LOCUS       NM_007478               3481 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ARF GTPase 3 (Arf3), transcript variant 1, mRNA.
ACCESSION   NM_007478
VERSION     NM_007478.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3481)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3481)
  AUTHORS   Matsuki,T., Hamada,N., Ito,H., Sugawara,R., Iwamoto,I., Nakayama,A.
            and Nagata,K.I.
  TITLE     Expression analysis of type I ARF small GTPases ARF1-3 during mouse
            brain development
  JOURNAL   Mol Biol Rep 51 (1), 106 (2024)
   PUBMED   38227057
  REMARK    GeneRIF: Expression analysis of type I ARF small GTPases ARF1-3
            during mouse brain development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3481)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3481)
  AUTHORS   Huang,D., Pei,Y., Dai,C., Huang,Y., Chen,H., Chen,X., Zhang,X.,
            Lin,C., Wang,H., Zhang,R., Wan,X. and Wang,L.
  TITLE     Up-regulated ADP-Ribosylation factor 3 promotes breast cancer cell
            proliferation through the participation of FOXO1
  JOURNAL   Exp Cell Res 384 (2), 111624 (2019)
   PUBMED   31539530
  REMARK    GeneRIF: ARF3 promotes breast cancer cell proliferation through the
            participation of FOXO1.
REFERENCE   5  (bases 1 to 3481)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3481)
  AUTHORS   Wu,J.Y. and Kuo,C.C.
  TITLE     ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine
            Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like
            Receptor 9 Trafficking
  JOURNAL   J Innate Immun 7 (6), 623-636 (2015)
   PUBMED   26067373
  REMARK    GeneRIF: activated ARF3 is associated with Unc93B1 and TLR9,
            suggesting that ARF3 conducts TLR9 trafficking by forming the
            TLR9-Unc93B1-ARF3 complex.
REFERENCE   7  (bases 1 to 3481)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 3481)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 3481)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
REFERENCE   10 (bases 1 to 3481)
  AUTHORS   Schurmann,A., Breiner,M., Becker,W., Huppertz,C., Kainulainen,H.,
            Kentrup,H. and Joost,H.G.
  TITLE     Cloning of two novel ADP-ribosylation factor-like proteins and
            characterization of their differential expression in 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (22), 15683-15688 (1994)
   PUBMED   8195219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156543.10.
            
            On Nov 17, 2006 this sequence version replaced NM_007478.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014778.1, AK154948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC156543.10        162250-162388       c
            140-376             AC156543.10        141863-142099       c
            377-487             AC156543.10        140594-140704       c
            488-612             AC156543.10        140261-140385       c
            613-3481            AC156543.10        136896-139764       c
FEATURES             Location/Qualifiers
     source          1..3481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.65 cM"
     gene            1..3481
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /note="ARF GTPase 3"
                     /db_xref="GeneID:11842"
                     /db_xref="MGI:MGI:99432"
     exon            1..139
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            140..376
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..774
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /codon_start=1
                     /product="ADP-ribosylation factor 3"
                     /protein_id="NP_031504.1"
                     /db_xref="CCDS:CCDS27804.1"
                     /db_xref="GeneID:11842"
                     /db_xref="MGI:MGI:99432"
                     /translation="MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNE
                     AREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCA
                     TSGDGLYEGLDWLANQLKNKK"
     exon            377..487
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            488..612
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            613..3481
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3463..3468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3481
                     /gene="Arf3"
