LOCUS       NM_001357756            2621 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ARF GTPase activating protein 3 (Arfgap3), transcript
            variant 1, mRNA.
ACCESSION   NM_001357756 XM_006521253
VERSION     NM_001357756.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2621)
  AUTHORS   Yi,Y., Wang,L., Li,S., Li,B., Liu,C. and Hong,L.
  TITLE     Effects of mechanical trauma on the differentiation and ArfGAP3
            expression of C2C12 myoblast and mouse levator ani muscle
  JOURNAL   Int Urogynecol J 31 (9), 1913-1924 (2020)
   PUBMED   31989201
  REMARK    GeneRIF: Effects of mechanical trauma on the differentiation and
            ArfGAP3 expression of C2C12 myoblast and mouse levator ani muscle.
REFERENCE   2  (bases 1 to 2621)
  AUTHORS   Dembla,M., Wahl,S., Katiyar,R. and Schmitz,F.
  TITLE     ArfGAP3 is a component of the photoreceptor synaptic ribbon complex
            and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE
            that is important for endocytosis
  JOURNAL   J Neurosci 34 (15), 5245-5260 (2014)
   PUBMED   24719103
  REMARK    GeneRIF: ArfGAP3 interacts with RIBEYE in an NAD(H)-dependent
            manner.
REFERENCE   3  (bases 1 to 2621)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165945.7.
            
            On Nov 4, 2017 this sequence version replaced XM_006521253.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007732.1, SRR13861889.146920.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC165945.7         89275-89441         c
            168-286             AC165945.7         82216-82334         c
            287-359             AC165945.7         75848-75920         c
            360-491             AC165945.7         73672-73803         c
            492-575             AC165945.7         71880-71963         c
            576-663             AC165945.7         69713-69800         c
            664-723             AC165945.7         66799-66858         c
            724-773             AC165945.7         63298-63347         c
            774-913             AC165945.7         61768-61907         c
            914-1042            AC165945.7         53534-53662         c
            1043-1186           AC165945.7         52663-52806         c
            1187-1321           AC165945.7         49444-49578         c
            1322-1445           AC165945.7         47247-47370         c
            1446-1536           AC165945.7         46075-46165         c
            1537-1658           AC165945.7         42297-42418         c
            1659-2621           AC165945.7         38934-39896         c
FEATURES             Location/Qualifiers
     source          1..2621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.4 cM"
     gene            1..2621
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /note="ARF GTPase activating protein 3"
                     /db_xref="GeneID:66251"
                     /db_xref="MGI:MGI:1913501"
     exon            1..167
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1676
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor GTPase activating protein 1; ARF
                     GAP 3; ADP-ribosylation factor GTPase activating protein
                     3"
                     /codon_start=1
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 3 isoform 1"
                     /protein_id="NP_001344685.1"
                     /db_xref="GeneID:66251"
                     /db_xref="MGI:MGI:1913501"
                     /translation="MGDPSKQDILAIFKRLRSVPTNKVCFDCGAKNPSWASISYGVFL
                     CIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNSNASSFFHQHGCATKDTN
                     AKYNSRAAQLYREKIKTLATQATRRHGTDLWLDSCAAPPVSPPPKEEDFFASHASLEV
                     SGAMQASAQPESASSTPWGLETTPEKHEGGPGQGPSVEGLNTPGKAAPAEVSSIIKKK
                     PNQAKKGLGAKKGSLGAQKLTNTSFTEIEKQAQAVDKRKEQEDLARGAPKEESIVSSL
                     RLAYKDLEISRKKDERLNLSGQKKVEAERLGMGFGSCRSGISHSVTSDMQTIEQESPT
                     LAKPRRKYQEDPEDSYFSSSSKWSEQSSSRYFDDPMELRSSSFSSWDDGADSYWKKDS
                     SRDPEPAMRSTGSSDRPSARRKPEYEPIGSTDEAQKKFGNVKAISSDMYFGIQAQTDF
                     ETRARLERLSTSSSISSADLFDEQRKQTAGNYNLSNVLPNAPDMAQFKQGVRSVAGKL
                     SVFANGVMTSIQDRYGS"
     exon            168..286
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..359
