LOCUS       NM_009705               1417 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus arginase type II (Arg2), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_009705
VERSION     NM_009705.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Zhang,Y., Higgins,C.B., Tica,S., Adams,J.A., Sun,J., Kelly,S.C.,
            Zong,X., Dietzen,D.J., Pietka,T., Ballentine,S.J., Shriver,L.P.,
            Patti,G.J., Cao,Y. and DeBosch,B.J.
  TITLE     Hierarchical tricarboxylic acid cycle regulation by hepatocyte
            arginase 2 links the urea cycle to oxidative metabolism
  JOURNAL   Cell Metab 36 (9), 2069-2085 (2024)
   PUBMED   39116884
  REMARK    GeneRIF: Hierarchical tricarboxylic acid cycle regulation by
            hepatocyte arginase 2 links the urea cycle to oxidative metabolism.
REFERENCE   2  (bases 1 to 1417)
  AUTHORS   Nagai,M., Okawa,T., Nakata,K., Takahashi,D., Miyajima,R.,
            Shiratori,H., Yamanaka,D., Nakamura,A., Oyama,C., Takahashi,S.I.,
            Toyama-Sorimachi,N., Suzuki,K., Ohashi,W., Dohi,T., Kawamura,Y.I.
            and Hase,K.
  TITLE     Sugar and arginine facilitate oral tolerance by ensuring the
            functionality of tolerogenic immune cell subsets in the intestine
  JOURNAL   Cell Rep 43 (7), 114490 (2024)
   PUBMED   38990720
REFERENCE   3  (bases 1 to 1417)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1417)
  AUTHORS   Zhou,L.Y., Liu,K., Yin,W.J., Xie,Y.L., Wang,J.L., Zuo,S.R.,
            Tang,Z.Y., Wu,Y.F. and Zuo,X.C.
  TITLE     Arginase2 mediates contrast-induced acute kidney injury via
            facilitating nitrosative stress in tubular cells
  JOURNAL   Redox Biol 67, 102929 (2023)
   PUBMED   37856999
REFERENCE   5  (bases 1 to 1417)
  AUTHORS   Zaidi,S.A.H., Xu,Z., Lemtalsi,T., Sandow,P., Athota,S., Liu,F.,
            Haigh,S., Huo,Y., Narayanan,S.P., Fulton,D.J.R., Rojas,M.A.,
            Fouda,A.Y., Caldwell,R.W. and Caldwell,R.B.
  TITLE     Calbindin 2-specific deletion of arginase 2 preserves visual
            function after optic nerve crush
  JOURNAL   Cell Death Dis 14 (10), 661 (2023)
   PUBMED   37816735
  REMARK    GeneRIF: Calbindin 2-specific deletion of arginase 2 preserves
            visual function after optic nerve crush.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1417)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   7  (bases 1 to 1417)
  AUTHORS   Shi,O., Morris,S.M. Jr., Zoghbi,H., Porter,C.W. and O'Brien,W.E.
  TITLE     Generation of a mouse model for arginase II deficiency by targeted
            disruption of the arginase II gene
  JOURNAL   Mol Cell Biol 21 (3), 811-813 (2001)
   PUBMED   11154268
REFERENCE   8  (bases 1 to 1417)
  AUTHORS   Morris,S.M. Jr., Kepka-Lenhart,D. and Chen,L.C.
  TITLE     Differential regulation of arginases and inducible nitric oxide
            synthase in murine macrophage cells
  JOURNAL   Am J Physiol 275 (5), E740-E747 (1998)
   PUBMED   9814991
REFERENCE   9  (bases 1 to 1417)
  AUTHORS   Shi,O., Kepka-Lenhart,D., Morris,S.M. Jr. and O'Brien,W.E.
  TITLE     Structure of the murine arginase II gene
  JOURNAL   Mamm Genome 9 (10), 822-824 (1998)
   PUBMED   9745037
REFERENCE   10 (bases 1 to 1417)
  AUTHORS   Iyer,R.K., Bando,J.M., Jenkinson,C.P., Vockley,J.G., Kim,P.S.,
            Kern,R.M., Cederbaum,S.D. and Grody,W.W.
  TITLE     Cloning and characterization of the mouse and rat type II arginase
            genes
  JOURNAL   Mol Genet Metab 63 (3), 168-175 (1998)
   PUBMED   9608538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV039756.1, AF032466.1 and AC154585.2.
