LOCUS       NM_007479               1689 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ARF GTPase 4 (Arf4), mRNA.
ACCESSION   NM_007479
VERSION     NM_007479.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Zhang,L., Fang,Z., Zhu,Q., Yang,S., Fu,J., Sun,Z., Lu,G., Wei,C.,
            Zhang,Z., Lee,K., Zhong,Y., Liu,R. and He,J.C.
  TITLE     Cholesterol 25-Hydroxylase Protects Against Diabetic Kidney Disease
            by Regulating ADP Ribosylation Factor 4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2309642 (2024)
   PUBMED   38816950
  REMARK    GeneRIF: Cholesterol 25-Hydroxylase Protects Against Diabetic
            Kidney Disease by Regulating ADP Ribosylation Factor 4.
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Hara,Y., Katsuyama,T., Fukaya,M., Sugawara,T., Shiroshima,T.,
            Sadakata,T., Osumi,N. and Sakagami,H.
  TITLE     ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through
            N-Cadherin Trafficking during Cerebral Cortical Development
  JOURNAL   eNeuro 10 (11) (2023)
   PUBMED   37848288
  REMARK    GeneRIF: ADP Ribosylation Factor 4 (Arf4) Regulates Radial
            Migration through N-Cadherin Trafficking during Cerebral Cortical
            Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   Gao,Y., Wei,G.Z., Forston,M.D., Rood,B., Hodges,E.R., Burke,D.,
            Andres,K., Morehouse,J., Armstrong,C., Glover,C., Slomnicki,L.P.,
            Ding,J., Chariker,J.H., Rouchka,E.C., Saraswat Ohri,S.,
            Whittemore,S.R. and Hetman,M.
  TITLE     Opposite modulation of functional recovery following contusive
            spinal cord injury in mice with oligodendrocyte-selective deletions
            of Atf4 and Chop/Ddit3
  JOURNAL   Sci Rep 13 (1), 9193 (2023)
   PUBMED   37280306
  REMARK    GeneRIF: Opposite modulation of functional recovery following
            contusive spinal cord injury in mice with oligodendrocyte-selective
            deletions of Atf4 and Chop/Ddit3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1689)
  AUTHORS   Hosoi,N., Shibasaki,K., Hosono,M., Konno,A., Shinoda,Y.,
            Kiyonari,H., Inoue,K., Muramatsu,S.I., Ishizaki,Y., Hirai,H.,
            Furuichi,T. and Sadakata,T.
  TITLE     Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor
            by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial
            Segments
  JOURNAL   J Neurosci 39 (32), 6339-6353 (2019)
   PUBMED   31201232
  REMARK    GeneRIF: ARF4(+/-)/ARF5(-/-) mice exhibited essential tremor
            (ET)-like behaviors and abnormal brain acitivity when moving.  The
            decreased expression of the class II ARF proteins in
            ARF4(+/-)/ARF5(-/-) mice leads to a haploinsufficiency of ARF4 in
            the absence of ARF5 and impairs the localization of Nav1.6 to the
            AIS and hence reduces the membrane excitability in PCs, resulting
            in the ET-like movement disorder.
REFERENCE   6  (bases 1 to 1689)
  AUTHORS   Almind,K., Kulkarni,R.N., Lannon,S.M. and Kahn,C.R.
  TITLE     Identification of interactive loci linked to insulin and leptin in
            mice with genetic insulin resistance
  JOURNAL   Diabetes 52 (6), 1535-1543 (2003)
   PUBMED   12765967
REFERENCE   7  (bases 1 to 1689)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1689)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   9  (bases 1 to 1689)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
REFERENCE   10 (bases 1 to 1689)
  AUTHORS   Schurmann,A., Breiner,M., Becker,W., Huppertz,C., Kainulainen,H.,
            Kentrup,H. and Joost,H.G.
  TITLE     Cloning of two novel ADP-ribosylation factor-like proteins and
            characterization of their differential expression in 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (22), 15683-15688 (1994)
   PUBMED   8195219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU080387.1, AK168793.1, AC121919.3 and AK081686.1.
