 11 (3), 302-317 (2012)
   PUBMED   22958929
  REMARK    Review article
REFERENCE   6  (bases 1 to 2969)
  AUTHORS   Wang,L., Yang,L., Filippi,M.D., Williams,D.A. and Zheng,Y.
  TITLE     Genetic deletion of Cdc42GAP reveals a role of Cdc42 in
            erythropoiesis and hematopoietic stem/progenitor cell survival,
            adhesion, and engraftment
  JOURNAL   Blood 107 (1), 98-105 (2006)
   PUBMED   16174757
REFERENCE   7  (bases 1 to 2969)
  AUTHORS   Wang,L., Yang,L., Burns,K., Kuan,C.Y. and Zheng,Y.
  TITLE     Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis
            and cell number during mammalian perinatal growth
  JOURNAL   Proc Natl Acad Sci U S A 102 (38), 13484-13489 (2005)
   PUBMED   16157885
REFERENCE   8  (bases 1 to 2969)
  AUTHORS   Pixley,F.J., Xiong,Y., Yu,R.Y., Sahai,E.A., Stanley,E.R. and
            Ye,B.H.
  TITLE     BCL6 suppresses RhoA activity to alter macrophage morphology and
            motility
  JOURNAL   J Cell Sci 118 (Pt 9), 1873-1883 (2005)
   PUBMED   15860730
REFERENCE   9  (bases 1 to 2969)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2969)
  AUTHORS   Prakash,S.K., Paylor,R., Jenna,S., Lamarche-Vane,N.,
            Armstrong,D.L., Xu,B., Mancini,M.A. and Zoghbi,H.Y.
  TITLE     Functional analysis of ARHGAP6, a novel GTPase-activating protein
            for RhoA
  JOURNAL   Hum Mol Genet 9 (4), 477-488 (2000)
   PUBMED   10699171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691489.21 and AL714023.12.
            
            On Jan 24, 2018 this sequence version replaced XM_006499246.3.
            
            Transcript Variant: This variant (6) differs in the 5' structure,
            resulting in a novel 5' UTR and the use of a downstream start
            codon, compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus compared to isoform 1. Variants 2 and 6 encode the same
            isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006592.1, SRR7345562.4100263.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AL691489.21        190163-190297
            136-195             AL691489.21        191809-191868
            196-357             AL691489.21        194091-194252
            358-453             AL691489.21        194481-194576
            454-541             AL714023.12        9479-9566
            542-673             AL714023.12        15378-15509
            674-760             AL714023.12        15667-15753
            761-859             AL714023.12        15910-16008
            860-967             AL714023.12        16367-16474
            968-1044            AL714023.12        16566-16642
            1045-1122           AL714023.12        16833-16910
            1123-1251           AL714023.12        17327-17455
            1252-1355           AL714023.12        17647-17750
            1356-2969           AL714023.12        17893-19506
FEATURES             Location/Qualifiers
     source          1..2969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.63 cM"
     gene            1..2969
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /note="Rho GTPase activating protein 1"
                     /db_xref="GeneID:228359"
                     /db_xref="MGI:MGI:2445003"
     exon            1..135
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            136..195
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            196..357
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1544
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /note="isoform 2 is encoded by transcript variant 6; rho
                     GTPase-activating protein 1; rho-type GTPase-activating
                     protein 1"
                     /codon_start=1
                     /product="rho GTPase-activating protein 1 isoform 2"
                     /protein_id="NP_001346899.1"
                     /db_xref="CCDS:CCDS16437.1"
                     /db_xref="GeneID:228359"
                     /db_xref="MGI:MGI:2445003"
                     /translation="MDPLSELQDDLTLDDTSQALNQLKLASIDEKNWPSDEMPDFPKS
                     DDSKSSSPEPVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHS
                     KLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYI
                     VHPTMFIKTLLILFKPLISFKFGRKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLK
                     STQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKSPGQDPIPIVLRETVAYLQAHALT
                     TEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDL
                     YPHVVGFLNIDESQRVEVTQQVLQTLPEENYQVLHFLTAFLVQISAHCDQNKMTNTNL
                     AVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSTDAQGV"
     exon            358..453
