LOCUS       NM_178065               5405 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus apoptosis resistant E3 ubiquitin protein ligase 1
            (Arel1), transcript variant 1, mRNA.
ACCESSION   NM_178065
VERSION     NM_178065.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5405)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5405)
  AUTHORS   Lear,T.B., McKelvey,A.C., Evankovich,J.W., Rajbhandari,S.,
            Coon,T.A., Dunn,S.R., Londino,J.D., McVerry,B.J., Zhang,Y.,
            Valenzi,E., Burton,C.L., Gordon,R., Gingras,S., Lockwood,K.C.,
            Jurczak,M.J., Lafyatis,R., Shlomchik,M.J., Liu,Y. and Chen,B.B.
  TITLE     KIAA0317 regulates pulmonary inflammation through SOCS2 degradation
  JOURNAL   JCI Insight 4 (19), 129110 (2019)
   PUBMED   31578312
  REMARK    GeneRIF: KIAA0317 regulates pulmonary inflammation through SOCS2
            degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5405)
  AUTHORS   Lear,T., McKelvey,A.C., Rajbhandari,S., Dunn,S.R., Coon,T.A.,
            Connelly,W., Zhao,J.Y., Kass,D.J., Zhang,Y., Liu,Y. and Chen,B.B.
  TITLE     Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through
            SUMO-E3 ligase PIAS4
  JOURNAL   J Exp Med 213 (6), 1029-1046 (2016)
   PUBMED   27162139
  REMARK    GeneRIF: new protein isoform encoded by KIAA0317, termed
            fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates
            the TGFbeta signaling pathway through the site-specific
            ubiquitination of PIAS4.
REFERENCE   4  (bases 1 to 5405)
  AUTHORS   Kim,J.B., Kim,S.Y., Kim,B.M., Lee,H., Kim,I., Yun,J., Jo,Y., Oh,T.,
            Jo,Y., Chae,H.D. and Shin,D.Y.
  TITLE     Identification of a novel anti-apoptotic E3 ubiquitin ligase that
            ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC,
            HtrA2, and ARTS
  JOURNAL   J Biol Chem 288 (17), 12014-12021 (2013)
   PUBMED   23479728
REFERENCE   5  (bases 1 to 5405)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   6  (bases 1 to 5405)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ128427.1, BC079590.1, BC060658.1 and AW045956.1.
            
            On Jun 12, 2018 this sequence version replaced NM_178065.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154529.1, BC079590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CJ128427.1         39-43
            6-2571              BC079590.1         1-2566
            2572-5397           BC060658.1         2178-5003
            5398-5405           AW045956.1         15-22               c
FEATURES             Location/Qualifiers
     source          1..5405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.46 cM"
     gene            1..5405
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /note="apoptosis resistant E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:68497"
                     /db_xref="MGI:MGI:1915747"
     exon            1..221
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            222..550
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            551..611
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..3067
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /EC_number="2.3.2.26"
                     /note="apoptosis-resistant HECT-type E3 ubiquitin
                     transferase 1"
                     /codon_start=1
                     /product="apoptosis-resistant E3 ubiquitin protein ligase
                     1"
                     /protein_id="NP_835166.3"
                     /db_xref="CCDS:CCDS26051.1"
                     /db_xref="GeneID:68497"
                     /db_xref="MGI:MGI:1915747"
                     /translation="MFYVIGGIIVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDR
                     TIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHI
                     SHVELAVDIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQP
                     GMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHSYSLAIHEL
                     GPQEEENNEVSFEKSVTSNRQTCQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVL
                     SENEKNIVERNVSTSGVSIYFEAYLYNANNCTSTPWHLPPMHMSSSQRRPSTAIEEDD
                     EDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGP
                     DPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQREL
                     RQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRR
