LOCUS       NM_029802               3277 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ARF interacting protein 2 (Arfip2), mRNA.
ACCESSION   NM_029802
VERSION     NM_029802.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3277)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3277)
  AUTHORS   Guo,H., Rogg,M., Keller,J., Scherzinger,A.K., Jackel,J., Meyer,C.,
            Sammarco,A., Helmstadter,M., Gorka,O., Gross,O., Schell,C. and
            Bechtel-Walz,W.
  TITLE     ADP-Ribosylation Factor-Interacting Protein 2 Acts as a Novel
            Regulator of Mitophagy and Autophagy in Podocytes in Diabetic
            Nephropathy
  JOURNAL   Antioxidants (Basel) 13 (1), 81 (2024)
   PUBMED   38247505
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3277)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3277)
  AUTHORS   Higgins,A.M., Banik,B.L. and Brown,J.L.
  TITLE     Geometry sensing through POR1 regulates Rac1 activity controlling
            early osteoblast differentiation in response to nanofiber diameter
  JOURNAL   Integr Biol (Camb) 7 (2), 229-236 (2015)
   PUBMED   25539497
  REMARK    GeneRIF: Highest level of Rac1 activation was achieved on the
            smallest nanofibers, a trend that was lost in POR1 knockdown. This
            supports the hypothesis that on small nanofibers, POR1 binds to
            highly curved cell membranes, allowing Rac1 to dissociate and
            activate.
REFERENCE   5  (bases 1 to 3277)
  AUTHORS   Felkl,M. and Leube,R.E.
  TITLE     Interaction assays in yeast and cultured cells confirm known and
            identify novel partners of the synaptic vesicle protein
            synaptophysin
  JOURNAL   Neuroscience 156 (2), 344-352 (2008)
   PUBMED   18706977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY203177.1, AK009100.1, BU583325.1 and AC125227.6.
            
            On Apr 29, 2009 this sequence version replaced NM_029802.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022942.1, AK154772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BY203177.1         1-63
            64-783              AK009100.1         2-721
            784-964             BU583325.1         239-419
            965-1358            AK009100.1         903-1296
            1359-1856           AK009100.1         1298-1795
            1857-3277           AC125227.6         145499-146919       c
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.92 cM"
     gene            1..3277
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /note="ARF interacting protein 2"
                     /db_xref="GeneID:76932"
                     /db_xref="MGI:MGI:1924182"
     exon            1..172
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..313
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1240
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /note="Arfaptin 2; ADP-ribosylation factor interacting
                     protein 2"
                     /codon_start=1
                     /product="arfaptin-2"
                     /protein_id="NP_084078.3"
                     /db_xref="CCDS:CCDS21656.1"
                     /db_xref="GeneID:76932"
                     /db_xref="MGI:MGI:1924182"
                     /translation="MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPN
                     LNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGPGDEVARGIAGEKFDIVKKWGIN
                     TYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQT
                     QHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTM
                     EDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLR
                     GDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEK
                     PSWLEEQ"
     exon            314..410
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..529
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..751
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..909
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1084
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..3277
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /note="major polyA site"
     regulatory      3249..3254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
                     /note="hexamer: AATAAA"
