LOCUS       NM_145760               2721 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ARF GTPase activating protein 1 (Arfgap1), transcript
            variant 1, mRNA.
ACCESSION   NM_145760
VERSION     NM_145760.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2721)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   2  (bases 1 to 2721)
  AUTHORS   Chornyy,S., Parnis,A., Shmoish,M. and Cassel,D.
  TITLE     High abundance of ArfGAP1 found in the mossy fibers in hilus of the
            dentate gyrus region of the mouse brain
  JOURNAL   PLoS One 12 (12), e0189659 (2017)
   PUBMED   29240824
  REMARK    GeneRIF: data suggest that ArfGAP1 can be used as a specific marker
            of the dentate mossy fibers and as for visualization of cortical
            layers in immunohistochemical studies
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2721)
  AUTHORS   Schultz,M.L., Tecedor,L., Stein,C.S., Stamnes,M.A. and
            Davidson,B.L.
  TITLE     CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and
            actin-dependent events
  JOURNAL   PLoS One 9 (5), e96647 (2014)
   PUBMED   24792215
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2721)
  AUTHORS   Xiong,Y., Yuan,C., Chen,R., Dawson,T.M. and Dawson,V.L.
  TITLE     ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal
            regulation of ArfGAP1 by LRRK2
  JOURNAL   J Neurosci 32 (11), 3877-3886 (2012)
   PUBMED   22423108
REFERENCE   5  (bases 1 to 2721)
  AUTHORS   Stafa,K., Trancikova,A., Webber,P.J., Glauser,L., West,A.B. and
            Moore,D.J.
  TITLE     GTPase activity and neuronal toxicity of Parkinson's
            disease-associated LRRK2 is regulated by ArfGAP1
  JOURNAL   PLoS Genet 8 (2), e1002526 (2012)
   PUBMED   22363216
REFERENCE   6  (bases 1 to 2721)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 2721)
  AUTHORS   Yang,Y., Beyer,B.J., Otto,J.F., O'Brien,T.P., Letts,V.A.,
            White,H.S. and Frankel,W.N.
  TITLE     Spontaneous deletion of epilepsy gene orthologs in a mutant mouse
            with a low electroconvulsive threshold
  JOURNAL   Hum Mol Genet 12 (9), 975-984 (2003)
   PUBMED   12700166
REFERENCE   8  (bases 1 to 2721)
  AUTHORS   Jacques,K.M., Nie,Z., Stauffer,S., Hirsch,D.S., Chen,L.X.,
            Stanley,K.T. and Randazzo,P.A.
  TITLE     Arf1 dissociates from the clathrin adaptor GGA prior to being
            inactivated by Arf GTPase-activating proteins
  JOURNAL   J Biol Chem 277 (49), 47235-47241 (2002)
   PUBMED   12376537
  REMARK    GeneRIF: termination of Arf1 signals mediated through GGA require
            that Arf1.GTP dissociates from GGA prior to interaction with GAP
            and consequent hydrolysis of GTP
REFERENCE   9  (bases 1 to 2721)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ149044.1, AK145879.1 and BY630306.1.
            
            On Apr 25, 2010 this sequence version replaced NM_145760.2.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168007.1, AK145879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CJ149044.1         1-17
            18-2655             AK145879.1         2-2639
            2656-2721           BY630306.1         330-395
FEATURES             Location/Qualifiers
     source          1..2721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.53 cM"
     gene            1..2721
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /note="ARF GTPase activating protein 1"
                     /db_xref="GeneID:228998"
                     /db_xref="MGI:MGI:2183559"
     exon            1..105
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            106..318
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            319..382
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1567
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /note="isoform a is encoded by transcript variant 1; ARF
                     GAP 1; ARF1-directed GTPase-activating protein; ARF1 GAP;
                     ADP-ribosylation factor GTPase activating protein 1;
                     ADP-ribosylation factor 1 GTPase activating protein"
                     /codon_start=1
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 1 isoform a"
                     /protein_id="NP_665703.2"
                     /db_xref="CCDS:CCDS17190.1"
                     /db_xref="GeneID:228998"
                     /db_xref="MGI:MGI:2183559"
                     /translation="MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLE
                     CSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLETQDDYEPSWSLQDK
                     YSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRASGQPQSAAASG
