LOCUS       NM_007482               1489 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus arginase, liver (Arg1), mRNA.
ACCESSION   NM_007482
VERSION     NM_007482.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1489)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 1489)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1489)
  AUTHORS   Shahror,R.A., Shosha,E., Morris,C., Wild,M., Mu,S., Csanyi,G.,
            Boerma,M., Rusch,N.J. and Fouda,A.Y.
  TITLE     Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate
            retinal ischemic injury
  JOURNAL   J Neuroinflammation 21 (1), 170 (2024)
   PUBMED   38997746
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1489)
  AUTHORS   Passino,R., Finneran,M.C., Hafner,H., Feng,Q., Huffman,L.D.,
            Zhao,X.F., Johnson,C.N., Kawaguchi,R., Oses-Prieto,J.A.,
            Burlingame,A.L., Geschwind,D.H., Benowitz,L.I. and Giger,R.J.
  TITLE     Neutrophil-inflicted vasculature damage suppresses immune-mediated
            optic nerve regeneration
  JOURNAL   Cell Rep 43 (3), 113931 (2024)
   PUBMED   38492223
REFERENCE   5  (bases 1 to 1489)
  AUTHORS   Hasby Saad,M.A., El-Saadi,E.G., Ali,D.A., Watany,M.M. and Eid,M.M.
  TITLE     Potential i-Nos/Arg-1 Switch with NLRP3 and Parasitic Load Down
            Regulation in Experimental Schistosoma mansoni Infection via
            Chloroquine Repurposing
  JOURNAL   Parasite Immunol 46 (3), e13030 (2024)
   PUBMED   38498004
  REMARK    GeneRIF: Potential i-Nos/Arg-1 Switch with NLRP3 and Parasitic Load
            Down Regulation in Experimental Schistosoma mansoni Infection via
            Chloroquine Repurposing.
REFERENCE   6  (bases 1 to 1489)
  AUTHORS   Louis,C.A., Mody,V., Henry,W.L. Jr., Reichner,J.S. and Albina,J.E.
  TITLE     Regulation of arginase isoforms I and II by IL-4 in cultured murine
            peritoneal macrophages
  JOURNAL   Am J Physiol 276 (1), R237-R242 (1999)
   PUBMED   9887201
REFERENCE   7  (bases 1 to 1489)
  AUTHORS   Iyer,R.K., Bando,J.M., Jenkinson,C.P., Vockley,J.G., Kim,P.S.,
            Kern,R.M., Cederbaum,S.D. and Grody,W.W.
  TITLE     Cloning and characterization of the mouse and rat type II arginase
            genes
  JOURNAL   Mol Genet Metab 63 (3), 168-175 (1998)
   PUBMED   9608538
REFERENCE   8  (bases 1 to 1489)
  AUTHORS   Rout,U.K., Krawetz,S.A. and Armant,D.R.
  TITLE     Ethanol-induced intracellular calcium mobilization rapidly alters
            gene expression in the mouse blastocyst
  JOURNAL   Cell Calcium 22 (6), 463-474 (1997)
   PUBMED   9502196
REFERENCE   9  (bases 1 to 1489)
  AUTHORS   Hashimoto,C., Masuda,H., Ayaki,M., Suzuki,Y., Uenaka,A., Seya,T.,
            Miyoshi,J., Takahashi,K. and Inui,Y.
  TITLE     Molecular cloning and sequence analysis of the cDNA for the mouse
            counterpart to adult hamster liver purified growth inhibitory
            factor
  JOURNAL   Biochim Biophys Acta 1355 (3), 205-208 (1997)
   PUBMED   9060991
REFERENCE   10 (bases 1 to 1489)
  AUTHORS   Ohtake,A., Takayanagi,M., Yamamoto,S., Nakajima,H. and Mori,M.
  TITLE     Ornithine transcarbamylase deficiency in spf and spf-ash mice:
            genes, mRNAs and mRNA precursors
  JOURNAL   Biochem Biophys Res Commun 146 (3), 1064-1070 (1987)
   PUBMED   3039990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB947842.1, AK149471.1 and U88541.1.
