LOCUS       NM_023854               3367 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ARF GTPase activating protein 2 (Arfgap2), transcript
            variant 2, mRNA.
ACCESSION   NM_023854
VERSION     NM_023854.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3367)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   2  (bases 1 to 3367)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
REFERENCE   3  (bases 1 to 3367)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   4  (bases 1 to 3367)
  AUTHORS   Singh,J., Itahana,Y., Parrinello,S., Murata,K. and Desprez,P.Y.
  TITLE     Molecular cloning and characterization of a zinc finger protein
            involved in Id-1-stimulated mammary epithelial cell growth
  JOURNAL   J Biol Chem 276 (15), 11852-11858 (2001)
   PUBMED   11278321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732478.7, AK169144.1,
            AK141749.1 and BY648993.1.
            
            On Oct 8, 2009 this sequence version replaced NM_023854.1.
            
            Summary: This gene encodes a zinc-finger-containing
            GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a
            small GTPase that plays a role in coatomer-mediated vesicular
            trafficking. This gene product stimulates the hydrolysis of
            ARF1-bound GTP, which may lead to dissociation of coatomer from
            Golgi-derived membranes to allow fusion with target membranes. It
            may regulate the retrograde transport from the Golgi complex to the
            endoplasmic reticulum. Expression of this gene has been shown to be
            controlled by inhibitor of DNA binding 1 (Id1). Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. A pseudogene of this gene was identified on
            chromosome 6. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The encoded protein (isoform 2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005495.1, AK169144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AL732478.7         194670-194847       c
            179-2926            AK169144.1         2-2749
            2927-3361           AK141749.1         1403-1837
            3362-3367           BY648993.1         441-446
FEATURES             Location/Qualifiers
     source          1..3367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.62 cM"
     gene            1..3367
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /note="ARF GTPase activating protein 2"
                     /db_xref="GeneID:77038"
                     /db_xref="MGI:MGI:1924288"
     exon            1..290
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1781
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /note="isoform 2 is encoded by transcript variant 2; ARF
                     GAP 2; GTPase-activating protein ZNF289; zinc finger
                     protein 289; ADP-ribosylation factor GTPase activating
                     protein 2"
                     /codon_start=1
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 2 isoform 2"
                     /protein_id="NP_076343.2"
                     /db_xref="CCDS:CCDS16430.1"
                     /db_xref="GeneID:77038"
                     /db_xref="MGI:MGI:1924288"
                     /translation="MAASPSKTEIQTIFKRLRAIPTNKACFDCGAKSPSWASITYGVF
                     LCIDCSGVHRSLGVHLSFIRSTELDSNWSWLQLRCMQVGGNANATAFFRQHGCMANDA
                     NTKYTSRAAQMYREKIRQLGSAALTRHGTDLWIDSMNSAPSHSPEKKDSDFFTEHTQA
                     PAWDTAATDPSGTQQPALPSESSSLAQPEQGPNTDLLGTSPQASLELKSSIIGKKKPA
                     AAKKGLGAKKGLGAQKVSNQSFTEIERQAQVAEKLREQQAADAKKQAEESMVASMRLA
                     YQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSISHSVLSEMQMIEQETPLSA
                     KSSRSQLDLFDDVGTFASGPPKYKDNPFSLGETFGSRWDSDAAWGMDRVEEKEPEVTI
                     SSIRPISERTASRREVETRSSGLESSEARQKFAGAKAISSDMFFGREVDSEYEARSRL
                     QQLSGSSAISSSDLFGNMDGAHGGGTVSLGNVLPTADIAQFKQGVKSVAGKMAVLANG
                     VMNSLQDRYGSY"
     exon            291..409
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            410..482
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            483..614
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            615..695
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            696..777
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            778..834
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            835..887
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1024
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1156
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1285
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1420
