LOCUS       NM_001304574            2269 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ARF GTPase 2 (Arf2), transcript variant 2, mRNA.
ACCESSION   NM_001304574 XM_006532043
VERSION     NM_001304574.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Matsuki,T., Hamada,N., Ito,H., Sugawara,R., Iwamoto,I., Nakayama,A.
            and Nagata,K.I.
  TITLE     Expression analysis of type I ARF small GTPases ARF1-3 during mouse
            brain development
  JOURNAL   Mol Biol Rep 51 (1), 106 (2024)
   PUBMED   38227057
  REMARK    GeneRIF: Expression analysis of type I ARF small GTPases ARF1-3
            during mouse brain development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Vazquez,P., Hernandez-Sanchez,C., Escalona-Garrido,C., Pereira,L.,
            Contreras,C., Lopez,M., Balsinde,J., de Pablo,F. and Valverde,A.M.
  TITLE     Increased FGF21 in brown adipose tissue of tyrosine hydroxylase
            heterozygous mice: implications for cold adaptation
  JOURNAL   J Lipid Res 59 (12), 2308-2320 (2018)
   PUBMED   30352954
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Juriloff,D.M., Harris,M.J., Dewell,S.L., Brown,C.J., Mager,D.L.,
            Gagnier,L. and Mah,D.G.
  TITLE     Investigations of the genomic region that contains the clf1
            mutation, a causal gene in multifactorial cleft lip and palate in
            mice
  JOURNAL   Birth Defects Res A Clin Mol Teratol 73 (2), 103-113 (2005)
   PUBMED   15690355
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Juriloff,D.M., Harris,M.J. and Dewell,S.L.
  TITLE     A digenic cause of cleft lip in A-strain mice and definition of
            candidate genes for the two loci
  JOURNAL   Birth Defects Res A Clin Mol Teratol 70 (8), 509-518 (2004)
   PUBMED   15329828
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Shiba,T., Kawasaki,M., Takatsu,H., Nogi,T., Matsugaki,N.,
            Igarashi,N., Suzuki,M., Kato,R., Nakayama,K. and Wakatsuki,S.
  TITLE     Molecular mechanism of membrane recruitment of GGA by ARF in
            lysosomal protein transport
  JOURNAL   Nat Struct Biol 10 (5), 386-393 (2003)
   PUBMED   12679809
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Schurmann,A., Breiner,M., Becker,W., Huppertz,C., Kainulainen,H.,
            Kentrup,H. and Joost,H.G.
  TITLE     Cloning of two novel ADP-ribosylation factor-like proteins and
            characterization of their differential expression in 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (22), 15683-15688 (1994)
   PUBMED   8195219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY129623.1, AK042977.1 and BY683617.1.
            
            On Feb 15, 2015 this sequence version replaced XM_006532043.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042977.1, AK167133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY129623.1         1-14
            15-2253             AK042977.1         3-2241
            2254-2269           BY683617.1         362-377
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.64 cM"
     gene            1..2269
                     /gene="Arf2"
                     /note="ARF GTPase 2"
                     /db_xref="GeneID:11841"
                     /db_xref="MGI:MGI:99595"
     exon            1..103
                     /gene="Arf2"
                     /inference="alignment:Splign:2.1.0"
     exon            104..270
                     /gene="Arf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..668
                     /gene="Arf2"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ADP-ribosylation factor 2"
                     /protein_id="NP_001291503.1"
                     /db_xref="CCDS:CCDS25525.1"