            
            On Nov 1, 2007 this sequence version replaced NM_007482.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149471.1, BC013341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               CB947842.1         5-687
            684-1474            AK149471.1         667-1457
            1475-1489           U88541.1           287-301
FEATURES             Location/Qualifiers
     source          1..1489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 12.26 cM"
     gene            1..1489
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /note="arginase, liver"
                     /db_xref="GeneID:11846"
                     /db_xref="MGI:MGI:88070"
     exon            1..159
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1074
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /EC_number="3.5.3.1"
                     /note="arginase I; type I arginase; liver-type arginase;
                     arginase 1, liver"
                     /codon_start=1
                     /product="arginase-1"
                     /protein_id="NP_031508.1"
                     /db_xref="CCDS:CCDS48523.1"
                     /db_xref="GeneID:11846"
                     /db_xref="MGI:MGI:88070"
                     /translation="MSSKPKSLEIIGAPFSKGQPRGGVEKGPAALRKAGLLEKLKETE
                     YDVRDHGDLAFVDVPNDSSFQIVKNPRSVGKANEELAGVVAEVQKNGRVSVVLGGDHS
                     LAVGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVSFLLKELKGKFPDVP
                     GFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSY
                     LLGRKKRPIHLSFDVDGLDPAFTPATGTPVLGGLSYREGLYITEEIYKTGLLSGLDIM
                     EVNPTLGKTAEEVKSTVNTAVALTLACFGTQREGNHKPGTDYLKPPK"
     exon            160..232
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            233..407
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            408..567
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            568..662
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            663..767
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            768..904
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1477
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1463
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /note="major polyA site"
ORIGIN      
        1 gaaaaagatg tgccctctgt cttttagggt tacggccggt ggagaggagc tggacagccc
       61 gagcacatgc agcagcagca gccgctggaa cccagagaga gcatgagctc caagccaaag
      121 tccttagaga ttatcggagc gcctttctca aaaggacagc ctcgaggagg ggtagagaaa
      181 ggccctgcag cactgaggaa agctggtctg ctggaaaaac ttaaagaaac agagtatgac
      241 gtgagagacc acggggacct ggcctttgtt gatgtcccta atgacagctc ctttcaaatt
      301 gtgaagaacc cacggtctgt ggggaaagcc aatgaagagc tggctggtgt ggtggcagag
      361 gtccagaaga atggaagagt cagtgtggtg ctgggtggag accacagtct ggcagttgga
      421 agcatctctg gccacgccag ggtccaccct gacctatgtg tcatttgggt ggatgctcac
      481 actgacatca acactcccct gacaaccagc tctgggaatc tgcatgggca acctgtgtcc
      541 tttctcctga aggaactgaa aggaaagttc ccagatgtac caggattctc ctgggtgact
      601 ccctgcatat ctgccaaaga catcgtgtac attggcttgc gagacgtaga ccctggggaa
      661 cactatataa taaaaactct gggaattaag tatttctcca tgactgaagt agacaagctg
      721 gggattggca aggtgatgga agagaccttc agctacctgc tgggaaggaa gaaaaggccg
      781 attcacctga gctttgatgt cgacgggctg gacccagcat tcaccccggc gaccggcacc
      841 ccggttctgg gaggcctatc ttacagagaa ggtctctaca tcacagaaga aatttacaag
      901 acagggctcc tttcaggact agatatcatg gaagtgaacc caactcttgg gaagacagca
      961 gaggaggtga agagtactgt gaacacggca gtggctttaa ccttggcttg cttcggaact
     1021 caacgggagg gtaaccataa gccagggact gactacctta aaccacctaa gtgactgtga
     1081 atgcgccaca tgaaaaccat ctggggcatc acagcaaagc agacagaact aagcaaacgc
     1141 cttctcctcc caagggcttg ttcttttaga aaaaaaaaaa attttttttc cagtaagtat
     1201 gtatcccagc agttcctttc tggtatgaaa ttcaggatgt ggaaatcaaa acagctataa
     1261 aactaggaaa catgtattcc ccattttagc ataagttatc cttaagaagt agtatccaat
     1321 taattttcaa ttaaaaaatg caccagcatt taaaatacac ggtgatgtta agtgtcaatt
     1381 cacagttgga agcaaaggta tccagagagg tagcctatat ccacgctgtt caaaagatgt
     1441 ataataaact ctttataata aaattctgtt gtctgcaaaa aaaaaaaaa
//