                     DKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNNAMSSLYSGWSSFTTGA
                     SKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLA
                     SKVQGVGSKGWRDVTTFFSGKAEDSSDRPLEGHSYQNSSGDNSQNSNIDQSFWETFGS
                     AEPPKAKSPSSDSWTCADASTGRRSSDSWDVWGSGSASNNKNSNSDGWESWEGASGEG
                     RAKATKKAAPSTADEGWDNQNW"
     exon            383..492
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            493..664
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            665..765
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            766..852
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            853..949
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1006
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1039
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1096
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1156
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1233
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..2721
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2657
                     /gene="Arfgap1"
                     /gene_synonym="Arf1gap"
                     /note="major polyA site"
ORIGIN      
        1 ttgcaaagcg cgacgtagcc ggaagctgct ggcggctggt ggggggatct gagcgcctag
       61 tccagcttgg cacctcggcc ggacccgacc tcctgggggc agcaggatcc cagtgtgcgg
      121 ccgtccagac cccccctccc ctgcctcccg gcctgtgagc tttaccgccc ttcagcctag
      181 cggttgcagg gacctacgtg gcccctcagc gctctggtcc cgagcagtct tggacgcaga
      241 ctggttctgc actgcccact ttgtcgggaa agggcctcag cccttcactt cgaaagaaga
      301 ttctgtccag aggtgccgca ccatggccag cccaagaacc aggaaagttc ttaaggaagt
      361 ccgggcacag gatgagaata atgtttgctt tgagtgtggt gcgttcaatc ctcagtgggt
      421 cagcgtgact tatggcatct ggatctgcct ggaatgctct gggagacacc gtgggcttgg
      481 ggtgcacctc agctttgtgc gctctgttac aatggacaaa tggaaggaca ttgagctgga
      541 gaagatgaag gctggtggga atgctaagtt ccgagagttc ctggagacac aggacgacta
      601 tgagcctagc tggtcactgc aggacaagta cagcagcaga gccgcggcgc tcttcaggga
      661 taaggtggct actttggcag aaggtaaaga gtggtctctg gagtcatcgc ctgcacagaa
      721 ctggacccca cctcagccca agacactgca gttcactgcc caccgagcct ctggccagcc
      781 acagagtgca gccgcctctg gggacaaggc ttttgaagat tggctgaatg atgacctggg
      841 ttcctaccag ggtgctcagg agaatcgcta tgtagggttt gggaacacag tgccacctca
      901 gaagagagaa gatgacttcc tcaacaatgc catgtcatcg ctgtactcgg gctggagcag
      961 ttttaccact ggggcgagca agtttgcatc tgcagcaaag gagggtgcta caaaatttgg
     1021 atctcaagca agtcagaagg cttcggagtt gggccacagc ctgaatgaga atgttctcaa
     1081 gcctgcacag gagaaggtga aggagggaag gatttttgat gatgtgtcca gtggggtctc
     1141 tcagttggca tccaaggtcc agggagttgg cagtaaggga tggcgtgatg tcactacttt
     1201 cttctctggg aaagccgaag actcttcaga cagaccctta gagggccaca gctaccagaa
     1261 cagcagtgga gacaactctc agaacagcaa catagaccag agcttctggg agacctttgg
     1321 gagtgctgag ccccccaagg ccaagtcccc aagcagtgac agctggacct gtgcagatgc
     1381 ttcaacaggg aggaggagct cggacagctg ggacgtttgg ggctcaggtt ccgcatccaa
     1441 caacaagaac agcaatagcg atggctggga gagttgggag ggagccagtg gggagggcag
     1501 ggcaaaggcc accaagaagg cagccccatc cacggctgat gagggctggg acaaccagaa
     1561 ctggtaggag cctagcaccc tagcccagcc ctgctgggga ccgctgtgtt tgcactttgc
     1621 ccttcttgtt cctcctgcat ttgacctcag tgtgaagaca gtggctcagg caggacttga
     1681 gttggtgctg cctgcctggt gtggggtggc tttctcttag acctcagggg acgtgtcatc
     1741 cacctgcctc ttgggtcctc tgagcagccc tcctggactc tgggttcttg ggacccaggc
     1801 attgtctctg cagccctagc acagcctggg actgcagccc tgtgcaatgt cagccaagtc
     1861 agacatctgc tttccttgaa atgtcttttt aaacttgaaa ggtctgctag ttctttcttc
     1921 ttgaagaaag tgcctggagc cttaaagctg gaaatgagat gacaaaagca atactggagc
     1981 tcacactgcc accgacaccc tcacctaagt ccacagcctg tgtggcctgt gctgtgaaac
     2041 tcaccttgtg accctccgcc tttcctgcat cagcctgtcc agccctcagt taaatgggac
     2101 aaactctcca cagatggcca cacaaagcag actgggctct ggtcctcctt ggacacctga
     2161 tttgaacttg gccagccctg gacagctcag aaatgaggaa aggagagtaa aggggccggg
     2221 agcatttcct acgtatctgc cgctcccacc tggtacaggg gagcctgagc atggaggggg
     2281 tgctcagggg ccaactgcca ctgccagggt caagcatctt aatggggacc ctccatccgg
     2341 gcagagcacc tgttagtatt tgccatgcat tgtgtctgtg acagcccagg ccttctccca
     2401 gcctgttcag gctgctcaga gcacacttgg ttgtgtctcc ctcagcatgc agctgtcctt
     2461 ccccacttat cgccatgtgg attttgtgga acactgcagt tgagacccat gtgttatcag
     2521 tggttggtgt gacagccgcc ccctcctagg attccgtgac tgctgtgtgc tgtggctgga
     2581 gagaccagct ggggtctctg tctccttaaa cccactcctg tctgaccctc agtttgacca
     2641 gcagtgcatg acctgaagtt ctgtggtttg tgtgtctgtc atgtttgctc ctactttcta
     2701 atgttgagct gtctgggccc t
//
