LOCUS       NM_007481               3740 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ARF GTPase 6 (Arf6), mRNA.
ACCESSION   NM_007481
VERSION     NM_007481.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3740)
  AUTHORS   Wee,Y., Wang,J., Wilson,E.C., Rich,C.P., Rogers,A., Tong,Z.,
            DeGroot,E., Gopal,Y.N.V., Davies,M.A., Ekiz,H.A., Tay,J.K.H.,
            Stubben,C., Boucher,K.M., Oviedo,J.M., Fairfax,K.C., Williams,M.A.,
            Holmen,S.L., Wolff,R.K. and Grossmann,A.H.
  TITLE     Tumour-intrinsic endomembrane trafficking by ARF6 shapes an
            immunosuppressive microenvironment that drives melanomagenesis and
            response to checkpoint blockade therapy
  JOURNAL   Nat Commun 15 (1), 6613 (2024)
   PUBMED   39098861
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3740)
  AUTHORS   Islam,M.T., Cai,J., Allen,S., Moreno,D.G., Bloom,S.I.,
            Bramwell,R.C., Mitton,J., Horn,A.G., Zhu,W., Donato,A.J.,
            Holland,W.L. and Lesniewski,L.A.
  TITLE     Endothelial-Specific Reduction in Arf6 Impairs Insulin-Stimulated
            Vasodilation and Skeletal Muscle Blood Flow Resulting in Systemic
            Insulin Resistance in Mice
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (5), 1101-1113 (2024)
   PUBMED   38545783
  REMARK    GeneRIF: Endothelial-Specific Reduction in Arf6 Impairs
            Insulin-Stimulated Vasodilation and Skeletal Muscle Blood Flow
            Resulting in Systemic Insulin Resistance in Mice.
REFERENCE   3  (bases 1 to 3740)
  AUTHORS   Wong,H.N., Chen,T., Wang,P.J. and Holzman,L.B.
  TITLE     ARF6, a component of intercellular bridges, is essential for
            spermatogenesis in mice
  JOURNAL   Dev Biol 508, 46-63 (2024)
   PUBMED   38242343
  REMARK    GeneRIF: ARF6, a component of intercellular bridges, is essential
            for spermatogenesis in mice.
REFERENCE   4  (bases 1 to 3740)
  AUTHORS   Kang,H., Kang,T., Jackson,L., Murphy,A. and Nitta,T.
  TITLE     Evidence for Involvement of ADP-Ribosylation Factor 6 in
            Intracellular Trafficking and Release of Murine Leukemia Virus Gag
  JOURNAL   Cells 13 (3), 270 (2024)
   PUBMED   38334661
  REMARK    GeneRIF: Evidence for Involvement of ADP-Ribosylation Factor 6 in
            Intracellular Trafficking and Release of Murine Leukemia Virus Gag.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3740)
  AUTHORS   Matsuki,T., Hamada,N., Ito,H., Sugawara,R., Iwamoto,I., Nakayama,A.
            and Nagata,K.I.
  TITLE     Expression analysis of type I ARF small GTPases ARF1-3 during mouse
            brain development
  JOURNAL   Mol Biol Rep 51 (1), 106 (2024)
   PUBMED   38227057
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3740)
  AUTHORS   Lawrence,J.T. and Birnbaum,M.J.
  TITLE     ADP-ribosylation factor 6 regulates insulin secretion through
            plasma membrane phosphatidylinositol 4,5-bisphosphate
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13320-13325 (2003)
   PUBMED   14585928
  REMARK    GeneRIF: ARF6 is required to sustain adequate levels of PI(4,5)P2
            during periods of increased PI(4,5)P2 metabolism such as regulated
            secretion
REFERENCE   7  (bases 1 to 3740)
  AUTHORS   Niedergang,F., Colucci-Guyon,E., Dubois,T., Raposo,G. and
            Chavrier,P.
  TITLE     ADP ribosylation factor 6 is activated and controls membrane
            delivery during phagocytosis in macrophages
  JOURNAL   J Cell Biol 161 (6), 1143-1150 (2003)
   PUBMED   12810696
  REMARK    GeneRIF: ARF6 is activated in macrophages when phagocytosis is
            initiated via receptors for the Fc portion of immunoglobulins
            (FcRs). A dominant-negative mutant of ARF6 dramatically affected
            FcR-mediated phagocytosis.
REFERENCE   8  (bases 1 to 3740)
  AUTHORS   Xu,L., Frankel,P., Jackson,D., Rotunda,T., Boshans,R.L.,
            D'Souza-Schorey,C. and Foster,D.A.