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..491
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..575
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..663
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..723
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..773
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..913
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1042
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1186
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1321
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1445
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1536
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1658
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..2621
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /note="hexamer: AATATA"
     polyA_site      2543
                     /gene="Arfgap3"
                     /gene_synonym="0610009H19Rik; 1810004P07Rik;
                     1810035F16Rik; 9130416J18Rik; Arfgap1"
                     /note="major polyA site"
ORIGIN      
        1 acgcgcagcc ccgcccctcg gtctccggga ggcggcaacc gctactcctt gtctcttccc
       61 ggttgtcggg gactgcttca cctcagttct cagtgactat gggggacccc agcaagcagg
      121 acatcctggc catcttcaag cgcctgcgct cggtgcccac taacaaggtg tgttttgact
      181 gtggtgccaa aaatcccagc tgggccagca taagctatgg ggtgtttctc tgcattgact
      241 gctctggatc acaccggtcg ctcggggttc acttgagttt tattcggtcc acagagctgg
      301 attcaaactg gtcgtggttc cagcttcgat gcatgcaagt tggagggaac tcaaatgctt
      361 cttccttctt ccaccaacat gggtgtgcca ccaaggacac caacgccaag tacaacagcc
      421 gtgcggctca gctctacagg gagaagatca agactctggc cacccaggcc acccgcagac
      481 acggcaccga tctgtggctg gacagctgtg cggctccacc tgtgtcccct cctccaaagg
      541 aggaagattt ttttgcttct cacgcctctc tggaggtcag tggtgctatg caggcatccg
      601 cacagccaga gtcagcctct tcaacaccgt ggggcttgga aaccactcca gaaaaacatg
      661 aaggtgggcc aggacaaggg ccaagcgtgg aaggtctgaa cacccctgga aaggctgcac
      721 cagcagaggt ttcatcgatt ataaaaaaga agccaaatca agcaaaaaaa ggacttggag
      781 ccaaaaaagg aagcttggga gcccagaaac tgacaaatac atccttcact gagatcgaaa
      841 agcaagctca ggctgtggat aagaggaagg agcaggaaga ccttgccagg ggtgccccaa
      901 aggaggagtc tattgtttcg tccttgcgac tggcctacaa ggatctggaa atcagcagga
      961 agaaagatga aagactgaac ctgagtggcc agaagaaggt ggaagccgag cggctgggca
     1021 tgggctttgg aagctgcagg agtggcatct cccactcggt gacttcagac atgcagacca
     1081 ttgagcagga gtcgcccaca ctggcaaagc cgaggaggaa gtaccaggag gacccagagg
     1141 actcgtactt cagctccagc tccaagtggt ctgagcagag cagcagcagg tactttgacg
     1201 accccatgga gttaagaagc agctccttct ctagctggga tgatggtgcc gattcctact
     1261 ggaagaaaga cagcagcaga gaccccgagc ctgccatgag aagcaccggc tcttcagaca
     1321 ggcccagtgc tcgccggaag ccagaatatg agcccattgg cagcacagat gaagcccaga
     1381 agaagtttgg caacgtcaag gccatctctt cagacatgta ctttggaatt caagcccaga
     1441 cagattttga aacccgggcg cggctggaga ggctctccac cagctcctcc ataagctctg
     1501 cagacctttt tgatgagcag aggaagcaga ctgcaggaaa ctacaacctt tccaatgtgc
     1561 tgcccaatgc cccagacatg gcgcagttca agcaaggtgt gcgctccgtt gctggaaaac
     1621 tttccgtctt cgccaatggg gtcatgacgt ccattcagga tcgctacggt tcttaatcct
     1681 ggtgccaggc tgtccaacct ggtaaaactc cacttcagat ggacctgaga ccacatctgg
     1741 ctgcgccaat gccccagctg ctttgtgggc aggctctact agttggcgag gcacctgcac
     1801 atttctgagt gtccatgttt cctttgagac atccccattt ctatgtaggt gggattttgc
     1861 tttcatttct gatttaaatt agctccttgt gtccttgctt tatctttggg gcatctttag
     1921 ttccaagaac tggaagccag agctgcaggc tcctcccacc tctctccagg ctggtgttga
     1981 ctgggcccgg aaatcaatcc ccagcactta cttctcactg caaaggagca aaacaacaaa
     2041 aacagcaaga ccagaagtgc ccagcccctt gctgacagat tgcttcgtgt gtgtccccac
     2101 acaacacaca cttaaagcca tctgtcactc tgtaagttat tttgtacatt ctctactctt
     2161 aaaagtgtcc cccagtcagt tcctttaaca gacctgagct tctatgatgc caagggcgtt
     2221 cactgcgacc tgggagtaaa cagggtgtcg ctgccctgtg agaggaagat ggggccaccc
     2281 cagggctccc aatgcactcg gaagtcagca gtaccaggag ctcaggctga gaaggacagc
     2341 agtgcggctt caggacgaag ctcagccagg gagagggcga ttataattgg gtagttttgt
     2401 taatattttt ttatcttgtc cttgatattc caaaagttac aggatagatg taaatcaata
     2461 aagtcatttg gctgtgtttt agacagctcc agaatatatt gttcagcgca gtaaaatata
     2521 tttggaattt gatgaaccaa aaatgtgatt tcagatgact attttgtgac tttcttaaaa
     2581 ggtctgattt gtagacttct aaatataaca cacagcacag c
//
