LOCUS       NM_001130408            2046 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ARF GTPase 1 (Arf1), transcript variant 1, mRNA.
ACCESSION   NM_001130408
VERSION     NM_001130408.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Matsuki,T., Hamada,N., Ito,H., Sugawara,R., Iwamoto,I., Nakayama,A.
            and Nagata,K.I.
  TITLE     Expression analysis of type I ARF small GTPases ARF1-3 during mouse
            brain development
  JOURNAL   Mol Biol Rep 51 (1), 106 (2024)
   PUBMED   38227057
  REMARK    GeneRIF: Expression analysis of type I ARF small GTPases ARF1-3
            during mouse brain development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2046)
  AUTHORS   Zhang,K.H., Zou,Y.J., Shan,M.M., Pan,Z.N., Ju,J.Q., Liu,J.C.,
            Ji,Y.M. and Sun,S.C.
  TITLE     Arf1 GTPase Regulates Golgi-Dependent G2/M Transition and Spindle
            Organization in Oocyte Meiosis
  JOURNAL   Adv Sci (Weinh) 11 (4), e2303009 (2024)
   PUBMED   38014604
  REMARK    GeneRIF: Arf1 GTPase Regulates Golgi-Dependent G2/M Transition and
            Spindle Organization in Oocyte Meiosis.
REFERENCE   3  (bases 1 to 2046)
  AUTHORS   Ma,H., Fang,W., Li,Q., Wang,Y. and Hou,S.X.
  TITLE     Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal
            Complex in DC to Enhance Anti-Tumor Immunity
  JOURNAL   Adv Sci (Weinh) 10 (32), e2305089 (2023)
   PUBMED   37786300
  REMARK    GeneRIF: Arf1 Ablation in Colorectal Cancer Cells Activates a Super
            Signal Complex in DC to Enhance Anti-Tumor Immunity.
REFERENCE   4  (bases 1 to 2046)
  AUTHORS   Yu,D., Dai,Q., Wang,Z., Hou,S.X. and Sun,L.V.
  TITLE     ARF1 maintains intestinal homeostasis by modulating gut microbiota
            and stem cell function
  JOURNAL   Life Sci 328, 121902 (2023)
   PUBMED   37392777
  REMARK    GeneRIF: ARF1 maintains intestinal homeostasis by modulating gut
            microbiota and stem cell function.
REFERENCE   5  (bases 1 to 2046)
  AUTHORS   Wang,G., Yin,W., Shin,H., Tian,Q., Lu,W. and Hou,S.X.
  TITLE     Neuronal accumulation of peroxidated lipids promotes demyelination
            and neurodegeneration through the activation of the microglial
            NLRP3 inflammasome
  JOURNAL   Nat Aging 1 (11), 1024-1037 (2021)
   PUBMED   37118341
REFERENCE   6  (bases 1 to 2046)
  AUTHORS   Jacques,K.M., Nie,Z., Stauffer,S., Hirsch,D.S., Chen,L.X.,
            Stanley,K.T. and Randazzo,P.A.
  TITLE     Arf1 dissociates from the clathrin adaptor GGA prior to being
            inactivated by Arf GTPase-activating proteins
  JOURNAL   J Biol Chem 277 (49), 47235-47241 (2002)
   PUBMED   12376537
  REMARK    GeneRIF: termination of Arf1 signals mediated through GGA require
            that Arf1.GTP dissociates from GGA prior to interaction with GAP
            and consequent hydrolysis of GTP
REFERENCE   7  (bases 1 to 2046)
  AUTHORS   Shvarts,A., Brummelkamp,T.R., Scheeren,F., Koh,E., Daley,G.Q.,
            Spits,H. and Bernards,R.
  TITLE     A senescence rescue screen identifies BCL6 as an inhibitor of
            anti-proliferative p19(ARF)-p53 signaling
  JOURNAL   Genes Dev 16 (6), 681-686 (2002)
   PUBMED   11914273
  REMARK    GeneRIF: A senescence rescue screen identifies BCL6 as an inhibitor
            of anti-proliferative p19(ARF)-p53 signaling
REFERENCE   8  (bases 1 to 2046)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
REFERENCE   9  (bases 1 to 2046)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
REFERENCE   10 (bases 1 to 2046)
  AUTHORS   Schurmann,A., Breiner,M., Becker,W., Huppertz,C., Kainulainen,H.,
            Kentrup,H. and Joost,H.G.
  TITLE     Cloning of two novel ADP-ribosylation factor-like proteins and
            characterization of their differential expression in 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (22), 15683-15688 (1994)
   PUBMED   8195219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645854.10.