  TITLE     Elevated phospholipase D activity in H-Ras- but not
            K-Ras-transformed cells by the synergistic action of RalA and ARF6
  JOURNAL   Mol Cell Biol 23 (2), 645-654 (2003)
   PUBMED   12509462
  REMARK    GeneRIF: ARF6 is activated by H-Ras, which along with RalA, leads
            to phospholipase D activation
REFERENCE   9  (bases 1 to 3740)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
REFERENCE   10 (bases 1 to 3740)
  AUTHORS   Schurmann,A., Breiner,M., Becker,W., Huppertz,C., Kainulainen,H.,
            Kentrup,H. and Joost,H.G.
  TITLE     Cloning of two novel ADP-ribosylation factor-like proteins and
            characterization of their differential expression in 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (22), 15683-15688 (1994)
   PUBMED   8195219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ167311.1, AC157822.2 and AV587828.1.
            
            On May 23, 2007 this sequence version replaced NM_007481.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083112.1, AK156960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               CJ167311.1         5-396
            393-3381            AC157822.2         107737-110725       c
            3382-3740           AV587828.1         1-359
FEATURES             Location/Qualifiers
     source          1..3740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.81 cM"
     gene            1..3740
                     /gene="Arf6"
                     /note="ARF GTPase 6"
                     /db_xref="GeneID:11845"
                     /db_xref="MGI:MGI:99435"
     exon            1..74
                     /gene="Arf6"
                     /inference="alignment:Splign:2.1.0"
     exon            75..3731
                     /gene="Arf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..1072
                     /gene="Arf6"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ADP-ribosylation factor 6"
                     /protein_id="NP_031507.1"
                     /db_xref="CCDS:CCDS25952.1"
                     /db_xref="GeneID:11845"
                     /db_xref="MGI:MGI:99435"
                     /translation="MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPT
                     VGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQE
                     LHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGD
                     GLYEGLTWLTSNYKS"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arf6"
                     /note="hexamer: AGTAAA"
     polyA_site      1539
                     /gene="Arf6"
                     /note="major polyA site"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arf6"
                     /note="hexamer: AATAAA"
     polyA_site      3731
                     /gene="Arf6"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gcagcagagc taggaggagg aggtggaggc cggagggaac ccgcgctcgg
       61 ggcggcggct ggaggcgagc acccgcgagt tcccgcgagg atccatgacc tgaccgggcg
      121 ccgagccgcg ctcgtcgtcg gggtggtgac cggggtcggt gccgagtccg gtgctcgcag
      181 gccggcaggc cggccgcagt tggagccggc gcgtgccgag gcggcggagg agctgtcggc
      241 ggcgcttgct cgctcgctcg ttcgcgcggc gcctgcgggg gggaagggca gttccgggcc
      301 ggccgcgcct cgcctcgcct cgcttgagca gggcggcggc tctcccggcg cagacgcagg
      361 gccccggcgg cgggcgatgc ccgagtgagc gcaggccggg cccctgctcc cctagccggc
      421 agcttcgcgc aggccgcagg gcgtcctcgc agcggggcgg cgacgtttcg ggctcgcggc
      481 ggcgttgtag gcttgagggg acccgggaca cctgaatgcc cccggccccg gctcttccga
      541 cgcgatgggg aaggtgctat ccaagatctt cgggaacaag gaaatgcgga tcctcatgct
      601 gggcctggac gcagccggca agacaacgat cctgtacaag ttgaagctgg gccaatcggt
      661 gaccaccatc cccacggtgg gcttcaacgt ggagacggtg acttacaaaa acgtcaagtt
      721 caacgtgtgg gatgtgggcg gccaggacaa gatccggccg ctctggcggc attactacac
