LOCUS       NM_009704               1215 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus amphiregulin (Areg), mRNA.
ACCESSION   NM_009704
VERSION     NM_009704.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1215)
  AUTHORS   Ke,X., van Soldt,B., Vlahos,L., Zhou,Y., Qian,J., George,J.,
            Capdevila,C., Glass,I., Yan,K., Califano,A. and Cardoso,W.V.
  TITLE     Morphogenesis and regeneration share a conserved core transition
            cell state program that controls lung epithelial cell fate
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39667932
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1215)
  AUTHORS   Zhao,R., Wang,Z., Wang,G., Geng,J., Wu,H., Liu,X., Bin,E., Sui,J.,
            Dai,H. and Tang,N.
  TITLE     Sustained amphiregulin expression in intermediate alveolar stem
            cells drives progressive fibrosis
  JOURNAL   Cell Stem Cell 31 (9), 1344-1358 (2024)
   PUBMED   39096904
REFERENCE   3  (bases 1 to 1215)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   4  (bases 1 to 1215)
  AUTHORS   Wachtendorf,S., Jonin,F., Ochel,A., Heinrich,F., Westendorf,A.M.,
            Tiegs,G. and Neumann,K.
  TITLE     The ST2+ Treg/amphiregulin axis protects from immune-mediated
            hepatitis
  JOURNAL   Front Immunol 15, 1351405 (2024)
   PUBMED   38571949
  REMARK    GeneRIF: The ST2[+] Treg/amphiregulin axis protects from
            immune-mediated hepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1215)
  AUTHORS   Li,N., Xia,N., He,J., Liu,M., Gu,M., Lu,Y., Yang,H., Hao,Z.,
            Zha,L., Wang,X., Wang,W., Hu,D., Hu,J. and Cheng,X.
  TITLE     Amphiregulin improves ventricular remodeling after myocardial
            infarction by modulating autophagy and apoptosis
  JOURNAL   FASEB J 38 (4), e23488 (2024)
   PUBMED   38358359
  REMARK    GeneRIF: Amphiregulin improves ventricular remodeling after
            myocardial infarction by modulating autophagy and apoptosis.
REFERENCE   6  (bases 1 to 1215)
  AUTHORS   Zaiss,D.M.W., Gause,W.C., Osborne,L.C. and Artis,D.
  TITLE     Emerging functions of amphiregulin in orchestrating immunity,
            inflammation, and tissue repair
  JOURNAL   Immunity 42 (2), 216-226 (2015)
   PUBMED   25692699
  REMARK    Review article
REFERENCE   7  (bases 1 to 1215)
  AUTHORS   Pathak,B.G., Gilbert,D.J., Harrison,C.A., Luetteke,N.C., Chen,X.,
            Klagsbrun,M., Plowman,G.D., Copeland,N.G., Jenkins,N.A. and
            Lee,D.C.
  TITLE     Mouse chromosomal location of three EGF receptor ligands:
            amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF
            (Hegfl)
  JOURNAL   Genomics 28 (1), 116-118 (1995)
   PUBMED   7590736
REFERENCE   8  (bases 1 to 1215)
  AUTHORS   Kenney,N.J., Huang,R.P., Johnson,G.R., Wu,J.X., Okamura,D.,
            Matheny,W., Kordon,E., Gullick,W.J., Plowman,G., Smith,G.H. et al.
  TITLE     Detection and location of amphiregulin and Cripto-1 expression in
            the developing postnatal mouse mammary gland
  JOURNAL   Mol Reprod Dev 41 (3), 277-286 (1995)
   PUBMED   8588926
REFERENCE   9  (bases 1 to 1215)
  AUTHORS   Johnson,S.E., Rothstein,J.L. and Knowles,B.B.
  TITLE     Expression of epidermal growth factor family gene members in early
            mouse development
  JOURNAL   Dev Dyn 201 (3), 216-226 (1994)
   PUBMED   7881126
REFERENCE   10 (bases 1 to 1215)
  AUTHORS   Sonoda,H., Yamaguchi,T. and Watanabe,S.
  TITLE     Androgen-responsive expression and mitogenic activity of
            schwannoma-derived growth factor on an androgen-dependent Shionogi
            mouse mammary carcinoma cell line
  JOURNAL   Biochem Biophys Res Commun 185 (1), 103-109 (1992)
   PUBMED   1318038
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK018590.1 and AC115067.7.
            
            On Aug 5, 2015 this sequence version replaced NM_009704.3.