            
            On Nov 15, 2022 this sequence version replaced NM_001130408.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152479.1, SRR13948564.5203595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AL645854.10        211219-211559       c
            342-525             AL645854.10        196683-196866       c
            526-636             AL645854.10        196486-196596       c
            637-761             AL645854.10        196164-196288       c
            762-2046            AL645854.10        194754-196038       c
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.05 cM"
     gene            1..2046
                     /gene="Arf1"
                     /note="ARF GTPase 1"
                     /db_xref="GeneID:11840"
                     /db_xref="MGI:MGI:99431"
     exon            1..341
                     /gene="Arf1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..525
                     /gene="Arf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..923
                     /gene="Arf1"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ADP-ribosylation factor 1"
                     /protein_id="NP_001123880.1"
                     /db_xref="CCDS:CCDS24765.1"
                     /db_xref="GeneID:11840"
                     /db_xref="MGI:MGI:99431"
                     /translation="MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVT
                     TIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNE
                     AREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCA
                     TSGDGLYEGLDWLSNQLRNQK"
     exon            526..636
                     /gene="Arf1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..761
                     /gene="Arf1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..2046
                     /gene="Arf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2024..2029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arf1"
                     /note="hexamer: AATAAA"
     polyA_site      2046
                     /gene="Arf1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggagcga aaccaacgcc tggctgggag cagccgccgc ggaggtgaga cgcggggcgc
       61 gctgaggccg aaactgggga ggccgcgggc tggtcatcgt gggagtcaag ggggcgctca
      121 gctgcggctg ctaaggaccg agtccggtcg ggcggcctga ggtctatgct cagtgagctc
      181 ggcggcaggc cggacagagg atcgggacgc cccggagtcc cgcgtcgccc acggccgctt
      241 ggccctcccc cactccgcgg cccttacgcc tgcctggccg cccgccgcgg gccgcagccc
      301 ggaagtccgg ccaggacgcc ggctcttctc caggaagcca ggtctttggc cagtatcgat
      361 tccacctgtc cacaaacatg gggaatatct ttgcaaacct cttcaagggc ctttttggca
      421 aaaaagaaat gcgcattctc atggtgggcc tggatgctgc agggaagaca acaattctat
      481 acaaacttaa gctgggcgaa attgtgacca ccattcccac cattggtttc aatgtggaga
      541 ctgttgaata caagaatatc agcttcaccg tgtgggatgt gggcggccag gacaagatcc
      601 ggccgctgtg gcgccactac ttccagaaca cccaaggctt gatcttcgta gtggacagca
      661 atgacagaga gcgtgtgaac gaggcccgtg aagagctcat gaggatgcta gctgaagatg
      721 agctccgaga tgctgttctc ttggtgtttg ccaacaagca ggacctcccc aatgccatga
      781 atgcggccga aatcacagac aagctggggc tgcactctct acgccacagg aactggtaca
      841 ttcaggccac ctgtgccacc agcggggacg ggctctatga aggactagat tggctgtcta
      901 atcagctccg gaaccagaag tgaaccagac ccctccctcc ccctcacttc ctcttctccg
      961 ccctcagctt tcctctcatg tggcaaacgt gcgactctgt ggtcctgagt gccagaagct
     1021 gtctccatgg gttggtcaca gtgtgcatcg caccgtgctg tacatgtgca gacgcagcct
     1081 gcagccaggt ttttatttaa tgtaaatagt ttctgtttcc actgaggcag tttctggtac
     1141 tcctatgcaa tattacttag cttttttatt gtaaaaagag aatcaactca actgtcagta
     1201 ctgagaaggg atttgggtgt aggggcacct ggcctccggg agccattggg ctgtagactg
     1261 gtgtcggtat ccatttggtg gttggttttt aacccaaact cagtgcattt tttaaaaata
     1321 gttaaaaata caggacaaga acacttgaac acacagaacg gagactatgc ctagtgtagg
     1381 ttttgcagtt aatggcctga atgctagata tcagatcacc tgtttcgctg tgggaacagg
     1441 agagaaggtg atgaacaaac caccatccgc tgcatggtca cagtagagcc cccgtgactc
     1501 gcctgtcttt gggtcacctg cattccatag cattgtgctt gtacttgtgc tcacacggtt
     1561 acctagggta ggctgggagc cattgtgggg tgcagggcct ggcttgtact tggtgtgtgc
     1621 aaggcccaat ggcagcctgc atacccagcc tactcttggg cccacttgga cgcgctggca
     1681 ggaggcctgg gtctcaccag caggagtgcg tgcaaggtgg gagggtcggt ccattacaga
     1741 cccacatcct ggagcacccc catctccatg tgtgaagtag cttcctccct cagcctgcaa
     1801 gggtccgatt tgccatcgaa agacgacctc tacttttttc ttttgtattt tgataaacac
     1861 tgaagaagct ggagctgtta aatttatctt ggggaaatct cagaactggt ttatttggtg
     1921 tcgtggaacc tcttaccgct ttcaatacac aattagtaat caactgtttt gtatacttgt
     1981 tttcagtttt catttcgaca agcactgtaa ttatagctgt tagaataaag tctcttaact
     2041 atttga
//