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            454..541
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            542..673
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            674..760
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            761..859
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            860..967
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1044
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1122
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1251
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1355
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..2969
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2947..2952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /note="hexamer: AATAAA"
     polyA_site      2969
                     /gene="Arhgap1"
                     /gene_synonym="B230365D05Rik; Cdc42GAP; p50rhoGAP"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtaggt agaagaaatg gcggaagtgg ttggggagct gggggccccc gagggggcgg
       61 ttcccattcc catctcggag ccggatgttt gccgagcttt gacaggcgtg gcagaggaag
      121 cattgccgga acgaggcttc atctacccat tgactagcag ataaacatcc ggctcccaga
      181 aggcaccaga agcagccagg cttctcttct gcttctcctt agccatggac cctctctcag
      241 agctgcaaga tgacctgacg ctggatgaca ccagccaagc tctgaaccag ttgaagctgg
      301 cctccattga tgagaagaac tggccttctg atgaaatgcc agacttcccc aagtcagatg
      361 actccaaaag cagctctcca gaacctgtga cacacctgaa gtgggatgac ccttactatg
      421 acattgcccg gcaccagatt gtggaagtag ccggtgatga taagtatggg cggaagatca
      481 ttgtattcag tgcttgccgg atgcccccca gccaccagct ggaccacagc aagctcttgg
      541 ggtatttgaa acacacattg gaccagtatg tggagagtga ctacacactc ctgtacctgc
      601 accatggcct gaccagtgac aacaagccct ccctcagctg gctacgggat gcctaccgag
      661 agtttgaccg caagtacaag aagaacatca aggctctgta catcgtgcac ccaaccatgt
      721 tcatcaaaac tctgcttatc ctctttaagc ctctcatcag tttcaagttt ggacggaaga
      781 tcttctacgt gaattacctg agtgagctga gcgagcacgt gaagctggag cagttgggga
      841 tccctcgcca agtgctcaag tatgatgact tcctcaaatc cacacagaaa agccctgcaa
      901 cagctcccaa gcccatgcca ccacggcccc ccctgcccaa tcagcagttt ggggtctcct
      961 tacagcacct ccaggagaaa agcccaggcc aggaccccat tcccattgtc ctcagggaga
     1021 ccgtcgccta cttgcaggct cacgctctca ccactgaggg catcttccgg aggtctgcca
     1081 acacccaggt tgtccgggaa gtgcagcaga aatacaatat ggggctgccg gtggactttg
     1141 accagtacaa cgagctgcac ttgcccgctg tcatcctcaa gacattcctt cgggagcttc
     1201 ctgaaccctt gctaaccttt gacctgtacc cccatgttgt gggcttcctc aatattgatg
     1261 aaagccagag agtggaagtg acacagcagg ttctccaaac tctgccagag gagaactacc
     1321 aggtgcttca tttcctgact gccttcctgg tgcagatatc tgcccactgt gaccagaaca
     1381 agatgaccaa cactaacttg gctgtagtct tcggccctaa cctgctctgg gctaaagatg
     1441 ctgccatcac cctcaaggct atcaatccca tcaacacctt cactaagttc ctcctggatc
     1501 atcaagggga attgttcccc agcacagatg cccagggggt ctgagctcac cacctccagc
     1561 cccttctctg gcagcccgag ttggacttgt cctcctggca ttaaccttac tggagtccag
     1621 ggctcctgcc taggaagggg ccctgaagcc ccagaagatg gaagttggag cctactaact
     1681 gggcagcccc tcctgtccct ctgcccgtcc caccttaccg gccctggagg cctctgttac
     1741 cgtaagacat tttctttgcc ttatacctct cactgcctct ctggttgctg ggcttggttc
     1801 ttctaggatt tagccacagt aaaccttttc ctttttcctg cctgtttccc tggcgagtgt
     1861 agaagactac atcactgctg gctgtgctgg tagctggggc tggtcctctc tttcctgatt
     1921 gctaggaagt gagcattggc ctgggtgcaa gttccctgtg cctgccctcc ctgctaatag
     1981 ggatgataag accagagttg gcctgtcact tctgcctcct gggtctgttc ttccccaagt
     2041 ggtactgccc ccagagtgta ctattccctc atttctgcca cacttggcac tttggatatc
     2101 aagactcaga atctgagtgt ctattgaaat ggtcctgtcc actcccaggg agagccgtag
     2161 tgtctggtag gatcagttac agcagtcctg gccctccatt cattctcatg tgcacagatc
     2221 ttcagccaaa ggctatagta ggtctttcag gtgtggagtc attttgatcc ctgttctagc
     2281 cagagatacc aatgtctctc actttctacc tggggactct cggagagtca gaaactcaga
     2341 agccctgaag actgacagag cttttactaa tagatcaccc ctgctggata ggttctagca
     2401 gcttccttag gggagtgtgg tggccacagg gcctcttgtc tttcagaaag ctgagcccca
     2461 gtgatgattg gtagctttca ttctattcct aatgaagcct tgtgactctt cccgaagtcc
     2521 actgcctaat gacagggagg tacctgcagt gaccttgccc tacaggtgtg gctaggcatg
     2581 acagctccag aggtggtact ggctaccatg agatctgtac tgatgatctt gcagctgagg
     2641 ctgggcctga cctcactggc tctttcttgc accactgttg tagcaggtct ctggtgccac
     2701 aagtgctgct gtcagtcccc agcctcacac ctgacccagc ctgggtcact ctgcttttgc
     2761 ccacattttt gtatcaagtg ttgctacact ccatttactg aggagccttt ggacctcttg
     2821 ttttcctcct gcccggtcct gtcagtctgt ggcaggggac gctcttactg tgaatctagt
     2881 gttcacattt accacgattt ccttggcacc aatcatgtat tttaccgttt gcactttttg
     2941 tatttcaata aaaatgtaaa tgaaaaaaa
//