                     /gene_synonym="5430400P17Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagccgggga gcgggccagc ggaccatctt caccgcggtc gggtcggctt gcggagcggg
       61 aggcagcggc cggagagccg ggcggaacct gcgggggcgg aggcggcggt ggcagccgcg
      121 gcgcagggag caggaacagg gtcaagtcct ccataccaag gaccaggcta aaaccagatt
      181 acactgcccc tccctgggcc ctattgactt aaagcagcca ctgtaatcat gggcaatatc
      241 tttgggaacc ttctgaagag cctaatcggc aagaaggaga tgcgcatcct gatggtgggc
      301 ctggatgctg ccgggaagac caccatcctc tacaagctga aactcgggga gattgtcacc
      361 accatcccga ccattgggtt taatgtggag acagtggaat ataagaatat cagcttcaca
      421 gtctgggacg taggtggcca ggacaagatt cggcccctct ggagacacta cttccagaac
      481 acccaaggct tgatatttgt ggttgacagc aatgatcggg agcgagtgaa cgaggcccgg
      541 gaagagctga tgaggatgct ggcggaggat gagctccggg atgctgtgct ccttgtgttt
      601 gcaaacaaac aggatttgcc gaatgctatg aatgctgctg agatcacaga caagctgggg
      661 ctgcactccc tgcgtcaccg caattggtac attcaggcca cctgtgctac cagcggggac
      721 gggctgtatg aaggcttgga ctggctggcc aatcagctca aaaacaagaa gtgagagcca
      781 ggcagccctc tctgactacc ccacccactc ctgacacaca cctgctgtct ccttacccca
      841 attttccctt cttcctcttg aaagtggcca aggtcctggg tatcatgtcc acatgcccag
      901 caagcgcctt gccttcctcc tcctcctcct cctccctcct ccctcctccc tccctgtaca
      961 ctgacacggt cagcccccaa ctgctgtcct gatgatgaat cattccaatt tactggattt
     1021 aaaacagaat gaagctgtta cggtttcgtg gggtggtccc cattggtttc aggaggaaga
     1081 gtggggtgtt ctctgtttgc tgtttggcac tggttgctgt gctcttggca tctgagtccc
     1141 ttccctgtgt ccctggccac tctcctccct gtcttccttt ccttctgaac cctctcctat
     1201 tctacatgga cattgcacgg gcctctctgt gtgtgcgtgc atgtgtgcgc ctgtatatat
     1261 gtgtatagag agatatatat gtagggtcag gggagggagc acagcgcagc tcagggctta
     1321 cagccgggac actgcgcact ggaacctgtc ccctgccctt ctgtgttggt gagataaggg
     1381 gatgtgggtg ggtcccgttg ttttcctctc tgcaggtggc attcctggat gttgggatac
     1441 atgatgggcg ccttcggcca tctgtcttac ctttccttct ccactatgat gagcacacga
     1501 agtggcattg gtctctgggt gactgttcct aaggagctgc cgtgctactc tgcctcatta
     1561 gtagcccact cacgctatca gtctagagtg ttgtattgat cctcccccac cgtcctcaga
     1621 tctgctcctc aggaactcag agggaggtgg gttagtggga cctgcatgta gaggtggaca
     1681 gtggtcgggg aaggcctagt tttccatctt actgtcataa ggaggagaag gtaaggcatg
     1741 gagcagtcct gttcctgcct tctggtctgt cagagatctt tccccttagt agttctgctg
     1801 gcctgatgag gactgaccaa gtggagtaac gagaagccat ggactggggg taacatagcc
     1861 gacctcagta tcaactccct gttcttcagt tctctgtcta gttcaggacc aggaaagatg
     1921 agtttctgtt gtcctcgatg tcctgtcccc ctccttcctg gcagctttcc ccagtcctca
     1981 ccctgtcctg aataggtctg tggggttgga gtagatgccg taggaccctg catggctgag
     2041 cctggaactg tgatcttcag ggccctccct ccctccatcc tctgcttgtt cagctgctgc
     2101 tgcaggtctg tagagggcgc ctattccaga agatctgacc tgggtcctga cttgtcactg
     2161 cactgaagct gtggctgttc tgtgggctcc tgtgtgtgct ggctgcgccc tgagctccaa
     2221 aacagctgcc cataacctct ctgctaaggt caggaccctg ggctctctgc agcttggcca
     2281 agggactctt cccagaggcc tgttctgagt tcctccactc agtggccagg tttcttgcca
     2341 cctttgtcta tagcaggcag ataggttccc cagcctaccg tcagctgagc tgtgcgaggt
     2401 tccaggatgt ctctcagtgc aagtagtgct gtgatacccc agacaccatg tgagcgtgtg
     2461 ctctagacct ggtgtgtgtg agtgtgtgtg tgtgtgtgtg tgtgtgtgta agtgtgagtg
     2521 tgtgtgagtg tgtgtgtgtg tgagtgtgag tgtgagtgtg tgtgtgtgtg tatgtgtgtg
     2581 tgtgtgtgtg tgtgtgtgtg tgtgagtgtg tgtgtgtgtg tgtgtgtgtg tgagtgtgtg
     2641 tgtgtgttct ctacatgggg gtgccaggga ttctgttcca ttttaaatgg gttccttcca
     2701 ttccctgcat tcctctcttt actgttcctg cgtccccctc tgtcgacctc actctctctg
     2761 ccgtttctaa gcccctaccc cctcctttct gttgctgctg tgagcgcctg tttgccttct
     2821 ccgttcactc accactttgc ctgtttggtt ttggttttgt cttctgtttg attttctgct
     2881 ctatctttgc tttgagattg gtgaggactt tgccttttgc tctgccacac tttctgacct
     2941 tcctgcttag atgctagttc cagataggtt ttgtacattg cagacatgag tccactcctg
     3001 caccccttac cagagcttat ttttctccac ctcctgggac caacctgagg ctgagcaggc
     3061 taaagcagcc ttgaatgttg ccttggtgca tgctgctcca gacacatcca gcagggagca
     3121 gtagcacctt ggtaacatcc ctggctttgt ggggaggtgg gggtgctttc tacattccct
     3181 aatccatctt tagggttggg tgtttcatcc catttctgtg aactccctct cttgcttttc
     3241 tcaagctggt tttatttttt atcttgttct acctttcttt ctggggactt ccccttccct
     3301 ccacctccag agtttgtggt gttacagtgg tatctgcagt tctgaagtgg gtttttttct
     3361 ttttgctttc tctggaatgt agactgtaca tgtttaataa cttgccttct ctatccttgc
     3421 tcaaaaatgt gggataatgc aatgactgtg ccctggttgg aaattaaact tgttttacgc
     3481 a
//