            
            Summary: This gene encodes a member of the epidermal growth factor
            (EGF) family and preproprotein that is proteolytically processed to
            generate a mature protein product. The encoded protein is a ligand
            of the epidermal growth factor receptor (EGFR) and has been shown
            to play a role in immunity, inflammation, tissue repair, and lung
            and mammary gland development. Homozygous knockout mice for this
            gene exhibit impaired immune system regulation in the skin and gene
            expression changes characteristic of chronic liver damage.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018590.1, BC009138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1206              AK018590.1         1-1206
            1207-1215           AC115067.7         81725-81733
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..1215
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /note="amphiregulin"
                     /db_xref="GeneID:11839"
                     /db_xref="MGI:MGI:88068"
     exon            1..276
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..962
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /note="schwannoma-derived growth factor"
                     /codon_start=1
                     /product="amphiregulin preproprotein"
                     /protein_id="NP_033834.1"
                     /db_xref="CCDS:CCDS19421.1"
                     /db_xref="GeneID:11839"
                     /db_xref="MGI:MGI:88068"
                     /translation="MRTPLLPLARSVLLLLVLGSGHYAAALELNDPSSGKGESLSGDH
                     SAGGLELSVGREVSTISEMPSGSELSTGDYDYSEEYDNEPQISGYIIDDSVRVEQVIK
                     PKKNKTEGEKSTEKPKRKKKGGKNGKGRRNKKKKNPCTAKFQNFCIHGECRYIENLEV
                     VTCNCHQDYFGERCGEKSMKTHSEDDKDLSKIAVVAVTIFVSAIILAAIGIGIVITVH
                     LWKRYFREYEGETEERRRLRQENGTVHAIA"
     exon            277..504
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /inference="alignment:Splign:2.1.0"
     exon            505..706
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /inference="alignment:Splign:2.1.0"
     exon            707..868
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /inference="alignment:Splign:2.1.0"
     exon            869..977
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1215
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1193..1198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /note="hexamer: ATTAAA"
     polyA_site      1213
                     /gene="Areg"
                     /gene_synonym="AR; Mcub; Sdgf"
                     /note="major polyA site"
ORIGIN      
        1 gatcccgctt ccttcgctcc cttctgaccc gcggccaccg cccggacatc tccagctgag
       61 cctgaggcgc tggccgctcc agccgtccgg agcccggcgg gctgggcttc cctgcgccgg
      121 tgctcgcccg ctgctccgtg gttccgctgc tcccgccgcc cggagccgct gtcgtgttgc
      181 tgcagagacc gagacgctgc cggccggtgg aaccaatgag aactccgctg ctaccgctgg
      241 cgcgctcagt gctgttgctg ctggtcttag gctcaggcca ttatgcagct gctttggagc
      301 tcaatgaccc cagctcaggg aaaggcgaat cgctttctgg ggaccacagt gccggtggac
      361 ttgagctttc tgtgggaaga gaggtttcca ccataagcga aatgccttct ggcagtgaac
      421 tctccacagg ggactacgac tactcagagg agtatgataa tgaaccacaa atatccggct
      481 atattataga tgattcagtc agagttgaac aggtgattaa gcccaagaaa aacaagacag
      541 aaggagaaaa gtctacagaa aaacccaaaa ggaagaaaaa gggaggcaaa aatggaaaag
      601 gcagaaggaa taagaagaaa aagaatccat gcactgccaa gtttcagaac ttttgcattc
      661 atggcgaatg cagatacatc gagaacctgg aggtggtgac atgcaattgt catcaagatt
      721 actttggtga acggtgtgga gaaaaatcca tgaagactca cagcgaggat gacaaggacc
      781 tatccaagat tgcagtagta gctgtcacta tctttgtctc tgccatcatc ctcgcagcta
      841 ttggcatcgg catcgttatc acagtgcacc tttggaaacg atacttcagg gaatatgaag
      901 gagaaacaga agaaagaagg aggcttcgac aagaaaacgg gactgtgcat gccattgcct
      961 agctgaggac aatgcagggt aaaagttgaa tcattgccaa gccacaccgg aaatgacatt
     1021 ggtccttctt tcagaaaagg aagtggagct ttcggatggt tccagatgcc cagttgtcac
     1081 tttttatgat agtcttactt ctgtacataa agagatgtgt gaagataaaa tatttttttt
     1141 tcatgttgta aataatttat ttaatattta agtgttattt attttatagc tcattaaact
     1201 ttttttaaac aaaca
//