            
            On Jul 14, 2009 this sequence version replaced NM_009705.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023349.1, AF032466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               DV039756.1         35-437
            404-1409            AF032466.1         356-1361
            1410-1417           AC154585.2         112258-112265
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..1417
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /note="arginase type II"
                     /db_xref="GeneID:11847"
                     /db_xref="MGI:MGI:1330806"
     exon            1..193
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1147
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /EC_number="3.5.3.1"
                     /note="arginase-2, mitochondrial; type II arginase;
                     kidney-type arginase; non-hepatic arginase; arginase II"
                     /codon_start=1
                     /product="arginase-2, mitochondrial precursor"
                     /protein_id="NP_033835.1"
                     /db_xref="CCDS:CCDS26007.1"
                     /db_xref="GeneID:11847"
                     /db_xref="MGI:MGI:1330806"
                     /translation="MFLRSSASRLLHGQIPCVLTRSVHSVAIVGAPFSRGQKKLGVEY
                     GPAAIREAGLLKRLSRLGCHLKDFGDLSFTNVPQDDPYNNLVVYPRSVGLANQELAEV
                     VSRAVSGGYSCVTMGGDHSLAIGTIIGHARHRPDLCVIWVDAHADINTPLTTVSGNIH
                     GQPLSFLIKELQDKVPQLPGFSWIKPCLSPPNIVYIGLRDVEPPEHFILKNYDIQYFS
                     MREIDRLGIQKVMEQTFDRLIGKRQRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREG
                     VYITEEIHNTGLLSALDLVEVNPHLATSEEEAKATARLAVDVIASSFGQTREGGHIVY
                     DHLPTPSSPHESENEECVRI"
     exon            194..266
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /inference="alignment:Splign:2.1.0"
     exon            267..444
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /inference="alignment:Splign:2.1.0"
     exon            445..604
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /inference="alignment:Splign:2.1.0"
     exon            605..699
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /inference="alignment:Splign:2.1.0"
     exon            700..804
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /inference="alignment:Splign:2.1.0"
     exon            805..941
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1417
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1385..1390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /note="hexamer: CATAAA"
     polyA_site      1410
                     /gene="Arg2"
                     /gene_synonym="AII"
                     /note="major polyA site"
ORIGIN      
        1 gaagctgtgg gaggctgcac tcactcgagg tcctgagttg caccgagccg gttctcctag
       61 ggtaatcccc tccctgccaa tcatgttcct gaggagcagc gcctcccgtc tcctccacgg
      121 gcaaattcct tgcgtcctga cgagatccgt ccactctgta gctatagtcg gagccccttt
      181 ctctcgggga cagaagaagc taggagtgga atatggtcca gctgccattc gagaagctgg
      241 cttgctgaag aggctctcca ggttgggatg ccacctaaaa gactttggag acttgagttt
      301 tactaatgtc ccacaagatg atccctacaa taatctggtt gtgtatcctc gttcagtggg
      361 ccttgccaac caggaactgg ctgaagtggt tagtagagct gtgtcaggtg gctacagctg
      421 tgtcaccatg ggaggagacc acagcctggc aataggtacc attatcggtc acgcccggca
      481 ccgcccagat ctctgtgtca tctgggttga tgctcatgcg gacattaata cacctctcac
      541 cactgtatct ggaaatatac atggacagcc actttccttt ctcatcaaag aactacaaga
      601 caaggtacca caactgccag gattttcctg gatcaaacct tgcctctctc ccccaaatat
      661 tgtgtacatt ggcctgagag atgtggagcc tcctgaacat tttattttaa agaattatga
      721 catccagtat ttttccatga gagagattga tcgacttggg atccagaagg tgatggaaca
      781 gacatttgat cggctgattg gcaaaaggca gaggccaatc cacctgagtt ttgacattga
      841 tgcatttgac cctaaactgg ctccagccac aggaacccct gttgtagggg gattaaccta
      901 cagagaagga gtgtatatta ctgaagaaat acataataca gggttgctgt cagctctgga
      961 tcttgttgaa gtcaatcctc atttggccac ttctgaggaa gaggccaagg caacagccag
     1021 actagcagtg gatgtgattg cttcaagttt tggtcagaca agagaaggag gacacattgt
     1081 ctatgaccac cttcctactc ctagttcacc acacgaatca gaaaatgaag aatgtgtgag
     1141 aatttaggaa atactgtact ctggcacctt tcacaacagc attacagagt tgcaaggcat
     1201 tcgaagggac agatatgaaa tggctgtctg gatcaatatt gccttaatga gaacatctgt
     1261 gcactctcac aactgtaaaa ctcccttctc tattttggtc accaacacta ttactgtaaa
     1321 tgtatttttt gttgtttttg aagtttacaa gctattaatg ttatacatgt aagtttgaag
     1381 gagtcataaa caacatttat taccttagta tatcata
//