            
            On Mar 28, 2018 this sequence version replaced NM_007479.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081686.1, AK168793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AU080387.1         62-104
            44-1072             AK168793.1         2-1030
            1073-1073           AC121919.3         87545-87545         c
            1074-1682           AK168793.1         1032-1640
            1683-1689           AK081686.1         1620-1626
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.09 cM"
     gene            1..1689
                     /gene="Arf4"
                     /note="ARF GTPase 4"
                     /db_xref="GeneID:11843"
                     /db_xref="MGI:MGI:99433"
     exon            1..353
                     /gene="Arf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..829
                     /gene="Arf4"
                     /codon_start=1
                     /product="ADP-ribosylation factor 4"
                     /protein_id="NP_031505.1"
                     /db_xref="CCDS:CCDS26881.1"
                     /db_xref="GeneID:11843"
                     /db_xref="MGI:MGI:99433"
                     /translation="MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIQE
                     GAAVLQKMLLEDELQDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCA
                     TQGTGLYEGLDWLSNELSKR"
     exon            354..434
                     /gene="Arf4"
                     /inference="alignment:Splign:2.1.0"
     exon            435..544
                     /gene="Arf4"
                     /inference="alignment:Splign:2.1.0"
     exon            545..616
                     /gene="Arf4"
                     /inference="alignment:Splign:2.1.0"
     exon            617..742
                     /gene="Arf4"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1689
                     /gene="Arf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1669..1674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arf4"
                     /note="hexamer: AATAAA"
     polyA_site      1688
                     /gene="Arf4"
                     /note="major polyA site"
ORIGIN      
        1 gacgcgattc tgtccgcgtt ggagcgggcg ggccgccgcc tgagtctccg cggccgccgt
       61 gtgacgtggc acagccgaac acttaacgcc gcgccggagc caccgcacca gacgcctagc
      121 aggtcccggt cccgctacgt cctgtcccgc ggcttcgccg acactccagc cagcgagaca
      181 ggtcttcagc gttttctcct ccgcccactc ggttgtgagc cggaaccgtg aaggcccgag
      241 ggcgcaccag accccctcct tttgaccgtc aagtgccacc accgctatgg gcctcaccat
      301 ctcctctctc ttctcgcgcc tgttcggcaa gaagcagatg cgcattttga tggttggatt
      361 ggatgctgct ggcaagacga caattctgta taaactgaaa ttaggggaaa tagtcaccac
      421 cattcctacc attggtttta atgtggaaac agtagaatat aagaacattt gtttcacagt
      481 atgggatgtt ggtggtcaag ataaaattag gcctctctgg aggcattact tccagaatac
      541 ccagggtctc atttttgtgg tagatagcaa tgatcgtgaa agaatccagg aaggagcagc
      601 tgtgctgcag aaaatgcttc tggaagatga gctgcaggat gcagtgctgc tcctttttgc
      661 aaacaaacag gatctgccaa acgctatggc catcagtgag atgacagaca agctaggtct
      721 gcagtctctc cgaaacagaa catggtatgt ccaagccact tgtgctacac aaggaactgg
      781 tctgtatgag ggactggatt ggctgtcaaa tgaactttca aaacgttaaa tgaagctgga
      841 tatctaacca aggacatgtt tgatagaatt ggtctaggct tgttacaaca aaattagttt
      901 gcatcttggt tattaaagga tatctgagac aggtttgggc agaaattaca gcgtttaaaa
      961 cttgttttgt tgccaattat tgtttaccaa gaacaatgtt gctatttagc aatatgcttg
     1021 ggtttaagag aaattctcct tgggaaagaa aagtatccat tattatgctt cccttgaacc
     1081 taaatgcctg gatacagagc tatcctgaca cctttagaca gatctgagtg gtttttgagc
     1141 ccaaaacaat aatgttttaa agttattccc ttgatacttt actgagacct ttatcattcc
     1201 tcagacagtc tgctgattta aaaatgtagc attccatttg tatttatttc taccctttgc
     1261 caaaaagatt tttctaataa tgcttgtaca ggccaaggcc gtggtccaaa acactattca
     1321 gttttcttgt actgaggatc cccccacccc accaccctca cattattgac tcctggcttc
     1381 tatcagccaa actttgatgt ggtttggatt tgatagccaa ttctgtgctg gttgcaaaga
     1441 gttcatattg agataacttt taatactcag cagattgtct tcctttatat tgttatcttt
     1501 tttatgttgc atgttgcttt tggaatcagc ctgactcttt gcccagtata tgatagttct
     1561 actggtattt tactgtttat tgatgaacat atcttcatta agaatttttt gaaaactcat
     1621 caaattcaat gaataagttt tcttcataac ccatttggaa ttattcctaa taaaatgatt
     1681 ttaaaaaac
//