                     /db_xref="GeneID:11841"
                     /db_xref="MGI:MGI:99595"
                     /translation="MGNVFEKLFKSLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNE
                     AREELTRMLAEDELRDAVLLVFVNKQDLPNAMNAAEITDKLGLHSLRQRNWYIQATCA
                     TSGDGLYEGLDWLSNQLKNQK"
     exon            271..381
                     /gene="Arf2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..506
                     /gene="Arf2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..2269
                     /gene="Arf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arf2"
                     /note="hexamer: AATAAA"
     polyA_site      2256
                     /gene="Arf2"
                     /note="major polyA site"
ORIGIN      
        1 agccagtcgc cattttattg aggcaaaccg aattcctcac agcggccgcg gccgagtagc
       61 gttttcgtga gtggctttgt gaaggtgttc gctgcggaga caggttgcag aattcagcta
      121 caatggggaa tgtctttgaa aagctgttta aaagcctatt tgggaaaaag gaaatgcgga
      181 ttctcatggt gggcttagat gcagctggca aaacgacgat cttgtacaaa ttgaagctag
      241 gagagattgt gacaaccatc cctaccatag gtttcaatgt ggagacagta gagtacaaaa
      301 acatcagctt cacagtctgg gatgttggtg gccaggacaa aattagacct ttgtggcgac
      361 attacttcca gaacactcaa ggtctgattt tcgtggttga cagtaatgac cgagagcggg
      421 tcaatgaggc ccgggaagaa ttgaccagaa tgctagcaga agatgagctc agagatgcag
      481 tcttgttggt gtttgtaaac aaacaggatc ttcctaatgc tatgaatgca gcagagatca
      541 cagacaagct tggcttacac tcccttcgcc agagaaactg gtacattcag gctacctgtg
      601 cgaccagtgg agatgggctt tacgaaggcc tggactggct ctccaaccag ctcaaaaacc
      661 agaagtgatc agaagcaacc cattccccat gcattgtggc aaagccagct ggcctttccc
      721 gtgtgcatgt gagcgtgtga ggagcccagg gggctgtgtg gctggagtgg gggcagcttt
      781 ctcacaccgt gccttataca cgctatacga aaaccagtat tccattttaa gaaaaccagt
      841 gttacatttt gaatgctacc ttccatttca ctagctttga tggtcatttt tgctgaggcc
      901 tccctgggtg tgatagccag agaatctcta gcctggaaaa gaagaaagca ggagccagac
      961 aggtcctgtt gttgccaacc tgggtctggc ctctccatac acccagaatt ctgttggacg
     1021 tcagtgtcct tttataaaag gaaaggaagg atctgtcatt ctttccattg tgccaaagct
     1081 agcagctcac ttgtagtgct ttaaagctcc cgagaagaaa agatgcatta ttaccacggg
     1141 tgtgaggaag ttcagaggga ctacttcccc aaagttctgt tagctcagac tgactcattt
     1201 aggtggtttt agcccaagga atcagtgacc tttttcatta gagtatcaag actgtaacac
     1261 tagagaagtt tccagcctgc tccaaacgtg ccaaatggaa actctgtggg ctgctggccc
     1321 agcaggaggc aggactcttc ccttaagcct catggtccac ggtggagtga aggttggctg
     1381 gaggaagtga agggaggtag ctcttgtgtt ctggcgtcat ggctcaggcc cttgaggctg
     1441 ctgctcccac ttctctgctc tgtgctgagt gttgttcaca tgaagcagac agttgtcctg
     1501 ggtggagttg tcactgtgtc ccgttgtccc agtctactgt aggcatttgg ttagtatctg
     1561 tttccagaac tgcgcaccgt gagttctgag agtttgtgag aaagtcggga ggttaatgta
     1621 ggagatgatg ttcccagtgg ccccgatact ccctgagatg gtgctaaact gtgctccgag
     1681 aagcatcttt cacttagact gctctcgagg cataggctcc ctcctcaatg gcagcggcat
     1741 ctgaagagtg gcttggaagt gtgtgctgtg ttgtcttgca gatgtagtga taggaaggcc
     1801 cagagaggag ctggcttcag ccctaagccc tctggccaca cagctctggg ccacatttgt
     1861 acctaagccc ttttactgct taacgtttta aaactccttt cagaaaaaaa ttgatccctg
     1921 ctgctacagg agggggaaca caagctgaac ttcaaataaa tcttgttcat tggtaacaaa
     1981 gttatactag gaaaaaattc catgccattg taaatgtggg ctgtaatgtt tttctttaaa
     2041 aagtatctta aagaatgttc attgcaatac tggtgactaa gtccagatgt gatttttaat
     2101 cacagatgaa ttcctgagaa atgttgaaat tgtacacctc ccattggctg ggagctcttg
     2161 ccctttgtaa ttatgcttag tgtgcctggc ctggtgctgg gctgcggtaa acatgtggtg
     2221 attggttaga caataaagaa cttactggga agtagacatg gtcatgttc
//
