LOCUS       NM_176849               1731 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus arginine and glutamate rich 1 (Arglu1), mRNA.
ACCESSION   NM_176849
VERSION     NM_176849.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1731)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1731)
  AUTHORS   Yao,F., Huang,S., Liu,J., Tan,C., Xu,M., Wang,D., Huang,M., Zhu,Y.,
            Huang,X. and He,S.
  TITLE     Deletion of ARGLU1 causes global defects in alternative splicing in
            vivo and mouse cortical malformations primarily via apoptosis
  JOURNAL   Cell Death Dis 14 (8), 543 (2023)
   PUBMED   37612280
  REMARK    GeneRIF: Deletion of ARGLU1 causes global defects in alternative
            splicing in vivo and mouse cortical malformations primarily via
            apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1731)
  AUTHORS   Magomedova,L., Tiefenbach,J., Zilberman,E., Le Billan,F.,
            Voisin,V., Saikali,M., Boivin,V., Robitaille,M., Gueroussov,S.,
            Irimia,M., Ray,D., Patel,R., Xu,C., Jeyasuria,P., Bader,G.D.,
            Hughes,T.R., Morris,Q.D., Scott,M.S., Krause,H., Angers,S.,
            Blencowe,B.J. and Cummins,C.L.
  TITLE     ARGLU1 is a transcriptional coactivator and splicing regulator
            important for stress hormone signaling and development
  JOURNAL   Nucleic Acids Res 47 (6), 2856-2870 (2019)
   PUBMED   30698747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB528163.1, BY756892.1, BU514203.1 and BC029219.1.
            
            On Mar 28, 2007 this sequence version replaced NM_176849.2.
            
            Sequence Note: This sequence is assembled by in silico methods with
            additional support of similarity to orthologous proteins contained
            in human BC050434.1 and rat BC091344.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.369506.1, AV471740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               CB528163.1         53-424
            373-787             BY756892.1         147-561
            788-1102            BU514203.1         435-749
            1103-1731           BC029219.1         2786-3414
FEATURES             Location/Qualifiers
     source          1..1731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 3.57 cM"
     gene            1..1731
                     /gene="Arglu1"
                     /gene_synonym="9430010O03Rik; C130008N12"
                     /note="arginine and glutamate rich 1"
                     /db_xref="GeneID:234023"
                     /db_xref="MGI:MGI:2442985"
     exon            1..561
                     /gene="Arglu1"
                     /gene_synonym="9430010O03Rik; C130008N12"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1036
                     /gene="Arglu1"
                     /gene_synonym="9430010O03Rik; C130008N12"
                     /codon_start=1
                     /product="arginine and glutamate-rich protein 1"
                     /protein_id="NP_789819.2"
                     /db_xref="CCDS:CCDS40215.1"
                     /db_xref="GeneID:234023"
                     /db_xref="MGI:MGI:2442985"
                     /translation="MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSR
                     ESKRNRRRESRSRSRSTNAAASRRERERASSPPDRIDIFGRTVSKRSSLDEKQKREEE
                     EKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVE
                     EAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLA
                     EEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD"
     exon            562..787
                     /gene="Arglu1"
                     /gene_synonym="9430010O03Rik; C130008N12"
                     /inference="alignment:Splign:2.1.0"
     exon            788..871
                     /gene="Arglu1"
                     /gene_synonym="9430010O03Rik; C130008N12"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1712
                     /gene="Arglu1"
                     /gene_synonym="9430010O03Rik; C130008N12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arglu1"
                     /gene_synonym="9430010O03Rik; C130008N12"
                     /note="hexamer: AATAAA"
     polyA_site      1712
                     /gene="Arglu1"
                     /gene_synonym="9430010O03Rik; C130008N12"
                     /note="major polyA site"
ORIGIN      
        1 ggggcattgt gggaagggcg gccggtgctg ccacagctgc catcttaggg actccgggcc
       61 gggcctgcta ggccttcgcg gcggaggcgg ccgtgtgcgt ggcgggtgcg cttggggcga
      121 ggcggagggt ccgcgggcgg ggggccgcgc ttcccagcgg cgagggggcg gcctgcggcg
      181 ggcagcgggc gacaggcggc gggcgccgcg cggcgcgagg atgggccggt cgcggagccg
      241 gagctcgtcc cgctctaagc acaccaagag ctccaagcac aacaagaagc gcagccgctc
      301 gcgctcgcgc tcgcgggaca aggagcgggt gcggaagcgc tccaagtccc gggagagcaa
      361 acggaaccgg cggcgggagt cgcgctcccg ctcgcgctcc accaacgcgg cggcatcccg
      421 gcgcgagcgg gagcgcgcct cgtccccgcc cgaccgcatc gacatcttcg ggcgcacggt
      481 gagcaagcgc agcagcctgg acgagaagca gaagcgcgag gaggaggaga agaaggcgga
      541 gttcgagcga cagcgaaaaa ttcggcagca ggaaatagaa gaaaaactca ttgaggaaga
      601 aacagcacga agagtggaag aattggtagc aaaaagggta gaagaagaat tggagaaaag
      661 gaaggatgaa attgagcgag aagttctccg aagggttgaa gaagccaaac gcatcatgga
      721 aaagcagttg ctcgaagaac tcgagcgaca gagacaagct gagcttgcag cacaaaaagc
      781 cagagaggag gaagagagag caaagcgtga ggaactggag cggatattag aagaaaataa
      841 ccggaaaatc gcagaagcac aagccaaact ggctgaagaa cagttgagaa ttgttgaaga
      901 acaaagaaag attcatgagg aaaggatgaa actagaacaa gaacgacagc gtcagcaaaa
      961 agaagaacaa aaaattatcc tgggcaaggg gaagtccagg ccaaaactgt ccttctcact
     1021 aaaaacccag gattgaatgg caaactctga actttttgca aagaaaaatg aaaaaacttc
     1081 gtattgtagc ttcatgttga agtggttttt ttgtttttgt tttctttttt cctttttttt
     1141 tttttttttt ttaatttgga aaatctggaa agttagcttg ttctaatagg ggctatgctc
     1201 tgcaatccct ttattttccc tcttttcctt cattaagtca agtccttatc agatcattgc
     1261 tgtcttgtag acgtggtgta ttttgcacct gttgggattc tgtactggct gggcctgctg
     1321 aagagcaggt cacttggtga ctggctggtc tggtaaggtg ttcactgacc actgacttcg
     1381 gagttatact ctgtttacta cgtcataatg ctggttttgc tgactttttg tttttttatg
     1441 catttataaa aaaagaaaaa gttggtaatt gcattgcaaa attcccaggg tttgactgga
     1501 cctgcggtgt tgttagagca gtgtccttgg gatgctgtgg ttcttgaggt tcctgacaac
     1561 aggtaaggaa acagttggtc acctgctaca gaaataacct gcagtgcagc attgtctctc
     1621 tcggactttt gtttctttca ttgacaaaat caaaccagca ttccccattg taaataaatg
     1681 attttgctga ataaagtaaa gtcttaaatt caaaaaaaaa aaaaaaaaaa a
//