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1547
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1641
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1760
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..3367
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /note="hexamer: AATAAA"
     polyA_site      2930
                     /gene="Arfgap2"
                     /gene_synonym="2310032E02Rik; Zfp289"
                     /note="major polyA site"
ORIGIN      
        1 agcgcggcgt tcactctcag gcccgtggtg gagctcccgg ctgctaacgt catgtttcag
       61 ccccgcccga cgttcattgg cccagatctg gtcgaatcac tccactcgta ggcgggtcgg
      121 ggccctgtcg tgaccggcgc ggtgagcctg ccttcgccgc cgaggattgg cccgcgccgg
      181 gacctgtcgg tcgcggttgt gtctgggaag gagagaaaat ggcggcgagc ccgagcaaga
      241 ccgaaatcca gactattttt aagagacttc gcgcaattcc caccaacaag gcctgtttcg
      301 attgtggcgc caagagtcct agttgggcca gcatcactta cggtgtattt ttgtgtattg
      361 actgctccgg agtgcatcgc tccttgggtg tccatctcag ctttatcagg tccacagagt
      421 tggattcgaa ctggagctgg ttgcagctga ggtgtatgca ggtcggcggg aatgccaatg
      481 cgactgcttt tttccgccaa cacggatgta tggccaatga tgctaacacc aaatatacga
      541 gccgagctgc ccagatgtac cgagagaaga tccggcagtt agggagtgca gctctgacta
      601 ggcatggtac tgatctttgg atagacagta tgaacagtgc tccaagtcac tctccagaga
      661 agaaagactc tgatttcttc acagaacata ctcaggcccc tgcttgggat acagcagcca
      721 ctgatccttc agggactcag caaccagccc taccttcaga gagcagtagc ctggcacaac
      781 ctgaacaagg ccctaacact gatctgctcg gaacctcacc ccaagcctct ctggaactga
      841 aaagctccat tattggcaag aagaagccag cagccgctaa gaaagggctg ggtgccaaga
      901 aaggcctggg agctcagaag gtgagcaacc agagctttac tgagattgag cggcaggccc
      961 aggtggcaga gaagctccga gagcagcagg cagctgatgc caagaagcag gcagaagagt
     1021 ccatggttgc ctccatgcgt ctggcctacc aggagctcca gattgatcgc aagaaggagg
     1081 agaaaaagct ccagaatctt gaaggaaaga agcgagagca ggctgaaagg ctgggcatgg
     1141 gcttggtgtc ccgaagctcc atctcccatt ctgtgctgtc tgagatgcag atgattgagc
     1201 aggaaacccc gctgagtgcg aaatcttccc gttcacagct tgacttgttt gatgatgttg
     1261 gaacatttgc atctggaccc ccaaagtaca aggacaaccc cttttccttg ggagaaactt
     1321 ttggttcccg ctgggattca gatgcagcct ggggtatgga cagggtagaa gagaaggaac
     1381 ctgaagttac catctccagc atccggccta tttcagaaag aactgcgagt cggagggaag
     1441 tggagactcg gagctcaggc cttgagtcca gtgaagcacg gcagaagttt gcaggagcca
     1501 aagccatctc gtccgacatg ttctttggtc gtgaggtgga ttctgagtat gaagctaggt
     1561 ctcggttaca gcagctttcg ggcagcagtg ccatcagctc ttcagacctt tttggaaaca
     1621 tggatggagc tcatggagga ggaactgtat ctctggggaa tgtacttcct acagctgaca
     1681 ttgcccagtt taagcagggt gtcaagtctg tggctggcaa gatggctgtg ctggccaatg
     1741 gtgtgatgaa ttccttacag gatcgctacg gttcctactg atccaggctc catggctcag
     1801 gcctgtggtg acgacagcaa gaaccctgag tcccaggctg gagatgccgg tcttgtgggt
     1861 ctggggagtt gttgactttg tgtgtgtggt gtgtgagttg gatgacttgg gaggatcttg
     1921 gagcggggaa tggtcggcat cagcccttgt cttcagcctg tgcatcgagt ccttgtcctc
     1981 atcccctcac actctccctc catgctagtg ttcttctcca gtcttgcccc aaagctgctg
     2041 ctgcttggcc tgctgcactg ggagtgaggg gggagctcca tcaggatggc tttatggatc
     2101 taattcttcc ccaaggaggg aaggcacaag gcttctgcag gctctaggat ccttgtaggt
     2161 ggtctggggg cttgggcgtc catcttctgg aaacagggga ggcctagcaa gagttgtgct
     2221 gtatcagccc tcagggagaa gttctggact cgtcactgct gttcctgtca gtggcctctt
     2281 ctgggttcca gggaagggtt aggagaagga tcctggtagc tcaccaagag ctagaacttt
     2341 tgcttggtac ccaaaggttt tatttgggat tagcccggag gcctgagcac tcttccattg
     2401 tcacagctgt cccttgaagg ctgacttctg cctaggtgtt tgagagcctt tatctaccat
     2461 tactgtgggt cacagcgccc tctgtctatg cttgaggtcc tctttgtgtc ctccttggcc
     2521 ctatggtgag tctcatctgt gtgtcctgcc tggatgctgt gaacctgtta gctgaggaag
     2581 ctaagactga gagaaagcag ccctggagct cagcttttat catctgcatc atcctggttt
     2641 aggggtcctg gacagcaccc catcaaccag tgagagtgtg agggcctgca gctgcaggct
     2701 ccacccactg gcagctgggc cacgcactgt gtcctccttg gtgccatctc acctgccaca
     2761 ctggcagtct ggcccaacct ctacctgtgg attgcaggtt gggctcccaa acaacacaga
     2821 ccactcttcc ctcatccctc cccagaggga catgactttc tttcagcact gtttgtattg
     2881 aaacaaagtg gtgtcaaaat aaagccccca aggggccctg tgggtcagtg tcctctccgt
     2941 cctgcctccc tgcccagtgt ggcccttcgc tcactctctg ggctcccacc gatatgggtt
     3001 gggcgttggt gccaaagctg agggcactgt ctccggggcc tccagcttgt ctcttccttc
     3061 aaagccaaag gcccctggct ccttgcccct ttgctgctgc ggggtccggt acagcctcga
     3121 cctcaccacc ctgttgcacg tggaggaaag aggtggtgtt agttggccct ttagtttgtc
     3181 tgcaacctca gtggttcagc acctcatcac aggaggcaga cagggacctg tttgtcatca
     3241 gagctctgtt tttgcttttg tttgagactg tctccacagc ccagactggc tttgtacttg
     3301 aaatcctcct gtctcggccc tggcgctgaa tggcaggcat ttagtaaaat gcctggcttg
     3361 gagaaac
//