                     EWFELICKALFDTTSQLFARFTDSNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYES
                     SLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELV
                     FAEEKYNKSGQLDKIVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKG
                     LNELVPENLLAIFDENELELLMCGTGDINVSDFKAHAVVVGGSWHFREKVMRWFWAVV
                     SSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPT
                     YDSYEEVHRMLQLAISEGCEGFGML"
     exon            612..838
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1076
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1246
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1427
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1675
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1753
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1895
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2017
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2093
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2203
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2383
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2509
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2639
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2698
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2788
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2964
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..5405
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5375..5380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /note="hexamer: AATAAA"
     regulatory      5392..5397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5397
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
                     /note="major polyA site"
     polyA_site      5405
                     /gene="Arel1"
                     /gene_synonym="1110018G07Rik"
ORIGIN      
        1 gtaaaagctc cgagccggct cctaacgctg gcggagatcg acactggaga tttttttggg
       61 gggcgggtgg agggtaggat ttgtgctgga tgaggccgct gcttcctcgg accccagaac
      121 taggacttgg ccacgttgca gcccccgttc gggtaacgtt tttcttcacg ccgcagccgg
      181 aggcagagcc cagccgaccg taggcaccag aattgctgaa ggaggatcct ggttccagaa
      241 cagatgcctc tttcagcatt ggttacatct ttcgctagag gagcccagga atgatacttt
      301 cttgggctct atttcttcac ccagcattca aatgcttcag tccaaaacca cttgactctt
      361 tgcttcctgg gacacactta acctcaatga agatttggag ggcagatcct ttctggtgac
      421 tttttggcct tttctttttc ttttcttttt ttttttttca aatgtgcaag ttagaagaca
      481 agtgaaagga gtggaaagtt gctgctttgg tgaataactt ggttcttaga acatgggccc
      541 tcgcttaaag ttgcagctgt gatcctcggc tgtccggtgg cgttgaagag acctgatgtt
      601 ttacgttatt ggtggaatca tagtgtctgt ggttgcattc ttcttcacaa ttaagttcct
      661 ctttgagctt gccgcacgtg tagtcagctt tcttcagaat gaagaccgtg agcgccgagg
      721 ggaccggact atttatgact acgtgcgggg aaattacctg gatccccggt cctgcaaagt
      781 gtcctgggat tggaaggacc cctatgaggt gggccacagc atggccttcc gagtgcattt
      841 gttctataag aatggacagc ctttccctgc acatcggccc gtgggactgc gggttcacat
      901 ctctcacgtt gaactagcag tggacattcc agtgacccag gaagtcctcc aggagccgaa
      961 ttctaacgtg gtgaaggtgg ccttcactgt gcgcaaggct gggcgctatg agatcactgt
     1021 gaagttgggt ggcttaaatg tggcctatag tccctactac aaaatttttc agcctggaat
     1081 ggtggttcct tccaaaacaa aaattgtgtg ccatttttct actctggtgt tgacgtgtgg
     1141 gcagccacac actctgcaga tagtgccccg agatgagtat gacaacccaa ccaacaattc
     1201 catgtccctg agagatgagc acagctacag cttagccatt cacgagcttg gtcctcaaga
     1261 agaagagaat aatgaagtct catttgagaa gtcagtgacg tccaacaggc agacttgcca
     1321 ggtgttcttg cggctcaccc tgcattcccg aggttgcttc catgcctgca tttcatatca
     1381 gaaccaaccc atcaataatg gcgaatttga cattattgtc cttagtgaga atgagaagaa
     1441 tattgttgaa cgaaatgtgt ccacctcagg agtgagcatt tactttgagg cttaccttta
     1501 caatgctaac aactgtacca gcacaccatg gcatcttcct cccatgcaca tgagctcttc
     1561 tcaacgccgg ccctccactg ctattgagga ggacgatgaa gactcaccct cagagtgtca
     1621 cacccctgag aaggtgaaga aaccgaagaa ggtgtactgc tatgtgtcac caaagcaatt
     1681 ctctgtgaag gaattctacc tgaaaatcat cccctggcgc ctctacacct tccgagtgtg
     1741 cccaggaaca aagttttcat accttggccc tgaccctgtt cacaagctcc tcacgctggt
     1801 ggtggatgac ggcattcagc ctccagtgga gctcagctgt aaagaaagga atatcctagc
     1861 agccactttc atccgttcct tgcacaagaa cattggaggc tctgagacct ttcaagacaa