     polyA_site      3271
                     /gene="Arfip2"
                     /gene_synonym="2310002N04Rik; POR; Por1"
ORIGIN      
        1 aaacgtcact tccgcccttt ttctctgcga cgtggccggc ttcttctgcc cagagagcat
       61 gtcacttccg ccaaatctct gacctgctgc taggatcgcg acgagaactg gaacccgagg
      121 tccccgcgcg gtccgggcct cgcgccctga ggggaagagc ggcccggccc agcgtgctgg
      181 ggtggagacc ttgactccag tcccttccct agccatgacg gacgggattc tagggaaggc
      241 agccacaatg gagattccca tccacggaaa tggcgaagct gggcagcttc ctgaagacga
      301 tgggctggag caggacctcc agcaggtgat ggtgtcagga cccaacctca atgaaactag
      361 cattgtgtct ggtggctatg ggggctctgg tgacggactc atccccacag ggtctggccg
      421 acatccatct cacagcacgt caccctctgg ccctggtgac gaggtggccc ggggcatcgc
      481 tggagaaaag tttgacatcg tcaagaaatg gggcatcaac acatataagt gcacaaagca
      541 gctgttatca gagagatttg gccgaggctc ccggactgtg gatctggagc tagagctgca
      601 gattgagttg ctgcgtgaga cgaagcgcaa gtatgaaagt gtcctgcagc tgggccgggc
      661 actgacagcc cacctctaca gcctgttgca gacccagcat gcactaggtg atgcctttgc
      721 tgacctcagc cagaagtccc cagagcttca ggaggaattt ggctataatg cagagacaca
      781 aaagctgctg tgcaagaatg gggagacgct gctaggggct gtgaacttct ttgtctctag
      841 catcaacaca ctggtcacca agaccatgga agacacactc atgactgtca aacagtatga
      901 ggctgccagg ctggaatatg atgcctaccg gacagactta gaagagctga gcctagggcc
      961 ccgggatgca gggactcgtg gtcgacttga gagtgcccag gccactttcc agacccatcg
     1021 ggacaaatat gagaagctgc ggggagatgt ggccatcaag ctgaagttcc tggaagaaaa
     1081 caagatcaag gtgatgcaca agcagctgct gctcttccac aatgccgtgt ctgcctactt
     1141 cgctgggaac cagaaacagc tggagcagac tcttcagcag ttcaacatca agctgcggcc
     1201 tccaggagcc gagaagcctt cctggttaga ggagcagtga gcagctccca gcccaacttg
     1261 gctatcaaga aggacactgg gcggggcagc cccagggtgg aggagattgg acatgggatg
     1321 tcctttgcca cttacttgct ggcttgggct cgttttttct gactggggtc tgacaccagt
     1381 tttgcccact gctgtggtct gaagaggccc gtaggcccgt aggcccagaa gctgctgtcc
     1441 tgccctttat cttcctggcc actgggcttc attcccagat cttttccttt cactccacag
     1501 ccaaaggcta tgacaaaaca ctccctggcc aatggcatca ctcctcaggc ctatccccag
     1561 ctcttgggat gtgcccctga ccaaagacag gacctcaaaa ggttctgtca gccaatggca
     1621 gctcttcttg ggctcctctg ggccaatagt gttgcctcca gtaccctttg ttccctcctc
     1681 aatgtgtgtc cattgcagag aaggggactg ggaccaaagg ggtggggata atggggagct
     1741 gcatttgtgg ccctgcatct gaatgggccc tcccctcatc cacccaccca gttgaactgt
     1801 gcttagaacc ccagaagact gggttctagc actaggaata aacctttcat aaaagcaggc
     1861 ccagtgaggt caatttgtgg gggactagag gagggtggat tggtaagaaa tgcccagtaa
     1921 tcttgcattc agttcctatg aattcagaag agctgcagct aagtttgaga agctgccgaa
     1981 ggcctgatgc ccctcacttt cagagccaac gctttatttt tctcttcccg ttagcaccaa
     2041 ggcaatctat gtgtctgaag agcatagggt ccagaggggg ttgggccggc taaccatcat
     2101 gcattcaatc atacagccga tgtttactga gtgcttttat ttgccaggca ctgcgttagg
     2161 ccctggggaa acatcagtga ataaaacgca gtccctgctc acagtgctta aggcctagtg
     2221 ggggatagag acaagtaacc aggcaactac aatacaatga gaaatgctag gatacaagat
     2281 gcagtgggag caccagataa ggggcatcta gcttagactg aggtagggat ggcgatgcca
     2341 gtttaaaagc tgagatctga aaagtaagta gcgaacagct gaggaagaaa ggccaatgct
     2401 cataaagtct gaataagaat tcagtccaga atgaaaaatt aagtgggtga gagacaagag
     2461 gcagacttga tctttggaga aatggaacta agaaacctct tagaggtctg gcagcacggg
     2521 agaagcgaag tgtagagaac atacttcctg gactattggg tagcctagtg acccttgctt
     2581 gtcactctaa gcatgaaccc tgcctgagct ccttcacatc cagtgagtag ctaccgcaga
     2641 gataaaggca ttctcaccgc acctgctgca acctgcactg ctcttgttga agtcaaacct
     2701 taattgtata agaaatcaca agaaaactcc cagcagcact ttagacaggg cttgagtgcg
     2761 gtcaactaca ggtccaaaga caactgcaga cttcttcagc attctgtccc ctctagaggg
     2821 tggagaaagg ggaccaaccc agtcagcagg ttcccacagc acagggtgca caccactctg
     2881 acttgactct ttgtcagtga taactgcaat ccccagccag gcttctgggg ctttaattag
     2941 cctttatgta gtcagctgtc tgccttgatt attagaggtg ctggttctct tattagcccc
     3001 ctactttatg ggccactgag gatttttgtt gtaagggcat tgaatcttca aatggttgga
     3061 gacagaacct gaaagcagag cccaaacatg gctccaccat tttctagctg attaggatta
     3121 atgcctgggg aacataagct cgctccgctc cttccgttgt aaagctgcta ataaaagcag
     3181 ctaccgatta cggttatgcg tattaaatga gataatgtat gtaaagtgat tagctctgtc
     3241 tggcacgtaa taaacactca gtccctgtta atgtaca
//