      781 cgggacccag ggtctgatct tcgtggtaga ctgcgccgac cgcgaccgca tcgacgaggc
      841 ccgccaggag ctgcaccgca ttatcaatga ccgggagatg agggacgcca tcatcctcat
      901 cttcgccaac aagcaggacc tgcccgatgc catgaaaccc catgagatcc aggagaaact
      961 gggcctgacc cggattcggg acaggaactg gtatgtgcag ccctcctgtg ccacctccgg
     1021 ggacggactc tatgaggggc tcacatggtt aacctctaac tacaaatcct aatgagcgtc
     1081 ctccacccag cccccggaag gagagaaatc caaaacccat tcctaggatt atcgccacct
     1141 ccatcacctc tttgaattgc cactctcttt ttgaatctga actctggagt tactgttcta
     1201 cagtttagtg gggttggggg ttttctttgt ttcctttttt tttttttttt ccctcttggc
     1261 tttgcgttag gatgctctga tctgacattt gacacgaata cagtgctaga tgccttgtga
     1321 cttccagcaa acggggtggg gtaatagcaa ctcttggtaa agtcctttat aataatggtt
     1381 tgattttttt atttcgagag aatcttcccc cccatgtatg ctttttttcc tttttgccca
     1441 ggttcttatc acttgctgta gatggcttat tttgcattca tgcagactat gttccaagtc
     1501 tgtttcatct agtaaactga aaattattgc ttaatcaaac tgccgtttgt cttttatatt
     1561 taaggcctcc ccccccttcc tccttagcgc taactttagc agtttcaaat gtgacctttt
     1621 atagccaaga ccagtatggt gaactaagcc cacagtggca agataatgag taatagcagt
     1681 gtaatgttcc agttgcacat gagtgtgtca gacaggtaat gtcaggagcc cctggcagtg
     1741 tcagccatta acgtgcatga ggaggagtac agctcgagct cccttcaccc tagctaactg
     1801 ccgcctagaa caagcagcgc agcctgtaaa gcctacaggt ctcttccact gcaaagttag
     1861 caacttcgct gtttccctct tcttaccttt aaaaatactc tttccagaaa atggagcaat
     1921 aatggtgtat gcctcacaca gatgaaatat ttgtagatat tttaaagtga cttttggaca
     1981 aaactggaat gttaccttgt ttcaaatgtc ttaagaccag tagttttaaa attactaaac
     2041 atttgctcac taataaaaca tttaaaaagt caaattatat gcccctttaa cgtagctgga
     2101 aagaaaatac acattcctgt tttcacgtta cagcagctga ctagaccgaa gataatgaca
     2161 ttttttaaat agatgagtga tctacatctc cattaagaca ctggaaaaga tgttttattt
     2221 taaaaaggta tttagttttg cttgattgta gggtttactc ctgcagatat cctgttggtt
     2281 cggtagtata tctatctcct gtaaggaagg aaatgtgctg aatgaatggc ttagatgtgg
     2341 atgacaaagg ggaagtaggc tggacgggaa gaacctacag atgacaatga atgtaaatta
     2401 actttaaggg taagcattgt gctggttgta tccggatctt aagatgatct ggctaggacc
     2461 tgtaactaga tggagaccac tatagtaact ttttgaacca aatgttaatg tcattccgaa
     2521 ttgtgaagca gcttctggtt tctctgtagc cttaaggatt aatttagcga tcctcaagga
     2581 attaaactta gggaatttgg gaaatgtaga ctgcacaggc agtgtactgg aaaaggtgga
     2641 attttttttt ttttttaatg agggtgtctg aaaattaaaa tcaagccgga tatcatggta
     2701 aagttggaca gtattggtcc ttcatgtttt ggccatattg tataatggag cttttaccaa
     2761 agatgtagga gaagcaggag gctatacaaa aatgagctgt aagtaaaaca tttaacctaa
     2821 agcagatgag aaaaggtgct atgttgtagg ctcctattgg tgcagaggga tttttgattc
     2881 aagacgcaac taaagcctaa cggcctcagt ttcacattaa tagaagcatc tctaggaatg
     2941 aggcggactc acttaagaac attttagttg cttttacagt tcccaaagct ccaccgtaaa
     3001 tgtaattctt agtgttttaa atgattacat tctaaggtac ataaatatgg ttatacaaat
     3061 atcaatgcta tagtaacatc ctgaaacaaa ataagcacaa aggtataaat gcctaaactg
     3121 gaggaaactt gaaaccctca tgttgattct taaatgtagt gttctacttg tgacagacag
     3181 attggtagac agccattttt ttgtgtctta aaataattgg gggcatagtt aaaattttat
     3241 acaagtgatt gctgttactg aatgttgcag gtgagatggg ttatttttag cttatttgag
     3301 atatctgaag aggtgggagg gggggagaca tatttgaaat ttgaaaaccc taaacctttt
     3361 ggaaagaaat tgtaattttc acttacattt ctttaagact ttaagagatt tataattgat
     3421 gtagttaagt caaaccataa ccattggtga ttatgaagca aaaattagag cctgcagaaa
     3481 aagttataat ggaaggatta aaaaaaatct aaagattttg ttttaattgc atcaatttct
     3541 gtatttgtgt gaatttataa acatgcagta agttttgaat gaggtaaatc ttgtctaata
     3601 taagtaaatg agtctgtaga ctgtgatccc ctcccccagc taaaaaaagt gcagtacttg
     3661 gaaattgttc tttatggttg tagtgttgct gaagcactaa catgcagaaa ataaaggaat
     3721 tacacagtgc aaaaaaaaaa
//