     1921 ggtgaacttt ttccagagag agcttcggca ggtacatatg aagagacctc attccaaagt
     1981 cactctgaag gtcagcagac acgccttgtt ggagtcgtct ttgaaggcca ctcggaactt
     2041 ttccatctca gactggagca agaactttga agtagttttc caggatgagg aagctttgga
     2101 ttggggaggg cctcgccggg aatggtttga gctaatctgc aaagcactgt ttgacaccac
     2161 cagtcagctc ttcgcccggt tcactgacag caaccaagca ctagtgcatc ctaaccctaa
     2221 ccgcccggct cacctgcgct tgaagatgta tgagtttgca gggcggctgg tgggcaagtg
     2281 tttgtatgaa tcctctctag ggggagccta caagcagttg gtccgtgccc ggttcactcg
     2341 gtctttcctg gcccaaatca taggactccg tatgcattac aagtactttg aaacggatga
     2401 cccagaattc tataagtcca aggtgtgctt tatcctcaac aatgacatga gtgagatgga
     2461 gctggtcttt gcagaagaga aatacaacaa atcaggtcaa ctggataaga ttgtagaact
     2521 catgacaggc ggagctcaaa ccccagtcac caatgcaaat aaaatcttct atttaaacct
     2581 gctggctcag tatcggctgg ccagtcaagt gaaagaggag gtggagcatt tcctgaaagg
     2641 cttgaatgag ctggttcctg agaacctcct ggctattttt gatgagaatg agcttgagct
     2701 gctgatgtgt gggactggag acatcaatgt atctgacttc aaagcccatg ctgtagtggt
     2761 tggtggatcc tggcatttca gagaaaaggt catgaggtgg ttttgggctg tggtttccag
     2821 tctgacccag gaggaactgg ctaggctgct tcagtttaca acaggctctt ctcagctccc
     2881 acctggagga tttgctgccc tctgtccctc atttcagatt attgctgctc caacccatag
     2941 cacgcttcct actgcacaca catgttttaa ccaactgtgc ctccctacat atgactcata
     3001 tgaagaggtg cacaggatgc tacagctggc catcagtgag ggttgcgagg gctttggcat
     3061 gctctgaccg ctcctctgtc acctgcttgg ctcccaagct ctctagagca tctggacaca
     3121 tgttaacaag catagccact gaccttaacc acaaccatta gccagaagat actgcatgct
     3181 cccttgtgtc tggagtattc tgtcatctgc aagccctgtt cttacctcac ctgtccacgt
     3241 tcaccacagg ccacttgagc acgtggcacc tatctgagct ctactcagtc atgagaggag
     3301 gaccatgctg ctgtcacttc gttggtccct tgaagatctc tgtgaccgga tctgcctccg
     3361 tggctgggag acattcataa cacagaggac tcagttctgt tggaaagcca gcatgtgaga
     3421 cccttccacc atgcctcatt ccagccctcc ttgagctcac tacttgacca gactgggtaa
     3481 tgcatcacct cttctcatca gtggtcagga gaagtgcagc tagaaagtgg cccacacaag
     3541 ccgtctgatt tgtcctccca cataatggca ggcacaggcc atggcactgg attagttctc
     3601 atggggactg gtagtacaaa aggatgtctt taaggtgaca gaactggaaa agatactccc
     3661 tgtgggcatt tttaaagatg atcattaatc tataaggaat ttgctaagct ttctcttgaa
     3721 tttgagccag tgagaaaagc agtcagaaga atgtgaagga tgtctgcgct gcagcctcca
     3781 gtgctgggta cgcttctctc gtggggaagg gccgtgtcca ggcatgtgga tggcttgaag
     3841 actactgatg ctttcctctg aattgttctt tgcactgaag gaggacttgg actgacctcc
     3901 gacttacata gtttgttaag agctgtcttt agcattctgc tggaagaatt ttgggagcaa
     3961 cagactggga cagagcctgc cagctgtggt ggtgatcttt ggcagtgcta aggcaaagga
     4021 gcggtgaagc cactggggac agacaaggtg gagacccagc agcagtaaat acctagcaat
     4081 tccaaggact tggtttcatc agttaccagg aagtggggga accatggagg gagaacgcta
     4141 tattgggttc acagttacat ggtgatcaaa gagaacttct cagtctccag gaagatagca
     4201 tcttttcatg agtgtttgaa tgaaaacaac acgaaggctc aatatcacat ggatttccca
     4261 gtttctgtct ttaataaggc tttcctacaa gccactattt tccatggggc actcactcag
     4321 aatattacaa gccattttat tgccaaaacc agcaagtaca ccgaatcctg agacaaggca
     4381 gttcttgtga cagtgccttg gcctcctgga agcagtctga gccctcctgt tcccaggatc
     4441 acgagaaaca agctctcctg agctgctaga accctgcctg acctcctttg cagtcatcat
     4501 ctgtcttttc ttggcgtggg tgctcacctc acttatcctc ggggtttggg acctggcatc
     4561 aggacctctc cacccaggat cctccatgcc acatggtcac tgctctcctc agggactggg
     4621 acaaggtgct gccgcctgcc cacagttttc ccaaggaaca cgtacaagat catttagcca
     4681 ctactctgct gcctctcagc ctctgctggg gcttccagct gggtacatgg ctgcttggcc
     4741 gtttggggcg gttcttcctc ctaggttctg caatccaggc tccagcaccc ctctgcagac
     4801 tacacagggg gtcagtgtgt gtgtgtgact agacctctca ttttaagctc tagtcgtagc
     4861 actttttcag agtctcctag gcgctgttgc agcccagctg gggcagctag catgccaggt
     4921 tggtctttag gcaccagagt ctttaacaaa aaaatcctct agtactgtgt ggttttctat
     4981 tcttccagtt cactctcctg actgttcaga agcattttgc tctcttttgc attttctttt
     5041 accttttttt tctaatactg ctttggtact agccagtgtg gggaagagat acagtatgtt
     5101 ggacagataa aaacatgtgt tatttcttgg tcaattttct attcatattc cttattttgg
     5161 ccagttcttt tgtttgtgct ttgtaacata ggtacttggg agaccagctg ccctcctggc
     5221 ttttggcttt ttggtgtcct tgaaggagac cagtcatgag taccaaggaa tttgtcagct
     5281 tggttctaga acttagcaga ggttgagctc tgctgcacat tggcagacca ggtcaggatg
     5341 tctgcagttg gagatgtaaa tattttgtac agtaaataaa atgcctacaa taataaagag
     5401 ctaaa
//
